Revue du Rhumatisme (Edition Francaise)最新文献

{"title":"Goutte tophacée étendue avec dépôts fessiers","authors":"Chen Li, Fanzhang Meng, Bohan Hu, Zixuan Shu, Zhimin Lin, Shengguang Li","doi":"10.1016/j.rhum.2025.09.018","DOIUrl":"10.1016/j.rhum.2025.09.018","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 572-573"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148693598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ostéoarthropathie hypertrophiante","authors":"Victoire Roblot, Domitille Renard, Sylvie Guan, Valérie Bousson","doi":"10.1016/j.rhum.2025.05.008","DOIUrl":"10.1016/j.rhum.2025.05.008","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 566-567"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ostéochondromes multiples héréditaires","authors":"Maria João Cadório, João Oliveira, André Pinto Saraiva","doi":"10.1016/j.rhum.2025.09.017","DOIUrl":"10.1016/j.rhum.2025.09.017","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 570-571"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148693600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nouvelles options thérapeutiques dans le rhumatisme psoriasique et la spondyloarthrite : l’interleukine-17 livre ses secrets de famille","authors":"Flavia Sunzini, Danai Vossou, Iain B. McInnes","doi":"10.1016/j.rhum.2025.12.004","DOIUrl":"10.1016/j.rhum.2025.12.004","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 467-474"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148693811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nouvelles stratégies thérapeutiques dans l’arthrose","authors":"Md Abu Bakar Siddiq, Win Min Oo, David J. Hunter","doi":"10.1016/j.rhum.2025.12.007","DOIUrl":"10.1016/j.rhum.2025.12.007","url":null,"abstract":"<div><div>Affection arthritique la plus prévalente, l’arthrose est responsable d’une part considérable des douleurs articulaires, handicaps physiques et pertes de mobilité. On recensait à la fin 2020 595 millions de personnes – soit 7,6 % de la population mondiale – souffrant d’arthrose, un chiffre qui devrait augmenter de façon exponentielle d’ici 2050. Si la physiopathologie complexe de cette maladie commence à se clarifier, il reste à trouver un traitement curatif. La prise en charge de l’arthrose consiste en général en mesures palliatives classiques, telles que l’administration d’analgésiques locaux et systémiques, y compris anti-inflammatoires non stéroïdiens, des programmes d’exercices thérapeutiques et le port d’orthèses. Dans certains cas, des injections intra-articulaires de glucocorticoïdes, une viscosupplémentation ou des interventions régénératives apportent un soulagement et un regain de mobilité temporaires ; dans d’autres, une arthroplastie peut être nécessaire. Les efforts de recherche se poursuivent pour découvrir une nouvelle thérapie ciblée efficace dans l’arthrose, capable d’agir sur les symptômes et d’arrêter la progression de la maladie. Cette revue de la littérature fournit des informations sur de nouvelles stratégies thérapeutiques dans l’arthrose : liposomes de dexaméthasone, microsphères de triamcinolone, antagonistes du facteur de croissance des nerfs (NGF), anti-ADAMTS-5 (<em>A Disintegrin And Metalloproteinase with Thrombospoidin Motifs-5</em>), polysulfate de pentosan sodique, cellules souches allogéniques, inhibiteurs du ligand 17 du récepteur CCR4 (<em>C-C chemokine receptor type-4</em>), inhibiteurs de la voie Wnt et médicaments contre l’obésité.</div></div><div><div>Osteoarthritis is the most prevalent arthritis-type and is a major contributor to chronic joint pain, impaired physical function, and limited mobility. By the end of 2020, a total of 595 million, equal to 7·6% of the global population had osteoarthritis; this figure is expected to rise exponentially by 2050. Even while the disorder's intricate pathophysiology is starting to appear intelligible, we are yet to have a cure for the disorder. Osteoarthritis is typically managed with traditional palliative measures, such as, topical and systemic analgesics, including non-steroidal anti-inflammatory drugs, therapeutic exercise, and braces. Sometimes, intra-articular glucocorticoids, viscosupplementation, or regenerative interventions provide short-term pain relief and functional improvement, some may require arthroplasty. Researchers continue their efforts to unveil a new therapeutic target to be effective in OA that modifies symptoms and arrests disease progression as well. In the present literature review, insights into new therapeutic strategies <em>in osteoarthritis, for example, liposome-based dexamethasone, microspore-based triamcinolone, nerve growth factor antagonist, anti-ADAMTS-5 (A Disintegrin And Metalloproteinase Thrombospoidin Motifs – 5), pent","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 549-560"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rôle de l’imagerie dans l’évaluation des dépôts goutteux : de la recherche à la clinique","authors":"Tristan Pascart","doi":"10.1016/j.rhum.2025.12.009","DOIUrl":"10.1016/j.rhum.2025.12.009","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 482-485"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lésion métastatique du talus mimant une monoarthrite","authors":"Arthur Gandiolle, Louis Jaulmes, Lionel Spielmann, Laura Lou Widawski, Laurent Messer, Paul Moreau, Hugo Bergier, Pierre-Marie Duret, Cédric Sztejkowski","doi":"10.1016/j.rhum.2025.06.003","DOIUrl":"10.1016/j.rhum.2025.06.003","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 568-569"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148693599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ce mois-ci dans Joint Bone Spine 2026 (juillet); 93/4","authors":"Marie-Christophe Boissier","doi":"10.1016/j.rhum.2026.04.003","DOIUrl":"10.1016/j.rhum.2026.04.003","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 465-466"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148693812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Métastases osseuses : données épidémiologiques et physiopathologiques récentes","authors":"Emmanuel Massy, Edith Bonnelye, Philippe Clézardin, Cyrille B. Confavreux","doi":"10.1016/j.rhum.2025.09.026","DOIUrl":"10.1016/j.rhum.2025.09.026","url":null,"abstract":"<div><div>Le cancer demeure un problème majeur de santé publique, avec plus de 430 000 nouveaux cas diagnostiqués en France en 2023. Malgré les progrès significatifs en matière de dépistage et de traitement, il représente encore la première cause de mortalité chez l’homme et la deuxième chez la femme. Les métastases osseuses constituent une complication fréquente et redoutée de plusieurs cancers, notamment ceux du sein, de la prostate et du poumon. Elles sont responsables d’une morbidité importante : douleurs osseuses, fractures pathologiques, hypercalcémie, et complications neurologiques et sont difficiles à traiter. En France, l’étude OPTIMOS a estimé à plus de 770 000 le nombre de nouveaux cas de métastases osseuses entre 2009 et 2018, avec une incidence croissante des événements osseux. Ce travail propose une synthèse des données épidémiologiques actuelles, suivie d’une exploration des mécanismes physiopathologiques responsables de la formation des métastases osseuses. La cascade métastatique implique la dissémination des cellules tumorales, leur survie dans la circulation, leur implantation dans la moelle osseuse et leur activation dans un microenvironnement qui leur est propice. La formation de niches pré-métastatiques, les rôles des chimiokines, des ostéoblastes, des ostéoclastes et des facteurs solubles tumoraux sont décrits. Une attention particulière est portée à la destruction osseuse via les mécanismes ostéolytiques, notamment l’axe RANK/RANKL/OPG, les interleukines, la PTHrP, ou encore les protéines inhibant la formation osseuse comme DKK1, SOST et Noggin. Mieux comprendre ces processus permet d’envisager de nouvelles approches thérapeutiques ciblées visant à bloquer l’implantation ou la progression des métastases osseuses.</div></div><div><div>Cancer remains a major public health concern, with over 430,000 new cases diagnosed in France in 2023. Despite significant advances in screening and treatment, it remains the leading cause of death in men and the second in women. Bone metastases are a frequent and serious complication of several cancers, particularly breast, prostate, and lung cancers. They are associated with substantial morbidity, including severe pain, pathological fractures, hypercalcemia, and neurological complications and are difficult to manage. In France, the OPTIMOS study estimated over 770,000 new cases of bone metastases between 2009 and 2018, with increasing incidence of skeletal related events. This paper presents an overview of current epidemiological data, followed by a detailed review of the pathophysiological mechanisms underlying bone metastasis formation. The metastatic cascade involves tumor cell dissemination, survival in circulation, homing to the bone marrow, and activation within a supportive microenvironment. The role of pre-metastatic niches, chemokines, osteoblasts, osteoclasts, and soluble tumor-derived factors is highlighted. Special focus is given to osteolytic mechanisms, including the RANK/RANKL","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 584-591"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peut-on prédire l’évolution individuelle de la maladie ? Apport de l’intelligence artificielle : exemple de la polyarthrite rhumatoïde","authors":"Yves-Marie Pers","doi":"10.1016/j.rhum.2025.12.016","DOIUrl":"10.1016/j.rhum.2025.12.016","url":null,"abstract":"","PeriodicalId":38943,"journal":{"name":"Revue du Rhumatisme (Edition Francaise)","volume":"93 4","pages":"Pages 486-489"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}