Iranian Journal of Psychiatry最新文献

{"title":"Neurocognitive Deficits in Individuals at Ultra-High-Risk for Psychosis: An Overview of Systematic Reviews.","authors":"Farnaz Asadiof, Mona Zamanpour, Ali Fawzi Al-Hussainy, Alhan Abd Al-Hassan Shalal, Mohammed Ubaid, Zinab H Aluquaily, Seyed Hamidreza Hashemian","doi":"10.18502/ijps.v20i1.17405","DOIUrl":"https://doi.org/10.18502/ijps.v20i1.17405","url":null,"abstract":"<p><p><b>Objective:</b> Identifying individuals at ultra-high risk for psychosis (UHRP) is crucial for early intervention and prevention strategies. Neurocognitive deficits have been increasingly recognized as potential predictors of psychosis onset. This overview aims to consolidate current evidence and elucidate the role of neurocognitive predictors in identifying UHRP individuals. <b>Method</b> <b>:</b> we systematically searched three scientific databases, i.e., PubMed, Scopus, and Google Scholar using predefined keywords related to predictive neurocognitive markers and ultra-high risk psychosis. By following the PRISMA procedure, we included all relevant systematic-reviews and meta-analyses in our data-synthesis. <b>Results:</b> Neurocognitive deficits, including impairments in working memory, attentional control, verbal learning, and executive functions, have been consistently identified as predictors of psychosis conversion in individuals at UHRP. Structural and functional neuroimaging studies have further revealed aberrant brain connectivity, reduced gray matter volume, and altered neural activation patterns in key brain regions to be involved in psychosis. Moreover, the combination of neurocognitive and clinical risk factors has been shown to enhance the accuracy of predicting psychosis onset and inform personalized intervention strategies. <b>Conclusion:</b> Neurocognitive deficits serve as valuable predictors of the risk of psychosis in individuals with UHRP, offering insights into the underlying neurobiological mechanisms and potential targets for early intervention. Future research should focus on refining predictive models, elucidating the neurodevelopmental trajectories, and evaluating the efficacy of targeted interventions in mitigating the psychosis risk.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"20 1","pages":"111-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arabic Version of the Leahy Emotional Schemas Scale-II.","authors":"Magda Ghassan Fathy, Khaled Jamal Mandoob","doi":"10.18502/ijps.v20i1.17403","DOIUrl":"https://doi.org/10.18502/ijps.v20i1.17403","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to translate the Leahy Emotional Schemas Scale-II (LESS-II) into Arabic and validate its psychometric properties among Iraqi university students. The hypothesis was that the Arabic version would retain the original factor structure and demonstrate robustness and validity. <b>Method</b>: The process involved translation, cultural adaptation, backward translation, and the bilingual method to ensure linguistic and cultural relevance. The sample consisted of 280 Iraqi university students (64% female, 36% male). Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were conducted to assess the factor structure. Reliability was tested using Cronbach's alpha and test-retest methods. <b>Results:</b> EFA identified a 14-factor structure aligned with Leahy's model, accounting for 91.83% of the total variance. CFA confirmed a good model fit (RMSEA = 0.08, CFI = 0.93, TLI = 0.90). The total scale's reliability (Cronbach's alpha) was 0.82, with test-retest reliability at 0.87. Pearson correlations indicated significant relationships between LESS-II factors, anxiety, and depression, supporting construct validity. <b>Conclusion:</b> The Arabic LESS-II was established as a valid and reliable tool for assessing emotional schemas. However, the study's reliance on a nonclinical sample limits generalizability. Future research should validate the scale in diverse and clinical populations, highlighting its potential utility in Arabic-speaking contexts for both research and clinical practice.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"20 1","pages":"77-92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Somayeh Agmashe, Gita Sadighi, Narges Radman, Robabeh Mazinani","doi":"10.18502/ijps.v20i1.17396","DOIUrl":"https://doi.org/10.18502/ijps.v20i1.17396","url":null,"abstract":"<p><p><b>Objective:</b> Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins - mainly group B vitamins - and the development of schizophrenia. In the present study, we aimed to examine the effect of the B vitamin group as an adjuvant treatment to antipsychotics in individuals with chronic schizophrenia. <b>Method</b> <b>:</b> In a randomized, double-blind clinical trial study, involving two groups of 25 patients with chronic schizophrenia, we compared the effects of a 12-week adjuvant treatment with a combination of B vitamins - B1 (15mg), B2 (15mg), B6 (10mg), B12 (10µg) and nicotinamide (50 mg) - with a placebo. The impact on negative, positive and cognitive symptoms of schizophrenia was assessed for both groups before the intervention (T0) and at 4, 8 and 12 weeks after the intervention (T1, T2, and T3, respectively). <b>Results:</b> Following the treatment, negative symptoms scores decreased in the treatment group at 12 weeks following the beginning of the treatment (F (4, 45) = 464.7, P < 0.0001). Although a trend toward improvement in positive symptoms and cognitive scores was seen, these changes were not significant. <b>Conclusion:</b> Our results suggest that selecting the group B vitamins as an adjuvant treatment to the antipsychotics may have beneficial effects on improving negative symptoms of patients with chronic schizophrenia.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"20 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability Assessment of the Arabic Version of the Social and Emotional Competencies Questionnaire in a Moroccan Nursing Student Population.","authors":"Jamal Ksiksou, Lhoussaine Maskour, Smail Alaoui, Rahma Bouali","doi":"10.18502/ijps.v20i1.17402","DOIUrl":"https://doi.org/10.18502/ijps.v20i1.17402","url":null,"abstract":"<p><p><b>Objective:</b> The Social and Emotional Competencies Questionnaire (SEC-Q) represents one of the existing tests for assessing these competences in students. The purpose of the present research was to examine the psychometric properties of the SEC-Q in Moroccan nursing students. <b>Method</b> <b>:</b> A sample of 320 Moroccan nursing students, including 190 women and 130 men, was selected using a stratified convenience sampling method. Methodology consisted of forward and backward translations, linguistic adaptation, and pilot revision. Structural validity was investigated using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Reliability was assessed through test-retest analysis using Pearson's correlation. <b>Results:</b> Factor analyses produced a four-factor version of 16 items with a range of factor loadings from 0.72 to 0.89. Cronbach's alpha values were 0.92 for the self-awareness factor, 0.91 for the self-management factor, 0.90 for the social awareness factor, and 0.92 for the decision-making factor. These high values indicate excellent reliability. The test-retest coefficient for a 20-day interval between two assessments gave an rtt value of 0.92, demonstrating excellent response reliability. A strong correlation between the SECQ-AV, WLEIS and PSS-CP was found, demonstrating satisfactory convergent and divergent validity (P < 0.05). <b>Conclusion:</b> The Arabic version of SECQ demonstrated its validity and reliability for assessing social and emotional competencies in Moroccan nursing students. However, the sample selected was drawn from a single nursing training institute, which limits the representativeness of the entire student population, and makes it difficult to generalize the results. A cross-sectional study will therefore produce much more varied results, by including a very large sample from different regions and different nursing training institutes in Morocco.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"20 1","pages":"59-76"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the Heritability of Hoarding Symptoms: Insights from a Classical Twin Study \"New Insights on the Nature of Clutter\".","authors":"Sepehr Pourkhalili, Reza Soltani Shal, Abbas Abolghasemi, Minoo Dianatkhah, Mojgan Gharipour","doi":"10.18502/ijps.v19i4.16555","DOIUrl":"10.18502/ijps.v19i4.16555","url":null,"abstract":"<p><p><b>Objective:</b> Hoarding disorder is a complex condition that significantly impacts individuals' lives, characterized by excessive acquiring, difficulty discarding, clutter, distress, and impairment. This study aimed to examine the extent to which genetics and environment influence difficulty discarding, excessive acquisition, and clutter through the implementation of a classical twin study. <b>Method</b> <b>:</b> This classical twin study, conducted between April and September 2021, enrolled 194 twins (97 pairs) from Isfahan, recruited through the Isfahan Twins Registry (ITR). A total of 194 twins, consisting of 100 monozygotic (MZ) and 94 dizygotic (DZ) twins, participated in this study. Participants aged 16-50 were invited electronically and completed an online consent form and questionnaire. Hoarding symptoms were assessed using the saving inventory-revised. Zygosity was determined using a self-report method based on Song <i>et al</i>.'s questionnaire. To estimate the heritability of hoarding symptoms, the classical univariate twin model was employed. <b>Results:</b> Based on the univariate analysis, the heritability estimates for difficulty discarding and excessive acquisition were found to be 0.43 and 0.52, respectively. However, the results did not provide support for the role of genetics in clutter. Instead, it was indicated that the common environment accounted for 0.54 of the variance in clutter, while the specific environment contributed 0.46 to this symptom. <b>Conclusion:</b> The difficulty discarding and excessive acquisition were found to be moderately heritable. On the other hand, considering the contribution of genetics and environment to clutter, the results raise doubts about the association of clutter with hoarding. The relatively low genetic influence suggests that this trait may overlap with other behaviors rather than hoarding.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"424-430"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Key Genes and Approved Medications Associated with Major Depressive Disorder Using Network Analysis and Systems Biology.","authors":"Yasin Parvizi, Seyed Mahdi Sadati, Pedram Porbaha, Shima Masumi, Saeid Mahdian, Seyed Alireza Vafaei, Saeid Afshar","doi":"10.18502/ijps.v19i4.16550","DOIUrl":"10.18502/ijps.v19i4.16550","url":null,"abstract":"<p><p><b>Objective:</b> Major depressive disorder (MDD) stands as one of the serious psychiatric conditions that detrimentally affect patients' quality of life and leads to a significant part of disability worldwide. Due to the limited understanding of the basic molecular mechanisms of depression and antidepressant medications, a clear understanding of the onset and development of MDD is unavailable. This study aims to figure out the pivotal genes and pathways implicated in the MDD development and identify medications that can potentially improve MDD treatment based on their relation with the key genes. <b>Method</b> <b>:</b> Symbols of human coding genes were retrieved from the HUGO Gene Nomenclature Committee database. These symbols were then queried for MDD-related associations using a Python script in PubMed. Subsequently, genes with two or more related articles to MDD were selected. A union of our search data and MDD-related genes in the DisGeNET database was found. The gene interaction network was generated and analyzed utilizing the STRING and Cytoscape, respectively. Finally, a drug-gene network was constructed and medications that can affect multiple genes were selected. <b>Results:</b> The union of our search data and DisGeNET data contained 1734 genes. Based on network analysis, TNF, IL1B, IL6, STAT1, and STAT3 were identified as the key genes in the MDD pathogenesis. Eleven drugs that affect more than one gene were detected through a drug-gene network. These medications include Acitretin, Adalimumab, Alteplase, Cisplatin, Digoxin, Etanercept, Infliximab, Insulin, Omeprazole, Pentoxifylline, and Rabeprazole. <b>Conclusion:</b> In summary, our findings identified five genes as key genes in MDD development, as well as medications related to key genes. This study provides a new vision of the pathogenesis and treatment of MDD. However, further experimental and clinical studies are necessary.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"367-383"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Checking the Validity and Reliability of the Delirium-O-Meter Questionnaire in the Persian Language.","authors":"Saeideh Ghaffarifar, Reza Naghdi Sadeh, Mehrdad Ghaemmaghami, Mohammad Hossein Parchehbaf Mohseni","doi":"10.18502/ijps.v19i4.16554","DOIUrl":"10.18502/ijps.v19i4.16554","url":null,"abstract":"<p><p><b>Objective:</b> Compiling and designing short and practical psychometric tools are among the benefits and strengths of a good standard test. The Delirium-O-Meter questionnaire measures patients' delirium status. Accordingly, the main aim of this research was to check the reliability and validity of the Persian version of this questionnaire. <b>Method</b> <b>:</b> This exploratory psychometric study was conducted from 2021 to 2022 at the therapeutic research training centers of Tabriz University of Medical Sciences. The study population included patients diagnosed with delirium. Content and construct validity were assessed using exploratory factor analysis and confirmatory factor analysis. Exploratory factor analysis was performed using SPSS 18, which helped identify the underlying factor structure, while confirmatory factor analysis in Smart PLS was employed to confirm the structure's fit. Pearson correlation was used to evaluate the consistency between different raters, and Cronbach's alpha was calculated to assess internal consistency. These methods were selected for their robustness in evaluating the instrument's psychometric properties, ensuring the reliability and validity of the Persian version of the Delirium-O-Meter questionnaire. <b>Results:</b> The Persian version of the Delirium-O-Meter questionnaire, consisting of 11 items, demonstrated strong psychometric properties. The average impact factor was 3.24, indicating a high relevance of the items. The content validity ratio was 0.78, and the content validity index was 0.87, both above the acceptable thresholds, confirming the content validity of the questionnaire. Cronbach's alpha coefficient for the entire questionnaire was 0.77, reflecting good internal consistency. The Kaiser-Meyer-Olkin index was 0.88, and Bartlett's sphericity test was significant (χ² = 278.45, P < 0.001), indicating the appropriateness of the data for factor analysis. Exploratory factor analysis revealed two factors that explained 76.09% of the total variance, supporting the questionnaire's construct validity. Additionally, Pearson's correlation coefficient between the assessments of two nurses was 0.91, signifying inter-rater solid reliability. <b>Conclusion:</b> The Persian version of the Delirium-O-Meter questionnaire demonstrates acceptable reliability and validity, as confirmed by the comprehensive psychometric evaluation conducted in this study. The strong internal consistency, significant content and construct validity, and high inter-rater reliability underscore its effectiveness in assessing delirium in Persian-speaking patients. These findings highlight the questionnaire's suitability for clinical use, providing a reliable and valid instrument for accurately diagnosing and managing delirium in diverse healthcare settings.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"412-423"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Association between Coping Styles and Social Identity in Adolescents of Marginal and Non-Marginal Areas.","authors":"Hadis Mosafer, Behnam Khaledi-Paveh, Nader Salari, Mahmoud Rahmati","doi":"10.18502/ijps.v19i4.16551","DOIUrl":"10.18502/ijps.v19i4.16551","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to investigate the relationship between coping styles and social identity among adolescents residing in marginal and non-marginal areas. <b>Method</b> <b>:</b> A cross-sectional study design with a descriptive-analytic approach was utilized. The study population consisted of adolescents aged 12 to 19 from Kermanshah city, with 222 participants evenly distributed between marginal and non-marginal areas. Adolescents were enrolled in the study using a multi-stage sampling method (stratified cluster, simple randomized method). Data were collected using the Standard Social Identity questionnaire and Lazarus and Folkman's Coping Styles questionnaire. The data were analyzed statistically in the SPSS software environment (version 25) using appropriate statistical tests. <b>Results:</b> The results of the study showed that there is a significant relationship between the components of social identity and coping styles in adolescents (P < 0.05). Emotion-focused and problem-focused coping styles had the ability to explain social identity in the adolescents of Kermanshah city. Also, in comparing the coping styles and social identity between adolescents from marginalized and non-marginalized areas in the city of Kermanshah, there was no significant difference (P < 0.05). <b>Conclusion:</b> This study underscores the importance of understanding how coping strategies influence social identity among adolescents across different socio-environmental contexts. The findings highlight the need for further research to explore the mechanisms underlying these relationships and consider the role of contextual factors in shaping adolescent development.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"384-392"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Chronic Exercise on Cognitive Function: An Overview of Reviews.","authors":"Saade Abdalkareem Jasim, Mandeep Singh, Aiman Mohammed Baqir Al-Dhalimy, Ahmed Hussein Zwamel, Israa Abed Jawad, Nagat Salah Shalaby","doi":"10.18502/ijps.v19i4.16561","DOIUrl":"10.18502/ijps.v19i4.16561","url":null,"abstract":"<p><p><b>Objective:</b> Understanding the associations between cognitive function and chronic exercise has gained significant attention in the last decade. This overview aims to consolidate current knowledge and shed light on potential benefits of long-term exercise on cognitive abilities. <b>Method</b> <b>:</b> Relevant databases, including Scopus, PubMed, and Web of Science, were searched through predefined keywords related to chronic exercise and cognitive function. We included all relevant systematic-reviews and meta-analysis in our data-synthesizing. <b>Results:</b> We identified 74 references across PubMed (33), Scopus (35), and Web of Sciences (6). After deduplication, 52 unique references remained. Screening by title and abstract yielded 28 relevant studies. Full-text review based on inclusion criteria resulted in nine eligible articles. Most were meta-analyses, examining 10 to 71 randomized controlled trials on executive functions across various age groups and health statuses. Both acute and chronic exercises demonstrated small to moderate positive effects on cognitive functions, with chronic exercise outcomes influenced by type, duration, frequency, session length, age, and cognitive status. <b>Conclusion:</b> Extensive research underscores a robust and compelling link between involving in regular, long-term physical exercise and enhancement of cognitive functioning. This connection emphasizes the critical role that consistent physical activity plays in safeguarding mental well-being and maintaining sharp cognitive abilities throughout various life stages. Positive effect of sustained physical exercise on cognitive functioning serves as a compelling reason to integrate exercise as a fundamental component of a holistic approach to mental wellness and cognitive longevity.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"463-472"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Relationship between Schizophrenia and Incidence Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Seyyed Muhammad Mahdi Mahdavinoor, Saeed Kargar-Soleimanabad, Amir-Hassan Bordbari, Aghil Mollaei, Leila Seddigh, Sorour Sarihi, Reihaneh FirooziKhojastefar, Raziye Dehbozorgi, Sara Farhang","doi":"10.18502/ijps.v19i4.16559","DOIUrl":"10.18502/ijps.v19i4.16559","url":null,"abstract":"<p><p><b>Objective:</b> Schizophrenia seems to have a complex association with various types of cancer, exerting a protective effect against some cancers while being a risk factor against some others. Therefore, we intended to conduct an updated systematic review and meta-analysis in order to examine the relationship between schizophrenia and the risk of breast cancer incidence. <b>Method</b> <b>:</b> We did a systematic search of databases, namely Web of Science, Scopus, Embase, PubMed, and PsycINFO up to August 15, 2024. Screening and data extraction were performed independently. Data was analyzed using Stata16 software. We used the random effect model to pool the results, while the heterogeneity between studies was calculated using Cochran's Q test and (I²) index. <b>Results:</b> We found 15 studies, among which 12 were included in this meta-analysis. The results indicated that the risk of breast cancer development is significantly increased in women with schizophrenia (SIR: 1.43, 95% CI: 1.08-1.85, P < 0.01; IRR: 1.19, 95% CI: 1.13-1.26, P < 0.01). Subgroup analysis revealed significant differences in the incidence of breast cancer rates among women with schizophrenia based on geographic location and duration of follow-up. <b>Conclusion:</b> The results indicate that schizophrenia increases the risk of developing breast cancer. Therefore, taking preventive measures concerning breast cancer among women with schizophrenia is crucial. Additionally, regular screening programs should be implemented to ensure early diagnosis and treatment in case breast cancer is detected.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"19 4","pages":"441-452"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}