Tunisie Medicale最新文献_第3页

Evaluation of learning abilities after role-playing method: Comparing outcomes of Active and Observer. 角色扮演法后的学习能力评估：比较主动者和观察者的结果

Tunisie Medicale Pub Date : 2024-11-05 DOI: 10.62438/tunismed.v102i11.4996

Olfa Hammami, Khedija Zaouche, Manel Kallel, Mariem Nouira

{"title":"Evaluation of learning abilities after role-playing method: Comparing outcomes of Active and Observer.","authors":"Olfa Hammami, Khedija Zaouche, Manel Kallel, Mariem Nouira","doi":"10.62438/tunismed.v102i11.4996","DOIUrl":"https://doi.org/10.62438/tunismed.v102i11.4996","url":null,"abstract":"Introduction: During a role-play simulation session, despite supporting observer learning, educators disagree about whether the learning outcomes of observers are like those of active participants.Aim: Evaluation of the degree of knowledge acquisition by these two types of learners during the same role-play session.Methods: We carried out a quasi-experimental pre-post intervention study to identify the learning outcomes among learners serving in observer (group 1) and active (group 2) roles during a role-play simulation session.Results: The role play involved 29 learners. In both groups, 65% of learners improved their overall score. The median post-test score was significantly higher in both groups (p=0.0001). Likewise, learners in group 1 (p=0.023) and in group 2 (p=0.008) showed an improvement in the overall score in the within-group evaluation study. The between-group evaluation study showed no statistically significant difference in overall score improvement (p=0.58), number of learners improving (p=0.05) or percentage improvement (p=0.3).Conclusion: Based on these findings, it is suggested that role-playing method is effective in achieving student-learning outcomes regardless of their status as active or observer.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 11","pages":"866-870"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Thesis to Publication: Unveiling the Predictive Factors for Cardiology Research at a North African Faculty of Medicine (Tunisia). 从论文到出版物：揭示北非医学院（突尼斯）心脏病学研究的预测因素。

Tunisie Medicale Pub Date : 2024-11-05 DOI: 10.62438/tunismed.v102i11.5230

Faten Yahia, Hamza Gazzeh, Fares Ben Mansour, Youssef Zanina, Elyes Neffati, Ahmed Ben Abdelaziz

{"title":"From Thesis to Publication: Unveiling the Predictive Factors for Cardiology Research at a North African Faculty of Medicine (Tunisia).","authors":"Faten Yahia, Hamza Gazzeh, Fares Ben Mansour, Youssef Zanina, Elyes Neffati, Ahmed Ben Abdelaziz","doi":"10.62438/tunismed.v102i11.5230","DOIUrl":"10.62438/tunismed.v102i11.5230","url":null,"abstract":"Introduction: The benchmark of a medical thesis' success is often its acceptance for publication in an indexed journal.Aim: To determine the publication rate of practice theses in the field of Cardiology at the Faculty of Medicine of Sousse (FMSo) in Tunisia and to identify predictive factors for successful publication.Methods: We conducted a descriptive bibliometric analysis of Cardiology theses defended at FMSo from 2000 to 2019. Data were extracted from the theses' cover pages, abstracts, and conclusions. The publication status was ascertained via searches in \"MEDLINE\", \"Scopus\", and \"Google Scholar\". Predictive factors for publication were identified using multivariate analysis with a 90% Confidence Interval (CI).Results: Of the 111 Cardiology theses defended at FMSo between 2000 and 2019, 36 were published yielding 42 scientific articles (publication rate of 32%). Notably, 86% of these articles were indexed in \"MEDLINE\" and/or \"Scopus\". In 79% of cases, doctoral candidates were co-authors of the resultant publications. Publication was significantly influenced by three factors: scientific mentorship by an Assistant or Associate Professor (aOR=3.021; 90%CI: 1.06-10.14; p=0.082), a prospective study design (aOR=2.536; 90%CI: 1.07-6.02; p=0.076), and a satisfactory quality of writing (aOR=2.384; 90%CI: 1.11-5.11; p=0.061).Conclusion: The publication of Cardiology theses at FMSo was found to be associated with the prospective design of the study and the quality of writing. Thus, it is imperative to enhance the research methodology and scientific communication skills of medical thesis candidates and their mentors to facilitate the transition from academic dissertations to medical articles.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 11","pages":"858-865"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of zinc enriched spirulina as an adjunct to conventional treatment of patients with Chronic Obstructive Pulmonary Disease: Study protocol for a North African randomized controlled trial (SPIRICOPD). 富锌螺旋藻作为慢性阻塞性肺病患者常规治疗的辅助疗法的影响：北非随机对照试验（SPIRICOPD）研究方案。

Tunisie Medicale Pub Date : 2024-11-05 DOI: 10.62438/tunismed.v102i11.4947

Amani Sayhi, Balsam Barkous, Khawla Mahmoudi, Nadia Ben Lazreg, Sawssen Mrad, Olfa Ben Naya, Khansa Derbel, Imed Latiri, Sonia Rouatbi

{"title":"Impacts of zinc enriched spirulina as an adjunct to conventional treatment of patients with Chronic Obstructive Pulmonary Disease: Study protocol for a North African randomized controlled trial (SPIRICOPD).","authors":"Amani Sayhi, Balsam Barkous, Khawla Mahmoudi, Nadia Ben Lazreg, Sawssen Mrad, Olfa Ben Naya, Khansa Derbel, Imed Latiri, Sonia Rouatbi","doi":"10.62438/tunismed.v102i11.4947","DOIUrl":"10.62438/tunismed.v102i11.4947","url":null,"abstract":"Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a respiratory condition strongly related to oxidative stress. Recent studies have explored the potential benefits of nutritional supplementation in managing several conditions.Aim: To investigate the effects of zinc-enriched Spirulina Supplementation (ZSS) on patients with COPD.Methods: This study is a monocentric randomized controlled clinical trial. COPD-eligible adult male patients under 65 years of age, receiving regular medical treatment, will be included. They will continue their conventional medical treatment following the GOLD 2023 guidelines for COPD. Ninety subjects will be randomly assigned to either the experimental group (G1) or the control group (G2) in a 1:1 ratio. G1 will receive ZSS (1 g/day) for 2 months, while G2 will continue only basic medical treatment. The study will assess oxidant-antioxidant balance, lung function through pulmonary function tests, functional capacity via the 6-minute walking test, lipid profile, dyspnea, and health-related quality of life. All outcomes will be measured at baseline and two months later after supplementation completion. After the 8-week treatment, patients will be followed up for an additional 4 weeks. Ethics approval was obtained from the faculty of medicine of Sousse ethics committee.Expected results: It is expected that ZSS can positively impact the oxidant/antioxidant balance in patients with COPD after two months of supplementation. The authors anticipate that ZSS may improve various physiological parameters, such as lung function, exercise capacity, endothelial function, and metabolic profile, leading to an overall improvement in the quality of life of patients with COPD.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 11","pages":"876-885"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Leiomyomatosis of the Uterus: An Intriguing Case Revealed through Anatomopathological Examination. 子宫静脉内雷肌瘤病：通过解剖病理学检查发现的一个耐人寻味的病例

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5139

Khaoula Magdoud, Abir Karoui, Nadia Boujelbene, Rim Ben Hmid

{"title":"Intravenous Leiomyomatosis of the Uterus: An Intriguing Case Revealed through Anatomopathological Examination.","authors":"Khaoula Magdoud, Abir Karoui, Nadia Boujelbene, Rim Ben Hmid","doi":"10.62438/tunismed.v102i10.5139","DOIUrl":"10.62438/tunismed.v102i10.5139","url":null,"abstract":"Introduction: Intravenous leiomyomatosis (IVL), a rare type of uterine leiomyoma (its incidence is about 0.25% to 0.40% of patients who present uterine fibroma), is characterized by the formation and growth of benign leiomyoma tissue within the vascular wall or lymphatic lumen. Herein, we presented a case of early stage of IVL successfully treated by surgical removal and a review of actual medical recommendations.Observation: A 49-year-old woman, gravida 2 para 2, presented to our department with hypogastric pain. On physical examination, a palpable mass in the hypogastrium was noted. Pelvic ultrasound showed a huge uterus with multiple heterogeneous leiomyomas. As the patient was symptomatic and as she had completed their family plan, the decision to perform a total abdominal hysterectomy with bilateral salpingo-oophorectomy was taken. On pathological examination, intravascular growth of benign smooth muscle cell was found within venous channels lined by endothelium. The diagnosis of IVL of the uterus without malignant transformation was confirmed. The patient was monitored for 14 months, and subsequent computed tomography did not reveal any evidence of tumor recurrence.Conclusion: IVL is a benign, rare and potentially lethal pathology. Clinical manifestations are nonspecific. IVL needs surgical treatment for diagnosis and therapeutic purposes. They require close and prolonged follow-up because of the high risk of recurrence.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"722-724"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of GPR score for non-invasive assessment of liver fibrosis in chronic hepatitis B Tunisian patients. 突尼斯慢性乙型肝炎患者肝纤维化无创评估的 GPR 评分性能。

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5091

Ikbel Ghachem, Lamine Hamzaoui, Asma Bachali, Chayma Rhimi, Mouna Medhioub, Moufida Mahmoudi, Amal Khsiba, Mohamed Msaddak Azouz

{"title":"Performance of GPR score for non-invasive assessment of liver fibrosis in chronic hepatitis B Tunisian patients.","authors":"Ikbel Ghachem, Lamine Hamzaoui, Asma Bachali, Chayma Rhimi, Mouna Medhioub, Moufida Mahmoudi, Amal Khsiba, Mohamed Msaddak Azouz","doi":"10.62438/tunismed.v102i10.5091","DOIUrl":"10.62438/tunismed.v102i10.5091","url":null,"abstract":"Introduction: Several non-invasive tests (NIT) have been reported for predicting liver fibrosis to avoid percutaneous liver biopsy (PLB).Aim: To evaluate the performance of NIT in Tunisian patients with chronic hepatitis B (CHB).Methods: We calculated the ASAT/platelet ratio index (APRI), GGT-to-platelet ratio (GPR), Fibrosis-4 score (FIB-4), and RDW/platelet ratio (RPR). The accuracy of NIT was compared with the Metavir score for the detection of liver fibrosis stage using the area under the ROC curves (AUROC).Results: Seventy-seven CHB patients were included. For predicting significant fibrosis, the AUROC of GPR (0.81; CI95% [0.68-0.93]; P < 0.001) was significantly higher than that of RPR (0.67; CI95% [0.52-0.82]; P = 0.03) and FIB-4 (0.746; CI95% [0.61-0.88]; P = 0.002), but was similar to APRI (0.88; CI95% [0.79-0.97]; P < 0.001). For advanced fibrosis, the AUROC of GPR (0.93; CI95% [0.84-1]; P < 0.001) was higher than that of RPR (0.83; CI95% [0.69-0.97]; P < 0.001) and FIB-4 (0.88; CI95% [0.76-0.99]; P < 0.001), but similar to APRI (0.93; CI95% [0.87-0.99]; P < 0.001). For predicting cirrhosis, the AUROC of GPR (0.98; CI95% [0.95-1]; P < 0.001) was higher than that of APRI (0.95; CI95% [0.90-1]; P = 0.02), similar to RPR (0.99; CI95% [0.98-1]; P < 0.001) but lower than that of FIB-4 (1; CI95% [1-1]; P < 0.001). In multivariate analysis, APRI (OR = 3.78; P = 0.002) and FIB-4 (OR = 2.65; P = 0.01) were independent predictors of significant fibrosis. GPR was the only independent predictor of advanced fibrosis (OR = 4.64; P = 0.001) and FIB-4 was the independent predictor of cirrhosis (OR = 2.85; P < 0.001).Conclusion: GPR does not demonstrate significant advantages over APRI, FIB-4, and RPR in identifying liver fibrosis in patients with chronic hepatitis B (CHB).","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"715-721"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological impact of peri-implant fractures: A cross-sectional study. 种植体周围骨折的心理影响：横断面研究

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5068

Brahim Demnati, Zakaria Chabihi, El Mehdi Boumediane, Siham Dkhissi, Fahd Idarrha, Yassine Fath Elkhir, Mohamed Amine Benhima, Imad Abkari, Mohamed Rafai, Samir Ibn Moussa, Mohamed Rahmi

{"title":"Psychological impact of peri-implant fractures: A cross-sectional study.","authors":"Brahim Demnati, Zakaria Chabihi, El Mehdi Boumediane, Siham Dkhissi, Fahd Idarrha, Yassine Fath Elkhir, Mohamed Amine Benhima, Imad Abkari, Mohamed Rafai, Samir Ibn Moussa, Mohamed Rahmi","doi":"10.62438/tunismed.v102i10.5068","DOIUrl":"10.62438/tunismed.v102i10.5068","url":null,"abstract":"Introduction: Peri-implant fractures (PIFs) are uncommon yet critical complications following orthopedic surgery. These complications can significantly impact a patient's psychological well-being and overall quality of life.Aim: This study aimed to investigate the psychological effects of PIFs.Methods: This was a cross-sectional study that involved 136 patients who underwent surgery for PIFs between 2018 and 2022. We utilized various validated scales and questionnaires such as Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS), Impact of Event Scale Revised (IES-R), 36-Item Short Form Survey (SF-36), and Brief COPE Inventory (BCI) to assess their psychological state.Result: The results revealed that patients with PIFs experienced higher levels of anxiety, depression, stress, and post-traumatic stress compared to the general population. Additionally, they reported lower physical and mental health. Factors such as the number of surgeries, treatment delay, post-operative pain levels, and complications significantly influenced their psychological outcomes. Notably, acceptance, positive reframing, and seeking emotional support were the most common coping mechanisms employed by these patients. Conversely, denial, substance use, and self blame were the least employed strategies.Conclusion: This study suggests that psychological interventions could significantly benefit patients with PIFs, potentially reducing their distress and improving their quality of life.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"708-714"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Implications of Military Attacks on Hospitals: A Critical Analysis of International Legal Standards and the Pursuit of Accountability. 军事袭击医院的挑战和影响：对国际法律标准和追究责任的批判性分析》。

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5106

Meriem Gaddas, Helmi Ben Saad

引用次数: 0

Depression among Alopecia Areata Patients: Prevalence and associated factors in a Tunisian sample. 脱发患者中的抑郁症：突尼斯样本中的患病率和相关因素。

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5119

Nour Faouel, Nadia Ghariani, Amjed Ben Haouala, Soukaina Maghfour, Maha Lahoual, Sana Mokni, Ahmed Mhalla, Mohamed Denguezli

{"title":"Depression among Alopecia Areata Patients: Prevalence and associated factors in a Tunisian sample.","authors":"Nour Faouel, Nadia Ghariani, Amjed Ben Haouala, Soukaina Maghfour, Maha Lahoual, Sana Mokni, Ahmed Mhalla, Mohamed Denguezli","doi":"10.62438/tunismed.v102i10.5119","DOIUrl":"10.62438/tunismed.v102i10.5119","url":null,"abstract":"Introduction Alopecia areata (AA) is a common, chronic inflammatory, non-scarring form of hair loss affecting 0.1-0.2% of the population. It is a psychosomatic disease involving a T-cell-mediated immune reaction against hair follicle antigens during the anagen phase. Psychiatric morbidity in dermatological patients can significantly affect their quality of life and disease progression. Identifying and addressing these comorbidities in AA patients is crucial. Aim This study aimed to estimate the prevalence of depression and its associated factors among patients diagnosed with alopecia areata (AA). Methods The present study is a cross-sectional, descriptive, and analytical study conducted at Farhat Hached Hospital in Sousse, Tunisia, during the period from August to December 2019. Participants were recruited from the Dermatology Outpatient Department. The questionnaire covered socio-demographic characteristics, personal and family history, AA history, clinical presentation, disease severity (SALT score), nail involvement, and depression assessment using the Hamilton Depression Scale (validated Arabic version). Results A total of 60 AA patients were enrolled, with a mean age of 37.6 ± 12.9 years. Females exhibited a predominant representation, with a male to female ratio (M/F) of 0.76. According to the Hamilton Depression Scale (HAM-D), 31 cases (51.7%) were depressed, with a mean depression scale score of 11.33 (±6.57 SD). The presence of depression was significantly associated with younger age (p=0.018), the presence of the eyelashes/eyebrows form (p=0.035), nail involvement (p= 0.03), and a poor response to treatment (p=0.004). Conclusion Our research highlights the importance of providing psychological support to alopecia areata patients.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"659-663"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of esophageal varices: Correlation between non-invasive tests and digestive endoscopy. 食管静脉曲张的诊断：无创检验与消化内镜检查的相关性。

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.5168

Asma Mensi, Amel Medhioub, Nouha Trad, Emna Bel Haj Mabrouk, Yosra Said, Radhouane Debbeche

{"title":"Diagnosis of esophageal varices: Correlation between non-invasive tests and digestive endoscopy.","authors":"Asma Mensi, Amel Medhioub, Nouha Trad, Emna Bel Haj Mabrouk, Yosra Said, Radhouane Debbeche","doi":"10.62438/tunismed.v102i10.5168","DOIUrl":"10.62438/tunismed.v102i10.5168","url":null,"abstract":"Introduction: Esophageal variceal bleeding (EVB) is one of the main causes of mortality and morbidity in cirrhotic patients. Non-invasive tests (NIT) of liver fibrosis have been developed to predict the presence of esophageal varices (EV).Aim: To evaluate the performance of NIT of liver fibrosis such as liver transient elastography (TE) and serum scores in predicting EV.Methods: We conducted a retrospective collecting patients with chronic liver disease. TE and serum scores were evaluated for all patients and correlated with endoscopic data.Results: One hundred and fifty patients were included with an average age of 58.98 years and a sex ratio of 0.68. Sixty-seven patients were cirrhotic. Viral origin C was found in 72% of cases. Thirty-three patients had EV. NIT of liver fibrosis such as TE and serum scores were statistically correlated to the presence of EV. TE had the better performance for the prediction of EV with a Cut-off of 13.5 Kpa and AUC of 0.855. In multivariate analysis, TE, AST to ALT ratio and platelet count were independent predictors of EV.Conclusion: The performance of TE and serum scores in the diagnosis of EV and LEV was demonstrated. These results suggest that NIT of liver fibrosis make it possible to select patients who are candidates for gastroscopy.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"635-640"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing valproic acid trough levels in epileptic children. 影响癫痫儿童丙戊酸谷值水平的因素。

Tunisie Medicale Pub Date : 2024-10-05 DOI: 10.62438/tunismed.v102i10.4881

Khouloud Ferchichi, Rim Charfi, Syrine Ben Hammamia, Mouna Ben Sassi, Emna Gaies, Mouna Daldoul, Riadh Daghfous, Sameh Trabelsi

{"title":"Factors influencing valproic acid trough levels in epileptic children.","authors":"Khouloud Ferchichi, Rim Charfi, Syrine Ben Hammamia, Mouna Ben Sassi, Emna Gaies, Mouna Daldoul, Riadh Daghfous, Sameh Trabelsi","doi":"10.62438/tunismed.v102i10.4881","DOIUrl":"10.62438/tunismed.v102i10.4881","url":null,"abstract":"Objective: In this study, we aimed to assess main factors influencing the Valproic Acid (V.Acid) plasma trough levels (C0) and to determine their degree of influence on V.Acid C0 in children with epilepsy who had Therapeutic Drug Monitoring (TDM).Methods: We conducted an observational study in the Department of Clinical Pharmacology including patients with generalized seizures' epilepsy aged between two and 18 years. Only the children that had benefited from at least two V.Acid C0 determinations were included. First, we assessed daily dose optimization, performed by the practitioners. Then we divided our population into two groups: group A with a final V.Acid C0 in the therapeutic range (TR) and group B with a final V. Acid C0 outside the TR to find out factors influencing V.Acid C0 journey.Results: We included 805 patients (2537 V.Acid C0). The median age was 6.24 years and the sex ratio (M/F) was 1.45. The median V.Acid normalized daily dose was 27.27mg/kg/day and the median V.Acid C0 was 57µg/mL. The children's first V.Acid C0 was in the TR in 59.4% and V.Acid daily dose optimization was performed by the practitioners in 72.3%. Comparing GroupA and B, we found that age and the number of V.Acid C0 determinations increases the chance to reach the TR by respectively 3.79% and 7.39%.Conclusion: Older children who benefit from higher number of performed V.Acid C0 were more likely to reach the TR. In children who beneficiate from a TDM of V.Acid, close follow-up is mandatory to reach and maintain therapeutic V.Acid C0.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":"102 10","pages":"690-695"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0