Tunisie Medicale最新文献_第4页

Prevalence and Risk Factors of Bronchopulmonary Dysplasia Among Very Premature Infants in a Tunisian Neonatal Intensive Care Unit. 突尼斯新生儿重症监护病房极早产儿支气管肺发育不良的患病率和风险因素。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.5110

Mouadh Benali, Nourzed Ben Hamida, Salsabil Jaouhari, Imen Ayadi, Emira Ben Hamida

{"title":"Prevalence and Risk Factors of Bronchopulmonary Dysplasia Among Very Premature Infants in a Tunisian Neonatal Intensive Care Unit.","authors":"Mouadh Benali, Nourzed Ben Hamida, Salsabil Jaouhari, Imen Ayadi, Emira Ben Hamida","doi":"10.62438/tunismed.v102i9.5110","DOIUrl":"10.62438/tunismed.v102i9.5110","url":null,"abstract":"Introduction: Bronchopulmonary dysplasia (BPD) stands as the primary chronic respiratory complication in premature infants, posing a substantial public health concern due to its rising prevalence, potential mortality, and socioeconomic burden.Aim: The aim of this study was to determine the prevalence of BPD in very preterm infants and identify its associated risk factors.Methods: We conducted a retrospective, descriptive, and analytical study including all premature infants born between 26 and 31 weeks of gestation age (GA) who survived beyond the 28th day of life, over a five-year period (2017-2021). Patients were divided into two groups based on the presence or absence of BPD, which was defined by the need for oxygen supplementation for at least 28 days.Results: we included 231 newborns. The prevalence of BPD was 37.7% among survivors on the 28th day of life and 36.7% among those reaching 36 weeks postmenstrual age. BPD was mild, moderate and severe in 25.2%, 4.9% and 6.6% of cases, respectively. Multivariate analysis identified maternal hypertensive disorders (RR=6.15, 95%CI=[2.27-16.67], p<0.001), chorioamnionitis (RR=4.23, 95%CI=[1.25 -14.27], p=0.02), intrauterine growth restriction (IUGR) (RR =20.4, 95%CI=[3.39 -122.66], p=0.001), GA less than 30 weeks (RR=26.97, 95%CI=[10.23 -71.14], p<0.001), and mechanical ventilation (MV) (RR=5.33, 95%CI=[1.95-14.54], p=0.001) as independent factors associated with BPD occurrence. The mortality rate was 10.3% among patients with BPD versus 0.7% in patients without BPD (p = 0.001).Conclusion: Our study revealed a high prevalence of BPD in very preterm infants and identified several independent risk factors such as maternal hypertensive disorders, IUGR, chorioamnionitis, MV, and GA less than 30 weeks.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing scorpion envenomations: A Gabes emergency department case study of 60 patients. 处理蝎子咬伤：加贝斯急诊科对 60 名患者的病例研究。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.4885

Amine Hamdaoui, Houcemeddine Turki, Taha Lassoued, Amal Samet, Imen Rejeb

{"title":"Managing scorpion envenomations: A Gabes emergency department case study of 60 patients.","authors":"Amine Hamdaoui, Houcemeddine Turki, Taha Lassoued, Amal Samet, Imen Rejeb","doi":"10.62438/tunismed.v102i9.4885","DOIUrl":"10.62438/tunismed.v102i9.4885","url":null,"abstract":"Introduction: Scorpion envenomation constitutes a major public health issue in Tunisia, especially in arid regions such as the Gulf of Gabes. It is necessary to understand the epidemiological and clinical characteristics of this condition and the importance of early management.Aim: This study aims to assess the epidemiological and clinical profile of patients admitted to the emergency department of Gabes University Hospital for scorpion envenomation, as well as the timing of management and intra-hospital evolution.Methods: A retrospective descriptive study of 60 patients admitted for scorpion envenomation to the Acute Assessement unit at the Emergency Department of the Gabes University Hospital from January 2020 to January 2023.Results: The average age was 35 years [1-85 years]. A slight male predominance (51.7%) was noted. Patients with chronic somatic diseases accounted for (25%) of our series. The predominant scorpion species was Androctonus australis (71.7%). The majority of incidents occurred during the nighttime (71.7%). Most patients were of rural origin (58.3%). The most common sting sites were the lower limbs (48.8%) and upper limbs (36.7%). Scorpion envenomation stages at admission were: Stage I (3.3%), Stage II (83.3%), and Stage III (8.33%). The average time to management was 2 hours. Patients classified as Stage II at admission or afterward were seen after an average of 3 hours. Patients initially classified as Stage III were seen after an average of 3 hours and 30 minutes, and those classified as Stage III during the hospitalization were seen after an average of 4 hours. The average time to management for patients transferred from the Emergency Department to the Intensive Care Unit was 4 hours.Conclusion: This study highlights the importance of early management of scorpion envenomation.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of splicing factor SRSF1 in gliomas grading: A meta-analysis. 剪接因子 SRSF1 在胶质瘤分级中的作用：荟萃分析

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.4954

Mona Mlika, Mohamed Majdi Zorgati, Aymen Makhlouf, Faouzi Mezni

{"title":"The utility of splicing factor SRSF1 in gliomas grading: A meta-analysis.","authors":"Mona Mlika, Mohamed Majdi Zorgati, Aymen Makhlouf, Faouzi Mezni","doi":"10.62438/tunismed.v102i9.4954","DOIUrl":"10.62438/tunismed.v102i9.4954","url":null,"abstract":"Introduction: The grading of glial tumors is based on morphological and sometimes on molecular features. Many markers have been assessed in order to grade the glial tumours without a real consensus. Some authors reported that SRSF1, a spiling factor, presents an expression correlated to the tumours grades.Aim: In this study, we aimed to assess the utility of the SRSF1 into the grading of gliomas based on its immunohistochemical expression.Methods: The authors conducted a meta-analysis under the PRISMA guidelines during a 10-year-period (2013-2023). The Meta-Disc software 5.4 (free version) was used. Q test and I2 statistics were carried out to explore the heterogeneity among studies. Meta-regression was performed in case of significant heterogeneity. Publication bias was assessed using the funnel plot test and the Egger's test (free version JASP).Results: According to the inclusion criteria, 4 studies from 193 articles were included. The pooled SEN, SPE and DOR accounted respectively for 0.592, 0.565 and 1.852. The AUC was estimated to 0.558 suggesting a bad diagnostic accuracy. The heterogeneity in the pooled SEN and SPE was statistically significant. The meta-regression analysis focusing on the technique used, the clones, the dilution, the interpretation technique revealed no covariate factors (P>0.05).Conclusion: Even if this meta-analysis highlighted the absence of a real diagnostic utility of the SRSF1 in grading the glial tumours, the heterogeneity revealed reinforces the need for more prospective studies performed according to the quality assessment criteria.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leadership style and gender. The case of health managers in Morocco. 领导风格与性别。摩洛哥卫生管理人员的案例。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.5111

Sahar Bouadel, Sakhr Ahizoune, Kenza Hassouni

{"title":"Leadership style and gender. The case of health managers in Morocco.","authors":"Sahar Bouadel, Sakhr Ahizoune, Kenza Hassouni","doi":"10.62438/tunismed.v102i9.5111","DOIUrl":"10.62438/tunismed.v102i9.5111","url":null,"abstract":"Objective: to assess the gender leadership style of managers in the Moroccan health sector.Method: Descriptive study. The Multifactor Leadership Questionnaire (MLQ), a questionnaire that evaluates leadership style, was used to collect data from 120 managers in the Moroccan healthcare sector (40 female managers and 80 male managers).Results: In Morocco, the representation of women in positions of responsibility and power is still lower than that of men. However, the average score on the transformational leadership style scales for female managers among the 120 people surveyed was 15.51, while the average score on the transactional leadership style scales was only 6.073. While the average score on the transformational leadership style scales for male managers among the 120 respondents was 10.26, the average score on the transactional leadership style scales was 8.57. These results demonstrated the existence of a difference between the leadership style and gender of managers in the healthcare sector.Conclusion: This study was able to confirm the theory underlining the difference between the two leadership styles of male and female managers, even in a sector such as healthcare.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive pulmonary aspergillosis in patients with acute leukemia. 急性白血病患者的侵袭性肺曲霉病。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.4770

Olfa Kassar, Aicha Ben Kahla, Yosra Fakhefakh, Wiem Feki, Fatma Cheikhrouhou, Moez Elloumi

{"title":"Invasive pulmonary aspergillosis in patients with acute leukemia.","authors":"Olfa Kassar, Aicha Ben Kahla, Yosra Fakhefakh, Wiem Feki, Fatma Cheikhrouhou, Moez Elloumi","doi":"10.62438/tunismed.v102i9.4770","DOIUrl":"10.62438/tunismed.v102i9.4770","url":null,"abstract":"Introduction: Invasive pulmonary aspergillosis is a serious complication in hematology.Aim: Describe the prevalence, diagnostic aspects, therapeutic modalities, and evolution of the IPA cases occurring in patients with acute leukemia.Methods: Our study was retrospective including patients with acute leukemia who developed invasive pulmonary aspergillosis during the period January 2009 and December 2020 at the hematology department in south Tunisia. The IPA was defined in three levels of probability according to the criteria of the EORTC / MSG 2019.Results: We collected 127 patients who presented with Invasive pulmonary aspergillosis. Sixty-three percent of our patients had acute myeloid leukemia. The diagnosis of invasive pulmonary aspergillosis was during the induction course in 76% of cases. Twenty-seven of our patients had chest pain. The chest Computed tomography (CT) scan showed the Halo sign in 89% of cases. The Aspergillus galactomannan antigen was positive in 38% of cases. Extrapulmonary aspergillosis involvement was noted in 18% of cases: IPA was possible and probable respectively in 59% and 41% of cases. All patients treated with Voriconazole with a favorable response in 54% of cases. The mortality rate was 46%. The overall survival at week 12 was 56%.Conclusion: The morbidity and mortality of patients who developed invasive pulmonary aspergillosis with acute leukemia in our series were high. We need to improve our strategy for early diagnosis and management.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Patient Safety Culture: Insights from a Neurological Institute. 评估患者安全文化：神经病学研究所的启示。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.4891

Hekma Hajji, Emna Bokri, Nader Baffoun, Nesrine Hasni, Chokri Kaddour

{"title":"Assessing Patient Safety Culture: Insights from a Neurological Institute.","authors":"Hekma Hajji, Emna Bokri, Nader Baffoun, Nesrine Hasni, Chokri Kaddour","doi":"10.62438/tunismed.v102i9.4891","DOIUrl":"10.62438/tunismed.v102i9.4891","url":null,"abstract":"Introduction-Aim: Assessment of patient safety culture is important for enhancing hospital service quality and clinical outcomes. This study aimed to evaluate the safety of patient culture among health professionals in a neurological institute, in order to identify areas of improvement. The second objective of our study was to determine the influence of the sociodemographic data of the participants on the awareness of patient safety.Methods: A cross-sectional descriptive study was conducted among healthcare workers exercising at a neurological institution using a validated Hospital Survey of Patient Safety Culture questionnaire containing ten safety care dimensions.Results: A total of 123 responses to the questionnaire were analyzed, accounting for 34.5% of the total (Cronbach's alpha=0.677). Among the participants, 61.8% considered the level of awareness regarding patient safety to be acceptable. The dimensions considered as strengths were \"Organizational learning and continuous improvement\" with the highest positive response (60.3%) \"Relationship patient-staff member\" (58.9%) and \"Teamwork within units\" (58.9%). However, the dimensions considered as weaknesses were \"Management support for patient safety\" with 28.5% of positive responses and \"Communication openness and non-punitive response to error\" (40%).Conclusion: Patient safety culture among healthcare professionals is at an average with \"Organizational learning and continuous improvement\" being a positive aspect. However, improvements should be made in all dimensions to enhance and promote patient safety within the institution.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital heart disease: Epidemiological, genetic and evolutive profil. 先天性心脏病：先天性心脏病：流行病学、遗传和演变概况。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.5060

Emna Marmech, Oumaima Barkallah, Ines Selmi, Nourzed Ben Hamida, Amani Guizani, Haifa Ouerda, Syrine Khlif, Jihen Ben Hfaiedh, Jihed Kanzari, Zied Khlayfia, Sonia Halioui, Ons Azzabi, Nadia Siala

{"title":"Congenital heart disease: Epidemiological, genetic and evolutive profil.","authors":"Emna Marmech, Oumaima Barkallah, Ines Selmi, Nourzed Ben Hamida, Amani Guizani, Haifa Ouerda, Syrine Khlif, Jihen Ben Hfaiedh, Jihed Kanzari, Zied Khlayfia, Sonia Halioui, Ons Azzabi, Nadia Siala","doi":"10.62438/tunismed.v102i9.5060","DOIUrl":"10.62438/tunismed.v102i9.5060","url":null,"abstract":"Introduction: Congenital heart disease is a heterogeneous group of malformations and one of the most common causes of mortality in children.Aim: The aim of this study was to investigate the clinical, genetic and evolutive characteristics of congenital heart disease.Methods: A retrospective, descriptive study was carried out between 2020 and 2023 at the pediatrics and neonatology department of Mongi Slim university hospital of Tunis. All children with confirmed congenital heart disease were included.Results: Forty-five patients were included, representing 5.7‰ of all admissions. The sex ratio was 1.4. A prenatal diagnosis of congenital heart disease was established in 9% of cases. The median age at the time of discovery was 18 days. The initial symptomatology was respiratory distress in 64% of cases. The main reasons for performing a cardiac ultrasound were heart murmur in 38% followed by polymalformative assessment in 27% of cases. Most of the cardiopathies were atrial septal defects (42%) and ventricular septal defects (40%). Cyanotic heart diseases represented 29% of cases, conotruncal ones 13% and ductodependent ones 16%. Congenital heart disease was associated with a genetic anomaly in 53% of patients, including 15 cases of trisomy 21 and four Di-George syndromes. The treatment was mainly medical (38%), associated with surgery in 5 cases. Death occurred in nine patients, representing a mortality rate of 20%.Conclusion: Efforts still need to be made to improve pre- and post-natal diagnosis and ensure rapid treatment in order to reduce morbidity and mortality in our country.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative study with mothers of children with atopic dermatitis: emotional and social impacts. 对特应性皮炎患儿母亲的定性研究：情感和社会影响。

Tunisie Medicale Pub Date : 2024-09-05 DOI: 10.62438/tunismed.v102i9.5072

Mariana Muzzolon, Nathaly Lamas Garcez, Renata R Imoto, Claire Lazzaretti, Vânia Oliveira de Carvalho

{"title":"Qualitative study with mothers of children with atopic dermatitis: emotional and social impacts.","authors":"Mariana Muzzolon, Nathaly Lamas Garcez, Renata R Imoto, Claire Lazzaretti, Vânia Oliveira de Carvalho","doi":"10.62438/tunismed.v102i9.5072","DOIUrl":"10.62438/tunismed.v102i9.5072","url":null,"abstract":"Introduction: Atopic Dermatitis (AD) is the most common skin disease in childhood and its control requires the support of the family members. This disease significantly interferes with the Quality of Life (QoL) of children and families, however, literature on the social and emotional impact of the disease on the caregivers is lacking.Objective: To evaluate the emotional and social impact of AD on mothers of children with the disease.Method: This is a qualitative study of semi-structured interviews with mothers of children diagnosed with AD. The following variables were evaluated: diagnosis and start of treatment, knowledge about the disease, and impact on the mothers' lives. The material was analyzed using Lawrence Bardin's content analysis technique. The AD severity was assessed by SCORAD.Results: A total of 23 interviews were conducted with mothers of children diagnosed with AD. In 82.6% of the cases, the mothers presented conflicts in the face of the first contacts with the disease. In 43.5% of cases, mothers were solely responsible for their children's treatment. About 56.6% defined AD as a cause of suffering and difficulty and 21.7% pointed out the AD experience as a learning experience.Conclusion: The AD is a chronic disease that has a psychological and social impact on the lives of mothers. In the treatment of AD, mothers must be screened and offered psychological support to improve adherence to treatment in the long term.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary tract infections in chronic kidney disease in Nephrology unit, University Hospital Center of Befelatanana, Antananarivo. 塔那那利佛贝费拉塔纳纳大学医院中心肾科慢性肾病患者的尿路感染。

Tunisie Medicale Pub Date : 2024-08-05 DOI: 10.62438/tunismed.v102i8.4830

Mihary Dodo, Faniry Notahiantsoa Ratrimoharilala, Benja Ramilitiana, Catherine Razafindrakoto, Nomenjanahary Andriniaina Rakotoarisoa, Lova Narindra Randriamanantsoa, Harilalaina Willy Franck Randriamarotia

{"title":"Urinary tract infections in chronic kidney disease in Nephrology unit, University Hospital Center of Befelatanana, Antananarivo.","authors":"Mihary Dodo, Faniry Notahiantsoa Ratrimoharilala, Benja Ramilitiana, Catherine Razafindrakoto, Nomenjanahary Andriniaina Rakotoarisoa, Lova Narindra Randriamanantsoa, Harilalaina Willy Franck Randriamarotia","doi":"10.62438/tunismed.v102i8.4830","DOIUrl":"10.62438/tunismed.v102i8.4830","url":null,"abstract":"Introduction: Urinary tract infection is the leading cause of nosocomial infection worldwide. It is a factor in the progression of chronic kidney disease.Aim: To determine the epidemiological, clinical, microbiological, therapeutic and evolving profile of patients with chronic kidney disease and urinary tract infection.Methods: This was a retrospective, descriptive study lasting 5 years, from January 2014 to december 2018 in chronic kidney disease with urinary tract infection.Results: Fifty-one patients (7.15%) were retained with a mean age of 53.03 years and a sex ratio of 0.55. Chronic kidney disease was in end-stage in 45.1% (n=23). Cystitis was found in 49.02% (n=25) and gram-negative bacilli were found in 74.50% (n=38), predominantly Escherichia coli (54.90%). Third generation of cephalosporins and fluoroquinolones were frequently prescribed as probabilistic antibiotics. Resistance to beta-lactam antibiotics was 50% for Escherichia coli. Factors influencing severe infection were: advanced age, male gender, urinary lithiasis, multiple antibiotic resistance and non-enterobacterial germs.Conclusion: Urinary tract infection in chronic kidney disease were frequent and particularly severe.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of long-term anti-RBD SARS-CoV-2 antibody response following different vaccination schemes in Tunisia. 突尼斯不同疫苗接种方案后长期抗 RBD SARS-CoV-2 抗体反应的比较。

Tunisie Medicale Pub Date : 2024-08-05 DOI: 10.62438/tunismed.v102i8.4944

Awatef Ben Jemaa, Rihab Bouabsa, Meriam Ben Othmen, Ridha Oueslati, Hamdi Dhaouadi

{"title":"Comparison of long-term anti-RBD SARS-CoV-2 antibody response following different vaccination schemes in Tunisia.","authors":"Awatef Ben Jemaa, Rihab Bouabsa, Meriam Ben Othmen, Ridha Oueslati, Hamdi Dhaouadi","doi":"10.62438/tunismed.v102i8.4944","DOIUrl":"10.62438/tunismed.v102i8.4944","url":null,"abstract":"Aim: The study aimed to compare long-term vaccine-induced humoral immunity following different vaccines regimens.Methods: Anti-S-RBD total antibody levels were measured in blood samples of 167 participants nearly 6 months post-vaccination. Participants had received one; two or four doses of Pfizer vaccine or who received a third dose of mRNA vaccine (Pfizer) and primed with mRNA (Pfizer/Moderna), adenoviral (AstraZeneca/Jonson & Jonson) or inactivated (CoronaVac/Sinopharm) vaccine.Results: Among all vaccination regimens, fourth dose of Pfizer achieved the highest S-RBD antibody titers. Nevertheless, the third dose of mRNA vaccine primed with adenoviral vaccine achieved the lowest titers of S-RBD antibody. Notably, the group that received a third dose of mRNA primed with two doses of mRNA vaccine exhibited higher S-RBD antibody compared to groups inoculated with a third dose of mRNA and primed with inactivated or adenovirus vaccine.Conclusion: Our data showed the superiority of three mRNA vaccinations compared to third heterologous vaccine (inactivated of adenoviral) including mRNA as booster in terms of humoral immunogenicity. Our findings supporting the use of additional booster shot from a more potent vaccine type such as mRNA vaccines. Nevertheless, due to the limited number of subjects, it is difficult to extrapolate the results of our study to the whole of Tunisian population. Future studies should investigate a larger cohort and other potential correlates of protection, such as cellular immunity and how it is affected by different vaccination schemes after long-term post-vaccination.","PeriodicalId":38818,"journal":{"name":"Tunisie Medicale","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0