P and T最新文献

{"title":"Improving Medication History at Admission Utilizing Pharmacy Students and Technicians: A Pharmacy-Driven Improvement Initiative.","authors":"Katerina Petrov,&nbsp;Ranjani Varadarajan,&nbsp;Martha Healy,&nbsp;Elmira Darvish,&nbsp;Cathleen Cowden","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Because of the frequency of medication errors related to care transitions, patient-safety initiatives have recently focused on improving the patient medication list. Pharmacy student and technician participation in the medication-history process has been shown to improve the quality of medication histories. To improve patient care, a pharmacy-driven medication-history service utilizing a unique hybrid team of pharmacy students and technicians was launched at Inova Loudoun Hospital (ILH).</p><p><strong>Objective: </strong>The objective of the service was to improve patient safety and therapy by providing the Best Possible Medication History (BPMH) for admitted acute-care patients.</p><p><strong>Methods: </strong>Data for the medication-history service was collected for six months from July 2015 to January 2016. The service included pharmacy technicians and fourth-year pharmacy students using the BPMH approach to verify patients' allergies, medications, doses, and frequencies, and to ensure optimal documentation in the Electronic Health Record (EHR). Data on types and numbers of discrepancies and interventions were collected during the process. Readmission rates for the study group were calculated and compared to readmission rates for all patients.</p><p><strong>Results: </strong>Out of 4,070 patients interviewed, 77.7% (3,162) had at least one discrepancy in their medication list. Per patient, the average number of medications was 7.47, with an average of 1.8 discrepancies. Pharmacy students identified more discrepancies per patient than pharmacy technicians, 2.3 versus 1.5, respectively. Readmission rates for patients interviewed by the medication-history team was lower than for all patients during the same period, as well as for all patients during the same period in the previous year.</p><p><strong>Conclusion: </strong>This pharmacy-driven medication-history service, staffed with pharmacy technicians and students using a structured BPMH approach, increased the accuracy of home-medication lists on patient admission. The service demonstrated a difference in the types of interventions provided by pharmacy students and technicians. Readmission rates were also lower for patients with completed BPMH.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"676-684"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205119/pdf/ptj43011676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36659732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Federal Safe Harbor for Value-Based Contracts Being Considered: P&T Committees Can Receive Data Beyond the Drug Label.","authors":"Stephen Barlas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>P&T committees may soon have access to more than drug-label information as HHS considers implementing a safe harbor for value-based contracts between drug manufacturers and health insurers.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"647-687"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205120/pdf/ptj43011647.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36708467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug and Device News.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Approvals, new indications, regulatory activities, and more.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"648-695"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205121/pdf/ptj43011648.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36708470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baxdela^TM (Delafloxacin): A Novel Fluoroquinolone for the Treatment of Acute Bacterial Skin and Skin Structure Infections.","authors":"Alexandra Adler,&nbsp;Saira Chaudhry,&nbsp;Tamara Goldberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Baxdela (delafloxacin) for treatment of acute bacterial skin and skin structure infections.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"662-666"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205123/pdf/ptj43011662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36659728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Prescription Patterns of Adenosine Diphosphate Receptor Inhibitors in Acute Coronary Syndrome.","authors":"Ellen B Yin,&nbsp;Huy Nguyen,&nbsp;Ishan Kamat,&nbsp;Maryam Bayat,&nbsp;Mahboob Alam","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the contemporary use of adenosine diphosphate (ADP) receptor inhibitors in acute coronary syndrome at a large, quaternary academic medical center.</p><p><strong>Methods: </strong>A retrospective observational study was conducted using health records to compare patients who were treated with ticagrelor (Brilinta, AstraZeneca), prasugrel, or clopidogrel for a primary diagnosis of new-onset acute coronary syndrome between January 2014 and December 2014.</p><p><strong>Results: </strong>A total of 275 patients were identified. Clopidogrel was the most commonly prescribed ADP receptor antagonist (52%), followed by ticagrelor (26%) and prasugrel (22%). Patients who were prescribed clopidogrel were more likely female (<i>P</i> < 0.01), 75 years of age or older (<i>P</i> < 0.01), and 60 kg or less in weight (<i>P</i> = 0.02), and they had more comorbidities. Of the patients on clopidogrel prior to admission, 21% were switched to prasugrel or ticagrelor for inadequate platelet inhibition, restenosis, or new stent placement. Of the patients on ticagrelor or prasugrel prior to admission, 17% were switched to clopidogrel for concerns about bleeding or cost. Clopidogrel was prescribed 13% of the time, prasugrel 13% of the time, and ticagrelor 4% of the time (<i>P</i> = 0.13) outside the recommended use per Food and Drug Administration-approved prescribing information based on relative or absolute contraindications.</p><p><strong>Conclusion: </strong>Clopidogrel continues to be the most commonly prescribed antiplatelet agent, particularly in older patients with more comorbidities.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"667-674"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205126/pdf/ptj43011667.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36659730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical Approval Update.","authors":"Michele B Kaufman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Arakoda (tafenoquine) for malaria; Annovera (segesterone acetate and ethinyl estradiol vaginal system) for contraception; and Oxervate (cenegermin-bkbj) for neurotrophic keratitis.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"659-661"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205122/pdf/ptj43011659.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36708471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin II Brings More Questions Than Answers.","authors":"Nicholas Farina,&nbsp;Alexandra Bixby,&nbsp;Cesar Alaniz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The approval of synthetic human angiotensin II (Giapreza, LaJolla Pharmaceuticals) by the FDA in December 2017 provides clinicians with a new tool in the treatment of distributive shock. Angiotensin II (ATII) was approved based on the results of the ATHOS-3 trial. In this trial, patients who received angiotensin II were more likely to achieve a mean arterial pressure of 75 mmHg or an increase in mean arterial pressure of 10 mmHg above that seen in patients who received a placebo. However, the results of ATHOS-3 also highlighted important concerns about thrombotic and infectious complications associated with ATII. Given that the cost of medication acquisition is approximately $1,500 per vial, practitioners must also decide how to implement ATII into practice in the most cost-effective manner. This commentary examines the current controversies surrounding both the safety and efficacy of ATII.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 11","pages":"685-687"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205124/pdf/ptj43011685.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36659731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical Approval Update.","authors":"Mary Choy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ivosidenib (Tibsovo) for acute myeloid leukemia; elagolix (Orilissa) for endometriosis; and mogamulizumab-kpkc (Poteligeo) for mycosis fungoides or Sézary syndrome.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 10","pages":"599-628"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152696/pdf/ptj4310599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36534194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naldemedine (Symproic) for the Treatment Of Opioid-Induced Constipation.","authors":"Kenneth Hu,&nbsp;Mary Barna Bridgeman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Naldemedine (Symproic) for opioid-induced constipation.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 10","pages":"601-627"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152697/pdf/ptj4310601.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDA Finalizes Drug Communication Guidance: P&T Committees Can Receive Data Beyond the Drug Label.","authors":"Stephen Barlas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The FDA has made it easier for P&T committees to make formulary coverage decisions by expanding the health care economics information that drug manufacturers can provide to them.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"43 10","pages":"587"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152691/pdf/ptj4310587.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36534191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}