{"title":"An IIOP architecture for Web-enabled physiological models","authors":"Shixin Zhang, C. Dewey","doi":"10.1109/IEMBS.2001.1019735","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019735","url":null,"abstract":"This paper develops a specific information architecture to serve complex physiological information models and a means of delivering these models in a manner that allows interactive and distributed use. By redesign of existing models for distributed use, the IIOP (Internet Inter-ORB Protocol) architecture provides general access across the Internet; the methods are replicable with many different types of physiological models that produce a variety of results. This paper defines and explains the complete architecture for the user interface, the model encapsulation, and the communication layer between the client and server by developing a general example. Using the equivalent of interactive browsers to access remote models and display the results, the IIOP architecture is built up using platform-independent technology such as CORBA, Java and XML. The existing physiological models are first encapsulated by a suitable software language respect to the legacy models. Then CORBA IDL-XML interfaces are built accordingly as a broker interface connecting user interfaces to encapsulating interfaces. Therefore, the standard user interfaces on the browsers are easily built to access these models through the CORBA ORB and the encapsulating interfaces. This interface software is capable of interpreting and displaying very high-level descriptors and model output such that the amount of data required to be transmitted over the Internet is reduced.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125340499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Messnarz, B. Tilg, R. Modre, G. Fischer, F. Hanser, P. Wach
{"title":"Linear inverse approaches for the reconstruction of epicardial and transmembrane potential patterns","authors":"B. Messnarz, B. Tilg, R. Modre, G. Fischer, F. Hanser, P. Wach","doi":"10.1109/IEMBS.2001.1018928","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1018928","url":null,"abstract":"In this study we compare two different linear inverse approaches to the inverse problem of electrocardiography. Method A is the standard Tikhonov zero order approach used as a reference method.. Method B is based on the general deconvolution theorem proposed by Greensite. Both methods are applied to both the epicardial potential and the transmembrane potential considered as the primary source. In order to compare the performance of both methods the activation time pattern is estimated.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125382994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Working on the Noltisalis database: measurement of nonlinear properties in heart rate variability signals","authors":"M. Signorini, R. Sassi, S. Cerutti","doi":"10.1109/IEMBS.2001.1018991","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1018991","url":null,"abstract":"We present results obtained from the analysis of 50 heart rate variability series (HRV) which have been extracted from Holter recordings in the 24-hours in normal subjects and pathological patients. Data have been collected inside a multicentric research program, which aimed at the nonlinear analysis of HRV series. Multifractal approaches such as generalized structure functions have been used to characterize the HRV signal. Moreover, classical parameters for the analysis of the HRV signal over long time scales have been considered to perform a proper comparison. We considered classical time-domain indexes, \"monofractal\" characteristics (1/f/sup /spl alpha// spectrum; detrended fluctuation analysis) and a regularity statistic (approximate entropy). The hypothesis of nonlinearity for the HRV signal has been verified by computing the generalized structure function on a set of surrogate data (amplitude adjusted surrogate data). In most cases, the multifractal spectrum of the original HRV series significantly differs (t-test), from those obtained from surrogate signals. This result can be associated with the presence of nonlinear correlations in the HRV signal. Moreover, results show that nonlinear parameters can be used to separate normal subjects from patients suffering from cardiovascular diseases.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125526919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative assessment of respiratory derivation algorithms","authors":"C. L. Mason, L. Tarassenko","doi":"10.1109/IEMBS.2001.1020622","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020622","url":null,"abstract":"A method for quantitatively assessing respiration derivation algorithms is presented. Algorithms for deriving respiration from the electrocardiogram using respiration-induced amplitude modulation of the QRS complex are investigated. The algorithms are tested on the MIT-BIH Polysomnography Database and evaluated and compared using the proposed assessment method.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126907846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commercialization of seizure prediction technology promises and pitfalls of biosignal analysis: seizure prediction and management (A case study)","authors":"M. Rise","doi":"10.1109/IEMBS.2001.1019765","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019765","url":null,"abstract":"This presentation will focus on the process of commercializing technology designed to predict/detect seizures. The author will present general design criteria for an implantable device used chronically by an individual with epilepsy to manage their seizures. He will also contrast the requirements of a commercial product with the sophisticated approaches of algorithm developers. Where an implantable product requires low power consumption, small size, and ease of use, the trends of algorithm developers is to make use of increasingly sophisticated. mathematical techniques and increasingly affordable, high speed, powerful desktop computers. A discussion of various design approaches will emphasize the trade offs which could be employed to accommodate important advances in algorithm development.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127035875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Jo, J. Ku, D. Jang, B.H. Cho, H. Ahn, J.M. Lee, Y.H. Choi, I.Y. Kim, S.I. Kim
{"title":"Movie-based VR therapy system for treatment of anthropophobia","authors":"H. Jo, J. Ku, D. Jang, B.H. Cho, H. Ahn, J.M. Lee, Y.H. Choi, I.Y. Kim, S.I. Kim","doi":"10.1109/IEMBS.2001.1019663","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019663","url":null,"abstract":"The fear of public speaking is a kind of social phobia. The patients having the fear of public-speaking show some symptoms like shame and timidity in the daily personal relationship. They are afraid that the other person would be puzzled, feel insulted, and they also fear that they should be underestimated for their mistakes. For the treatment of the fear of public speaking, the cognitive-behavioral therapy is generally used. The cognitive-behavioral therapy is the method that makes the patients gradually experience some situations inducing the fears and overcome those at last. But if the real situations inducing fears cause dangerous symptoms or the patients have difficulty in imagining the situations, the effect of this method is notably reduced. And making the situations inducing the fears to patients requires a vast amount of effort and time. In this study, we developed the public-speaking simulator and the virtual environment for the treatment of the fear of public speaking. The head-mounted display, the head-tracker and the 3-dimensional sound system were used for immersing in the virtual environment. The virtual environment of this system is suggested in a seminar room where 6 virtual audiences are seated. The virtual audiences were made with real movies and inserted into the virtual environment. The patient speaks in front of these virtual audiences and the therapist can make virtual audience members respond with some motions. Moreover, clinical tests have been made to verify the effectiveness of the treatment.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115248625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Method for accurate unsupervised cell nucleus segmentation","authors":"P. Bamford, Brian C. Lovell","doi":"10.1109/IEMBS.2001.1017341","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1017341","url":null,"abstract":"To achieve the extreme accuracy rates demanded by applications in unsupervised automated cytology, it is frequently necessary to supplement the primary segmentation algorithm with a segmentation quality control system. The more robust the segmentation strategy, the less severe the data pruning need be at the segmentation validation stage. These issues are addressed as we describe our cell nucleus segmentation strategy which is able to achieve 100% accurate segmentation from a data set of 19946 cell nucleus images by automatically discarding the most difficult cell images. The automatic quality checking is applied to enhance-the performance of a robust energy minimisation based segmentation scheme which already achieved a 99.47% accurate segmentation rate.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115581919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Model-based design of stimulus trains for selective microstimulation of targeted neuronal populations","authors":"C. McIntyre, W. Grill","doi":"10.1109/IEMBS.2001.1019063","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019063","url":null,"abstract":"Selective activation of targeted neuronal populations is required for central nervous system (CNS) neuroprosthetic device efficacy. However in many regions of the CNS, cells and fibers of passages are intermingled. The goal of this project was to design stimulus trains that would enhance selectivity between microstimulation of cells and fibers of passage. Detailed computer-based models were developed that accurately reproduced the dynamic firing properties of mammalian neurons. The neuron models were coupled to a three-dimensional finite element model of the spinal cord that solved for the potentials generated in the tissue medium by an extracellular electrode. The results demonstrate that alterations in the stimulus frequency, based on differences in the post-action-potential recovery cycles of cells and axons, enabled differential activation of cells or fibers of passage. The results also show that asymmetrical charge-balanced biphasic stimulus waveforms, designed to exploit the non-linear conductance properties of the neural elements, can be used in combination with the appropriate stimulus frequency to further enhance selectivity. These outcomes provide useful tools for selective stimulation of the CNS, as well as basis for understanding frequency-dependent outputs during CNS stimulation.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"42 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115986050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Powers, C. Lloyd, H.-Y. Mason, M. Dice, R. Tingy, C. Estes, A. Duncan, B. Wade, W. Ellis
{"title":"Microbioengineering: microbe capture and detection","authors":"L. Powers, C. Lloyd, H.-Y. Mason, M. Dice, R. Tingy, C. Estes, A. Duncan, B. Wade, W. Ellis","doi":"10.1109/IEMBS.2001.1019739","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1019739","url":null,"abstract":"Summary form only given. Recent deaths from outbreaks of microbial contamination particularly in foods, but also in water and air, the recent threats of biological warfare/terrorism, and the re-emergence of such diseases as tuberculosis have emphasized the importance of quick and accurate assessments of microbial contamination. In addition, microbial contamination of sterile surfaces, such as those of medical and surgical instruments and devices, cause considerable danger. Using a unique combination of leading edge technologies, microbe capture chips and a hand-held prototype detector have been developed which are capable of statistically sampling the environment for pathogens [including spores] and exotoxins, identifying the specific pathogens/exotoxins, and determining cell viability. This system is sensitive enough to detect very low levels [/spl sim/20 cells/sq cm] of infectious bacteria in minutes. The microbe capture technology is based on molecular recognition and pathogenesis using iron acquisition and eukaryotic receptor adhesion strategies. These non-antibody-based ligands are tethered to the sensor chip in a patterned array. In addition to statistically sampling the environment, pathogen identification can be made based on which ligands are bound by microbes. Capture events are detected using intrinsic fluorescence of the cells and spores such as that from metabolites, amino acids, and other specific cell components. The multi-wavelength fluorescence detection device incorporates integrated parallel 'readout' of the sensor chip and employs a pattern recognition algorithm for pathogen identification. This system is both several orders of magnitude more sensitive and several orders of magnitude faster than current field sensors.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"30 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116201315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of role of vision in human upright posture control","authors":"T. Nagata, Y. Fukuoka, A. Ishida, H. Minamitani","doi":"10.1109/IEMBS.2001.1020396","DOIUrl":"https://doi.org/10.1109/IEMBS.2001.1020396","url":null,"abstract":"We investigated the role of visual feedback in human upright posture control. To make the role of vision clear, we compared the visual, vestibular and somatosensory feedback systems in their ability to perceive movement and suppress short- and long-term sway. First, we measured thresholds for the perception of movement Then effects of each feedback system to suppress short- and long-term sway were analyzed through posture control experiments, in which the available sensory input was limited. The visual and somatosensory thresholds were small (<0.1 degree) while the vestibular threshold was relatively large (>0.5 degree). The results of the posture control experiments suggested that the visual system contributed to suppression of sway in the frequency range below 0.4 Hz and the system had a minor effect in frequencies above 0.5 Hz. These results support our previous finding that the visual system does not allow a normal subject to maintain an upright posture by itself. The somatosensory system, on the other hand, suppressed body sway around 0.2 and 0.9 Hz. The higher frequency range might enable the system to maintain an upright posture by itself.","PeriodicalId":386546,"journal":{"name":"2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116389718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}