Advances in Neuroimmune Biology最新文献_第4页

The Sympathetic Nervous System Regulates Inflammation in Amoebic Liver Abscess in Hamsters 交感神经系统调节仓鼠阿米巴肝脓肿的炎症

Advances in Neuroimmune Biology Pub Date : 2015-01-01 DOI: 10.3233/NIB-150108

M. Ávila-Blanco, M. Muñoz-Ortega, M. Garcia-Lorenzana, A. Quintanar-Stephano, M. R. Campos-Esparza, R. Campos-Rodríguez, J. Ventura-Juárez

{"title":"The Sympathetic Nervous System Regulates Inflammation in Amoebic Liver Abscess in Hamsters","authors":"M. Ávila-Blanco, M. Muñoz-Ortega, M. Garcia-Lorenzana, A. Quintanar-Stephano, M. R. Campos-Esparza, R. Campos-Rodríguez, J. Ventura-Juárez","doi":"10.3233/NIB-150108","DOIUrl":"https://doi.org/10.3233/NIB-150108","url":null,"abstract":"An inflammation is generated during formation of Amoebic Liver Abscess. We analyzed chemically sympathectomized hamsters with Amoebic Liver Abscess, in a period between 6 hours to 7 days. The liver tissue samples were analyzed by haematoxylin and eosin staining, immunohistochemistry, immunofluorescence and morphometry. Sympathectomy caused a lower production of collagen and absence of granuloma tissue of Amoebic Liver Abscess. At the 6 h of development, proinflammatory cytokines were reduced, also reduced 12 hours – 7 days; while IL-10 production was incresed for this time; Transforming Growth Factorproducing cells only increased from 4 to 7 days. Nuclear factor kappa-light-chain-enhancer of activated B cells were diminished throughout the Amoebic Liver Abscess, while Toll Like Receptor 4 + macrophages decreased in the period of 2 to 7 days; and Toll Like Receptor 4 + neutrophils decreased between 4 and 7 days. The population of trophozoites was increased in sympathectomized animals between 4 and 7 days. The chemical sympathectomy reduces the collagen deposition and induces an anti-inflammatory state during the development of Amoebic Liver Abscess, then; allows the spread and reproduction of Entamoeba histolytica trophozoites.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"43-57"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-150108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Immunomodulation of Inflammatory Markers in Activated Macrophages by Leaf Extracts of Gingko Biloba 银杏叶提取物对活化巨噬细胞炎症标志物的免疫调节作用

Advances in Neuroimmune Biology Pub Date : 2015-01-01 DOI: 10.3233/NIB-150103

M. Mir, R. Al-Baradie

{"title":"Immunomodulation of Inflammatory Markers in Activated Macrophages by Leaf Extracts of Gingko Biloba","authors":"M. Mir, R. Al-Baradie","doi":"10.3233/NIB-150103","DOIUrl":"https://doi.org/10.3233/NIB-150103","url":null,"abstract":"Much recent attention has been given to traditional medicines and natural products with potential and promising anti-inflammatory properties. Leaf extract of Ginkgo biloba GbE-761, possesses several clinical beneficial effects and is now used in a broad spectrum of pharmacological actions. However, mechanisms associated with its anti-inflammatory effect are not very much clear. Previously we established that GbE-761 exerts a neuroprotective effect against ischemic brain injury through an anti-apoptotic mechanism. In this study we investigated the anti-inflammatory effect of GbE-761 in LPS-activated murine macrophage. Our results demonstrate that GbE-761 potently inhibited LPS-induced NO and PGE2 production and these observations were consistent with the inhibition in the protein and mRNA expression levels of inducible iNOS and COX-2 enzymes in a dose dependent manner. Not only this, GbE-761 attenuated the production of pro-inflammatory cytokines like IL-1 , IL-6 and TNFin LPS-activated murine macrophages in concentration dependent manner. In addition we reported inhibition in the protein and mRNA expression levels of IL-1 , IL-6 and TNF. Furthermore, GbE-761 inhibited the NFB activation induced by LPS. Together these results suggest that anti-inflammatory properties of GbE-761 extract might be the results of inhibition of iNOS and COX-2 by upregulating anti-oxidative enzymes and inhibition of pro-inflammatory cytokines (IL-1 , IL-6 and TNF) expression through the down-regulation of NF-kB activation in murine macrophages.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-150103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Calcitonin Gene-Related Peptide and its Influences on the Cutaneous Immune System 降钙素基因相关肽及其对皮肤免疫系统的影响

Advances in Neuroimmune Biology Pub Date : 2015-01-01 DOI: 10.3233/NIB-150107

Claire J. Guo, R. Granstein

引用次数: 0

Targeting CXCL13 During Neuroinflammation. 神经炎症期间靶向CXCL13

Advances in Neuroimmune Biology Pub Date : 2015-01-01 DOI: 10.3233/NIB-150101

A. Huber, D. Irani

引用次数: 34

Role of TGF-β1 in the Behavior Disorders TGF-β1在行为障碍中的作用

Advances in Neuroimmune Biology Pub Date : 2015-01-01 DOI: 10.3233/NIB-150105

A. Depino

引用次数: 2

Typical Neuron Guiding Molecules Constitutively Control Thymus Physiology 典型的神经元引导分子组成性地控制胸腺生理

Advances in Neuroimmune Biology Pub Date : 2014-01-01 DOI: 10.3233/NIB-140087

D. Mendes-da-Cruz, W. Savino

引用次数: 1

The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems 免疫和神经内分泌系统中糖皮质激素受体活性与翻译后修饰之间的相互作用

Advances in Neuroimmune Biology Pub Date : 2014-01-01 DOI: 10.3233/NIB-140083

María Antunica-Noguerol, Fernando Aprile-Garcia, M. Budziñski, Luciano Proto-Cassina, A. Liberman, E. Arzt

{"title":"The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems","authors":"María Antunica-Noguerol, Fernando Aprile-Garcia, M. Budziñski, Luciano Proto-Cassina, A. Liberman, E. Arzt","doi":"10.3233/NIB-140083","DOIUrl":"https://doi.org/10.3233/NIB-140083","url":null,"abstract":"Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post- translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"5 1","pages":"19-32"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-140083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cholinergic Activity in Mononuclear Cells of Nile Tilapia (Oreochromis niloticus) Fish 尼罗罗非鱼(Oreochromis niloticus)鱼单核细胞胆碱能活性

Advances in Neuroimmune Biology Pub Date : 2014-01-01 DOI: 10.3233/NIB-140091

G. A. Toledo-Ibarra, K. Da, Calzada México-Xochimilco

引用次数: 7

Bacterial Melanin Ameliorates Symptoms of Experimental Autoimmune Encephalomyelitis in Rats 细菌性黑色素可改善大鼠实验性自身免疫性脑脊髓炎的症状

Advances in Neuroimmune Biology Pub Date : 2014-01-01 DOI: 10.3233/NIB-140088

T. Petrosyan, A. Hovsepyan

{"title":"Bacterial Melanin Ameliorates Symptoms of Experimental Autoimmune Encephalomyelitis in Rats","authors":"T. Petrosyan, A. Hovsepyan","doi":"10.3233/NIB-140088","DOIUrl":"https://doi.org/10.3233/NIB-140088","url":null,"abstract":"Experimental autoimmune encephalomyelitis (EAE) is a T cell autoimmune inflammatory disease of the central nervous system (CNS) that is a widely used animal model for the human demyelinating disease, multiple sclerosis. Bacterial melanin has proved to be a potent neuroprotector. It supports regeneration and motor recovery after CNS lesions. It is established that bacterial melanin can induce suppression of inflammatory process. Studies have revealed the negative correlation between skin pigmentation, vitamin D and the prevalence of autoimmune disease. Therefore we analyzed the anti-inflammatory effects of bacterial melanin in a rat EAE model. EAE was induced in adult albino male rats by immunizing with a rat spinal cord encephalitogenic emulsion. The development of EAE and neurological signs were evaluated by a standard protocol. Walking track analysis was conducted to evaluate motor recovery. Histomorphological analysis was applied to show cell infiltration into the spinal cord and effects of BM on the EAE pathomorphology. Pretreatment of EAE rats with bacterial melanin inhibited the development of disease, providing significant protective effect compared to control rats. BM treated rats showed lower degree of neurological deficit and higher level of motor recovery than controls. In treated rats histomorphological analysis demonstrated that brain infiltration with mononuclears was less expressed in bacterial melanin treated rats. Results show that bacterial melanin has protective effects in EAE and ameliorates symptoms of EAE.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"5 1","pages":"181-188"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-140088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Immunoregulation by Hypophyseal Hormones 垂体激素的免疫调节作用

Advances in Neuroimmune Biology Pub Date : 2014-01-01 DOI: 10.3233/NIB-140096

K. Nava-Castro, R. Hernández-Cervantes, I. Bérczi, J. M. Montor

引用次数: 0