Advances in Neuroimmune Biology最新文献

{"title":"The Role of Brain –Pineal –Thymus System in the Determination of Lifespan: The Autoimmune Aging Theory","authors":"G. Csaba","doi":"10.3233/NIB-160118","DOIUrl":"https://doi.org/10.3233/NIB-160118","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"42 1","pages":"139-148"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Restraint Stress on Lipopolysaccharide-Induced Reactions of Orexinergic System","authors":"E. Korneva, S. Perekrest, K. Shainidze, N. Novikova, V. Pugach, A. Nasredinova","doi":"10.3233/NIB-160115","DOIUrl":"https://doi.org/10.3233/NIB-160115","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a Psychoneuroimmunendocrine Hypothesis of Breast Cancer","authors":"Iván Montes-Nogueira, G. Gutiérrez-Ospina, T. Romo-González","doi":"10.3233/NIB-170122","DOIUrl":"https://doi.org/10.3233/NIB-170122","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-170122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysfunction of Glial Cells in Neurological and Psychological Disorders: From Bench to Bedside","authors":"T. Katafuchi, M. Noda","doi":"10.3233/NIB-169001","DOIUrl":"https://doi.org/10.3233/NIB-169001","url":null,"abstract":"There is growing evidence that glia is not only supporting neurons passively but also physiologically controlling development and plasticity of the nervous system [1]. It is well known that astrocytes, which are most abundant in the central nervous system (CNS), play important roles in neurovascular coupling to regulate blood flow to the active neurons and tripartite synapse formation consisting of presynaptic membrane, postsynaptic membrane and surrounding astrocyte to produce effective neurotransmission. On the other hand, microglial cells are the essential players in the pruning of unnecessary synapses during development. In addition to the physiological roles, glial cell are deeply involved in pathological conditions such as neurodegenerative and demyelinating disorders in the CNS [2]. The main pathology of these diseases is called neuroinflammation, which is characterized by glial activation along with production of cytokines, radicals and their related substances. It is now known that neuroinflammation is also an essential pathology in other diseases than neurodegenerative/demyelinating diseases. For example, the chronic fatigue syndrome and its animal models show neuroinflammation causing severe fatigue [3, 4]. Furthermore it has been shown that neuroinflammation is also involved in some psychiatric diseases such as schizophrenia, depression and autism, which will be reviewed in this issue. This special issue on glial cells introduces recent findings (1) that some species of glycerophospholipids can induce cellular signaling in glia to protect neuroinflammation, (2) that glial cells regulate the establishment of blood-brain barrier (BBB), barriergenesis, and angiogenesis in the brain development, (3) that psychiatric diseases such as schizophrenia, bipolar disorder, depression and autism involve abnormalities in expression of some microglial markers, (4) that not only microglia but also astrocytes and oligodendrocytes show their dysfunctions in various psychiatric disorders. And neuronal and glial cells can be directly induced from skin fibroblast and blood cells of psychiatric patients to understand the pathology of the diseases, and (5) that nicotine has neuroprotective effect through its action on both astrocytes and microglial cells. M.S. Hossain and T. Katafuchi reviewed antineuroinflammatory and anti-apoptotic actions of ether-linked glycerophospholipids, plasmalogens (Pls), to inhibit glial activation through the activation of protein kinases, Akt and ERK1/2. Interestingly Pls are shown to activate these kinases through some orphan G protein coupled receptors (GPCRs), suggesting that Pls can be ligands for those GPCRs. They also review the differential effects of other bioactive lipids in the brain on glial activation. A.B. Salmina et al. discussed the importance of glial cells in the development of BBB, barriergenesis, and angiogenesis in terms of the relationship between BBB impairment and cognitive dysfunction, aberrant behavior ","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-169001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glial Dysfunction and Blood-Brain Barrier Impairment in the Developing Brain","authors":"A. Salmina, E. Pozhilenkova, A. Morgun, N. V. Kuvacheva, A. Shuvaev, O. Lopatina, E. Boitsova, T. E. Taranushenko","doi":"10.3233/NIB-160114","DOIUrl":"https://doi.org/10.3233/NIB-160114","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"69-82"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of Brain Lipids in Glial Activation","authors":"Md Shamim Hossain, T. Katafuchi","doi":"10.3233/NIB-160120","DOIUrl":"https://doi.org/10.3233/NIB-160120","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial Gene Expression Alterations in the Brains of Patients with Psychiatric Disorders","authors":"Mai Sakai, Yuta Takahashi, Zhiqian Yu, H. Tomita","doi":"10.3233/NIB-160110","DOIUrl":"https://doi.org/10.3233/NIB-160110","url":null,"abstract":"As recent studies have shown that microglia play a key role in inflammation and immunological challenges as well as have broader roles in synaptic modulation in the brain, studies on psychiatric disorders have increasingly focused on microglia. Microglial abnormalities have consistently been observed in psychiatric postmortem brain studies, including altered microglial activation and changes in the protein and mRNA expression levels of microglial marker molecules, such as major histocompatibility complex, class II, DR (HLA-DR), complement receptor type 3 (CD11b), ionized calcium binding adaptor molecule 1 (IBA-1), macrosialin (CD68) and glucose transporter type 5 (GLUT5). Microglial abnormalities have also been observed in positron emission tomography (PET) studies. Recent advances in omics-based microglial gene expression profiling of psychiatric brains may elucidate microglial involvement in the pathogeneses of psychiatric disorders. In the present paper, we review the current status of research on expression profiling of microglia-relevant molecules in psychiatric postmortem and imaging studies and we discuss future research directions.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"83-93"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders","authors":"Takahiro A. Kato, Masahiro Ohgidani, N. Sagata, S. Kanba","doi":"10.3233/NIB-160109","DOIUrl":"https://doi.org/10.3233/NIB-160109","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"95-105"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70146335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of Nicotine-Induced Neuroprotection: Inhibition of NADPH Oxidase and Subsequent Proton Channel Activation by Stimulating α7 Nicotinic Acetylcholine Receptor in Activated Microglia","authors":"M. Noda","doi":"10.3233/NIB-160119","DOIUrl":"https://doi.org/10.3233/NIB-160119","url":null,"abstract":"","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"41 1","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-160119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Risk of Infection in Bereaved Older Adults: From Broken Heart to Broken Immune System","authors":"Ana Vitlić, J. Lord, D. Carroll, A. Phillips","doi":"10.3233/NIB-150106","DOIUrl":"https://doi.org/10.3233/NIB-150106","url":null,"abstract":"Bereavement, the loss of someone close, is frequently followed by grief and can have serious implications for physical and mental health, from the increased symptoms of depression and anxiety, sleep disturbances and indigestion, and more serious physical health consequences such as cardiovascular and immune related illness. Another key factor associated with a deterioration of the body’s defence mechanisms, such as the immune system, is ageing. This review has as its focus the combined effects of bereavement and ageing on immune function. First, the relationship between bereavement and increased mortality is examined, followed by its link to various physical and mental health morbidities. Second, the effects of ageing per se on immune functions are considered. Finally, the joint impact of both ageing and bereavement are discussed, focussing on recent studies of immune function after bereavement in young and older adults.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"6 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-150106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70145844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}