Acta medica academica最新文献_第3页

Workplace Violence Against Nurses in Croatia: A Cross-Sectional Study on Its Frequency, Impact, and Solutions. 克罗地亚对护士的工作场所暴力：对其频率，影响和解决方案的横断面研究。

Acta medica academica Pub Date : 2026-04-01 DOI: 10.5644/ama2006-124.505

Danela Relić, Ivica Matić, Livia Puljak, Marta Čivljak

{"title":"Workplace Violence Against Nurses in Croatia: A Cross-Sectional Study on Its Frequency, Impact, and Solutions.","authors":"Danela Relić, Ivica Matić, Livia Puljak, Marta Čivljak","doi":"10.5644/ama2006-124.505","DOIUrl":"10.5644/ama2006-124.505","url":null,"abstract":"Objective: This study aimed to analyze the frequency of workplace violence against nurses in Croatia, its psychological consequences, and existing institutional measures to address this issue.Materials and methods: A cross-sectional online survey was conducted among Croatian nurses in October and November 2023 using a convenience sample recruited via a social media platform. The questionnaire included 38 closed-ended questions covering socio-demographic data, experiences of physical, verbal, and sexual violence, and measures implemented to prevent or address workplace violence.Results: A total of 318 nurses participated in the study. Most participants (70%) reported experiencing some form of workplace violence in the past 12 months. Verbal violence was most frequent (66%), followed by physical (21%) and sexual violence (13%). Patients were the most common perpetrators of physical violence (84%), followed by relatives and healthcare staff. No statistically significant differences were found between the reporting of violent incidents and the level of nurses' education, nor between the intensity of psychological consequences and years of nurses' work experience. Nearly half of the participants (48%) stated that no formal measures existed in their workplace to prevent or respond to violence.Conclusion: Among nurses participating in this study, workplace violence was frequently reported, while work experience was not associated with psychological consequences. The findings indicate that workplace violence remains a relevant issue and may inform future efforts to improve preventive measures in healthcare settings.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"39-59"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Criterion Validity of the Yale Physical Activity Survey (YPAS) in Croatian Older Adults. 克罗地亚老年人耶鲁体育活动调查（YPAS）的标准效度。

Acta medica academica Pub Date : 2026-04-01 DOI: 10.5644/ama2006-124.504

Maja Ban, Toni Ćosić, Irena Canjuga, Ivica Matić, Vesna Mijoč

{"title":"Criterion Validity of the Yale Physical Activity Survey (YPAS) in Croatian Older Adults.","authors":"Maja Ban, Toni Ćosić, Irena Canjuga, Ivica Matić, Vesna Mijoč","doi":"10.5644/ama2006-124.504","DOIUrl":"10.5644/ama2006-124.504","url":null,"abstract":"Objective: The Yale Physical Activity Survey (YPAS) is one of the most commonly used questionnaires to assess physical activity (PA) levels in older adults. Although previous studies have explored its validity properties against accelerometry, to date, no evidence has been provided in Croatian older adults. Therefore, the primary purpose of this study was to examine whether the YPAS is a valid tool for measuring PA levels.Materials and methods: A total of 46 older women (mean age 72.3±1.2 years) were recruited from three randomly selected public residential aged-care facilities. During the first stage, all participants wore a triaxial GENEActiv accelerometer on their non-dominant hand for 7 consecutive days. After the wearing period, the participants completed the YPAS questionnaire. The correlations between the YPAS and GENEActiv data were calculated using Spearman's order-rank coefficients.Results: The YPAS total PA was positively and moderately correlated with the number of steps, light and moderate PA, and moderate-to-vigorous PA (MVPA; ρ=0.48-0.64), yet a low positive correlation was found with vigorous PA (ρ=0.33). The YPAS total energy expenditure (EE) and the number of stairs performance showed similar correlation patterns with GENEActiv accelerometry data as the total PA (ρ=0.33-0.64). The summary index score exhibited moderate and positive correlations with the number of steps, light, moderate, and vigorous PA and MVPA (ρ=0.28-0.49).Conclusion: This study shows that the YPAS is a valid tool for assessing PA patterns in older Croatian adults.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appendiceal Neuroendocrine Tumors in Children and Adolescents. 儿童和青少年阑尾神经内分泌肿瘤。

Acta medica academica Pub Date : 2026-04-01 DOI: 10.5644/ama2006-124.496

Jelena Roganovic, Luisa Santoro, Calogero Virgone

{"title":"Appendiceal Neuroendocrine Tumors in Children and Adolescents.","authors":"Jelena Roganovic, Luisa Santoro, Calogero Virgone","doi":"10.5644/ama2006-124.496","DOIUrl":"10.5644/ama2006-124.496","url":null,"abstract":"Objective: To synthesize current evidence on the diagnosis, histopathological evaluation, clinical features, management, and follow-up of appendiceal neuroendocrine tumors (aNETs) in children and adolescents, and to outline key differences from their adult counterparts.Background: Pediatric aNETs are rare gastrointestinal neoplasms that typically exhibit an indolent clinical course with minimal risk of recurrence or metastasis. Their biological and prognostic features differ from those in adults, limiting the applicability of adult-derived guidelines in children.Methods: A mini review of the current literature was conducted, focusing on epidemiology, clinical presentation, diagnostic workup, key pathological features, surgical management, and follow- up strategies for pediatric aNETs.Discussion: Contemporary evidence supports a de-escalated, risk-adapted approach to management, with simple appendectomy being curative in most cases. Multidisciplinary Team (MDT) discussion remains critical for atypical or borderline cases requiring individualized decision-making. Differences from adult aNETs highlight the need for pediatric-specific clinical decision-making.Conclusion: Early recognition, accurate histopathologic evaluation, and tailored surgical management are essential to optimize outcomes for children and adolescents with aNETs.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"72-76"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociodemographic Characteristics of Patients with Schizophrenia: A Comparative Study with Healthy Controls. 精神分裂症患者的社会人口学特征：与健康对照的比较研究

Acta medica academica Pub Date : 2026-04-01 DOI: 10.5644/ama2006-124.499

Pejana Rastović, Marko Pavlović, Josip Kvesić, Ana Džidić Bevanda, Maja Pandža Topić

{"title":"Sociodemographic Characteristics of Patients with Schizophrenia: A Comparative Study with Healthy Controls.","authors":"Pejana Rastović, Marko Pavlović, Josip Kvesić, Ana Džidić Bevanda, Maja Pandža Topić","doi":"10.5644/ama2006-124.499","DOIUrl":"10.5644/ama2006-124.499","url":null,"abstract":"Objective: This study aimed to assess selected sociodemographic characteristics of patients with schizophrenia and compare them with those of a healthy control group, as well as within the group of patients with schizophrenia.Patients and methods: A retrospective observational study was conducted involving 400 patients with schizophrenia and 200 healthy controls from the Herzegovina-Neretva Canton. The diagnosis of schizophrenia was made according to ICD-10 criteria, and sociodemographic data were obtained through structured interviews.Results: Individuals with schizophrenia are more likely to be older, less educated, unemployed, single, and smokers compared to healthy controls. Among patients with schizophrenia, analyses controlling for age showed that gender was significantly associated with both age of onset and duration of illness, with significant gender-by-age interactions. Marital status was significantly related to age at onset and demonstrated a significant interaction with age in relation to illness duration. Education level was associated with age at onset but not with illness duration. No significant differences in illness onset were found across employment groups.Conclusion: Sociodemographic characteristics are closely associated with key clinical features of schizophrenia, including age at onset and illness duration. These findings highlight the importance of considering gender, marital status, and educational background when interpreting illness trajectories. The results further underscore the need for early intervention strategies, psychoeducation, and integrated social and healthcare support aimed at improving functional outcomes and quality of life for individuals with schizophrenia and their caregivers.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connections Between Prefrontal Cortex Anatomy and Autism Spectrum Disorder: A Literature Review. 前额皮质解剖与自闭症谱系障碍之间的联系：文献综述。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.492

Efthalia Tzila, Eleni Panagouli, Maria Tsouka, Amir Shihada, Dionysios Venieratos, Dimosthenis Chrysikos, Theodore Troupis

{"title":"Connections Between Prefrontal Cortex Anatomy and Autism Spectrum Disorder: A Literature Review.","authors":"Efthalia Tzila, Eleni Panagouli, Maria Tsouka, Amir Shihada, Dionysios Venieratos, Dimosthenis Chrysikos, Theodore Troupis","doi":"10.5644/ama2006-124.492","DOIUrl":"10.5644/ama2006-124.492","url":null,"abstract":"Objective: This review examines the existing literature on the structural and functional changes in the anatomy of the prefrontal cortex (PFC) associated with autism spectrum disorder (ASD), focusing on the roles of molecular signaling disruptions and trace element imbalances.Methods: A literature review was performed through a structured search of academic publications from 2010 to 2025.Discussion: Anatomic variations and structural and functional abnormalities within the PFC, including disruptions in neural connectivity, synaptic plasticity, and neurochemical balance, significantly contribute to the cognitive, social, and emotional deficits observed in ASD. The interplay between brain-derived neurotrophic factor dysregulation, oxidative stress, and trace element imbalances further exacerbates these dysfunctions.Conclusion: According to our findings, the anatomy of the PFC appears to play a crucial role in the pathophysiology of ASD, given its involvement in executive function, emotional processing, and social cognition, suggesting a multifactorial pathophysiology that demands a multidimensional research approach.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B2 Thymoma with Intracardiac Extension Presenting as Superior Vena Cava Syndrome: Case Report and Literature Review. B2胸腺瘤伴心内扩张表现为上腔静脉综合征：1例报告及文献复习。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.491

Almedina Muhić, Šefika Umihanić, Hasan Osmić, Elma Mujaković, Faruk Šadić, Amila Kovčić Harčinović, Agan Muhić

{"title":"B2 Thymoma with Intracardiac Extension Presenting as Superior Vena Cava Syndrome: Case Report and Literature Review.","authors":"Almedina Muhić, Šefika Umihanić, Hasan Osmić, Elma Mujaković, Faruk Šadić, Amila Kovčić Harčinović, Agan Muhić","doi":"10.5644/ama2006-124.491","DOIUrl":"10.5644/ama2006-124.491","url":null,"abstract":"Objective: This article aims to emphasize the importance of considering invasive thymoma in the differential diagnosis of mediastinal masses and highlights the critical role of timely surgical and oncological management in improving patient outcomes.Case report: We present the case of a 70-year-old woman who presented with signs of superior vena cava syndrome, including dyspnea, facial swelling, and fatigue. Advanced imaging and intraoperative findings revealed a large anterior mediastinal mass infiltrating the left brachiocephalic vein and superior vena cava, extending into both the right atrium and right ventricle. Surgical intervention was performed, and histopathological analysis confirmed B2 thymoma with a high Ki-67 proliferation index. Despite surgical intervention, the patient's condition deteriorated, and she ultimately succumbed to the disease.Conclusion: To the best of our knowledge, this is the first reported Bosnian case of B2 thymoma invading the brachiocephalic vein and superior vena cava and infiltrating both the right atrium and ventricle, causing superior vena cava syndrome. Despite their rarity, thymomas should always be considered in patients presenting with an enlarged mediastinum.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"262-268"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Histoplasma Evades the Human Immune System. 组织浆体如何逃避人体免疫系统。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.494

Albert Jefferson Kurniawan, Jolene Eleora Mok, Anathapindika Putra, Sem Samuel Surja

{"title":"How Histoplasma Evades the Human Immune System.","authors":"Albert Jefferson Kurniawan, Jolene Eleora Mok, Anathapindika Putra, Sem Samuel Surja","doi":"10.5644/ama2006-124.494","DOIUrl":"10.5644/ama2006-124.494","url":null,"abstract":"This review summarises the current knowledge of the interactions between Histoplasma capsulatum (Hc) and the human immune system, with particular emphasis on host immune responses and fungal immune evasion mechanisms that modulate disease pathogenesis and clinical outcomes. Histoplasmosis is a disease caused by Hc, a fungus found worldwide. Upon inhalation, complex interactions occur between the pathogen and the human immune system, primarily involving the recognition of fungal cell wall components. Both innate and adaptive immune responses are orchestrated to eliminate the fungus through a tightly regulated balance. However, Hc has evolved multiple strategies to evade host defences and establish infection. The clinical spectrum of histoplasmosis varies, ranging from isolated pulmonary involvement to disseminated disease, depending on host factors and pathogen characteristics. CONCLUSION: Overall, host-pathogen interactions between Hc and the human immune system play a central role in determining disease outcomes and represent key targets for improving preventive, diagnostic, and treatment strategies.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"54 3","pages":"220-237"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ansa Pancreatica: Clinical Significance in Recurrent Acute Pancreatitis. 胰腺Ansa：复发性急性胰腺炎的临床意义。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.490

Athanasios Sakellariadis, Amir Shihada, Alexandros Samolis, Nikoleta Sinou, Dimitrios Filippou

{"title":"Ansa Pancreatica: Clinical Significance in Recurrent Acute Pancreatitis.","authors":"Athanasios Sakellariadis, Amir Shihada, Alexandros Samolis, Nikoleta Sinou, Dimitrios Filippou","doi":"10.5644/ama2006-124.490","DOIUrl":"10.5644/ama2006-124.490","url":null,"abstract":"Objective: This study aimed to conduct a thorough literature review regarding the ansa pancreatica as a potential risk factor for recurrent acute pancreatitis, exploring its pathophysiological mechanisms and possible complications during the surgical management of pancreatic conditions.Methods: A comprehensive search was performed in the PubMed and Scopus databases using the keyword 'Ansa Pancreatica', yielding a total of 80 articles (PubMed: 34, Scopus: 46, with 52 unique articles). After applying strict inclusion and exclusion criteria, unrelated and duplicate articles were removed, resulting in the selection of 38 relevant studies.Results: Ansa pancreatica was found to be a statistically significant independent risk factor for recurrent acute pancreatitis in the majority of the literature reviewed. The suggested pathophysiological mechanism involves anatomical obstruction and subsequent pre-activation of the pancreatic enzymes, causing an inflammatory cascade. Diagnosis can be established using Endoscopic Retrograde Cholangiopancreatography, Magnetic Resonance Cholangiopancreatography, or Endoscopic Ultrasonography, while treatment options are either conservative or surgical, with the invasive procedures being associated with a significant risk of complications. Furthermore, some studies have indicated a correlation between ansa pancreatica and intraductal mucinous neoplasms.Conclusion: The findings clearly show that Ansa Pancreatica is a rare anatomical variant with significant clinical and surgical implications, underscoring the necessity for clinicians to be aware of it to mitigate complications and effectively manage pancreatic diseases.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"54 3","pages":"205-212"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PhD Theses Defended in Croatia (1992-2023): A Retrospective Analysis of Trends, Institutional Contributions, and Data Collection Challenges. 克罗地亚博士论文答辩（1992-2023）：趋势、机构贡献和数据收集挑战的回顾性分析。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.488

Livia Puljak, Damir Sapunar

{"title":"PhD Theses Defended in Croatia (1992-2023): A Retrospective Analysis of Trends, Institutional Contributions, and Data Collection Challenges.","authors":"Livia Puljak, Damir Sapunar","doi":"10.5644/ama2006-124.488","DOIUrl":"10.5644/ama2006-124.488","url":null,"abstract":"Objective: This study analyzed PhD theses defended in Croatia between 1992 and 2023, with the aim of examining national trends, institutional contributions, disciplinary patterns, and data-related challenges.Methods: This retrospective time-trend study utilized the administrative data obtained from the Croatian Bureau of Statistics. Data on the number of defended PhD theses were collected by year, university, and school/department. Linear regression models were applied to assess temporal trends at both the national and institutional levels.Results: A total of 17,578 PhD theses were defended in Croatia between 1992 and 2023. The national output increased substantially, reaching a peak of 1,338 theses in 2012, followed by a subsequent decline and a gradual recovery. The University of Zagreb accounted for 74.8% of all defended theses, followed by the Universities of Osijek, Rijeka, and Split. Across institutions, the medical, economic, and engineering faculties were the most productive. Linear regression analyses demonstrated statistically significant upward trends at both the national level and across all major public universities. Collectively, medical schools produced 18% of all theses, with newer institutions, particularly those in Split and Osijek, exhibiting later but consistent growth. However, notable data inconsistencies were observed, including non-standardized institutional nomenclature, variable data granularity, and discrepancies among official reports.Conclusion: Croatia's PhD output expanded markedly after 2000, reflecting the maturation and expansion of its higher education system. Regional universities and medical schools substantially increased their contributions, indicating national academic growth. Sustained institutional support will be essential to sustain progress and foster disciplinary development.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"183-194"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Spitzoid Melanoma: A Case Report. 儿童Spitzoid Melanoma: 1例报告。

Acta medica academica Pub Date : 2025-12-01 DOI: 10.5644/ama2006-124.482

Jelena Roganović, Mia Radošević, Andrea Dekanić

{"title":"Pediatric Spitzoid Melanoma: A Case Report.","authors":"Jelena Roganović, Mia Radošević, Andrea Dekanić","doi":"10.5644/ama2006-124.482","DOIUrl":"10.5644/ama2006-124.482","url":null,"abstract":"Objective: To highlight the diagnostic and therapeutic challenges of Spitzoid melanoma in childhood, with a focus on its potential genetic predisposition.Case report: A 7-year-old female patient presented with a growing nodular lesion on her upper leg. Excision was performed, and histopathological analysis confirmed a diagnosis of Spitzoid melanoma, classified as pT2a. Following a multidisciplinary review, wide local re-excision and sentinel lymph node biopsy (SLNB) were recommended. No residual tumor was found, and the SLNB was negative. A comprehensive diagnostic evaluation ruled out systemic disease, and no additional treatment was required. Germline genetic testing identified a pathogenic CHEK2 variant (c.444+1G>A), prompting recommendations for genetic counseling and close follow-up.Conclusion: This case report contributes to the limited body of knowledge on pediatric Spitzoid melanomas and underscores the importance of genetic insights in guiding both diagnostic and treatment decisions. The detection of a CHEK2 mutation underscores the importance of genetic profiling in family counseling.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"250-254"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0