Acta medica academica最新文献

{"title":"Lyssa: Goddess, Drug, Illness and Shield in Hellenic Antiquity.","authors":"Gregory Tsoucalas","doi":"10.5644/ama2006-124.444","DOIUrl":"10.5644/ama2006-124.444","url":null,"abstract":"<p><p>The aim of this historical review is to present the beliefs of the ancient Greeks related to lyssa and how the mythology surrounding this disease was created. In Greek antiquity Lyssa was a secondary goddess, a personification of a zoonotic disease which could be transmitted after an animal bite. Also named hydrophobia, the illness lyssa presented with an acute loss of mental stability, offensive frenzy and madness, and fear of water in the patient, who was seen to be possessed by a daemon as a divine punishment. In the Trojan War, lyssa was seen as a drug to Greek warriors, to demonstrate unreal power during battle. Homer was the first to refer to the hound of Orion, who was the greatest ancient Greek hunter. The hound, named Sirius, as a carrier of lyssa, was used as a bio-weapon to inflict death among the Trojans. Soranus of Ephesus and Galen gave descriptions of the disease, and proposed a sponge soaked with various herbal drugs as a therapeutic measure. The Greco-Roman physician Caelius Aurelianus noted that ancient Greeks knew about lyssa, and was the first to suggest that this was a neuro-disease. Lyssa was a figure in Greek Tragedy, depicted as a young female with a dog-like crown, related to Erinyes and Maniae. CONCLUSION: Lyssa was noted as a disease in Hellenic literature more than 2500 years ago. It was used as a bio-weapon to inflict madness. This vignette reveals Lyssa within a historical framework for the reader to understand the disease's origins.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"233-236"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium and Triple Negative Breast Cancer.","authors":"Despoina Sidira, Angeliki Siafaka, Dimosthenis Chrysikos, Georgios Papadopoulos, Epameinondas Stratopoulos, Dimitrios Filippou","doi":"10.5644/ama2006-124.450","DOIUrl":"10.5644/ama2006-124.450","url":null,"abstract":"<p><strong>Background: </strong>The deadliest, most dangerous subtype of breast cancer is triple-negative, which lacks treatment targets and accounts for 30% of all breast cancer-related deaths worldwide. TNBC is characterized by the expression of no estrogen, progesterone, or human epidermal growth factor 2 receptors. This suggests that new treatment modalities with fewer adverse effects are required.</p><p><strong>Objective: </strong>The aim of the present study was to investigate the therapeutic potential of selenium compounds as an adjuvant therapy for Triple Negative Breast Cancer (TNBC), either on their own or in conjunction with nutritional supplements and chemotherapy medications.</p><p><strong>Methods: </strong>Using the keywords \"selenium\" and \"triple negative breast cancer\", a thorough search was conducted in the PubMed database, yielding 23 articles. The following factors were taken into consideration for inclusion: studies using TNBC cell culture lines or in vivo tumors/specimens; full-text articles from the PubMed database; studies published in the English language; experiments with statistically significant results; and selenium used alone or in combination with other antioxidants or chemotherapy. This led to the evaluation of 13 articles in this review.</p><p><strong>Results: </strong>The results show that selenium therapy increased the anti-cancer drug's effects and produced tumor cytotoxicity, while reducing the cellular features of the cancer (hyperproliferation, growth, and metastasis).</p><p><strong>Discussion: </strong>This study evaluated the various selenium compounds tested, the cell lines and model organisms used, the assays performed, and the cellular pathways affected.</p><p><strong>Conclusion: </strong>Examining the possible benefits of selenium in TNBC treatment highlights the need for more studies to confirm selenium compounds as viable co-therapeutic agents.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"53 2","pages":"155-164"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academician Milivoje Sarvan: The Founder of Modern Paediatrics in Bosnia and Herzegovina.","authors":"Husref Tahirović, Jelena Jovanović Simić","doi":"10.5644/ama2006-124.457","DOIUrl":"10.5644/ama2006-124.457","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The aim of the article is to present to the medical, and then to the general public, the person and work of Milivoje Sarvan (1896-1978)-one of the pioneers of social paediatrics in Serbia and one of the most prominent paediatricians, scientists and organizers of health services in Bosnia and Herzegovina in the second half of the 20th century. Milivoje Sarvan was born in 1896 in Požega, in the Kingdom of Serbia. He completed his medical studies in Lyon (France) in 1921. Upon his return to Serbia, he was a county physician in Aleksinac for three years and, shortly after the establishment of the University Children's Hospital in Belgrade in 1924, he was among the first assistants employed there. Out of the total of 23 years of professional work in Serbia, for 19 years he was an assistant and assistant professor at the Faculty of Medicine in Belgrade. At the end of 1946, at the initiative of the Ministry of Public Health of the People's Republic of Bosnia and Herzegovina, Dr. Milivoje Sarvan was appointed full professor and head of the Department of Paediatrics at the newly established Faculty of Medicine in Sarajevo. At the same time, he was elected head of the Paediatric Clinic in Sarajevo when it was established, and he would later manage it from 1947 until his retirement in 1967. Already at the beginning, Prof. Sarvan developed the activities of the Clinic in several directions: he created the conditions for clinical, teaching and scientific research work. He took care of the education of future paediatricians and child care workers, organized courses in social paediatrics for general practitioners and professional training for paediatricians in the country and abroad. The next period of his activities was marked by the intensive development of the Clinic in all areas of its work. He published more than 120 professional and scientific papers in national and foreign medical journals, and several health education books on mother and child care that have been published in several editions, with large print runs. He was the dean of the Faculty of Medicine and vice-rector of the University of Sarajevo, founder of the Paediatric Section of the Society of Physicians of Bosnia and Herzegovina, lifetime president of the Association of Paediatricians of Yugoslavia, a member of the Scientific Society of Bosnia and Herzegovina from 1955 and the Academy of Sciences and Arts of Bosnia and Herzegovina from its foundation in 1966. He was honoured with high level social awards and recognitions, including the highest state award of the Socialist Federative Republic of Yugoslavia-the AVNOJ award. After his retirement (1967), he lived in Belgrade, where he died in 1978. CONCLUSION: Bearing all of this in mind, there is no doubt that Dr. Milivoje Sarvan is one of the significant figures in the field of professional, scientific and organizational work in the field of children's health care in the former Yugoslavia, leaving a significant and indelible mark in the","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"53 2","pages":"209-232"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Workshops Versus Live Medical Education on Self-Medication Literacy for Middle School Students. What Is the Best Pedagogic Method?","authors":"Ghita Dubory, Victor Housset, Roxanne Liard, Claire Bastard, Marine Joulin, Angelo V Vasiliadis, Arnaud Dubory, Vasileios Giovanoulis","doi":"10.5644/ama2006-124.449","DOIUrl":"10.5644/ama2006-124.449","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine which pedagogic method, online workshops or live medical education, was the better way to teach about self-medication for middle school students.</p><p><strong>Methods: </strong>The following groups were formed: group O (students receiving online education), group L (students participating in live medical education animated by a medical practitioner and a science teacher) and group C (students without any medical learning). To compare them, the students answered three multiple choice questions before and after the educational intervention. The students in group L were evaluated immediately after the live medical training and group O immediately after the online workshops (t1). Group C was only evaluated at t0.</p><p><strong>Results: </strong>Group C N=195), group L (N=219) and group O (N=200, but 101 students who participated in the online workshops students dropped out before the end) were equivalent in terms of gender, but their ages and school grades were statistically different (P<0.001). A post-hoc test revealed that students in group O were older and in a higher grade than those in the other two groups (P<0.001) but the mean ages and school grades were equivalent in group L and group C. At t0, the results obtained were equivalent in the 3 groups. At t1, school students obtained better results in both groups (P<0.001) but these same results were significantly better in group L than those obtained in group O (P<0.001). Age, gender, school grade and school level had no effect on the students' results.</p><p><strong>Conclusion: </strong>The study's findings suggest that live medical education is a superior approach for imparting self-medication knowledge to middle school students.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"53 2","pages":"146-154"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Pressure Recording Analytical Method in Patients Undergoing Endovascular Repair for Abdominal Aortic Aneurysm: The Impact on Clinical Decisions for the Appropriate Postoperative Setting and Cost-effective Analysis","authors":"E. Giacomelli, W. Dorigo, S. Romano, Andrea Casini, C. Giglioli, Chiara Papini, A. Fargion, N. Marchionni, C. Pratesi, R. Pulli, E. Cecchi","doi":"10.5644/ama2006-124.442","DOIUrl":"https://doi.org/10.5644/ama2006-124.442","url":null,"abstract":"Objective. To analyze the use of the Pressure Recording Analytical Method (PRAM), an hemodynamic monitoring system, in evaluating intraoperative and postoperative hemodynamic instability in patients undergoing endovascular repair for abdominal aortic aneurysm, and to evaluate if the decision to refer patients to a ordinary ward or to a Cardiac Step-Down Unit (CSDU) after the intervention on the basis of intraoperative hemodynamic monitoring could be more cost-effective. \u0000Materials and Methods. After preoperative clinical evaluation, 44 patients were divided in this non-randomised study into two groups accord- ing to their postoperative destination: Group 1-ward (N=22) and Group 2-CSDU (N=22). All patients underwent monitoring with PRAM during the intervention and in the 24 postoperative hours, measuring several indices of myocardial contractility and other hemodynamic variables. \u0000 Results. According to the variability of two parameters, Stroke Volume Variation and Pulse Pressure Variation, patients were classified as stable or unstable. Unstable patients showed a significant alteration in several hemodynamic indices, in comparison to stable ones. According to the intraoperative monitoring, eight high risk patients could have been sent to an ordinary ward due to their stability, with a reduction in the improper use of CSDU and, consequently, in costs. \u0000Conclusions. Hemodynamic monitoring with PRAM can be useful in these patients, both for intraoperative management and for the choice of the more appropriate postoperative setting, possibly reducing the improper use of CSDU for hemodynami- cally stable patients who are judged to be at high risk preoperatively, and re-evaluating low surgical risk patients with an unstable intraoperative pattern, with a possible reduction in costs.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"77 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genesis of Multidisciplinary Health Professionals Teams for Pain Management. A History from the Hellenic Antiquity to Modern Palliative Medicine","authors":"Heleni Karassava, Loukas Agorgianitis, Evaggelos Mavrommatis","doi":"10.5644/ama2006-124.439","DOIUrl":"https://doi.org/10.5644/ama2006-124.439","url":null,"abstract":"No abstract available.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"24 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Adverse Effects after Treatment for Childhood Acute Leukemia","authors":"Jelena Roganovic, Riccardo Haupt, E. Bárdi, L. Hjorth, Gisela Michel, Vesna Pavasovic, Katrin Scheinemann, H. V. D. van der Pal, L. Zadravec Zaletel, Ana E. Amariutei, Roderick Skinner, PanCare Board","doi":"10.5644/ama2006-124.438","DOIUrl":"https://doi.org/10.5644/ama2006-124.438","url":null,"abstract":"The aim of this review is to raise awareness and knowledge among healthcare professionals and policymakers about late adverse effects in survivors of childhood leukemia. With contemporary treatment, over 90% of children with acute lymphoblastic leukemia (ALL) and over 60% with acute myeloid leukemia (AML) are cured. Large cohort studies demonstrate that 20% of ALL and most AML survivors have at least one chronic health condition by 20-25 years after diagnosis. These are life-changing or threatening in some survivors and contribute to increased premature mortality. We describe the frequency, causes, clinical features, and natural history of the most frequent and severe late adverse effects in childhood leukemia survivors, including subsequent malignant neoplasms, metabolic toxicity, gonadotoxicity and impaired fertility, endocrinopathy and growth disturbances, bone toxicity, central and peripheral neurotoxicity, cardiotoxicity, psychosocial late effects, accelerated ageing and late mortality. The wide range of late effects in survivors of haemopoietic stem cell transplant is highlighted. Recent developments informing the approach to long-term survivorship care are discussed, including electronic personalized patient-specific treatment summaries and care plans such as the Survivor Passport (SurPass), surveillance guidelines and models of care. The importance of ongoing vigilance is stressed given the increasing use of novel targeted drugs with limited experience of long-term outcomes. \u0000Conclusion. It is vital to raise awareness of the existence and severity of late effects of childhood leukemia therapy among parents, patients, health professionals, and policymakers. Structured long-term surveillance recommendations are necessary to standardize follow-up care.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"289 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficulties in Accessing the List and Full Text of the Defended PhD Theses from Medical Schools: a Retrospective Case Study from Croatia.","authors":"Livia Puljak, Matea Tolić, Marko Sablić, Vlatko Silobrčić, Marija Heffer, Bojan Polić, O. Barcot, D. Sapunar","doi":"10.5644/ama2006-124.437","DOIUrl":"https://doi.org/10.5644/ama2006-124.437","url":null,"abstract":"OBJECTIVE\u0000To conduct scientometric studies on PhD (\"Doctor of Philosophy\") theses (i.e., doctoral theses), researchers should be able to access the theses. We aimed to explore how to obtain a list and full text of the defended PhD theses from medical schools in Croatia over 30 years (from the beginning of 1992 to the end of 2021).\u0000\u0000\u0000METHODS\u0000We tried to obtain information from the Croatian Bureau of Statistics, the National and University Library in Zagreb (NSK), universities, medical schools and online repositories.\u0000\u0000\u0000RESULTS\u0000We could not find a single list (source) of all PhD theses. Based on 4 different sources (website of the University of Zagreb and Medical School in Rijeka; school administrator from Split; library catalog from Osijek), we gathered information that from the beginning of 1992 to the end of 2021, there were 2955 PhD theses defended at medical schools in Croatia - 357 in Osijek, 550 in Rijeka, 337 in Split and 1711 in Zagreb. In May 2022, the online Croatian Digital Dissertations Repository contained 631 (22%) of full-text theses in Portable Document Format (PDF). University of Zagreb School of Medicine has its own repository that holds the full text of 834 (49%) of their PhD theses. One of the three PhD programs of the University of Split School of Medicine, namely Translational Research in Biomedicine (TRIBE), published full texts of all PhD theses defended at that program on its website. NSK held 2650 (90%) of the theses in a printed version.\u0000\u0000\u0000CONCLUSION\u0000It was extremely challenging to access the list and full texts of doctoral theses defended in Croatia. Making PhD theses publicly available would ensure transparency and enable analyses that should improve scientific policy.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"21 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140722019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Unified Register of Donor Sexual Gametes in the Republic of Kazakhstan.","authors":"Leila Chalova, Vyacheslav Lokshin, Vladimir Kiyan, Botagoz Turdaliyeva, A. Kinzhibayev","doi":"10.5644/ama2006-124.436","DOIUrl":"https://doi.org/10.5644/ama2006-124.436","url":null,"abstract":"OBJECTIVE\u0000The purpose of this narrative review paper was to review the state and development of the field of donor gametes in Kazakhstan, compare its legislative and technical capabilities with other countries and identify key steps towards the establishment of a unified register of donor gametes in the Republic.\u0000\u0000\u0000MATERIALS AND METHODS\u0000The narrative review paper conducted an analysis of scientific publications and legal documents to examine the implementation of Assisted Reproductive Technologies (ART), focusing on Donor Sexual Gametes (DSG), globally. It utilized medical publications from 2019 to 2023, legal acts, and recommendations from global health organizations to analyze eligibility criteria, legal regulations, and the social aspects of ART across different regions.\u0000\u0000\u0000RESULTS\u0000In Kazakhstan, ART is regulated by legislation, with DSG procedures governed by age limits, medical screening, and restrictions on the number of children born from donated gametes. Worldwide, practices vary, but there is growing interest in establishing a unified register of reproductive donor material to enhance transparency and accountability. However, legal gaps and ethical considerations must be addressed.\u0000\u0000\u0000CONCLUSION\u0000The study identifies gaps in Kazakhstan's legislation compared to Western countries, emphasizing the necessity for enhanced legal rights for donors and recipients, including options for anonymity. Ethical concerns highlight the importance of confidentiality and data security in accessing the donor registry. Overall, implementing such a register promises to enhance transparency, safety, and accountability in reproductive medicine.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"250 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"George Sclavunos (1869-1954): Anatomical Insights and His Contribution into the \"Magenstrasse of Waldeyer\".","authors":"Ioanna Verzoviti, Michail Saintanis, Dimosthenis Chrysikos, Dimitrios Filippou, Dimitrios Schizas, Ioannis K Antonopoulos, Theodore Troupis","doi":"10.5644/ama2006-124.433","DOIUrl":"10.5644/ama2006-124.433","url":null,"abstract":"<p><p>The purpose of this article is to present a well-known physician and highlight his contribution into an essential, but neglected anatomical feature. George Sclavunos (1869-1954) was a 20th century Greek physician, whose scientific work was a significant milestone in global medical knowledge. In 1899 he became Professor of Anatomy and Head Director of the Department of Anatomy. In 1906 Sclavunos G. published the first volume of the three volume book \"Human Anatomy\" (1906-1926), which is characterized by its unparalleled illustrations. For more than a century it was the most important book of medical literature in Greece. In 1926 he became a Full Member of the Academy of Athens and was named Life Partner of the International Anatomical Society. His interests included Anatomy, Physiology, Histology, as well as Osteology and Syndesmology. In his book \"Human Anatomy\", he described for first time the \"Sialine Groove of the Stomach\", which was described by Waldeyer-Hartz almost at the same time as the \"Magenstrasse\", a German word that means \"stomach road\". It is a ribbon-like path that extends along the lesser curvature of the stomach from the gastric cardia to the antrum and releases the gastric content directly into the small intestine. Its importance is confirmed by its association not only with drug delivery, but also with anti-obesity surgical techniques. The old German term has come back into common medical usage in view of the commonly performed Magenstrasse and Mill procedure, a form of bariatric surgery. CONCLUSION: Sclavunos G. managed to observe an anatomical structure that has remained of great importance until today.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"106-113"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}