Forensic Science Review最新文献

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Driving under the influence of non-alcohol drugs--An update. Part II: Experimental studies. 在非酒精类药物影响下开车最新情况第二部分:实验研究。
Forensic Science Review Pub Date : 2016-07-01
M C Strand, H Gjerde, J Mørland
{"title":"Driving under the influence of non-alcohol drugs--An update. Part II: Experimental studies.","authors":"M C Strand,&nbsp;H Gjerde,&nbsp;J Mørland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental studies on the impairing effects of drugs of relevance to driving-related performance published between 1998 and 2015 were reviewed. Studies with on-the-road driving, driving simulators, and performance tests were included for benzodiazepines and related drugs, cannabis, opioids, stimulants, GHB, ketamine, antihistamines, and antidepressants. The findings in these experimental studies were briefly discussed in relation to a review of epidemiological studies published recently. The studies mainly concluded that there may be a significant psychomotor impairment after using benzodiazepines or related drugs, cannabis, opioids, GHB, or ketamine. Low doses of central stimulants did not seem to cause impairment of driving behavior. </p>","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"28 2","pages":"79-101"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34437726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORENSIC SCIENCE AROUND THE WORLD. 世界各地的法医科学。
Forensic Science Review Pub Date : 2015-07-01
J Teitelbaum
{"title":"FORENSIC SCIENCE AROUND THE WORLD.","authors":"J Teitelbaum","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"70-2"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34000976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism and Disposition of Prescription Opioids: A Review. 处方阿片类药物的代谢和处置:综述。
Forensic Science Review Pub Date : 2015-07-01
A Z DePriest, B L Puet, A C Holt, A Roberts, E J Cone
{"title":"Metabolism and Disposition of Prescription Opioids: A Review.","authors":"A Z DePriest,&nbsp;B L Puet,&nbsp;A C Holt,&nbsp;A Roberts,&nbsp;E J Cone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Opioid analgesics are commonly prescribed for acute and chronic pain, but are subject to abuse. Consequently, toxicology testing programs are frequently implemented for both forensic and clinical applications. Understanding opioid metabolism and disposition is essential for assessing risk of toxicity and, in some cases, providing additional information regarding risk of therapeutic failure. Opioids significantly metabolized by the cytochromeP450 (CYP450) enzyme system maybe subjectto drug-drug interactions, including codeine, hydrocodone, oxycodone, fentanyl, meperidine, methadone, buprenorphine, and tramadol. CYP2D6 metabolism is polymorphic, and pharmacogenetic testing has been investigated for codeine, tramadol, oxycodone, and hydrocodone. CYP2B6 pharmacogenetic testing of methadone may reduce the risk of cardiac toxicity associated with the S-enantiomer. Opioids metabolized primarily by uridine 5'-diphospho-glucuronsyltransferase (UGT) enzymes include morphine, hydromorphone, dihydrocodeine, oxymorphone, levorphanol, and tapentadol. Parent and metabolite disposition is described for blood, oral fluid, and urine. Parent drug is most commonly detected in blood and oral fluid, whereas metabolites typically predominate in urine. Oral fluid/blood ratios exceed 1 for most opioids, making this an excellent alternative matrix for testing of this drug class. Metabolites of codeine, hydrocodone, and oxycodone are commercially available, and knowledge of metabolism is necessary for correct interpretation.</p>","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"115-45"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34051861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Forensic Technology Center of Excellence--Recent and Upcoming Activities. 卓越的法医技术中心——最近和即将开展的活动。
Forensic Science Review Pub Date : 2015-07-01
J D Ropero-Miller
{"title":"The Forensic Technology Center of Excellence--Recent and Upcoming Activities.","authors":"J D Ropero-Miller","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"74-7"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34000978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORENSIC SCIENCE EDUCATIONAL PROGRAMS--United Kingdom (UK) & Ireland. 法医学教育项目——英国和爱尔兰。
Forensic Science Review Pub Date : 2015-07-01
Yung-Chun Lin
{"title":"FORENSIC SCIENCE EDUCATIONAL PROGRAMS--United Kingdom (UK) & Ireland.","authors":"Yung-Chun Lin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34000980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
20th Scientific Meeting of the Society of Hair Testing. 第20届头发测试学会科学会议。
Forensic Science Review Pub Date : 2015-07-01
D Ropero-Miller, E Umpierrez
{"title":"20th Scientific Meeting of the Society of Hair Testing.","authors":"D Ropero-Miller,&nbsp;E Umpierrez","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"77"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34000979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driving Under the Influence of Non-Alcohol Drugs--An Update Part I: Epidemiological Studies. 非酒精类药物影响下的驾驶——更新第一部分:流行病学研究。
Forensic Science Review Pub Date : 2015-07-01
H Gjerde, M C Strand, J Mørland
{"title":"Driving Under the Influence of Non-Alcohol Drugs--An Update Part I: Epidemiological Studies.","authors":"H Gjerde,&nbsp;M C Strand,&nbsp;J Mørland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epidemiological studies of the association between drug use and involvement in road traffic crashes (RTCs) published from January 1998 to February 2015 have been reviewed. Cohort andpopulation studies compared RTC involvement among drug users and non-drug users, case-control studies compared drug use among RTC-involved and non-RTC-involved drivers, and responsibility studies and case-crossover studies were performed for RTC-involved drivers. Difficulties associated with the types of studies are discussed with a special focus on case-control studies. Statistically significant associations between drug use and RTC involvement were found for benzodiazepines and z-hypnotics in 25 out of 28 studies, for cannabis in 23 out of 36 studies, for opioids in 17 out of 25 studies, for amphetamines in 8 out of 10 studies, for cocaine in 5 out of 9 studies, and for antidepressants in 9 out of 13 studies. It was a general trend among studies that did not report significant associations between the use of these drugs and increased RTC risk that they often had either poor statistical power or poor study design compared to studies that found an association. Simultaneous use of two or more psychoactive drugs was associated with higher RTC risk. Studies on the combination of alcohol and drugs have not been reviewed in this article even though this combination is known to be associated with the highest RTC risk.</p>","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"89-113"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34051860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIST Forensic Science Research Update. NIST法医科学研究更新。
Forensic Science Review Pub Date : 2015-07-01
{"title":"NIST Forensic Science Research Update.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 2","pages":"72-4"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34000977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Improved Forensic Science Information Search. 一种改进的法医学信息检索方法。
Forensic Science Review Pub Date : 2015-01-01
J Teitelbaum
{"title":"An Improved Forensic Science Information Search.","authors":"J Teitelbaum","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although thousands of search engines and databases are available online, finding answers to specific forensic science questions can be a challenge even to experienced Internet users. Because there is no central repository for forensic science information, and because of the sheer number of disciplines under the forensic science umbrella, forensic scientists are often unable to locate material that is relevant to their needs. The author contends that using six publicly accessible search engines and databases can produce high-quality search results. The six resources are Google, PubMed, Google Scholar, Google Books, WorldCat, and the National Criminal Justice Reference Service. Carefully selected keywords and keyword combinations, designating a keyword phrase so that the search engine will search on the phrase and not individual keywords, and prompting search engines to retrieve PDF files are among the techniques discussed. </p>","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 1","pages":"41-52"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33883180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genetics of skin, hair, and eye color variation and its relevance to forensic pigmentation predictive tests. 皮肤、头发和眼睛颜色变异的遗传学及其与法医色素沉着预测测试的相关性。
Forensic Science Review Pub Date : 2015-01-01
O Maroñas, J Söchtig, Y Ruiz, C Phillips, Á Carracedo, M V Lareu
{"title":"The genetics of skin, hair, and eye color variation and its relevance to forensic pigmentation predictive tests.","authors":"O Maroñas,&nbsp;J Söchtig,&nbsp;Y Ruiz,&nbsp;C Phillips,&nbsp;Á Carracedo,&nbsp;M V Lareu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review examines the potential application of single nucleotide polymorphism (SNP)-based predictive tests for skin, hair, and eye color to forensic analysis in support of police investigations lacking DNA database matches or eyewitness testimony. Brief descriptions of the biology of melanogenesis and the main genes involved are presented in order to understand the basis of common pigmentation variation in humans. We outline the most recently developed forensically sensitive multiplex tests that can be applied to investigative analyses. The review also describes the biology of the SNPs with the closest associations to, and therefore the best predictors for, common variation in eye, hair, and skin pigmentation. Because pigmentation pathways are complex in their patterns, many of the better-studied human albinism traits provide insight into how pigmentation SNPs interact, control, or modify gene expression and show varying degrees of association with the key genes identified to date. These aspects of SNP action are discussed in an overview of each of the functional groups of pigmentation genes. </p>","PeriodicalId":38192,"journal":{"name":"Forensic Science Review","volume":"27 1","pages":"13-40"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33883179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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