Rwanda Medical Journal最新文献_第4页

Comparative effects of intravenous esmolol and lidocaine on bispectral index during propofol-fentanyl induction in patients scheduled for elective surgeries under general anaesthesia 静脉注射艾司洛尔和利多卡因对计划在全身麻醉下进行择期手术的患者在异丙酚-芬太尼诱导过程中双频谱指数的影响比较

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.8

O. O. Oladosu, B. Bolaji, O. Ige, I. I. Enaworu, A. Alawode

{"title":"Comparative effects of intravenous esmolol and lidocaine on bispectral index during propofol-fentanyl induction in patients scheduled for elective surgeries under general anaesthesia","authors":"O. O. Oladosu, B. Bolaji, O. Ige, I. I. Enaworu, A. Alawode","doi":"10.4314/rmj.v80i4.8","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.8","url":null,"abstract":"INTRODUCTION: Laryngoscopy and endotracheal intubation at induction of anaesthesia have been associated with awareness and haemodynamic fluctuations. Agents that can mitigate these effects should create better anaesthetic conditions. This study aimed to compare the effects of intravenous esmolol and lidocaine on the bispectral index (BIS) and haemodynamic responses during induction of general anaesthesia with propofol/fentanyl in adult patients scheduled for elective surgical procedures. \u0000METHODS: This was a prospective randomized controlled study in ninety patients aged 18-65 years who were randomized into three groups to receive either IV esmolol 0.5 mg/kg, IV lidocaine 1.5 mg/kg or normal saline prior to induction of general anaesthesia. \u0000RESULTS: The esmolol group had a significantly shorter induction time (p<0.0001) and a lower dose of propofol consumed (p<0.0001) than the lidocaine group. The mean pulse rate was significantly lower at the 1st min to 4th min post-intubation in esmolol and lidocaine groups compared to the control group (p values; 1 min= 0.005, 2 min= 0.008, 3 min= 0.023, 4 min= 0.018). There was a significant difference in the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in the three groups at 2 min post-intubation. \u0000CONCLUSION: Pre-induction intravenous esmolol 0.5 mg/kg was more effective than intravenous lidocaine 1.5 mg/kg in reducing the induction dose of propofol and the induction time. Esmolol also prevented increases in BIS better than lidocaine following endotracheal intubation but both agents were equally effective in attenuating the haemodynamic changes associated with laryngoscopy and endotracheal intubation.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"385 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the effectiveness of thrower’s specific exercise program with regular warm-up program in recreational cricket bowlers 比较投掷手专项训练计划和常规热身计划对休闲板球保龄球运动员的效果

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.7

P. S. Timothy, S. Subramanian

{"title":"Comparing the effectiveness of thrower’s specific exercise program with regular warm-up program in recreational cricket bowlers","authors":"P. S. Timothy, S. Subramanian","doi":"10.4314/rmj.v80i4.7","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.7","url":null,"abstract":"INTRODUCTION: Thrower’s Ten program is a thrower-specific workout program that increases upper-extremity strength, power, and endurance, especially in overhead athletes. The study compares the thrower's ten-exercise program to the regular warm-up program in recreational cricket bowlers' posterior capsule tightness, internal rotator strength, upper extremity stability, and explosive power. \u0000METHODS: Based on inclusion and exclusion criteria, 82 recreational cricket bowlers were divided into experimental (n=41) and control (n=41) groups. The experimental group received Thrower's ten warm-up programs three times a week for six weeks, along with the standard warm-up. Control maintained its warm-up routine. Before and after six weeks, participants were tested for shoulder internal rotator strength, posterior capsule tightness, stability, and explosive power. SPSS software was used to calculate outcome measures mean, standard deviation, independent t-test, and paired t-test. \u0000RESULTS: After six weeks, all outcome measures exhibited a significant difference (p<0.05) within the experimental group, whereas none of the outcome measures depicted a significant difference (p>0.05) within the control group. A significant difference (p<0.05) was seen between the groups for post-test strength and upper extremity stability measures. However, a non-significant difference (p>0.05) was noted between groups for posterior capsule tightness and upper extremity explosive power. \u0000CONCLUSION: Compared to the usual warm-up program used by recreational cricket bowlers, the thrower’s customized warm-up routine is more successful in improving internal rotator strength and upper extremity stability. Both warm-up programs enhance posterior capsule tightness and upper extremity explosive power.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of first- and second-hand smoking on cardiac diseases in Yogyakarta, Indonesia: a preliminary cross-sectional study 印度尼西亚日惹市一手烟和二手烟对心脏病的影响：初步横断面研究

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.4

P. E. Nirmala Dewi, M. Octavia, W. Himawan, D. Sugiyo

{"title":"Impact of first- and second-hand smoking on cardiac diseases in Yogyakarta, Indonesia: a preliminary cross-sectional study","authors":"P. E. Nirmala Dewi, M. Octavia, W. Himawan, D. Sugiyo","doi":"10.4314/rmj.v80i4.4","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.4","url":null,"abstract":"INTRODUCTION: Toxic agents from cigarette smoke can affect the cardiovascular system, especially coronary heart disease (CHD). The implication to the second-hand smoker was 80%–90%, similar to the first-hand smoker. This study aimed to provide preliminary data on the smoking effect among first- and second-hand smokers according to cardiac diseases in Yogyakarta, Indonesia. \u0000METHODS: This descriptive cross-sectional study was conducted by prospectively collecting data from two secondary hospitals in Yogyakarta, Indonesia. The collected data were descriptively analyzed to compare the first- and second-hand smokers to the variables. ANOVA or the Mann- Whitney Test, was also used to obtain the correlation of each variable across both smoking groups. \u0000RESULTS: Among the 101 participants, we found that smoking habits can have a similar or even higher impact among second-hand smokers compared to first-hand smokers with respect to congestive heart failure (CHF) diagnoses (48% vs. 56%), IHD diagnoses (36% vs. 27.9%), suffering chest pain (39.3% vs. 27.8%), and shortness of breath (38.7% vs. 33.3%). \u0000CONCLUSION: Smoking habits can increase the risk of CHD, especially CHF, and IHD, among first- and second-hand smokers. Indonesia's government should protect second-hand smokers and limit the exposure of first-hand smokers to cigarettes.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"149 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and socio-demographic factors associated with depression among students on clinical rotation in a private university in Ekiti state, Nigeria 尼日利亚埃基蒂州一所私立大学临床轮转学生对抑郁症的了解及相关社会人口因素

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.3

A. A. Omotoso, J. Ojo, T. Ipinnimo, T. Alao, M. Chimah, E. Uchuno, H. Mohammed, A. Etuk, B. Osho, O. Olasehinde

{"title":"Knowledge and socio-demographic factors associated with depression among students on clinical rotation in a private university in Ekiti state, Nigeria","authors":"A. A. Omotoso, J. Ojo, T. Ipinnimo, T. Alao, M. Chimah, E. Uchuno, H. Mohammed, A. Etuk, B. Osho, O. Olasehinde","doi":"10.4314/rmj.v80i4.3","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.3","url":null,"abstract":"NTRODUCTION: Depression is among the most common mental and public health problems globally. Depression is generally common among university students and is especially high among undergraduates on clinical postings. Clinical students are exposed to varying kinds of stressors ensuing from difficulties integrating into the hospital system and implicated in causing academic failure, disability, and poor quality of life. This study aimed to assess the knowledge and the socio-demographic factors associated with depression among clinical undergraduates in a private university. \u0000METHODS: This was a cross-sectional study conducted among 242 students of the College of Medicine and Health Sciences of a private university who were undergoing their clinical rotations. Data was collected on the socio-demographic variable and knowledge of depression. The proportion of students with depression was determined with the 20-itemZung self-rating depression scale. \u0000RESULTS: Less than half (43.0%) of the respondents had good knowledge of depression, with the majority using social media (82.6%) and one-third of Journals/textbooks (34.3%) as sources of information. The identified predictors of depression were being female (AOR:2.624; 95%CI:1.006-7.600) and having poor knowledge of depression (AOR:2.806; 95%CI:1.121-3.975). \u0000CONCLUSION: This study revealed that less than half of the students had good knowledge of depression. Poor knowledge and female gender were identified as positive predictors of depression. Therefore, more effort should also be taken by the school authority to educate these students on depression.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"406 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of malaria preventive strategies among pregnant women at Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria 尼日利亚伊巴丹 Adeoyo 妇产教学医院孕妇对疟疾预防策略的利用情况

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.6

Olaolu O. Oni, O. Bello

{"title":"Utilization of malaria preventive strategies among pregnant women at Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria","authors":"Olaolu O. Oni, O. Bello","doi":"10.4314/rmj.v80i4.6","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.6","url":null,"abstract":"INTRODUCTION: Malaria in pregnancy is associated with a high rate of maternal and perinatal morbidity and mortality. Utilization of preventive strategies during pregnancy is an integral part of controlling the burden of malaria in pregnancy. This study evaluated the malaria preventive strategies utilized and the prevalence of asymptomatic malaria among pregnant women at Adeoyo Maternity Teaching Hospital (AMTH), Ibadan, Nigeria. \u0000METHODS: A facility-based descriptive cross-sectional study among 223 pregnant women in Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria. Information on socio-demographic and obstetric characteristics, malaria symptoms, and the preventive strategies utilized were obtained using a structured questionnaire. Descriptive and bivariate analysis using chi-square test and multivariate analysis at 95% confidence interval and p< 0.05 was used to determine the predictors of asymptomatic malaria infection in relation to socio-demographic characteristics and malaria preventive strategies utilized. \u0000RESULTS: The mean age was 30±5 years. More than half (53.4%) of them used insecticide-treated nets consistently, 49.3% sprayed the room regularly with insecticides, while the majority (88.3%) reported they maintained a clean environment. However, 11.7% tested positive for the malaria parasite. Consistency in the use of insecticide-treated net (ITN) and participants age were factors associated with malaria occurrence (p=0.01). The use of ITN and being >30 years of age are protective factors against having malaria infection among pregnant women (AOR= 0.34; 95%, CI=0.14-0.84) and (AOR=0.31; 95% CI=0.13-0.76) respectively. \u0000CONCLUSION: Irrespective of all other malaria preventive strategies adopted by pregnant women, consistent use of ITN was independently a protective factor against developing malaria in pregnancy.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"397 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between erectile dysfunction and cardiovascular risk factors in a Nigeria tertiary hospital 尼日利亚一家三级医院中勃起功能障碍与心血管风险因素之间的关系

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.2

I. Tor-Anyiin, O. E. Omokhua, L. T. Swende

{"title":"Association between erectile dysfunction and cardiovascular risk factors in a Nigeria tertiary hospital","authors":"I. Tor-Anyiin, O. E. Omokhua, L. T. Swende","doi":"10.4314/rmj.v80i4.2","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.2","url":null,"abstract":"INTRODUCTION: Erectile dysfunction has adverse effects on the marital harmony and self-esteem of affected persons. It is shrouded in shame in our environment, hence affecting self-reporting of the condition. It is linked to CVDs in its etiology. The objective was to determine the relationship between erectile dysfunction (ED) and cardiovascular risk factors to recommend them as indicators for screening for ED in our environment. \u0000METHODS: This was a cross-sectional analytical study of 243 men at a tertiary hospital in Nigeria. Participants were recruited by systematic random sampling, excluding those on aphrodisiacs. Erectile dysfunction was measured using the International Index of Erectile Function (IIEF-5), and ED was defined as a score <17. CVD risk factors were obtained from history and examination. Univariate analysis and logistic regressions were used to elicit associations between ED and cardiovascular risk factors. \u0000RESULTS: The prevalence of ED was 47.3%. Erectile dysfunction was associated with increasing age (χ2=27, p<0.01), harmful alcohol use (χ2=3.08, p= 0.079), diabetes (χ2=8.29, p=0.04), and hypertension (χ2=12.28, p =0.01) following bivariate analysis. However, only advanced age (aOR=0.04, 95% CI: 0.00-0.54, p = 0.014) and harmful alcohol use (aOR = 0.37, 95% CI: 0.04-0.97, p=0.043) were independently associated with ED after binary logistic regression. \u0000CONCLUSION: The prevalence of ED is high high. It is associated with age, harmful alcohol use, diabetes mellitus, and hypertension, hence the need to screen for ED, especially in the presence of these factors.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"130 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative epidemiology and outcomes among trauma patients transported by private and formal pre-hospital care modes in Kigali, Rwanda 卢旺达基加利由私人和正规院前护理模式运送的外伤患者的流行病学和治疗效果比较

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.1

J. Nzabandora, S. Bilal, L. Jing, M. B. Henry, A. Beeman, G. Mbanjumucyo, N. Rosenberg, J. Nyinawankusi, V. Sharma, V. Ndebwanimana, J. Muaragizi, E. Odoom, A. Aluisio

{"title":"Comparative epidemiology and outcomes among trauma patients transported by private and formal pre-hospital care modes in Kigali, Rwanda","authors":"J. Nzabandora, S. Bilal, L. Jing, M. B. Henry, A. Beeman, G. Mbanjumucyo, N. Rosenberg, J. Nyinawankusi, V. Sharma, V. Ndebwanimana, J. Muaragizi, E. Odoom, A. Aluisio","doi":"10.4314/rmj.v80i4.1","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.1","url":null,"abstract":"INTRODUCTION: The burden of injuries is high in low- and middle-income countries where pre-hospital systems are being developed to improve acute injury care. This study compares the characteristics and outcomes between trauma patients transported by formal emergency medical services (EMS) and by private transport to the emergency department (ED) of the Centre Hospitalier Universitaire de Kigali (CHUK) in Rwanda. \u0000METHODS: This retrospective cohort study analyzed a random sample of trauma patients presenting between 1 August 2015 and 30 July 2016. Descriptive analyses were performed, and differences in outcomes were assessed based on transport modalities via Pearson Chi-Squared or Fisher’s Exact tests. \u0000RESULTS: Of the 556 trauma patients analyzed, 87.1% were transported by private transport and the remainder by EMS. The median inpatient length of stay for private transport patients was 7 days (IQR:3-16 days), compared to 9.5 days for EMS patients (IQR:4-18 days) (p=0.301). More EMS-transported patients died in the ED (p=0.005), and more were admitted to the hospital. There was a higher mortality rate among patients admitted to the hospital who arrived by private transport, but the difference was not statistically significant. \u0000CONCLUSION: The higher ED death rate among EMS-transported patients and the higher in-hospital death rate among private transport patients suggest that major differences in the two groups may or may not be related to how trauma patients are brought to the ED.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"250 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid masses in Sierra Leone: a one-year retrospective clinico- pathological study 塞拉利昂的甲状腺肿块：为期一年的回顾性临床病理研究

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.5

M. S. Kabba, N. T. Onyishi, A. Kalawa, R. K. Adeyinka, B. M. Duduyemi

{"title":"Thyroid masses in Sierra Leone: a one-year retrospective clinico- pathological study","authors":"M. S. Kabba, N. T. Onyishi, A. Kalawa, R. K. Adeyinka, B. M. Duduyemi","doi":"10.4314/rmj.v80i4.5","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.5","url":null,"abstract":"INTRODUCTION: Thyroid disorders are the second most common endocrine diseases in humans. There has been no study of thyroid masses in our setting in spite of recurrent presentations. We undertook a retrospective study of incident thyroidectomy cases in our anatomic pathology laboratory over one year to establish the frequency and clinico-pathologic features of thyroid masses. \u0000METHODS: All thyroid specimens submitted to the anatomic pathology laboratory of the University of Sierra Leone Teaching Hospital Connaught from January 1, 2021 to December 31, 2021, were included in the study. Data was extracted from archived request forms, pathology reports, and patient’s case notes retrieved from the records department. The data obtained was analyzed with SPSS software. \u0000RESULTS: Twenty-seven thyroidectomy specimens (4.5% of all surgical pathology cases) were seen over a one-year period. Ninety-two percent were from women, while 7.4% were from men. The age range of patients was 17 to 65 years; the median age (IQR) was 40 (35-48) years. Duration of mass before presentation ranged from 3 months to 50 years. About 75% of the resected thyroid masses weighed 5 to 21 times more than a normal thyroid gland. Multinodular goiter was the most common histology (70.4%). Twenty-two percent of the resected masses were malignant. \u0000CONCLUSION: Thyroid masses constitute about 4.5% of all surgical specimens in our laboratory. Most thyroid masses are borne for years with no serious consequences. Some of the resected masses were up to 20 times the size of a normal gland. The frequency of malignant diagnoses in thyroid masses was 22.5%.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and phenotypic presentation of Usher syndrome - a case report 乌谢尔综合征的遗传和表型表现--病例报告

Rwanda Medical Journal Pub Date : 2024-01-28 DOI: 10.4314/rmj.v80i4.10

N. Dukuze, E. Uwibambe, P. Sesonga, J. Niyongere, B. Tuyishimire, A. Urungwiro, J. Ndinkabandi, A. Rwamatwara, S. Niyoyita, G. Isingizwe, J. Batamuliza, C. Nsanzabaganwa, J. Bukuru, F. Rutagarama, O. Karangwa, A. Ndatinya, C. Muhizi, L. Mutesa

{"title":"Genetic and phenotypic presentation of Usher syndrome - a case report","authors":"N. Dukuze, E. Uwibambe, P. Sesonga, J. Niyongere, B. Tuyishimire, A. Urungwiro, J. Ndinkabandi, A. Rwamatwara, S. Niyoyita, G. Isingizwe, J. Batamuliza, C. Nsanzabaganwa, J. Bukuru, F. Rutagarama, O. Karangwa, A. Ndatinya, C. Muhizi, L. Mutesa","doi":"10.4314/rmj.v80i4.10","DOIUrl":"https://doi.org/10.4314/rmj.v80i4.10","url":null,"abstract":"Usher syndrome is a genetic, clinically heterogeneous condition characterized by sensorineural hearing loss, progressive retinal degeneration, and vestibular dysfunction. There are three phenotypically recognizable types of Usher syndrome. Individuals with Usher syndrome type 1 have no vestibular function and profound sensorineural hearing loss. Individuals with Usher syndrome type 2 have normal vestibular function and mild-to-severe hearing loss with visual impairment that is presented later in life. People with Usher syndrome type III experience hearing and vision loss beginning later in life. In this case report, we are reporting a 7-year-old boy consulted for progressive hearing loss and bilateral vision impairment, and fundus exam revealed mild bilateral retinal vessel attenuation and bone spicule deposits in both eyes. A molecular genetic test done by next-generation sequencing identified a homozygous pathogenic variant in the CDH23 gene (NM_022124.5:c.2255del variant coordinate with amino acid change of p.(Gly752Valfs*13)), confirming the diagnosis of autosomal recessive Usher syndrome type ID (USH1D). The patient had a remarkable improvement with visual and optical aids. Genetic counseling, including reproductive counseling, was provided to the parents. Clinical evaluation, visual hearing tests, and genetic workup confirmed Usher syndrome, which is a rare but dangerous cause of hearing loss and visual impairment that needs to be thoroughly evaluated by a multi-disciplinary team approach.","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

25-hydroxy vitamin D concentrations negatively correlated with HbA1c in type 2 diabetes mellitus patients: a cross-sectional study in Mampang, South Jakarta 25-羟基维生素D浓度与2型糖尿病患者HbA1c呈负相关:南雅加达Mampang的一项横断面研究

Rwanda Medical Journal Pub Date : 2023-10-13 DOI: 10.4314/rmj.v80i3.3

None Alvina, None Pusparini

{"title":"25-hydroxy vitamin D concentrations negatively correlated with HbA1c in type 2 diabetes mellitus patients: a cross-sectional study in Mampang, South Jakarta","authors":"None Alvina, None Pusparini","doi":"10.4314/rmj.v80i3.3","DOIUrl":"https://doi.org/10.4314/rmj.v80i3.3","url":null,"abstract":"   INTRODUCTION: Insulin resistance plays a central role in type 2 diabetes mellitus (T2DM). Another possible cause of T2DM is a deficiency o f 25-hydroxy vitamin D [ 25(OH)D], although the underlying mechanism is not yet clearly understood. The most frequently used laboratory parameters for monitoring T2DM are fasting blood glucose (FBG) and HbA1c. Determining any association of vitamin D with HbA1c and FBG in T2DM. METHODS: A cross-sectional study involving 100 T2DM patients with the following characteristics: 18-year and older persons of both genders, not having kidney and liver disease, not on insulin therapy, not pregnant or lactating, a nd n ot consuming vitamin D i n t he last three months. Spearman’s correlation coefficient was use d to test any association of 25(OH)D with HbA1 c and fasting blood glucose (FBG) (p<0.05). RESULTS: Subjects comprised 74 females and 26 males with a median age of 56 years. Median HbA1c, 25(OH)D, and FBG were 8.05%, 11.2 ng/mL, and 127 mg/dL, respectively. The Spearman correlation coefficient for vitamin D and HbA1c was r=-0.217 (p=0.03), and for vitamin D and FBG,it was r =-0.153 (p=0.128). CONCLUSION: There was a significant negative correlation of vitamin D with HbA1c but not with FBG. Administration of vitamin D should be considered for additional treatment of T2DM.  ","PeriodicalId":38181,"journal":{"name":"Rwanda Medical Journal","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135923490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0