Interdisciplinary Neurosurgery: Advanced Techniques and Case Management最新文献

{"title":"Effects of steroids on vasogenic edema due to brain tumors, a narrative review","authors":"Marzieh Shahrabi ,&nbsp;Azin Abdollahi ,&nbsp;Mohammad Niakan Lahiji ,&nbsp;Tahereh Sorbi ,&nbsp;Mohammad Solduzian","doi":"10.1016/j.inat.2025.102106","DOIUrl":"10.1016/j.inat.2025.102106","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Tumor-associated edema is a serious condition that can lead to severe complications. Corticosteroids in the treatment of edema can be administered postoperatively or preoperatively. Each method has its benefits and drawbacks, and there still isn’t a consensus on choosing the best approach. In this review, the effects of different types of corticosteroids will be discussed in the management of tumor-associated edema, also it provides basis for further investigation due to the lack of data in this regard.</div></div><div><h3>Method</h3><div>PubMed, Google Scholar, and Scopus were used for search from inception to February 13, 2025<strong>.</strong> The Scale for the Assessment of Narrative Review Article was used for evaluation and it received the score of 10.</div></div><div><h3>Result</h3><div>Conducted search resulted in 965 relevant articles. In total, 19 of them matched to our purpose of the study.</div></div><div><h3>Conclusion</h3><div>There are more studies focused on dexamethasone than on the other agents. Due to its lower mineralocorticoid effects, dexamethasone is usually the corticosteroid of choice, except in cases where the patient has a history of an allergic reaction to it. Preoperative administration of these medications can provide benefits, such as decreasing complications and improving the patient’s clinical status. Postoperative use of corticosteroids may also reduce the length of hospitalization.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102106"},"PeriodicalIF":0.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A complicated intrathecal baclofen pump implantation in a child with spastic Diplegia: Should a genetic mimic of cerebral palsy be Considered?","authors":"Mohamed Ashraf ,&nbsp;Peter Emad Khalil ,&nbsp;Omnia Fathy ElRashidi ,&nbsp;Jacob Edwar Ibrahem ,&nbsp;Hedayat Khaled Mansour ,&nbsp;Ahmed Wael Ibrahim ,&nbsp;Mohamed Ismael Ali ,&nbsp;Hesham Nafea ,&nbsp;Mostafa G. Mahran ,&nbsp;Abdelwahab Marzouk ,&nbsp;Walid Abdel Ghany","doi":"10.1016/j.inat.2025.102113","DOIUrl":"10.1016/j.inat.2025.102113","url":null,"abstract":"<div><h3>Background</h3><div>Management of hypertonia in children with cerebral palsy was challenged over decades including physical rehabilitation, splinting, orthopedic procedures, Botulinum toxin injection, ablative neurosurgical techniques and neuromodulation procedures including intrathecal baclofen infusion. Neurological decline is not a common fate of the classic cerebral palsy (perinatal insult). <strong>Observations:</strong> We report a 14-year-old boy child with spastic cerebral palsy diplegia showing rapid decline of neurological status following intrathecal baclofen pump implantation. The whole exome genetic sequencing of the child showed an ultra-rare bi-allelic mutation in the NFU1 gene. This gene mutation has a wide spectrum of symptoms including fatal leukoencephalopathy, muscular hypotonia, psychomotor regression, swallowing difficulties and pulmonary hypertension. <strong>Lessons:</strong> Genetic mimics of cerebral palsy may be overlooked and must be put into consideration before making surgical decisions.</div><div><strong>Previous presentations::</strong> An abstract was accepted for oral presentation in the Ain shams Neurosurgery Congress (ASNS) in Cairo, Egypt in May 2023. There are no other presentations or submissions of publications for this case.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102113"},"PeriodicalIF":0.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of traumatic intracranial aneurysms: Insights into diagnosis, treatment, and prognosis","authors":"Mohammad Shirani ,&nbsp;Arad Iranmehr ,&nbsp;Abolghasem Mortazavi ,&nbsp;Kourosh Karimi Yarandi ,&nbsp;Masoud SohrabiAsl","doi":"10.1016/j.inat.2025.102108","DOIUrl":"10.1016/j.inat.2025.102108","url":null,"abstract":"<div><h3>Objective</h3><div>To provide a comprehensive overview of the incidence, diagnosis, treatment, and outcomes of traumatic intracranial aneurysms (TICAs).</div></div><div><h3>Methods</h3><div>A systematic review was conducted following the PRISMA guidelines. Five studies published between 2000 and 2015 were included, encompassing a total of 732 patients. Data on patient demographics, mechanisms of injury, diagnostic timing and modalities, aneurysm characteristics, treatment approaches, and outcomes were extracted and analyzed.</div></div><div><h3>Results</h3><div>Out of 732 patients, 92 were diagnosed with TICAs. The incidence of TICAs varied across studies, with a higher prevalence in males. The mean age of patients ranged from 10.74 to 47.3 years. Closed head injuries were the predominant cause of TICAs, except in one study where penetrating injuries were more common. Diagnostic imaging, primarily using digital subtraction angiography (DSA) and computed tomography angiography (CTA), were critical for accurate detection. The most common aneurysm locations were the anterior cerebral artery (ACA) and middle cerebral artery (MCA), with mean sizes ranging from 4.08 mm to 4.72 mm. Treatment modalities included surgical and endovascular interventions, with endovascular treatment showing favorable neurological outcomes and better parent artery preservation in most reported cases. Mortality rates varied, with the lowest reported at 0.08.</div></div><div><h3>Conclusion</h3><div>TICAs are a rare but serious complication of head trauma that require prompt diagnosis and treatment. Advanced imaging techniques and early intervention, particularly through endovascular methods, significantly improve patient outcomes. Further research is needed to establish standardized diagnostic and therapeutic protocols for the optimal management of TICAs.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102108"},"PeriodicalIF":0.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPINAL CORD TERATOMA WITH DIPLOMYELIA","authors":"Maria Mercedes Castano-Sosa ,&nbsp;Orlando Michael Rosas-Fernandez ,&nbsp;Leticia Silva y Silva ,&nbsp;Nidelhvia Ballesteros-Gonzalez ,&nbsp;Gerardo Salvador Lechuga-Rodriguez","doi":"10.1016/j.inat.2025.102107","DOIUrl":"10.1016/j.inat.2025.102107","url":null,"abstract":"<div><h3>Background</h3><div>Intramedullary spinal cord teratomas are exceedingly rare, accounting for only 0.1–0.5% of all spinal cord tumors [1,2]. These tumors are particularly uncommon in adults, with few reported cases achieving complete recovery of motor and sensory functions.</div></div><div><h3>Case description</h3><div>We present the case of a 56-year-old woman who experienced right leg pain and weakness accompanied by paresthesia in the right abdominal region. Magnetic resonance imaging revealed an intramedullary lesion at T2–T3, associated with vertebral body atrophy from T2 to T4 and diplomyelia at the T5 level. The patient underwent a posterior thoracic approach with laminectomy and complete tumor resection. Histopathological analysis confirmed the diagnosis of a mature teratoma comprising elements from all three germ layers.</div></div><div><h3>Conclusions</h3><div>This case illustrates the possibility of successful management of rare intramedullary spinal cord teratomas with associated diplomyelia in adults, demonstrating that complete surgical excision can lead to favorable neurological outcomes.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102107"},"PeriodicalIF":0.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous kyphoplasty and vertebroplasty in children: A systematic review","authors":"Beaudelaire Romulus Assan ,&nbsp;Mèhomè Wilfried Dossou ,&nbsp;Wilfried Innocent Munkado Meuga ,&nbsp;Yannelle Agbodjogbé ,&nbsp;Raïssa Abibatou Yasmina Diaby ,&nbsp;Joël Emmanuel N’guessan Brou ,&nbsp;Laté Dzidoula Lawson ,&nbsp;Nourou Dine Adeniran Bankolé","doi":"10.1016/j.inat.2025.102105","DOIUrl":"10.1016/j.inat.2025.102105","url":null,"abstract":"<div><h3>Background</h3><div>Currently, vertebral augmentation is primarily used to treat vertebral compression fractures in adults. However, an increasing literature reports its use in the paediatric population.</div></div><div><h3>Aim</h3><div>To summarise the indications, technical aspects and results of paediatric percutaneous kyphoplasty and vertebroplasty.</div></div><div><h3>Methods</h3><div>We performed an electronic search of PubMed/ Medline English literature on PKP and PVP without time limitation.</div></div><div><h3>Results</h3><div>Seven studies (3 case reports and 4 case series) with a total of 21 patients and 46 vertebral augmentations were included. The procedure is mainly performed in adolescents with a mean age of 10.2 years (range 5–13, SD 2.9) and a sex ratio of 4.3. Indications can be divided into 4 groups (traumatic, malformative, tumour and osteoporotic). Balloon percutaneous kyphoplasty and vertebroplasty were the techniques used for thoracic and lumbar vertebrae, with posterior fixation in 57 % of cases. Polymethylmethacrylate was the only cement used and no leakage was reported. The mean operative time was 118 min (range 77–148, SD 14). Results were excellent in terms of pain reduction, neurological dysfunction and restoration of spinal alignment. Mortality was 19 %, exclusively due to malignant progression.</div></div><div><h3>Conclusion</h3><div>This review provides evidence of the feasibility and efficacy of percutaneous kyphoplasty and vertebroplasty in children. No evidence of complications was found, suggesting that the technique is safe. Further studies involving larger patient groups would allow us to refine these aspects further.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102105"},"PeriodicalIF":0.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive arachnoiditis following spine surgery: a case report","authors":"Robert E. Carrier ,&nbsp;David M. Kruger","doi":"10.1016/j.inat.2025.102103","DOIUrl":"10.1016/j.inat.2025.102103","url":null,"abstract":"<div><div>Spinal adhesive arachnoiditis is a rare condition with unclear etiology and limited treatment options. This case describes a patient who developed arachnoiditis after L4/L5 and L5-S1 decompression laminectomies with foraminotomies. Post-surgical MRI suggested a lesion within the spine initially thought to be an intrathecal pooling of blood, and later imaging revealed probable early onset adhesive arachnoiditis. The diagnosis was ultimately made using the imaging and the patient’s broad, evolving range of neurological symptoms. Despite the diagnostic complexity, the patient eventually made a full recovery following conservative management and careful monitoring. This case is significant in that it demonstrates how adhesive arachnoiditis can unfold progressively over time, presenting as a series of overlapping and misleading pathologies. This case also emphasizes the importance of how multidisciplinary collaboration plays a vital role in accurately identifying and managing such cases in current practice. Given the diagnostic complexity, further research is needed to clarify the pathophysiology and to define specific clinical and radiologic patterns that facilitate earlier recognition.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102103"},"PeriodicalIF":0.4,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined surgical revascularization and endovascular trapping of a large/giant thrombosed aneurysm of the distal anterior cerebral artery: A report of two cases","authors":"Songhyon Lee,&nbsp;Michio Nakamura,&nbsp;Tadashi Miyazaki,&nbsp;Satoru Kurihara,&nbsp;Tomoko Yoneyama-Sarnecky","doi":"10.1016/j.inat.2025.102102","DOIUrl":"10.1016/j.inat.2025.102102","url":null,"abstract":"<div><h3>Background</h3><div>Large and giant thrombosed aneurysms of the distal anterior cerebral artery (d-ACA), despite being rare, are associated with high mortality rates due to rupture. Direct clipping and endovascular embolization are often unfeasible due to the aneurysm’s morphology, necessitating trapping and bypass surgery. Recently, combined surgical revascularization and endovascular trapping have been found to be effective for complex vascular lesions.</div></div><div><h3>Case Description</h3><div>In Case 1, an 82-year-old woman underwent A3-A3 and STA-ACA bypass followed by endovascular embolization and internal trapping, resulting in significant shrinkage of the aneurysm and favorable recovery. In Case 2, a 76-year-old woman with an enlarging aneurysm underwent A3-A3 bypass with endovascular trapping but developed postoperative epidural hematoma.</div></div><div><h3>Conclusions</h3><div>Combined surgical revascularization and endovascular trapping is effective in protecting distal blood flow and reducing surgical invasiveness, though it predisposes patients to hemorrhagic complications.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102102"},"PeriodicalIF":0.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric variation of the C1 posterior arch","authors":"Nicole Schneider ,&nbsp;Timothy Lasswell ,&nbsp;Martine McGregor ,&nbsp;Parham Rasoulinejad ,&nbsp;Stewart McLachlin","doi":"10.1016/j.inat.2025.102101","DOIUrl":"10.1016/j.inat.2025.102101","url":null,"abstract":"<div><div>Surgical stabilization of the atlantoaxial joint (C1–C2) is required in various conditions, including type II odontoid fractures, rheumatoid arthritis, congenital malformations, tumors, and infections. However, the unique morphology of the C1 vertebra presents challenges for implant fixation due to the proximity of critical neurovascular structures and limited bony surface. While dimensions related to lateral mass screw placement have been well studied, less is known about the morphometric variation of the C1 posterior arch for alternative fixation methods such as hooks and clamps. This study aimed to characterize posterior arch morphology using both anatomic measurements and statistical shape modeling (SSM). A retrospective review of cervical spine CT scans from patients aged 65 or older was conducted to evaluate 77 intact C1 vertebrae. Using 3D Slicer software, fiducial landmarks were placed on five sagittal slices (midline, ±8 mm, ±15 mm) to obtain measurements of posterior arch height, width, and slope. Anatomical symmetry was analyzed, and principal component analysis was used in SSM to assess 3D shape variation. The analysis revealed substantial variability in posterior arch morphology, with no clear correlation between height and width across sagittal slices. The average coronal slope was approximately 15°, but ranged widely from 2° to over 30°. Lateral symmetry in height, width, and slope was generally preserved. SSM showed the greatest variation occurred in the transverse plane, with larger sagittal cross-sections associated with increased posterior curvature. These findings underscore the wide anatomical variation in the size, shape, and curvature of the C1 posterior arch—critical considerations for implant design and surgical planning. This study is the first to quantify variation in coronal slope and provides important guidance for developing alternative fixation techniques. Hooks and clamps must be designed to accommodate the full spectrum of posterior arch anatomy to ensure safe and effective stabilization.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102101"},"PeriodicalIF":0.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Inception to innovation: A historical perspective on neurosurgery in Kuwait","authors":"Dragan Savić ,&nbsp;Joachim Oertel ,&nbsp;Waleed Yousef ,&nbsp;Hamad AlKhader ,&nbsp;Tarik AlSheikh","doi":"10.1016/j.inat.2025.102099","DOIUrl":"10.1016/j.inat.2025.102099","url":null,"abstract":"<div><div>This paper aims to highlight the chronological succession and development of the neurosurgical services in Kuwait; it also addresses the developmental history of the adjacent services such as the neuro-interventional radiology and the radiosurgery departments which played a massive role in improving the quality of patients’ health care. Finally, it gives a glimpse of future projects in these fields.</div><div>The leaders of the neurosurgical society in Kuwait have personally played an integral role in authoring this manuscript. This is noted as Dr. Abbas and Dr. Ali were the pioneers of starting the neurosurgical centers and services in Kuwait. Dr. Tarik started the pediatric and skull base services, while Dr. Faisal initiated the functional and epilepsy neurosurgical team. Dr. Savić as well as Dr. Waleed were responsible for beginning the vascular neurosurgical care.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102099"},"PeriodicalIF":0.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case of a high flow A-V shunt associated with an extracranial vertebral-artery dissecting aneurysm treated with a flow diverter stent","authors":"Kosuke Takigawa ,&nbsp;Yoshimasa Fukui ,&nbsp;Kousei Maruyama ,&nbsp;Takashi Fujii ,&nbsp;Noriaki Tashiro ,&nbsp;Hidetoshi Matsukawa ,&nbsp;Yoshiya Hashiguchi ,&nbsp;Masahiro Yasaka ,&nbsp;Hiroshi Aikawa ,&nbsp;Yoshinori Go ,&nbsp;Kiyoshi Kazekawa","doi":"10.1016/j.inat.2025.102087","DOIUrl":"10.1016/j.inat.2025.102087","url":null,"abstract":"<div><h3>Objective</h3><div>Vertebrovenous fistula (VV-AVF) is a rare disease that is often caused by trauma, but occasionally associated with congenital anomalies. To date, no standardized treatment has been established, and the use of a flow diverter (FD) has been reported in only one case.</div></div><div><h3>Case Presentations</h3><div>A 59-year-old woman had received chiropractic treatment that focused on her neck 1 month prior to symptom onset. She subsequently developed headaches and bilateral tinnitus. MRI and cerebral angiography revealed that demonstrated a dissection of the right vertebral artery (VA) at the level of the transverse foramen of C6, resulting in a dissecting aneurysm with no distal flow visualized. In addition, at the same level, a fistula formed with the surrounding venous plexus, and blood drained into multiple jugular veins. We decided to use FD to cover the dissecting aneurysm and close the fistula as treatment. However, due to persistent early shunt flow, a transvenous coil embolization was additionally performed. One week later, follow-up angiography confirmed restoration of antegrade flow in the VA and complete obliteration of the fistula.</div></div><div><h3>Conclusion</h3><div>The use of FD in combination with VV-AVF may result in rapidly improve normal perfusion, whereas the combination of FD and Trans venous embolization (TVE) has been shown to have an even more rapid therapeutic effect. To our knowledge, this is the first reported case on FD + TVE, although its effectiveness has been demonstrated in this case.</div></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"41 ","pages":"Article 102087"},"PeriodicalIF":0.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}