Interdisciplinary Neurosurgery: Advanced Techniques and Case Management最新文献

{"title":"Validity of D-penicillamine in experimental cerebral vasospasm therapy","authors":"Ersin Haciyakupoglu ,&nbsp;Evren Yüvrük ,&nbsp;Sebahattin Haciyakupoglu ,&nbsp;Milos Arsenovic ,&nbsp;Erol Akgül ,&nbsp;Dervis Mansuri Yilmaz ,&nbsp;Sait Polat","doi":"10.1016/j.inat.2023.101917","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101917","url":null,"abstract":"<div><h3>Background</h3><p>Cerebral vasospasm is a reversible vessel constriction following subarachnoid hemorrhage. Immunoreactive and inflammatory mechanisms induce long-term vasoconstriction and vessel dilatation inhibition. We hypothesized that D-penicillamine depresses this process given that it reduces the concentration of free oxygen (O₂) radicals. We evaluated the effects of D-penicillamine on cerebral vasospasm in rabbits induced with subarachnoid hemorrhage, achieved by autologous blood injection in the basal cistern.</p></div><div><h3>Materials and methods</h3><p>Four experimental groups were studied: Group 1: basilar angiography, Group 2: basilar angiography + D-penicillamine, Group 3: subarachnoid hemorrhage (SAH), and Group 4: SAH + D-penicillamine. Vessel diameter and cerebral vasospasm were evaluated angiographically in each group. Vascular degeneration was studied by electron microscopy of the basilar artery. Free O₂ radicals were investigated based on measurements of the levels of vascular superoxide dismutase and malondialdehyde. Myasthenia gravis–like side effects of D-penicillamine application were analyzed by electromyography and electron microscopy of the orbicularis oculi muscle.</p></div><div><h3>Results</h3><p>We detected a 9.03% decrease in basilar artery constriction in Group 4 compared with Group 3. In addition, levels of free O₂ radicals were reduced in Groups 2 and 4. Application of D-penicillamine resulted in the prevention of basilar artery wall degeneration, without myasthenia gravis–like side effects.</p></div><div><h3>Conclusion</h3><p>Our study indicated that D-penicillamine application induced vasodilatation and had anti-inflammatory effects.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101917"},"PeriodicalIF":0.4,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002001/pdfft?md5=75037aff3d8c9b55d826c8e984a7eb1a&pid=1-s2.0-S2214751923002001-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138472837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular treatment with Onyx of arterio-venous fistula around the transverse sinus presenting with ocular symptoms. Case report","authors":"N. Velinov ,&nbsp;M. Petrov ,&nbsp;T. Sakelarova ,&nbsp;P. Yordanov ,&nbsp;I. Martinov ,&nbsp;N. Gabrovsky","doi":"10.1016/j.inat.2023.101932","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101932","url":null,"abstract":"<div><h3>Introduction</h3><p>Dural arterio-venous fistulas /DAVF/ are rare vascular malformations that represent around 10-15% of all intracranial vascular malformations. The DAVF could be asymptomatic or produce a variety of symptoms – headache, pulsatile tinnitus, characteristic bruit over the site of the fistula, ocular symptoms – chemosis, proptosis, or other neurological symptoms due to intracerebral haemorrhage of the DAVF. We present a rare clinical case of a transverse sinus DAVF with ipsilateral ocular symptoms and maybe the first case to our knowledge occluded with Onyx.</p><p>Clinical case:</p><p>A 46-year-old male patient presented with headache, redness of the left eye and left-sided proptosis. The symptoms started after a heavy physical exertion two months ago. MRI scan and DSA confirmed the presence of a DAVF located around the left transverse sinus with venous ectasia and retrograde flow up to the left cavernous sinus. Transarterial endovascular embolization of the DAVF with Onyx was performed with complete resolution of the symptoms of the patient.</p></div><div><h3>Discussion</h3><p>The more posteriorly located the DAVF the less likely is to present with ocular symptoms. Sometimes these are the first signs of the presence of a DAVF and especially of higher grade DAVF that could lead to intracerebral haemorrhage. The Borden Grade 2 and 3 DAVF risk of intracerebral haemorrhage is 17% and 46%, respectively. Cognard Grade IIa+b around 40% and all grades III-V - 80-100%. The high risk of intracranial haemorrhage and the ocular symptoms are indication for treatment.</p></div><div><h3>Conclusion</h3><p>Transarterial embolization of DAVF with Onyx is safe, with high initial occlusion rate (55-85%). Ocular symptoms of DAVF have a benign course after successful embolization.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101932"},"PeriodicalIF":0.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002153/pdfft?md5=c3df7fab75a712efb61558aa28558b28&pid=1-s2.0-S2214751923002153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138472839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome predictors in a series of 40 patients after surgery for low-grade gliomas","authors":"M. Dobran,&nbsp;M. Capece,&nbsp;D. Aiudi,&nbsp;E. Carrassi,&nbsp;M.R. Fasinella,&nbsp;M. Lorenzetti,&nbsp;A. Di Rienzo,&nbsp;M. Iacoangeli","doi":"10.1016/j.inat.2023.101920","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101920","url":null,"abstract":"<div><h3>Objective</h3><p>Low grade gliomas (LGGs) account for 15 % of primary brain tumors. The paper has the aim to identifying prognostic factors affecting overall survival (OS) and progression-free survival (PFS), and to evaluate the outcome of patients.</p></div><div><h3>Methods</h3><p>A total of 40 patients undergoing surgery for cerebral LGG (WHO grades I and II) at Our Institute were enrolled in the retrospective study. Inclusion criteria were: histological diagnosis of LGG, availability of complete clinical-instrumental documentation and follow-up data. For each patient, the following were analyzed: the clinical parameters in the preoperative and postoperative phases, the histological variant of the tumor, the extent of surgical resection (EOR) and any use of intraoperative methods, the Mib-1/Ki-67 proliferation index, the administration of adjuvant chemotherapy and/or radiotherapy and the occurrence of any complications.</p></div><div><h3>Results</h3><p>The cohort included 14 males and 26 females. The independent predictors of OS at multivariate analysis were: age, pre-operative KPS, Ki67/Mib-1, EOR and adjuvant chemotherapy. With regard to PFS, statistical significance on multivariate analysis was observed for pre-operative KPS, Ki67/Mib-1, EOR, post-operative tumor volume and radiotherapy. An EOR &lt; 80 % was confirmed as negative prognostic factor for both OS and PFS. Lastly, the pre-operative tumor volume and the use of Intra-operative Electrophysiological Monitoring were significantly associated with EOR.</p></div><div><h3>Conclusion</h3><p>In this study, according to the literature, several prognostic factors determining the outcome of LGG patients, both in terms of OS and PFS, were confirmed. Knowing the impact of these parameters in terms of prognosis would guide the choice of treatment, which will necessarily be multidisciplinary and tailored.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101920"},"PeriodicalIF":0.4,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002037/pdfft?md5=324456c45bd3cd43fdc61dd97b17eb2c&pid=1-s2.0-S2214751923002037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pituitary adenoma: Preliminary experience with endoscopic endonasal transphenoidal surgery in a developing country. Example of Senegal about 180 cases","authors":"Maguette Mbaye ,&nbsp;Mbaye Thioub ,&nbsp;Demba Diedhiou ,&nbsp;Lounceny Fatoumata Barry ,&nbsp;Hugues Ghislain Atakla ,&nbsp;El Hadj Cheikh Ndiaye Sy ,&nbsp;Daouda Wague ,&nbsp;Alioune Badara Thiam ,&nbsp;Ndaraw Ndoye ,&nbsp;Momar Code Ba","doi":"10.1016/j.inat.2023.101903","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101903","url":null,"abstract":"<div><h3>Introduction</h3><p>Endoscopic endonasal transsphenoidal surgery is currently the gold-standard therapeutic approach for pituitary adenomas. Although being spread worldwide, the endoscopic endonasal approach for pituitary adenomas is recently implemented in Senegal.</p><p>This study aimed to report our results and the complications observed in the context of an under-equipped facility.</p></div><div><h3>Materials and methods</h3><p>We conducted a retrospective study including all patients with a pituitary adenoma treated who underwent endonasal transsphenoidal resection under a single endoscopic approach from January 2014 to May 2022, in the Neurosurgery Department of Fann National Hospital Centre, Dakar. All patients were assessed according to clinical, radiological, and endocrinological criteria. They all were operated by the same team with an average follow-up of 24 months.</p></div><div><h3>Results</h3><p>In this series of 180 patients, including 57.7 % women and 42.3% men with a mean age of 44.8 years (extremes of 18 and 76 years), the visual deficit was the most frequent onset symptom (69.4 %), followed by clinical forms of hormone hypersecretion (30.5 %). Twelve cases of pituitary apoplexy and 1 case of incidentaloma were reported. The most frequent tumors were non-functional tumors (61.6 %). Among the functional adenomas, the most frequent was prolactinoma (15.5 %). Regarding tumor size, 75 % were macroadenomas, 15.5 % were microadenomas, and 9.5 % were giants. Cavernous sinus invasion (Knosp grade ≥ 3) and suprasellar extension were noted in 14.4 % and 53.3 %, respectively. The resection was total in 80 % of cases, subtotal in 18.8 %, and partial in 1.2 %. Partial improvement of sight was observed in 91.1% and endocrine hypersecretion remission in 76.6 %. As for complications, the most frequent was transient diabetes insipidus (32.7 %).</p></div><div><h3>Conclusion</h3><p>Despite the scanty resources, our results are similar to the best-reported series and strengthen scientific evidence on the efficacy and safety of performing this technique in an under-equipped setting context.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101903"},"PeriodicalIF":0.4,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221475192300186X/pdfft?md5=9c7895f4c0db399f8c306ce6b664d8b7&pid=1-s2.0-S221475192300186X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep multi-task learning structure for segmentation and classification of supratentorial brain tumors in MR images","authors":"Shirin Kordnoori ,&nbsp;Maliheh Sabeti ,&nbsp;Mohammad Hossein Shakoor ,&nbsp;Ehsan Moradi","doi":"10.1016/j.inat.2023.101931","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101931","url":null,"abstract":"<div><p>Identification of brain tumors border and determination of their possible pathology in MR images is an important step in pre-operation analyzing of this serious medical condition. Manual segmentation and classification of brain tumors could be challenge full in neurosurgical practice because of vast differences between brain tumors characteristic such as shape, border irregularity, consistency and etc. as well as interobserver variations. To solve this problem, some automatic methods have been proposed for brain tumors segmentation or classification during recent years, but an intelligence-based method for simultaneous identification of tumor type and tumor border in MR images has not proposed till now. Here, we have planned a unique automatic model includes a common encoder for feature representation, one decoder for segmentation and a multi-layer perceptron for classification of three common primary brain tumors (meningiomas, gliomas and pituitary adenomas) in brain MR images. The proposed model was examined on a brain tumor images dataset and the output were evaluated in both multi-task and single-task learning model. The multi-task learning model gains significant improvement in simultaneous classification and segmentation of brain tumors with promising accuracy of 97% for each task. So, this model could serve as a primary screening tool for early diagnosis of common primary brain tumors in general practice with a high success rate.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101931"},"PeriodicalIF":0.4,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002141/pdfft?md5=6bb847c38397e52bb8ae844551eb78d2&pid=1-s2.0-S2214751923002141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138448337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penetrating intracranial injury through temporal bone with a retained stab: A case report and literature review","authors":"Endris Hussen Ali MD, NEUROSURGERY RESIDENT ,&nbsp;Milena Gebreegziabher Haile MD, NEUROSURGEON","doi":"10.1016/j.inat.2023.101930","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101930","url":null,"abstract":"<div><h3>Background</h3><p>An instrument that penetrates the dura mater and the thickness of the skull bone is considered to have produced a penetrating craniocerebral injury. Nonmissile penetrants and missiles are two types of penetrating agents. Nonmissile penetrants can travel at low speeds or at high speeds (&gt;100 m/s). It might stay inside the skull or come out of another place. One item that can inflict piercing injuries on civilians is a knife. Although the precise frequency of penetrating head injuries in the general population is unknown, current estimates suggest that bullets account for 4.6 % of these injuries, while puncture wounds from stabs, nails, and other trauma account for 0.4 %. Unlike European reports, Reportedly, male assailants in South Africa are much more likely to have suffered a single head-stab wound. The frontal bone is the most frontal, thickest, and most accessible section of the skull for assailants; nevertheless, the orbit and squamous portion of the temporal bone are thinner, more fragile, and more appealing to skilled attackers.</p></div><div><h3>Case presentation</h3><p>This is a 29-year-old male patient referred to our hospital after being referred from the primary hospital. He sustained a stab injury to the left temporal area of the head, bleeding from the scalp, and loss of consciousness. The stab is retained in the brain, with its tip visible in the left temporal area (<span>Fig. 1</span>). GCS is 10/15; the pupils are midsized and non-reactive bilaterally, and he had a left-side preference. On a brain CT scan, there is a left temporal area foreign body seen penetrating through the scalp, skull temporal bone, temporal lobe, and occipital lobe of the brain with a stab tip at the edge of the left tentorium cerebelli, and there is an associated left massive acute subdural hematoma and intraventricular hemorrhage extending from the lateral ventricle to the fourth ventricle (<span>Fig. 2</span>). We did left-side decompressive craniectomy, expansile duraplasty, and removed a foreign body (stab) safely (<span>Fig. 3</span>), and postoperatively, the patient was discharged with stable vital signs and no neurologic deficit with improved GCS 15/15.</p></div><div><h3>Conclusion</h3><p>The main idea is to wait to remove the knife until after a thorough investigation has been completed and the interdisciplinary team is ready to remove the instrument using suitable techniques. Removing the penetrating object should allow the knife to follow its original path. It’s important to avoid making any rocking motions during the extraction process that could endanger vital neurovascular structures at risk at the knife's tip.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101930"},"PeriodicalIF":0.4,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221475192300213X/pdfft?md5=dec9ae1ef69c74f078233b55fa1083e9&pid=1-s2.0-S221475192300213X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the radiological outcome of cerebral aneurysm treatment with machine learning algorithms; a systematic review and diagnostic meta-analysis","authors":"Mohammad Amin Habibi ,&nbsp;Hanieh Amani ,&nbsp;Mohammad Sina Mirjani ,&nbsp;Ayoob Molla","doi":"10.1016/j.inat.2023.101929","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101929","url":null,"abstract":"<div><h3>Background</h3><p>Up now, several model were proposed for predicting the outcome of treating brain aneurysm. This study aims to investigate the performance of Machine learning (ML) in predicting the outcome of intracranial aneurysm after endovascular or microsurgical management.</p></div><div><h3>Method</h3><p>This systematic review and <em>meta</em>-analysis was prepared with adhering to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. The electronic databases of PubMed/Medline, Embase, Scopus, and Web of Science were systematically reviewed up to 5th June 2023. All statistical analysis was done by STATA/mp V.20.</p></div><div><h3>Results</h3><p>Recent studies have utilized ML models to forecast the results of cerebral aneurysm treatment. The models exhibit a sensitivity of 0.88 and a specificity of 0.80, with the latter revealing substantial variability across the various studies. Meanwhile, the sensitivity remained consistent. The models displayed a positive DLR (PLR) of 4.5 and a negative DLR (NLR) of 0.15. The aggregate diagnostic score determined that heterogeneity was negligible, with a value of 3.41. However, the diagnostic odds ratio 30.29 indicated noteworthy heterogeneity among the studies. The pooled AUC of 0.90 showcased the ML's ability to predict cerebral aneurysm treatment outcomes accurately.</p></div><div><h3>Conclusion</h3><p>Predicting treatment outcomes in patients with intracranial aneurysms non-invasively is a promising approach with good diagnostic performance. However, further studies are required to improve the accuracy of ML algorithms, as the pooled metrics had a wide confidence interval. This will not only enhance the reliability of the predictions but also facilitate the integration of these algorithms into daily clinical practice.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101929"},"PeriodicalIF":0.4,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002128/pdfft?md5=d29cd4384c5f10ad4b72938f45036e0e&pid=1-s2.0-S2214751923002128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscape of epilepsy research: Analysis and future trajectory","authors":"Manisha Sharma ,&nbsp;Satyajit Anand ,&nbsp;Rajeev Pourush","doi":"10.1016/j.inat.2023.101879","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101879","url":null,"abstract":"<div><p>Epilepsy is a neurological condition characterized by temporary disruptions in the brain's electrical activity. This disorder can significantly impact the quality of life for those affected, leading to limitations on driving and employment opportunities. The seriousness of epilepsy is further emphasized by the risk of SUDEP (sudden unexpected death in epilepsy). Additionally, individuals with epilepsy commonly experience memory problems and emotional disorders. In this article, we present a bibliometrix analysis of epilepsy research, examining influential articles, keywords, authors, institutions, and countries. Our analysis focuses on research articles published from 2015 to 2023.The findings of our analysis reveal that China and India are the leading countries in terms of epilepsy publications and total citations. Furthermore, we propose a framework that encompasses technology, enablers, and barriers, providing valuable insights into the future trajectory of epilepsy research. Various factors can contribute to the development of epilepsy, including neurotransmitter imbalances, tumors, strokes, brain damage resulting from illnesses or injuries, or a combination of these causes. To gather scientific papers related to epilepsy seizures, we employed the Scopus database and extracted information such as titles, authors, contributing institutes, source journals, times cited, and countries. For data analysis, we used the R package (Bibliometricx R package), VOSviewer, and SciMAT facilitated co-authorship and co-occurrence analyses, allowing us to visualize the results. By shedding light on the current state of epilepsy research and identifying emerging trends, the aim of this study is to provide guidance for future investigations in understanding, managing, and treating epilepsy more effectively.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101879"},"PeriodicalIF":0.4,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923001627/pdfft?md5=c7beca3bedaf574b2ea1a87a3621a5fb&pid=1-s2.0-S2214751923001627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracolumbar junction fracture and long instrumented fusion, a trial on a standardized surgical technique with long term clinical outcomes","authors":"Mehdi Mahmoodkhani ,&nbsp;Nima Najafi Babadi ,&nbsp;Majid Rezvani ,&nbsp;Ali Nasrollahizadeh ,&nbsp;Arman Sourani ,&nbsp;Mina Foroughi ,&nbsp;Sadegh Baradaran Mahdavi ,&nbsp;Donya Sheibani Tehrani ,&nbsp;Roham Nik Khah","doi":"10.1016/j.inat.2023.101928","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101928","url":null,"abstract":"<div><h3>Aim</h3><p>To investigate the role of fusion construct properties, vertebral column reconstruction (VCR) techniques, steroid therapy, laminectomy versus ligamentotaxis in treatment of thoracolumbar junction fractures (TLJF).</p></div><div><h3>Methods</h3><p>A non-randomized clinical trial was conducted. All the eligible patients with TLJF (T12-L2) were operated with a standardized long fusion protocol and followed. Fusion rate, hardware failure, sagittal imbalance and functional outcome were identified as the primary outcome. P &lt; 0.05 was defined as significant.</p></div><div><h3>Results</h3><p>Ninety-nine long fusions were reviewed in the final analysis. The mean age was 35.7 ± 13.80 years with 79.8 % male predominance. Fifty-eight percent of the patients were neurological intact. Fifty-six percent underwent concurrent laminectomy and VCR using autografts while the remaining 43.4 % received ligamentotaxis. The patients follow up (median = 25 months) showed 93.9 % solid fusion rate, 70.7 % activity independency, 1% hardware failure, 10.1 % sagittal imbalance and 4 % wound complications. Sagittal imbalance was associated with steroid therapy (p = 0.006), laminectomy (p = 0.003) and preoperative neurological deficits (p = 0.0001) and age (p = 0.049). Interestingly, Steroid therapy was associated with improved neurological and functional outcomes in impaired patients (p &lt; 0.05). Laminectomy was associated with favorable functional outcome (OR = 9.7, CI: 2.09–45.67).</p></div><div><h3>Conclusion</h3><p>Our standardized long fusion protocol was associated with significant outcomes with low morbidities. Autograft mixture yield to a robust union in and over fusion construct. Methylprednisolone therapy in non-intact patients was associated with improved clinical outcomes but simultaneously, has negative impact on sagittal imbalance. Laminectomy and steroid therapy should be carefully considered in impaired patients due to their negative impact on sagittal balance.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101928"},"PeriodicalIF":0.4,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923002116/pdfft?md5=3416466dfc0e75ced83db286a656c3aa&pid=1-s2.0-S2214751923002116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eagle syndrome an overlooked cause of internal carotid artery dissection, Case series","authors":"Abeer Sabry Safan ,&nbsp;Mohamed A. Atta ,&nbsp;Isra Eltazi ,&nbsp;Gayane Melikyan ,&nbsp;Ahmed El Sotouhy ,&nbsp;Yahia Imam","doi":"10.1016/j.inat.2023.101873","DOIUrl":"https://doi.org/10.1016/j.inat.2023.101873","url":null,"abstract":"<div><h3>Background</h3><p>Eagle syndrome is a rare condition with a prevalence estimated at 4%, with 0.16% exhibiting symptoms of Eagle’s syndrome resulting from an elongated styloid process or a calcified stylohyoid ligament, compressing over nearby vessels and nerves. Symptoms range from simple headache, neck pain, and odynophagia to cerebral ischemia. Since it can be an incidental finding, management is controversial and ranges from conservative treatment to surgical intervention, including internal carotid stenting and styloidectomy.</p></div><div><h3>Clinical presentation</h3><p>We report two cases of Eagle’s syndrome. Case one (Vascular variant): 44 years old presented with left-sided weakness with Magnetic Resonance Imaging and an angiogram of the brain showing a right middle cerebral artery hemispheric infarct with a right internal carotid artery (ICA) dissection and elongated styloid processes more on the left. The patient’s condition improved with supportive care. He was treated with aspirin, atorvastatin, and an intensive 16-week rehabilitation program. Case two (Classic variant): 41 years old presented with refractory occipital headache and neck pain without vascular insult. Magnetic resonance of both patients showed a long styloid process.</p></div><div><h3>Conclusions</h3><p>Eagle’s Syndrome is a rare entity and perhaps overlooked as an anatomical variant that ought to be considered a possible etiology in atraumatic ICA dissection in patients with no discernable risk factors. As observed in case one, with atraumatic ICA dissection and unremarkable connective tissue disease work-up, highlighting anatomical variant, as an etiology to his ischemic stroke. Styloidectomy should be considered to avert risk of recurrent IC dissections in such patients with atraumatic IC dissection and classic eagle’s syndrome with refractory orofacial pain syndromes exacerbated by head movement or yawning.</p></div>","PeriodicalId":38138,"journal":{"name":"Interdisciplinary Neurosurgery: Advanced Techniques and Case Management","volume":"36 ","pages":"Article 101873"},"PeriodicalIF":0.4,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214751923001561/pdfft?md5=8b0e9f7469b816f29977e4f004dcdbc5&pid=1-s2.0-S2214751923001561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138438014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}