Journal of Electrical Bioimpedance最新文献

{"title":"Electromagnetic validation of a multichannel coplanar four-electrode bioimpedance sensing platform for perfused 3D tumor-on-chip systems.","authors":"Félix Royer, Thomas Meynard, Robin Houssier, Jérôme Vicogne, Ørjan G Martinsen, Isabelle Van Seuningen, Vincent Senez","doi":"10.2478/joeb-2026-0015","DOIUrl":"https://doi.org/10.2478/joeb-2026-0015","url":null,"abstract":"<p><p>Three-dimensional tumor-on-chip systems better reproduce the spatial organization of tumor cells within extracellular-matrix-based microenvironments than conventional two-dimensional cultures, yet their integration with quantitative, non-destructive monitoring tools remains limited. Electrical bioimpedance provides a label-free approach for real-time assessment of living 3D tissues, but its implementation in perfused millimeter-scale microfluidic environments requires rigorous electrical and geometrical validation. In this study, we designed and electromagnetically validated an integrated coplanar four-electrode bioimpedance sensor embedded within a perfused 3D tumor-on-chip platform compatible with collagen-based hydrogels. Three-dimensional finite-element simulations were used to compute sensitivity fields and quantify the effective measurement volume. Calibration with conductivity standards showed quantitative agreement between experimental measurements and numerical predictions, with relative deviations below 10%, enabling reliable extraction of the cell constant. Chamber height was identified as the dominant geometrical parameter affecting impedance magnitude, whereas lateral misalignment had limited impact. Temperature-dependent conductivity changes induced impedance drifts of up to 25% during thermal equilibration, highlighting the need for strict temperature control. Acellular collagen I hydrogels exhibited concentration-dependent impedance variations, while increased gel loading before chamber closure modified impedance, likely through matrix compression and reorganization. These results demonstrate that the extracellular matrix significantly contributes to the measured electrical response. In static 3D cultures, embedding pancreatic cancer cells within collagen I produced a reproducible decrease in impedance magnitude at 10 kHz compared with acellular controls, confirming a measurable cell-dependent baseline shift. Under continuous perfusion, gradual cellular evolution did not generate a reproducible impedance trajectory, whereas Triton X-100-induced cell disruption increased impedance toward the acellular collagen I baseline. Overall, this study demonstrates that coplanar impedance sensing can detect cell-dependent baseline differences and strong endpoint perturbations in millimeter-scale 3D tumor models. However, dynamic impedance variations under perfusion remain influenced by matrix, thermal, geometrical, and conductive-pathway contributions, emphasizing the need for careful calibration before biological interpretation.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"137-158"},"PeriodicalIF":0.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13682677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149239849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomimetic anthropomorphic leg phantom for wearable bioimpedance sensing in lymphedema monitoring.","authors":"Anna Bublex, Amalric Montalibet, Bertrand Massot, Claudine Gehin","doi":"10.2478/joeb-2026-0014","DOIUrl":"10.2478/joeb-2026-0014","url":null,"abstract":"<p><p>This study aims to develop a reproducible, biomimetic, anthropomorphic leg phantom as a controlled platform for the development and evaluation of wearable sensors for low-frequency bioimpedance monitoring of lymphedema. As a proof of concept, a 20-cm multilayer model was developed to establish and characterise the materials and fabrication approach required for future full-scale sensor validation. Electrical and mechanical characterisation of polyvinyl alcohol cryogel (PVA-C) and PVA-based fat and muscle phantoms was performed. The influence of freeze-thaw cycle number and duration on electrical properties and Shore hardness was investigated to support large-scale multilayer fabrication. Muscle anisotropy was reproduced via directional structuring. Reproducibility of electrical properties and long-term stability of PVA-C hydrogels were evaluated under refrigerated, vacuum-sealed storage. A practical methodology for assembling multilayer anthropomorphic leg phantoms was implemented. Electrical properties remained stable across the investigated freeze/thaw conditions, whereas Shore hardness increased with the number of cycles. Two 20-cm-high, three-layer anthropomorphic leg phantoms, representing healthy and stage 2 pathological condition, were fabricated using 3D-printed moulds integrating bone, muscle, and fat. Interfacial bonding between the layers provided mechanical cohesion and electrical continuity. Bioimpedance measurements showed consistent differences between the healthy and lymphedema-mimicking configurations. The methodology enables fabrication and assembly of multilayer anthropomorphic leg phantoms with electrical stability and mechanical cohesion. This proof-of-concept provides a basis for the development of a full-scale anthropomorphic model and its subsequent integration with wearable bioimpedance sensing technologies for lymphedema monitoring.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"121-136"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided structural fusion enhances the interpretability of electrical impedance tomography for layered tissue imaging.","authors":"Md Mainuddin Sagar, Israt Jahan Nipa, Kihan Park","doi":"10.2478/joeb-2026-0013","DOIUrl":"10.2478/joeb-2026-0013","url":null,"abstract":"<p><p>Electrical Impedance Tomography (EIT) provides low-cost functional impedance imaging, whereas ultrasound offers high-resolution morphological visualization. In this study, a hybrid Ultrasound-EIT (EIT-US) fusion framework is developed for soft-tissue characterization in layered ex vivo biological phantoms using controlled chicken tissue models. A custom EIT acquisition system recorded 208 boundary voltage measurements per acquisition across three tissue layers and multiple frequency-voltage conditions, with experiments repeated across three anatomical tissue configurations. Five FEM-based reconstruction methods-Back Projection (BP), Gauss-Newton (GN), Tikhonov regularization (TIK), GREIT, and a linearized EIDORS-like approach-were implemented within a stand-alone MATLAB framework. Ultrasound images acquired using a GE VScan Air CL probe (musculoskeletal mode) were integrated with EIT reconstructions through a multimodal fusion pipeline incorporating impedance imaging, ultrasound texture-echogenicity mapping, and statistical correlation analysis. Quantitative evaluation demonstrated consistent layer differentiation with moderate structural-electrical agreement (<i>r</i> ≈ 0.37-0.45). ESI increased by more than 60% at the evaluated layer interfaces during the fusion approach compared to EIT-only reconstructions, along with an increase in boundary detection performance (AUC improvement of approximately 0.13-0.15). Structural similarity (SSIM) of the fused images relative to ultrasound boundaries ranged from 0.71 to 0.78, indicating preserved spatial coherence. Frequency and voltage variations influenced reconstruction stability and contrast recovery. Overall, multimodal fusion improved the structural interpretability of EIT by anchoring conductivity distributions to ultrasound-derived morphological boundaries. These results indicate that incorporating ultrasound-derived structural priors improves the interpretability of EIT reconstructions by providing spatial context to conductivity distributions. This framework provides a practical experimental approach for integrating complementary electrical and acoustic sensing modalities, with potential relevance to future low-cost and portable soft-tissue imaging systems.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"95-120"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement error in bioimpedance spectroscopy: The role of electrode type and analyzer.","authors":"Carina M Velasquez, Ainsley E Way, Christian Rodriguez, Ethan G Tinoco, Christine M Florez, Madelin R Siedler, Todd J Freeborn, Grant M Tinsley","doi":"10.2478/joeb-2026-0012","DOIUrl":"10.2478/joeb-2026-0012","url":null,"abstract":"<p><p>Bioimpedance spectroscopy (BIS) is a non-invasive method used to assess body composition in a variety of settings. Although BIS has been reported as an accurate measure of body composition, the magnitude of within-day technical error associated with different BIS devices and electrode types remains unknown. Therefore, the purpose of this study was to assess the technical error of measurement (TEM) between single-tab and double-tab electrodes across two BIS devices for resistance, reactance, phase angle, total body water, fat-free mass, and fat mass. One hundred and four adults reported to the laboratory for a single visit, undergoing twelve different assessments utilizing single- and double-tab electrodes on two BIS analyzers of the same model. The within-day technical error was assessed as the absolute and relative TEM for each of the variables. The results indicated that intra-analyzer assessments displayed the lowest amount of error for all the variables (relative TEM = 0.05 - 0.28%) while the largest TEMs were observed for comparisons between single-tab and double-tab assessments (relative TEM = 1.04 - 3.68%), except for reactance. For reactance alone, the TEMs were greatest for the inter-analyzer comparison with double-tab electrodes (absolute TEM = 1.07 Ω; relative TEM = 1.68%). While all assessments displayed relatively low technical error, the present results reinforce the importance of consistently using the same analyzer and electrode type to minimize errors when assessing body composition using BIS, particularly when seeking to identify subtle changes in BIS output.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"84-94"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13531431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic induction spectroscopy (MIS) as potential non-contact label-free technique for DNA amplification follow-up.","authors":"César A González-Díaz, Amelia Laveille, Ulascan Yuce, Franck M André, Lluis M Mir","doi":"10.2478/joeb-2026-0011","DOIUrl":"https://doi.org/10.2478/joeb-2026-0011","url":null,"abstract":"<p><p>Gene amplification and detection techniques such as polymerase chain reaction (PCR) or quantitative PCR (qPCR) require the use of fluorescent reagents and probes or dyes. Both PCR and qPCR must be performed by trained personnel. The aim of this work was to assess the potential use of magnetic induction spectroscopy (MIS) as a non-contact, label-free and easy-to-use technique to detect gene amplification in final PCR products. We extracted Deoxyribonucleic Acids (DNA) from samples of mouse tissue and processed it for gene amplification through PCR. We considered six different biological samples for the exploration of four genotypes and their corresponding blank controls. In every sample, we carried out MIS measurements in two stages (before and after PCR) in the range of 0.073 to 1.125 MHz and compared the differences. The results indicate a MIS magnitude differential pattern in the range of 500 to 650 kHz, which warrants the potential use of the MIS technique for the development of a fully contactless, label-free biosensor and capable of detecting DNA directly from PCR products.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"78-83"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining within-session test-retest reliability of four bioimpedance devices among adults across a wide age range.","authors":"Kworweinski Lafontant, David H Fukuda, Sofea Smith, Jack Livingston, Michelle Da Silva Barbera, Ngoc Linh Nhi Nguyen, Edwin Rodriguez-Cruz, Susan Kampiyil, Katie R Hirsch, Sarah K Fretti, Jeffrey R Stout","doi":"10.2478/joeb-2026-0010","DOIUrl":"https://doi.org/10.2478/joeb-2026-0010","url":null,"abstract":"<p><p>Bioimpedance is increasingly growing in clinical utility for within-session monitoring; however, many studies neglect to report the test-retest reliability of their devices. The purpose of this study was to examine the within-session test-retest reliability of whole-body bioelectrical variables measured by four common bioimpedance devices among adults. Ninety-six adults (age = 46.1 ± 21.7yrs, female = 63.5%, BMI = 26.4 ± 5.2 kg/m²) were tested in the morning-time on each device after providing a urine sample to confirm euhydration in addition to 10 minutes of passive rest in each device's respective testing position (standing or supine). Each device assessed whole-body impedance, resistance, reactance, and phase angle in duplicate with approximately 10 seconds between trials; bioelectrical variables were extracted at 5, 50, 250, 500, and 1000 kHz as available from each device. Reliability was assessed using intraclass correlation coefficients (ICC_2,1) and coefficients of variation (CV). At 5, 50, and 250 kHz, reliability across devices and measures was excellent (ICC_2,1 > 0.90, CV = 0.78 ± 0.55%). Precision at 500 kHz for PhA (CV = 5.41%) and Xc (CV = 4.9%) was low and approaching low, respectively. Measures of Xc and PhA at higher frequencies (500 and 1000 kHz) may be less precise, but further research is needed to confirm, particularly with 1000 kHz where negative Xc values may limit the interpretability of CVs. Clinicians, researchers, and practitioners using these devices for within-session monitoring of raw bioelectrical variables should ideally test the reliability of their own devices but may use the data within this manuscript as a point of reference.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"67-77"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13477199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of indirect methods for estimating body fat in dogs using electrical bioimpedance and morphometry.","authors":"Daniel Montoya-Barbosa, Clara Helena González-Correa, William Narváez-Solarte","doi":"10.2478/joeb-2026-0009","DOIUrl":"10.2478/joeb-2026-0009","url":null,"abstract":"<p><p>Canine obesity causes metabolic issues and reduces quality of life. Assessing adiposity remains challenging due to limited indirect and reference methods. Electrical bioimpedance (BIA) is a proposed tool, but agreement between morphometric and BIA equations, and the body condition score (BCS) role, remains poorly explored in heterogeneous canine populations.</p><p><strong>Objective: </strong>To evaluate agreement among indirect methods (BCS, morphometry, BIA) for estimating canine body fat and assess BIA's viability for nutritional evaluation.</p><p><strong>Materials and methods: </strong>A cross-sectional study included 17 healthy dogs from Villamaría, Colombia. Body condition was assessed using 5- and 9-point scales. Morphometric variables and single-frequency 50 kHz BIA parameters (resistance, reactance, phase angle) were recorded. Body fat percentage (%BF) was estimated using four established equations. Method agreement was evaluated via Bland-Altman analysis and Lin's concordance correlation coefficient (CCC). Differences in bioelectrical parameters and lipid profiles between obese and lean dogs were analyzed using independent t-tests.</p><p><strong>Results: </strong>Morphometric methods showed the highest agreement (CCC = 0.759). Conversely, comparisons involving BIA-derived equations exhibited low or negative agreement, with Bland-Altman analyses revealing wide limits of agreement. Obese dogs had higher resistance and lower phase angles than lean dogs, though differences were not statistically significant (p > 0.05). This lack of significance must be interpreted cautiously due to the small sample size, particularly the obese group (n = 4). HDL cholesterol was significantly lower in obese dogs (p = 0.030), with no differences in total cholesterol.</p><p><strong>Conclusion: </strong>The evaluated indirect methods showed poor agreement and are not clinically interchangeable. Without a reference method like DEXA, accuracy cannot be determined. While raw BIA parameters aligned physiologically with body condition, their use remains preliminary and requires validation in larger, reference-controlled studies.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13431023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of hydration on electrodermal activity: A Comparison between AC bioimpedance and DC skin potential metrics.","authors":"Ardawan A Youssif, Dindar S Bari, Haval Y Yacoob Aldosky","doi":"10.2478/joeb-2026-0008","DOIUrl":"10.2478/joeb-2026-0008","url":null,"abstract":"<p><p>This study evaluates the comparative sensitivity and stability of tonic and phasic electrodermal activity (EDA) parameters, specifically skin conductance (SC), susceptance (SS), and potential (SP), following a localized moisturizer intervention. Utilizing a single-group pretest-posttest design (N = 55), the research demonstrates that AC bioimpedance-based metrics (SC and SS) exhibit distinct response dynamics compared to conventional DC-based measures. Tonic-level analysis revealed that SCL and SSL produced nearly identical relative percentage increases (52.6%) compared to SPL (34.46%). While SCL provided the largest absolute change, SSL emerged as the most statistically stable indicator across the cohort, characterized by a highly uniform signal-to-noise ratio (d = 1.23). Phasic analysis revealed that Skin Susceptance Responses (ΔSSRs) demonstrated a highly pronounced downward shift following the intervention, characterized by a -70.2% change from baseline. This negative shift was significantly divergent from the potential response (p < 0.001, d = -0.55), highlighting a distinct directional sensitivity for ΔSSRs under these experimental conditions. These findings suggest that AC-based EDA parameters are highly responsive to the resistive and capacitive shifts within the stratum corneum interface. The results suggest that for applications evaluating localized skin surface changes, a multimodal approach incorporating AC bioimpedance-based metrics may provide a highly responsive framework for detecting acute alterations at the electrode-skin interface compared with traditional potential-based measurements.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elicitation and habituation of the electrodermal activity responses: Implications for neurophysiological applications.","authors":"Zainab H Ahmed, Dindar S Bari","doi":"10.2478/joeb-2026-0006","DOIUrl":"10.2478/joeb-2026-0006","url":null,"abstract":"<p><p>Electrodermal activity (EDA) serves as a reliable indicator of sympathetic activation for the measurement of emotional arousal. Despite extensive use of EDA in psychophysiological and neurophysiological research, little is known about how repeated stimulus presentation influences EDA responses, particularly when more than one parameter is measured simultaneously. This study examined the influence of repeated stimulus presentation on three EDA parameters (SCRs, SPRs, and SSRs). A total of sixty healthy subjects participated in the study. They were exposed to four external stimuli: sound, image, taste, and smell. Each of the four stimuli was repeated five times to investigate the effect of their repetition on SCRs, SPRs, and SSRs. Significant (p < 0.001) impacts of repeated stimulus presentation and introducing a novel stimulus on three EDA parameters were observed. The study results indicated that SCRs, SPRs, and SSRs were reduced following stimulus repetitions and habituation, exhibiting exponential decay, and they recovered following a change in stimulus category. This suggests that using different stimuli may better preserve physiological reactivity by limiting within-trial habituation. This information should be considered in neurotechnological applications, such as amygdala function, where repeated presentation of the same stimulus may inadvertently decrease amygdala activation, potentially mimicking volitional downregulation.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEM-based volume estimation using electrode catheter measurements.","authors":"Daniel Voss, Jöran Rixen, Steffen Leonhardt, Marian Walter","doi":"10.2478/joeb-2026-0007","DOIUrl":"10.2478/joeb-2026-0007","url":null,"abstract":"<p><p>Cardiovascular diseases are the leading cause of death worldwide, and accurate assessment of left ventricular volume (LVV) is crucial for diagnosis, therapy guidance, and long-term monitoring in these patients. Existing clinical techniques either require substantial resources, depend strongly on operator expertise, or lack the precision required for continuous monitoring. In this work we investigate the feasibility of a finite-element- method-based (FEM) algorithm for estimating volume and catheter offset from catheter-based admittance measurements to provide the basis for a new LVV estimation method. The present paper describes the underlying ventricle FEM model, a sensitivity-guided selection of informative 4-electrode configurations, and a constrained Gauss-Newton estimation algorithm. The algorithm was evaluated using numerical simulations and measurements obtained with a dynamic 3D-printed ventricle phantom with controllable volume changes. In both simulation and experiment, the reduced measurement set achieved volume reconstructions comparable to the full measurement set. In the phantom experiments, volume estimation errors of approximately 3-4% were observed over a wide range of volumes. These results demonstrate the feasibility of FEM-based parameter estimation and show that a small number of optimized electrode configurations can provide sufficient information for robust volume estimation. While the present study uses simplified geometries and a controlled phantom setup, the proposed approach provides a methodological basis for future investigations using more realistic anatomical models and biological experiments.</p>","PeriodicalId":38125,"journal":{"name":"Journal of Electrical Bioimpedance","volume":"17 1","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}