Digital journal of ophthalmology : DJO最新文献

{"title":"From normalcy to pandemic: analyzing cataract surgery patterns through case volumes and Google Trends (2014-2020).","authors":"Vinit Majmudar, Monali S Ardeshna, Raghav Vadhul","doi":"10.5693/djo.01.2025.08.001","DOIUrl":"10.5693/djo.01.2025.08.001","url":null,"abstract":"<p><strong>Purpose: </strong>To examine cataract surgery rates among Medicare beneficiaries alongside Google Trends data to unveil insights into patient engagement and healthcare dynamics before and during the COVID-19 pandemic (2014 to 2020).</p><p><strong>Methods: </strong>Data of Google Trends (GT) relative search volumes (RSV) was collected for 9 total Google search terms related to cataracts or cataract procedures. Univariate linear regression was used to determine the correlation between average annual Google RSV for each search term and the total annual case volumes among US Medicare beneficiaries. Seasonal and pandemic trends were also studied.</p><p><strong>Results: </strong>There were statistically significant positive correlations between search data and the annual case volumes for cataract surgeries among Medicare beneficiaries for 5 of the 9 search terms selected. There was greater search traffic in summer and fall. Annual case volumes remained consistent and increasing from 2019 to 2020 during the pandemic, but search traffic decreased sharply.</p><p><strong>Conclusions: </strong>The stable rate in cataract surgeries among Medicare beneficiaries despite decreased patient engagement during the pandemic represents successful maintenance of health-care continuity. Google Trends is useful in understanding public interest and determining resource allocation and healthcare needs.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple mathematical approach to identifying baseline predictors of the effectiveness of carbonic anhydrase inhibitors in intraocular pressure reduction.","authors":"Wichapol Dendumrongsup","doi":"10.5693/djo.01.2025.04.001","DOIUrl":"10.5693/djo.01.2025.04.001","url":null,"abstract":"<p><strong>Purpose: </strong>To identify mathematically the baseline physiological predictors of the intraocular pressure (IOP)-lowering effectiveness of topical carbonic anhydrase inhibitors (CAIs).</p><p><strong>Materials and methods: </strong>Assuming a steady state of aqueous humor flow, mathematical equations describing IOP were formulated by incorporating related physiological variables. Global sensitivity analysis was then performed, in which all variables were varied simultaneously across their clinically reported ranges. This computational approach quantified the percentage reduction in IOP achieved by CAIs and identified the key determinants underlying variability in their effectiveness.</p><p><strong>Results: </strong>A reduction in the solute influx via active transport by the ciliary epithelium, mediated by CAIs, was positively associated with the magnitude of IOP reduction. Among the physiological parameters in this model-trabecular outflow facility, uveoscleral outflow fraction, episcleral venous pressure, mean arterial pressure, plasma protein concentration, albumin/globulin ratio, and plasma osmolarity-a higher baseline trabecular outflow facility was the strongest predictor of reduced effectiveness of CAIs, in terms of the percentage of IOP reduction. Other baseline physiological parameters had no significant effect on the effectiveness of CAIs.</p><p><strong>Conclusions: </strong>Certain patient characteristics may be associated with compromised effectiveness of CAIs in terms of percentage IOP reduction. These characteristics, potentially associated with higher trabecular outflow facility, may include a lower baseline IOP or prior use of other trabecular outflow-enhancing medications before CAI initiation. Further studies are required to validate the clinical significance of these findings.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 46-year-old woman with bilateral white retinal vessels.","authors":"Joanne Christine E Macenas-Wong, Aaron W Joe","doi":"10.5693/djo.03.2024.10.003","DOIUrl":"10.5693/djo.03.2024.10.003","url":null,"abstract":"","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 43-year-old woman with nontraumatic profuse ocular hemorrhage.","authors":"Mohammad O Tallouzi, Maryam Noeman, Matthew Azzopardi, Yu Jeat Chong","doi":"10.5693/djo.03.2025.04.003","DOIUrl":"10.5693/djo.03.2025.04.003","url":null,"abstract":"","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"130-132"},"PeriodicalIF":0.0,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective response to intravitreal faricimab in a patient with myopic neovascular membrane resistant to aflibercept.","authors":"Nelson C Capelanes, Bernardo K Moscovici, Caio V Regatieri, Renata F B Sugai, Ana A C Concer","doi":"10.5693/djo.02.2025.08.002","DOIUrl":"10.5693/djo.02.2025.08.002","url":null,"abstract":"<p><p>A 56-year-old woman with pathological myopia and macular neovascularization in the right eye was treated with 20 intravitreal injections of aflibercept following a treat-and-extend protocol, with no significant clinical improvement. A single intravitreal injection of faricimab was administered, after which the patient showed complete resolution of subretinal fluid and reduced neovascular lesions. Her visual acuity improved from 20/200 to 20/80 in the right eye, and she remained stable for 9 months without further signs of neovascular activity. Faricimab, which targets both VEGF-A and Ang-2, may be an effective alternative in myopic neovascular membranes resistant to aflibercept. Larger studies are needed to explore the long-term efficacy of faricimab in treating pathological myopia.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"115-117"},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of large submacular hemorrhage in a patient undergoing neurosurgical intervention for moyamoya.","authors":"Cindy S Zhao, Lucie Guo, Akira Féliz, Anna Toth, Vinit B Mahajan, Charles M T DeBoer","doi":"10.5693/djo.02.2025.03.005","DOIUrl":"10.5693/djo.02.2025.03.005","url":null,"abstract":"<p><p>We report the case of a 30-year-old woman with diabetes and newly diagnosed moyamoya disease who experienced submacular hemorrhage and acute vision loss. She presented with facial droop and slurred speech, and examination disclosed high-grade stenosis of the intracranial carotid artery. She was scheduled for urgent neurosurgery. The day before surgery, she lost vision in her left eye and was found to have diffuse multilayered hemorrhage with submacular hemorrhage. Pneumatic displacement was performed. Pars plana vitrectomy and drainage of the submacular hemorrhage were performed subsequently, with postoperative improvement in vision.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"118-124"},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subconjunctival triamcinolone acetonide injection around lumen of XEN Gel Stent effectively resolves persistent choroidal effusion.","authors":"Anny M S Cheng, Geetha G Vedula, Shailesh K Gupta, Argyrios Agritis, David T Y Yang, Elizabeth S Yang, Aarup A Kubal","doi":"10.5693/djo.02.2025.08.003","DOIUrl":"10.5693/djo.02.2025.08.003","url":null,"abstract":"<p><p>The XEN Gel Stent is a minimally invasive surgical implant for glaucoma designed to reduce intraocular pressure (IOP) while minimizing hypotony by creating an aqueous outflow pathway into the subconjunctival area. The XEN stent has been shown to reduce IOP effectively, with few adverse events reported; however, complications due to hypotony, such as choroidal detachment, may still occur. We report the case of an 86-year-old woman with primary open-angle glaucoma who underwent XEN stent placement followed by Nd:YAG laser lysis to clear the fibrin-obstructed lumen. Postoperatively, she experienced refractory choroidal detachment, which progressed despite cycloplegic and frequent topical steroid treatment but was successfully managed by a subconjunctival injection of triamcinolone acetonide surrounding the bleb. This is the first reported case of subconjunctival triamcinolone acetonide injection for the management of refractory choroidal detachment after XEN placement.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unilateral choroidal involvement revealing an acute leukemia.","authors":"Soundouss Sebbata, Taoufik Abdellaoui, Soufiane Laksir, Soukaina Laaouina, Houda Brarou, Yassine Mouzari","doi":"10.5693/djo.02.2024.10.003","DOIUrl":"10.5693/djo.02.2024.10.003","url":null,"abstract":"<p><p>A 56-year-old man presented with unilateral subacute visual loss secondary to an exudative serous retinal detachment of the left eye. The clinical course was later complicated by choroidal thickening and uveal effusion. Laboratory investigations revealed acute myeloid leukemia. Systemic chemotherapy was initiated, resulting in regression of the initial ocular findings, while the more typical ocular manifestations associated with leukemia subsequently became apparent. Choroidal infiltration in acute leukemia is rare, particularly as a presenting feature. Retinal abnormalities resolved markedly following successful management of the leukemia, supporting the conclusion that the ocular manifestations were a direct consequence of leukemic infiltration of the choroid.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"106-110"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unique cause of blepharoptosis associated with <i>RYR1</i> mutation.","authors":"Imanouel M Samai, Brian R Wong","doi":"10.5693/djo.02.2025.01.003","DOIUrl":"10.5693/djo.02.2025.01.003","url":null,"abstract":"<p><p>We present the case of a 56-year-old man with a recessive <i>RYR1</i> mutation (10318G>A) who presented with bilateral ptosis and ophthalmoplegia. Despite a history of rhabdomyolysis and Graves' disease, he had not previously reported visual complaints. Following bilateral frontalis fixation surgery, his visual acuity improved. <i>RYR1</i> mutations typically manifest as myopathies and susceptibility to malignant hyperthermia. To our knowledge, this is only the second reported case of a patient with the 10318G>A mutation presenting with blepharoptosis with ophthalmoplegia. Here, we outline the spectrum of <i>RYR1</i> mutations as well as their ophthalmic and systemic effects.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 4","pages":"103-105"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of an artificial intelligence chatbot in identifying congenital glaucoma from other ocular etiologies.","authors":"Nur Cardakli, Bo Wang, Jefferson J Doyle, Courtney L Kraus","doi":"10.5693/djo.01.2025.03.003","DOIUrl":"10.5693/djo.01.2025.03.003","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the accuracy and appropriateness of responses provided by ChatGPT in identifying congenital glaucoma from a series of written and image-based prompts.</p><p><strong>Methods: </strong>A series of questions regarding common signs and symptoms of congenital glaucoma were developed and queried to ChatGPT-3.5 and ChatGPT-4.0, and a set of publicly available images of patients with congenital glaucoma were queried to the image search function of ChatGPT-4.0. Outputs were graded by three pediatric ophthalmologists with expertise in congenital glaucoma. Completeness of response, accuracy, potential for harm, and concern for glaucoma were assessed by each reviewer.</p><p><strong>Results: </strong>A higher proportion of prompt responses from ChatGPT-4.0 were graded to be acceptable/appropriate than from ChatGPT-3.5 (22/33 vs 9/33 [<i>P</i> = 0.001]) among text-based queries. A higher proportion of ChatGPT-4.0 responses were felt to raise appropriate concern for congenital glaucoma (8/11 vs 2/11 [<i>P</i> = 0.03]) and a lower proportion of responses had incorrect or inappropriate information of major clinical significance (0/33 vs 6/33 [<i>P</i> = 0.02]) than ChatGPT-3.5 responses. There was no significant difference in the proportion of responses from ChatGPT-3.5 and ChatGPT-4.0 that were deemed to have potential likelihood of harm (<i>P</i> = 0.17). Among clinical images queried to ChatGPT-4.0, responses to two of three images were universally felt to be unacceptable with a major amount of incorrect or inappropriate clinical information and high/definitive likelihood of harm. Among readability indices, the SMOG Index score showed more difficult readability scores for ChatGPT-4.0 than for ChatGPT-3.5 (14.8 ± 1.2 vs 14.0 ± 1.4 [<i>P</i> = 0.009]).</p><p><strong>Conclusions: </strong>Despite superior performance from ChatGPT-4.0 compared with ChatGPT-3.5 in raising concern for congenital glaucoma and appropriateness of responses from text-based prompts, it performed poorly in recognizing clinical images of congenital glaucoma.</p>","PeriodicalId":38112,"journal":{"name":"Digital journal of ophthalmology : DJO","volume":"31 3","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}