MicroRNA (Shariqah, United Arab Emirates)最新文献_第5页

Instead of Calories, Should We Be Counting our Consumption of Exosomes and MicroRNAs? 我们应该计算外泌体和微rna的消耗，而不是卡路里吗?

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230331083455

Kendal Dee Hirschi, Vignesh Nalliah, Hormat Shadgou Rhein

引用次数: 0

Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder. 自闭症谱系障碍小鼠模型中EP3受体mRNA的表达降低。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230427152647

Kusnandar Anggadiredja, Neng Fisheri Kurniati, Atsushi Kasai, Hitoshi Hashimoto

{"title":"Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder.","authors":"Kusnandar Anggadiredja, Neng Fisheri Kurniati, Atsushi Kasai, Hitoshi Hashimoto","doi":"10.2174/2211536612666230427152647","DOIUrl":"10.2174/2211536612666230427152647","url":null,"abstract":"Background: Accumulating evidence has implicated the role of neuroinflammation in the pathology of autism spectrum disorder (ASD), a neurodevelopmental disorder.Objectives: To investigate the expression of prostaglandin EP3 (EP3) receptor mRNA in the brain of ASD mouse model.Methods: Pregnant mice were injected with valproic acid (VPA) 500 mg/kg intraperitoneally at 12.5 d gestation. The offspring were tested at the age of 5-6 weeks old for their social interaction behavior. Each mouse was assessed for prostaglandin EP3 receptor expression in the prefrontal cortical, hippocampal and cerebellar areas one day after the behavioral test.Results: Compared to the naive, mice born to dams treated with VPA demonstrated a significantly shorter duration of sniffing behavior, a model of social interaction. Results further showed that the expression of EP3 receptor mRNA was significantly lower in all three brain regions of the mice born to VPA-treated dams.Conclusion: The present study provides further evidence of the relevance of the arachidonic acid cascade as an essential part of neuroinflammation in the pathology of ASD.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9711722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR/Cas9 Tool for MicroRNAs Editing in Cardiac Development, Function, and Disease. CRISPR/Cas9工具用于心脏发育、功能和疾病中的microrna编辑。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536611666220922092601

Leila Abkhooie, Shirin Saberianpour

{"title":"CRISPR/Cas9 Tool for MicroRNAs Editing in Cardiac Development, Function, and Disease.","authors":"Leila Abkhooie, Shirin Saberianpour","doi":"10.2174/2211536611666220922092601","DOIUrl":"https://doi.org/10.2174/2211536611666220922092601","url":null,"abstract":"CRISPR/Cas9 is a powerful gene-editing technology. Extensive scientific data exist that the CRISPR/Cas9 system can target small, non-coding, active RNA molecules, including microRNAs (miRNAs). miRNAs have been recognized as key regulators of different cell biological processes, such as the modulation of fibrosis and cardiac hypertrophy, as well as the regulation of cardiomyocytes. Also, it has been demonstrated that miRNAs strongly affect organ evolution, and that the concentration of miRNAs can involve the differentiation, development, and function of different organs. In addition, the current findings clearly indicate that miRNAs can select and control their targets based on their concentrations. CRISPR/Cas9 genome-editing technology is a stronger system for stopping miRNAs than previous methods, including antisense inhibitors. CRISPR/Cas9 tools can be used to eliminate small areas of DNA and determine miRNA in cases where similar groups of miRNAs are in the same strand. Herein, besides other emerging strategies, we critically summarize the recent investigations linking miRNA-targeted therapeutics and CRISPR/Cas9 system to clarify and combine different delivery platforms and cell-fate engineering of miRNAs function and miRNA-based therapeutic intervention in cardiac development, function, and disease. Based on our findings from the literature, it appears that the use of the CRISPR/Cas technology provides new perspectives for understanding the molecular mechanism of cardiovascular disease and can be effective in treating and controlling cardiac development, function, and disease in the future.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9290027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular Compartmentalization: A Key Determinant of MicroRNA Functions. 细胞内分隔：微小核糖核酸功能的关键决定因素。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230330184006

Rohit Nalawade, Mohini Singh

引用次数: 0

MicroRNAs Regulate Inhibitor of Apoptosis Proteins (IAPs) in Colorectal Cancer. microrna调控结直肠癌细胞凋亡抑制蛋白(IAPs)。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230915105323

Hamid Tanzadehpanah, Amir Avan, Majid Ghayour-Mobarhan, Gordon A Ferns, Hamed Manoochehri, Mohsen Sheykhhasan, Hanie Mahaki

{"title":"MicroRNAs Regulate Inhibitor of Apoptosis Proteins (IAPs) in Colorectal Cancer.","authors":"Hamid Tanzadehpanah, Amir Avan, Majid Ghayour-Mobarhan, Gordon A Ferns, Hamed Manoochehri, Mohsen Sheykhhasan, Hanie Mahaki","doi":"10.2174/2211536612666230915105323","DOIUrl":"10.2174/2211536612666230915105323","url":null,"abstract":"Colorectal cancer (CRC) is the second most common cause of cancer mortality, with approximately 1.9 million new cases and 0.9 million deaths globally in 2020. One of the potential ways to treat colorectal cancer may be through the use of molecular methods to induce cell apoptosis. Apoptosis is a natural cellular event that regulates the growth and proliferation of body cells and prevents cancer. In this pathway, several molecules are involved; one group promotes this process, and some molecules that are representative of inhibitors of apoptosis proteins (IAPs) inhibit apoptosis. The most important human IAPs include c-IAP1, c-IAP2, NAIP, Survivin, XIAP, Bruce, ILP-2, and Livin. Several studies have shown that the inhibition of IAPs may be useful in cancer treatment. MicroRNAs (miRNAs) may be effective in regulating the expression of various proteins, including those of the IAPs family; they are a large subgroup of non-coding RNAs that are evolutionarily conserved. Therefore, in this review, the miRNAs that may be used to target IAPs in colorectal cancer were discussed.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10651967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miRNA as an Ultimate and Emerging Diagnostic Approach for the Detection of Alzheimer's Disease. miRNA作为检测阿尔茨海默病的一种最终和新兴的诊断方法。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/0122115366243970230925061819

Mukul Jain, Shrishti Agarwal, Aarzu Rana, Ankit Tiwari, Nil Patil

{"title":"miRNA as an Ultimate and Emerging Diagnostic Approach for the Detection of Alzheimer's Disease.","authors":"Mukul Jain, Shrishti Agarwal, Aarzu Rana, Ankit Tiwari, Nil Patil","doi":"10.2174/0122115366243970230925061819","DOIUrl":"10.2174/0122115366243970230925061819","url":null,"abstract":"Alzheimer's disease is a prevalent neurodegenerative disorder primarily affecting elderly individuals, characterized by cognitive decline and dysfunction in the nervous system. The disease is hallmarked by the presence of neurofibrillary tangles and amyloid-β plaques. Approximately 10.7% of the global population aged 65 and above suffer from Alzheimer's disease, and this number is projected to rise significantly in the foreseeable future. By the year 2050, the worldwide prevalence is estimated to reach 139 million cases, compared to the current 55 million cases. The identification of reliable biomarkers that can facilitate the diagnosis and prognosis of Alzheimer's disease is crucial. MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that play a significant role in mRNA regulation and protein level maintenance through mRNA degradation. Over the past decade, researchers have primarily focused on elucidating the functions and expression patterns of miRNAs in various diseases, including Alzheimer's disease, to uncover their potential as diagnostic biomarkers. This review emphasizes the potential of miRNAs as diagnostic biomarkers for Alzheimer's disease and explores their roles and therapeutic possibilities. MiRNAs possess several features that make them ideal biomarkers, including their ability to be easily detected in body fluids. Moreover, the extraction process is minimally invasive, as miRNAs can be readily extracted. Advances in technology have facilitated the integration of miRNAs into micro-assays, enhancing the reliability and utility of miRNAs as diagnostic biomarkers for Alzheimer's disease.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka. 尿微量RNA分析表明斯里兰卡不明病因慢性肾脏疾病的表观遗传学调控。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230202152932

Thanuri Edirithilake, Nishantha Nanayakkara, Xiao Xiao Lin, Patrick J Biggs, Rohana Chandrajith, Sampath Lokugalappatti, Saumya Wickramasinghe

{"title":"Urinary MicroRNA Analysis Indicates an Epigenetic Regulation of Chronic Kidney Disease of Unknown Etiology in Sri Lanka.","authors":"Thanuri Edirithilake, Nishantha Nanayakkara, Xiao Xiao Lin, Patrick J Biggs, Rohana Chandrajith, Sampath Lokugalappatti, Saumya Wickramasinghe","doi":"10.2174/2211536612666230202152932","DOIUrl":"10.2174/2211536612666230202152932","url":null,"abstract":"BACKGROUND\u0000Chronic kidney disease of unknown etiology (CKDu) is reported among male paddy farmers in the dry zone of Sri Lanka. The exact cause of this disease remains undetermined. Genetic susceptibility is identified as a major risk factor for CKDu.\u0000\u0000\u0000OBJECTIVES\u0000In this study, small urinary RNAs were characterized in CKDu patients, healthy endemic and non-endemic controls. Differently expressed urinary miRNAs and their associated pathways were identified in the study population.\u0000\u0000\u0000METHODS\u0000Healthy and diseased male volunteers (n=9) were recruited from Girandurukotte (endemic) and Mawanella (non-endemic) districts. Urinary small RNAs were purified and sequenced using Illumina MiSeqTM. The sequence trace files were assembled and analyzed. Differentially expressed miRNAs among these three groups were identified and pathway analysis was conducted.\u0000\u0000\u0000RESULTS\u0000The urine samples contained 130,623 sequence reads identified as non-coding RNAs, PIWI-interacting RNAs (piRNA), and miRNAs. Approximately four percent of the total small RNA reads represented miRNA, and 29% represented piRNA. A total of 409 miRNA species were expressed in urine. Interestingly, both diseased and endemic controls population showed significantly low expression of miRNA and piRNA. Regardless of the health status, the endemic population expressed significantly low levels of miR-10a, miR-21, miR-148a, and miR-30a which have been linked with several environmental toxins.\u0000\u0000\u0000CONCLUSION\u0000Significant downregulation of miRNA and piRNA expression in both diseased and healthy endemic samples indicates an epigenetic regulation of CKDu involving genetic and environmental interaction. Further studies of specific miRNA species are required to develop a miRNA panel to identify individuals susceptible to CKDu.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10097604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Urinary miRNAs in the Diagnosis, Management and Follow- Up of Prostatic Cancer. 尿miRNA在癌症诊断、治疗和随访中的作用。

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230324102850

Afroditi Ziogou, Alexios Giannakodimos, Ilias Giannakodimos

引用次数: 0

Role of lncRNAs and circRNAs in Orofacial Clefts. lncRNA和circRNA在口腔颌面裂中的作用

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2023-01-01 DOI: 10.2174/2211536612666230524153442

Ratnam S Seelan, Robert M Greene, M Michele Pisano

引用次数: 0

WITHDRAWN: In silico and Experimental Analysis of miR-125b-5 and miR-485-5p Expression in Serum of Patients with Breast Cancer 撤回：乳腺癌患者血清中 miR-125b-5 和 miR-485-5p 表达的硅学和实验分析

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2022-05-23 DOI: 10.2174/2211536611666220523100057

Zahra Bahmanpour, Roghayeh Sheervalilou, Mahmoud Shekari Khaniani, Arash Poursheikhani, Vahid Montazeri, Mahsa Tahmasebivand, Sima Mansoori Derakhshan

{"title":"WITHDRAWN: In silico and Experimental Analysis of miR-125b-5 and miR-485-5p Expression in Serum of Patients with Breast Cancer","authors":"Zahra Bahmanpour, Roghayeh Sheervalilou, Mahmoud Shekari Khaniani, Arash Poursheikhani, Vahid Montazeri, Mahsa Tahmasebivand, Sima Mansoori Derakhshan","doi":"10.2174/2211536611666220523100057","DOIUrl":"10.2174/2211536611666220523100057","url":null,"abstract":"Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has\u0000been withdrawn.Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policiesmain.\u0000phpBentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously\u0000submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere\u0000must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting\u0000the article for publication the authors agree that the publishers have the legal right to take appropriate action against the\u0000authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright\u0000of their article is transferred to the publishers if and when the article is accepted for publication.","PeriodicalId":38067,"journal":{"name":"MicroRNA (Shariqah, United Arab Emirates)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10753779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0