Addictive Behaviors Reports最新文献

{"title":"Overlapping Phenotypes of Compulsive Buying-Shopping Disorder and Borderline Personality Disorder: An Evidence-Based Model","authors":"Nora M. Laskowski,&nbsp;Luisa Sabel,&nbsp;Gerrit Brandt,&nbsp;Georgios Paslakis","doi":"10.1016/j.abrep.2026.100669","DOIUrl":"10.1016/j.abrep.2026.100669","url":null,"abstract":"<div><h3>Background</h3><div>Compulsive Buying-Shopping Disorder (CBSD) and Borderline Personality Disorder (BPD) are two clinically relevant conditions that frequently co-occur. Previous studies suggest overlapping etiological pathways, yet a structured comparison of the two disorders is missing. This paper aimed to map and contrast the key psychological constructs associated with CBSD and BPD based on established diagnostic criteria and the existing literature.</div></div><div><h3>Methods</h3><div>A comprehensive, iterative literature search was conducted in PubMed and Google Scholar without publication date restrictions, including qualitative, quantitative, and review studies in English and German. Constructs were categorized based on the strength and consistency of the evidence, and findings were synthesized narratively and illustrated visually.</div></div><div><h3>Results</h3><div>Shared constructs include impulsivity, affective/emotional stability and regulation, self-regulation/control, self-concept/identity, attachment style/emotional dependence, decision-making, perfectionism, and novelty seeking. For CBSD, constructs such as cue-reactivity/craving, compulsivity, behavioral inhibition/activation system, materialism, attachment to possessions, and approach-oriented personality traits were more prominent. In contrast, BPD-specific constructs include internal representations of self and others/object relations, mentalization, chronic emptiness, perceptual/interpretation bias, non-suicidal self-injurious behavior, social relationships, and dissociative symptoms.</div></div><div><h3>Conclusion</h3><div>The resulting model offers a preliminary framework to distinguish shared and unique features of CBSD and BPD, supporting transdiagnostic understanding and contributing to improved diagnostic precision and intervention strategies.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100669"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Environmental Stimulation Therapy (REST) in methamphetamine use disorder: a pilot study","authors":"Emily M. Choquette ,&nbsp;McKenna Garland ,&nbsp;Gregory Morrissey ,&nbsp;Nicolas Wilzok ,&nbsp;Raminta Wilson ,&nbsp;Abhinita Premkumar ,&nbsp;Jennifer L. Stewart ,&nbsp;Sahib S. Khalsa","doi":"10.1016/j.abrep.2025.100651","DOIUrl":"10.1016/j.abrep.2025.100651","url":null,"abstract":"<div><div>Existing treatments for methamphetamine use disorder (MUD) are suboptimal in addressing withdrawal and preventing relapse. Models of addiction have proposed that negative affect plays an influential role in drug craving and relapse. Although Reduced Environmental Stimulation Therapy (REST) has been associated with attenuated negative affect in other psychiatric conditions, it has not been examined as an intervention for MUD. To address this gap, the present study investigated the feasibility, tolerability, and safety of a single session of REST via floatation pool (pool-REST) in treatment-enrolled individuals with MUD. In a within-subject crossover design, participants (<em>n</em> = 78) consented to complete one session each of pool-REST and chair-REST, an active comparator controlling for the effects of simple relaxation and expectation. Feasibility was assessed via completion rate, tolerability via duration of REST utilization, and safety via adverse event incidence. Secondary outcomes were assessed via measurement of self-reported affect, interoceptive sensation, and degree of stimulant craving. 74 % of all recruited participants (<em>n</em> = 58) completed both REST sessions, which were well-tolerated. There were no serious adverse events and participants provided more frequent endorsements of positive versus negative experiences. Although both REST conditions showed significant decreases in ratings of stress/anxiety, negative affect, and stimulant craving, pool-REST was associated with greater increases in positive affect, cardiorespiratory interoceptive awareness, heart rate, and systolic blood pressure than chair-REST. These results demonstrate that REST sessions are feasible, well-tolerated, and safe in individuals with MUD. Randomized control trials are warranted to explore potential salutary effects of pool-REST on MUD remission and recovery.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100651"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of residential greenness and season on discontinuation of medication treatment for opioid use disorder across rural to urban community types","authors":"Melissa N. Poulsen ,&nbsp;Cara M. Nordberg ,&nbsp;Karen Bandeen-Roche ,&nbsp;Joseph DeWalle ,&nbsp;Wade Berrettini ,&nbsp;Brian S. Schwartz","doi":"10.1016/j.abrep.2025.100661","DOIUrl":"10.1016/j.abrep.2025.100661","url":null,"abstract":"<div><h3>Introduction</h3><div>Medications for opioid use disorder (MOUD) are standard of care for opioid use disorder (OUD), but high rates of treatment discontinuation limit their impact on recovery. Nature exposure and engagement holds promise as a potential adjunctive treatment to MOUD through stress reduction and mental health benefits. This study evaluated whether nature exposure influenced MOUD treatment participation by analyzing associations of residential greenness with MOUD discontinuation across a diverse geography in Pennsylvania, while considering interrelated factors—season and community type.</div></div><div><h3>Methods</h3><div>We analyzed electronic health records from 2,570 adults receiving MOUD from an outpatient addiction treatment program. Weekly MOUD participation was derived from medication days’ supply of buprenorphine or naltrexone. Average weekly greenness (normalized difference vegetation index) was assigned to buffers surrounding participants’ residential address. We applied mixed-effects logistic regression of pooled person-weeks in treatment to model the odds of MOUD discontinuation, clustered by patient and with robust standard errors.</div></div><div><h3>Results</h3><div>In models adjusted for sociodemographic factors, residential greenness was not associated with MOUD discontinuation. We observed associations of season with MOUD discontinuation: compared to spring weeks, the odds of MOUD discontinuation were 20–27% higher during summer, fall, and winter weeks. In season-stratified models, we observed a non-linear association of greenness and MOUD discontinuation during the spring season.</div></div><div><h3>Conclusions</h3><div>Understanding factors contributing to MOUD discontinuation is essential to improving recovery outcomes for those with OUD. Findings suggest that passive greenness exposure may have little influence on MOUD participation but identified the potential importance of season on MOUD outcomes.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100661"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of anxiety and depression symptoms in the relationship between ADHD symptoms and polysubstance use among French university students: the i-share study","authors":"François A.M. Jean ,&nbsp;Charline Galesne ,&nbsp;Noelia Retuerto ,&nbsp;Marie C. Navarro ,&nbsp;Zeineb Azouz ,&nbsp;Agathe Tabyaoui ,&nbsp;Mélissa Macalli ,&nbsp;Christophe Tzourio ,&nbsp;Cédric Galéra","doi":"10.1016/j.abrep.2025.100652","DOIUrl":"10.1016/j.abrep.2025.100652","url":null,"abstract":"<div><h3>Introduction</h3><div>Polysubstance use, depressive disorder, and anxiety disorder are frequent comorbidities in adults with ADHD. This study aimed to explore the mediation role of anxiety and depression symptoms in the association between ADHD symptoms and polysubstance use.</div></div><div><h3>Methods</h3><div>The study included 1675 French university students from February 2013 to July 2020 as part of the i-Share cohort. Time 1: ADHD symptoms were assessed using the Adult ADHD Self-Report Scale. Time 2: Anxiety and depression symptoms were evaluated using the State-Trait Anxiety Inventory-Y trait and the Patient Health Questionnaire-9, respectively. Time 3: Substance use was assessed through a self-reported questionnaire. We conducted a mediation analysis using structural equation modeling.</div></div><div><h3>Results</h3><div>The study included 1675 participants. At time 1, the level of ADHD symptoms was moderate (m: 10.66, sd: 3.99). At time 2, both anxiety (m: 47.11, sd: 10.57) and depression (m: 6.92, sd: 5.33) symptoms were moderate. At time 3, 93.49% (1566) of participants had used substances. The direct effect between ADHD factor and polysubstance use factor was of 1.66 (1.04–2.48). The indirect effects between ADHD factor and polysubstance use factor were through anxiety factor −0.68 (−1.15 to −0.37) and through depression factor −0.57 (−0.94 to −0.32). Although the mediation effects through anxiety and depression factors were negative, the total effect remained positive and significant (0.41 (0.27 to 0.59)).</div></div><div><h3>Discussion</h3><div>Anxiety factor and depression factor acted as negative and partial mediators in the association between ADHD factor and polysubstance use factor.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100652"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal patterns of adolescent screen time and compulsive internet use in Moroccan high school students","authors":"Samiha Imrani ,&nbsp;Bouzekri Touri ,&nbsp;Lucia Romo ,&nbsp;Oulmann Zerhouni","doi":"10.1016/j.abrep.2026.100667","DOIUrl":"10.1016/j.abrep.2026.100667","url":null,"abstract":"<div><div><strong>Objective</strong>: Although compulsive internet use reflects interactions between personal vulnerabilities and situational triggers, adolescents’ day-to-day screen time patterns, especially in non-Western contexts, remain understudied. We aim to examine temporal patterns of screen time among Moroccan adolescents and their associations with compulsive internet use (CIU) and sociodemographic factors. <strong>Methods</strong>: This study uses an intensive daily design to capture short-term fluctuations in screen use across a week, identifying weekday–weekend shifts and other dynamics. A total of 334 Moroccan high school students (M_age = 16.02 years, 52 % female) from three public schools in urban and rural areas reported their daily screen time and CIU over seven consecutive days, their platform-specific usage and their scores on the CIUS. Latent class analysis (LCA) was used to identify subgroups with distinct weekly trajectories, and latent growth modeling (LGM) was used to assess temporal change. Linear mixed-effects models tested predictors, including age, sex, CIUS scores, school type, device preference, and primary internet activity. <strong>Results</strong>: Two distinct usage profiles emerged: steady-low and weekend-high. The weekend-high profile was more common among older girls and showed strong Sunday peaks. Mixed-effects and latent class models showed that higher CIUS scores, being female, and the day of the week (especially Sunday, with an increase of 74 min compared to weekdays) predicted heavier, multi-platform engagement. <strong>Conclusions</strong>: Moroccan adolescents show heterogeneous temporal patterns of screen use, with compulsive use linked to heavier, weekend-centered engagement. Prevention efforts should target overall exposure and high-risk time windows, especially on weekends.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100667"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample","authors":"Shelley Alyse Gresko ,&nbsp;Robin P. Corley ,&nbsp;Erik G. Willcutt ,&nbsp;Michael C. Stallings ,&nbsp;Christian J. Hopfer ,&nbsp;Soo Hyun Rhee","doi":"10.1016/j.abrep.2025.100664","DOIUrl":"10.1016/j.abrep.2025.100664","url":null,"abstract":"<div><h3>Background</h3><div>Subjective effects (SEs) are positively associated with substance use disorders in clinical samples. However, the etiology of these associations remains unclear. The present study utilized a clinical sample selected for elevated polysubstance use disorder (SUD) criteria to address the following questions: Are positive and negative polysubstance SEs and SUD criteria associated? Are cross-sectional and longitudinal results consistent? Is there evidence for common genetic influences between SEs and SUDs?</div></div><div><h3>Methods</h3><div>Cross-sectional and longitudinal analyses using the Defries Fulker regression method were conducted in clinical probands (<em>n =</em> 476) and their full (<em>n =</em> 557) and half siblings (<em>n =</em> 65). SEs were assessed in adolescence and SUD criteria were assessed once in adolescence and twice in adulthood.</div></div><div><h3>Results</h3><div>SEs were correlated with SUD criteria from adolescence to adulthood in clinical probands (<em>r =</em> 0.12–0.40) and during adolescence (<em>r =</em> 0.36–0.39) in full siblings of clinical probands. Results were inconsistent with common genetic influences between elevated SUDs and SEs.</div></div><div><h3>Conclusions</h3><div>Elevated SUDs and SEs were mostly explained by familial influences independent of genetics. There was little support for common genetic influences on elevated SUDs and SEs, possibly due to low power. Future research should focus on individual factors driving associations between these constructs.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100664"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption patterns and withdrawal symptoms in dual cannabis-tobacco users in Spain: Cross-sectional study","authors":"Judith Saura ,&nbsp;Marta Enríquez ,&nbsp;Ariadna Feliu ,&nbsp;Xavier Roca ,&nbsp;Silvia Mondón ,&nbsp;Pablo Barrio ,&nbsp;Magalí Andreu ,&nbsp;Lidia Segura ,&nbsp;Montse Ballbè ,&nbsp;Marcela Fu ,&nbsp;Esteve Fernández ,&nbsp;Cristina Martínez ,&nbsp;DuCATA clinical group","doi":"10.1016/j.abrep.2025.100656","DOIUrl":"10.1016/j.abrep.2025.100656","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis use has increased worldwide, with over 188 million users annually. In Spain, past-year prevalence among people aged 15–64 is 10.6%. Dual use of cannabis and tobacco is common, increasing health risks and complicating cessation. This study examines consumption patterns and cannabis withdrawal severity among dual users undergoing treatment for cannabis use disorder (CUD).</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted in substance use treatment programs in Catalonia, Spain. Participants were cannabis users initiating CUD treatment. A questionnaire collected sociodemographic data, cannabis and tobacco use characteristics (e.g., number of spliffs, tobacco amount), nicotine dependence, motivation to quit, and cannabis withdrawal symptoms. Hierarchical cluster analysis using Gower’s distance identified behavioral patterns among participants.</div></div><div><h3>Results</h3><div>Data from 94 participants seeking CUD treatment were included. Daily tobacco use was reported by 91.5%, with a mean Fagerström score of 4.2/10. Most participants (88.1%) co-used cannabis with tobacco, and 75.8% experienced cannabis withdrawal symptoms, with women reporting greater severity. Cluster analysis revealed two profiles: Cluster 1 (71.0%) included mostly older males with higher motivation to quit and fewer withdrawal symptoms; Cluster 2 (29.0%) was younger, more sex-balanced, and showed higher nicotine dependence, and more severe withdrawal symptoms.</div></div><div><h3>Conclusions</h3><div>Co-use of cannabis and tobacco is highly prevalent among individuals entering CUD treatment. Higher nicotine dependence is associated with more severe withdrawal symptoms. Older males with higher motivation and fewer withdrawal symptoms may have better prognosis, highlighting motivation as cessation predictor. Findings underscore the need to enhance motivation to quit both substances and integrated treatment.</div><div><strong>Trial registration number.</strong> The DuCATA project has been registered at <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> under the identifier [NCT05512091].</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100656"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social, Economic, and health risks among people who use Methamphetamine: Comparing three patterns of opioid Co-Use","authors":"Kimberly Page ,&nbsp;Mia Rae Kirk ,&nbsp;Tristin Garcia ,&nbsp;Haley Etchart ,&nbsp;Benjamin Chase ,&nbsp;Robert W. Harding ,&nbsp;Jess Anderson ,&nbsp;May McCarthy ,&nbsp;Phillip Fiuty ,&nbsp;Kathleen Reich ,&nbsp;Kelly Mytinger ,&nbsp;Olufemi Erinoso ,&nbsp;Karla D. Wagner","doi":"10.1016/j.abrep.2025.100660","DOIUrl":"10.1016/j.abrep.2025.100660","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine how persons using different methamphetamine-opioid combinations differ with respect to social, risk, and health characteristics, and to identify patterns of vulnerability across simultaneous, sequential, and independent use.</div></div><div><h3>Methods</h3><div>414 people who use illicit drugs were surveyed, 384 of whom reported polydrug use involving methamphetamine, in Nevada and New Mexico between June 2022 and August 2023. Participants were classified into three mutually exclusive groups based on self-reported methamphetamine and opioid use patterns: simultaneous use (<u>deliberately</u> using both drugs together), sequential use (using both drugs but not deliberately using simultaneously), and independent use (using methamphetamine alone or with non-opioid drugs). Prevalence ratios were calculated to examine associations between use patterns and social, economic, health, and drug use characteristics.</div></div><div><h3>Results</h3><div>We identified three distinct use patterns: simultaneous (53.1%), sequential (17.7%), and independent (29.2%). Individuals in these risk groups exhibited differential social, economic, carceral, and health-related risk: those engaged in simultaneous showed higher vulnerability relative to people who use independently and sequentially. Healthcare engagement was associated with lower simultaneous use.</div></div><div><h3>Conclusions</h3><div>These findings suggest the need to support development of strategies to support transition from higher to lower-risk drug use patterns.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100660"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between fear of missing out and problematic smartphone use: A latent profile analysis of problematic social media use","authors":"Rocco Servidio ,&nbsp;Paolo Soraci ,&nbsp;Zsolt Demetrovics ,&nbsp;Zsolt Horváth ,&nbsp;Mark D. Griffiths","doi":"10.1016/j.abrep.2025.100655","DOIUrl":"10.1016/j.abrep.2025.100655","url":null,"abstract":"<div><div>Problematic social media use (PSMU) has emerged as a societal and behavioral concern, especially among young adults. However, individual differences in symptom manifestation remain understudied. The present study adopted a person-centered approach to identify distinct profiles of PSMU and to examine the predictive roles of fear of missing out (FoMO), problematic smartphone use (PSU), age, and sex among a sample of 625 Italian university students aged 18 to 40 years (<em>M</em> = 25.31 years, <em>SD</em> = 5.85) who completed a self-report online survey. Using latent profile analysis (LPA) on a sample of Italian university students who use <em>Instagram</em>, five profiles were identified. Salience, tolerance, mood modification, withdrawal, and conflict symptoms sharply differentiated the high-risk with withdrawal symptom group from the other groups, supporting a cross-sectional pattern consistent with (but not demonstrating) a dimensional progression model. FoMO predicted high-risk with withdrawal symptoms and high-risk without withdrawal symptom membership, suggesting its role as an early vulnerability factor, whereas PSU strongly predicted high-risk with withdrawal symptoms classification. Sex differences also emerged, with females being more likely to belong to higher risk with withdrawal symptoms profiles. Analysis also indicated that younger participants were more at risk of belonging to the high-risk PSMU group. The findings offer nuanced insight into how psychological factors shape social online behavior and suggest tailored intervention strategies for users’ risk levels. However, the findings should be interpreted within the context of the <em>Instagram</em> social platform and the study’s sample-specific characteristics.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100655"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between substance use treatment and ketamine use: A hypothesis-generating analysis","authors":"Fares Qeadan,&nbsp;Shanti O’Neil","doi":"10.1016/j.abrep.2025.100650","DOIUrl":"10.1016/j.abrep.2025.100650","url":null,"abstract":"<div><h3>Background</h3><div>Ketamine is increasingly used in clinical settings for mental health and pain management, yet its misuse poses public health risks. While prior studies have examined ketamine trends, few have explored its use among individuals receiving treatment for substance use disorders (SUD).</div></div><div><h3>Methods</h3><div>Using 2021–2023 data from the National Survey on Drug Use and Health (NSDUH), we analyzed the association between past-year ketamine use and receipt of SUD treatment among U.S. residents aged 12 and older. Stratified analyses by substance type and use category (use, misuse, and disorder) were conducted using adjusted logistic regression models.</div></div><div><h3>Results</h3><div>Among 173,808 participants who reported substance use, 3.19 % received past-year treatment and 0.26 % reported past-year ketamine use. Ketamine use was more common among those in treatment (1.39 %) than not (0.22 %). Across SUD strata, treatment was associated with higher odds of ketamine use, including alcohol SUD (aOR = 2.73; 95 % CI: 1.58–4.71), marijuana SUD (2.32; 1.34–4.02), inhalant SUD (5.22; 1.96–13.94), methamphetamine SUD (5.10; 2.08–12.48), pain reliever SUD (2.62; 1.16–5.90), and opioid SUD (2.76; 1.23–6.18). Among misuse strata, associations included pain relievers (2.69; 1.40–5.16), opioids (3.13; 1.71–5.74), and psychotherapeutics (2.09; 1.21–3.62). Among use strata, treatment was associated with higher odds for cigarettes, alcohol, marijuana, heroin, PCP, DMT/AMT/FOXY, methamphetamine, pain relievers, tranquilizers, and stimulants.</div></div><div><h3>Conclusions</h3><div>Past-year treatment is a marker of elevated ketamine exposure across multiple substance domains. Findings are hypothesis-generating and underscore the need for clinical screening, patient education on unsupervised ketamine risks, and research clarifying timing, intent, and outcomes of ketamine use in SUD populations.</div></div>","PeriodicalId":38040,"journal":{"name":"Addictive Behaviors Reports","volume":"23 ","pages":"Article 100650"},"PeriodicalIF":2.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}