Medicina Moderna - Modern Medicine最新文献_第2页

The Multidisciplinary Approach to Vaginal Leiomyosarcoma, an Extremely Rare Diagnosis - Case Report 多学科方法治疗极罕见的阴道子宫纵隔肉瘤--病例报告

Medicina Moderna - Modern Medicine Pub Date : 2023-12-12 DOI: 10.31689/rmm.2023.30.4.347

Evelina-Elena Stoica, L. Bohiltea, Adrian Dumitru, Cătălin Aliuș, M. Cirstoiu

{"title":"The Multidisciplinary Approach to Vaginal Leiomyosarcoma, an Extremely Rare Diagnosis - Case Report","authors":"Evelina-Elena Stoica, L. Bohiltea, Adrian Dumitru, Cătălin Aliuș, M. Cirstoiu","doi":"10.31689/rmm.2023.30.4.347","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.4.347","url":null,"abstract":"Primary vaginal sarcoma is an extremely rare malignant condition within the field of gynecological pathologies. We present the case of a 53-year old patient with no history of gynecological issues or associated comorbidities who presented to our clinic with recurrent vaginal bleeding during menopause. We want to emphasize the importance of diagnostic management, going through all the necessary steps from local gynecological examination to vaginal biopsy, optimizing results with advanced imaging techniques. Once the histopathological diagnosis of vaginal leiomyosarcoma was established, the therapeutic approach was discussed within a multidisciplinary committee consisting of a gynecologist, surgeon, and oncologist. As a result, the patient underwent tailored surgical intervention relatively quickly after presentation, followed by referral to the oncology department, where she is currently undergoing her third course of adjuvant chemotherapy. Our current objective is the long-term follow-up of the patient and the acquisition of data regarding her survival and quality of life. These facts may contribute in the future to the implementation of standardized therapeutic guidelines for such a rare condition","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"78 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications 2型糖尿病伴与不伴并发症患者AGEs和hs-CRP的差异

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.117

Alfino Validita Sidiq, Y. Hernaningsih, Puspa Wardhani, S. Soelistijo

{"title":"Differences in AGEs and hs-CRP between Type 2 Diabetes Mellitus with and without Complications","authors":"Alfino Validita Sidiq, Y. Hernaningsih, Puspa Wardhani, S. Soelistijo","doi":"10.31689/rmm.2023.30.2.117","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.117","url":null,"abstract":"Background: Diabetes mellitus is a metabolic disease that can lead to macrovascular and microvascular complications that can cause death and reduce the quality of life. The level of serum AGEs increases with diabetes or a state of hyperglycemia. Increased AGEs in patients with diabetes mellitus can increase the risk of macrovascular and microvascular complications and increase the formation of hs-CRP. This study aims to assess the differences in AGEs and hs-CRP between type 2 diabetes mellitus patients with and without complications and the relationship between AGEs and hs-CRP. Methods: A cross-sectional study was conducted with 30 subjects of type 2 diabetes mellitus with complications and 30 subjects of diabetes mellitus without complications. Data were collected from September to December 2022. AGEs were measured using ELISA and hs-CRP using the turbidimetric method. Data were statistically processed to determine the difference and relationship between AGEs and hs-CRP. Results: AGEs and hs-CRP values in patients with type 2 diabetes mellitus with complications were 0.671±0.194 ng/ mL and 2.08(0.98-15.3) mg/L. In patients with uncomplicated type 2 diabetes 0.561±0.127 ng/mL and 1.69(0.22-9.25) mg/L. Differences in AGEs and hs-CRP between the two subject groups had significant results (AGEs p=0.012, hs-CRP p=0.038). The relationship between AGEs and hs-CRP in each subject group showed no significant results (With complications r=0.659 p=0.659, Without complications r=0.253 p=0.253). Conclusion: There are differences in AGEs and hs-CRP values between patients with type 2 diabetes mellitus with and without complications and there is no relationship between AGEs and hs-CRP values in each subject.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"1770 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127455145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second Primary Lung Cancer after Breast Cancer: Challenges and Approaches 乳腺癌后第二原发性肺癌:挑战和方法

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.157

Boghici Elena-Monica, A. Paroșanu, Ion Cristian Iaciu, M. Olaru, C. Pirlog, Cristina Orlov-Slavu, A. Popa, C. Nitipir

引用次数: 1

Posterior Perforation of Gastric Ulcer with Giant Retroperitoneal Abscess – a Rare Case 胃溃疡后穿孔合并腹膜后巨大脓肿1例

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.147

L. S. Andrei, A. Andrei, Alexandru Micu

{"title":"Posterior Perforation of Gastric Ulcer with Giant Retroperitoneal Abscess – a Rare Case","authors":"L. S. Andrei, A. Andrei, Alexandru Micu","doi":"10.31689/rmm.2023.30.2.147","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.147","url":null,"abstract":"Spontaneous perforation of a gastric ulcer is a rare entity and can often be overlooked considering the frequently silent clinical picture. The posterior erosion of the ulcer through the omental bursa in the retroperitoneal space determines local inflammation which, together with the fibrosis of the retroperitoneal tissue facilitates the enclosure of the gastric content. We present the case of a 49-year old patient investigated for pain in the upper abdomen. The endoscopy performed one month before the admission described a retractile area with a central ulcer on the posterior surface of the stomach, adjacent to the lesser curvature. Given the fact that the abdominal x-ray was normal, a CT scan was performed and a voluminous retroperitoneal cystic lesion was discovered. Combining all the preoperative informations the diagnosis was of retroperitoneal abscess by posterior perforation of a gastric ulcer. Surgical intervention was performed, the abscess was evacuated and it’s wall was completely resected; because of local conditions a distal hemigastrectomy with Roux en Y gastro-enteroanastomosis was chosen over gastrorhaphy and omentoplasty.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134501117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cross-sectional Study to Assess the Incidence of Adverse Drug Reactions to the Covishield Vaccine among Healthcare Workers of a Tertiary Care Government Institute in North India 一项横断面研究，以评估在印度北部三级保健政府研究所的医护人员对Covishield疫苗药物不良反应的发生率

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.133

Kamaleshbhai Trivedi, Punam Jakhar, R. Chaudhary, L. Sharma, A. Bansal, Mahima Makhija

{"title":"A Cross-sectional Study to Assess the Incidence of Adverse Drug Reactions to the Covishield Vaccine among Healthcare Workers of a Tertiary Care Government Institute in North India","authors":"Kamaleshbhai Trivedi, Punam Jakhar, R. Chaudhary, L. Sharma, A. Bansal, Mahima Makhija","doi":"10.31689/rmm.2023.30.2.133","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.133","url":null,"abstract":"Background: Vaccines are a key strategy to stop the COVID19 pandemic. The present study was conducted to assess the incidence of Adverse Drug Reactions to the Covishield vaccine among healthcare workers. Materials and Methods: A cross-sectional, observational, questionnaire-based study was carried out on healthcare workers of R.U.H.S. College of Medical Sciences, Jaipur, Rajasthan. The study tool consisted of a digital questionnaire. Results: The present study was carried out among 316 healthcare workers who received the first dose of the Covishield vaccine. 83 (26.26%) participants complained of side effects after receiving the first dose of the Covishield vaccine. Fatigue (64), fever (52), body ache (40), swelling at the vaccination site (35), headache (25), and pain in the limb (18) were the most prevalent symptoms. Most post-vaccination symptoms were found to be mild. 67 participants showed side effects of vaccination within 24 hours while 16 showed side effects after 24 hours. Conclusion: This study reflects that onefourth of participants complained of side effects after receiving the first dose of the Covishield vaccine. These side effects are not severe and should not be an obstacle to the successful control of the Covid-19 pandemic in India.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133171442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study Regarding the Importance of Water Intake in The Treatment of Bladder Lithiasis 饮水在膀胱结石治疗中的重要性研究

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.151

Diana M. Serbanescu, I. Codreanu

引用次数: 0

Estimation of Cardiovascular Risk by Framingham Score in a Cross-sectional Sample of Schizophrenia Inpatients 用Framingham评分估计精神分裂症住院患者的心血管风险

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.101

C. Moga, I. Micluția, C. Crișan

{"title":"Estimation of Cardiovascular Risk by Framingham Score in a Cross-sectional Sample of Schizophrenia Inpatients","authors":"C. Moga, I. Micluția, C. Crișan","doi":"10.31689/rmm.2023.30.2.101","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.101","url":null,"abstract":"The lifespan of schizophrenia (SCZ) patients is considered 25 years shorter compared to the general population, primarily due to cardiovascular (CV) disease. This study aims to assess the CV profile of the SCZ inpatients from Psychiatry Clinic I and II of Cluj-Napoca between 2018-2019. Methods: The following indicators were documented from interview and laboratory data: arterial hypertension (AHT), smoking, dyslipidemia, obesity, metabolic syndrome (MS), medication adherence (MA), Framingham score (FS), and CV diagnosis (CVd). The sample was separated into two groups based on FS and CV diagnosis: high-risk/CVd and medium/low-risk. Results: 50 SCZ patients were included in the study. 58% had AHT and 10% were prediagnosed, 90% had lipids perturbations of which 26.7% were prediagnosed, 66 % met the criteria for MS from which one prediagnosis, 12% had a CVd and the average FS was 12.7% corresponding to intermediate risk category. MA subjects had a lower risk to be in the high risk/CVd group (OR=1/0.22, p=0.02) and no association was found for the gender-CV risk categories (p=0.08). Conclusion: 1. The known CV risk factors are underdiagnosed in SCZ patients 2. SCZ might attenuate the gender CV risk stratification; and 3. MA might decrease the CV risk in SCZ.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134623357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological Effects of Creatine Monohydrate Supplementation on Muscle Tissue in Wistar Rats 补充一水肌酸对Wistar大鼠肌肉组织的组织学影响

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.111

Isabela Ferreira Silveira Arruda, Amilton Iatecola, Vanessa Zanoni Carvalhaes, M. R. da Cunha, Victor Augusto Ramos Fernandes

{"title":"Histological Effects of Creatine Monohydrate Supplementation on Muscle Tissue in Wistar Rats","authors":"Isabela Ferreira Silveira Arruda, Amilton Iatecola, Vanessa Zanoni Carvalhaes, M. R. da Cunha, Victor Augusto Ramos Fernandes","doi":"10.31689/rmm.2023.30.2.111","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.111","url":null,"abstract":"Creatine is a dietary supplement with the potential to stimulate the phosphocreatine pathway and protein synthesis, through the stimulation of PI3eK/AKT and mTOR responsible for the proliferation and differentiation of satellite cells, responsible for hypertrophy. The present study aimed to evaluate the morphological effects of the use of creatine monohydrate on the soleus muscle tissue of 26-month-old Wistar rats. Methods: Twelve Wistar rats were divided into two groups of six animals each. Group 1 was not supplemented with creatine and received a standard diet consisting of water and food. Group 2 received the same diet, but was supplemented with creatine monohydrate at a dose of 0.03 mg/kg of body weight diluted in 200 ml of drinking water for 8 weeks. Results: The supplementation promoted morphological and morphometric effects on the soleus muscle tissue, promoting changes in the perimeter and area of the muscles of the animals treated with the supplement. It is estimated that this supplement may promote, in addition to increasing the cross-sectional area of myocytes, increased stimulation of the protein synthesis pathway associated with PI3K/AKT.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127600500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Myopia Prevalence and its Correlation with Demographic Characteristics Before the COVID-19 Pandemic among Acehnese School Children (6-19 years) in Indonesia 2019冠状病毒病大流行前印尼亚齐6-19岁学龄儿童近视患病率及其与人口统计学特征的相关性

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.125

Yusni Yusni, F. Meutia

{"title":"Myopia Prevalence and its Correlation with Demographic Characteristics Before the COVID-19 Pandemic among Acehnese School Children (6-19 years) in Indonesia","authors":"Yusni Yusni, F. Meutia","doi":"10.31689/rmm.2023.30.2.125","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.125","url":null,"abstract":"The prevalence of myopia in school-age children has increased dramatically year by year. Myopia is an impact on academic achievement, and blindness, and increases the economic burden. The research objective was to analyze the prevalence of myopia and its relationship with demographic characteristics (age and gender) in school-age children. This study was a cross-sectional design. The respondents were male (M), female (F), and school-age children (aged 6-19 years). The total subjects were 1171 school students, Elementary Schools (n=661; M=326, F=335), Junior High Schools (n=307; M=138, F=169), and High Schools (n=203; M=84, F=119). Data analysis was descriptive and chi-square tests (p<0.05). We found that the prevalence of myopia in school-age children was 14.61%. The highest rate of myopia is at the age of 19 years, girls (15.73%) more than boys (13.32%), in the late adolescent group (23.53%) more than the early adolescent group (18.75%), and childhood age (9.32%). Myopia in high school-age children (23.15%) was more than in junior high school students (20.85%), and elementary school students (9.07%). There was a relationship between age (p<0.001*), age group (p<0.001*), and school level (p<0.001*), but otherwise, there was no association between gender (p=0.24) with myopia in school-age children. In conclusion: myopia prevalence is highest at the age of 19 years, a group of late teens, high school, and females more than males. Myopia is associated with age among Acehnese school children (6-19 years) in Indonesian, so that’s why we recommend performing visual acuity tests routinely.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131410084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy 甲状旁腺切除术后术中PTH激素值与术前显像的相关性

Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.95

I. Slavu, C. Nitipir, Cristina Orlov-Slavu, Alexandru Dogaru, R. Tulin, C. Oprescu, A. Tulin

{"title":"Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy","authors":"I. Slavu, C. Nitipir, Cristina Orlov-Slavu, Alexandru Dogaru, R. Tulin, C. Oprescu, A. Tulin","doi":"10.31689/rmm.2023.30.2.95","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.95","url":null,"abstract":"Preoperative parathyroid evaluation through nuclear medicine and intraoperative hormone monitoring has significantly increased the success of the surgical intervention. Material and method: Our study is descriptive, the database is retrospective but it is maintained prospectively. The preoperative protocol included single photon emission computed tomography (SPECT) with the use of technetium-99 sestamibi tracer. We preferred this approach as it allowed 3-D localization of the adenomas. PTH values were obtained from blood drawn from the ipsilateral jugular vein at the regular intervals of 5, 10 and 15 minutes post excision. Results: We had 6 cases with false negative which led to the necessary dissection of the contralateral neck. Two had previous surgery and 4 had tumors in other locations which were observed after the surgical intervention through methodical investigations. We encountered 3 patients with false positive results. 2 had intrathyroidal adenomas and 1 was diagnosed with thyroid papillary carcinoma. Causes of a misinterpretation are related to thyroid disease in association with hyperparathyroidism, a history of parathyroid surgery or multiple locations of hyperproductive parathyroid glands.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131806390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0