Medicina Moderna - Modern Medicine最新文献

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A Cross-sectional Study to Assess the Incidence of Adverse Drug Reactions to the Covishield Vaccine among Healthcare Workers of a Tertiary Care Government Institute in North India 一项横断面研究,以评估在印度北部三级保健政府研究所的医护人员对Covishield疫苗药物不良反应的发生率
Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.133
Kamaleshbhai Trivedi, Punam Jakhar, R. Chaudhary, L. Sharma, A. Bansal, Mahima Makhija
{"title":"A Cross-sectional Study to Assess the Incidence of Adverse Drug Reactions to the Covishield Vaccine among Healthcare Workers of a Tertiary Care Government Institute in North India","authors":"Kamaleshbhai Trivedi, Punam Jakhar, R. Chaudhary, L. Sharma, A. Bansal, Mahima Makhija","doi":"10.31689/rmm.2023.30.2.133","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.133","url":null,"abstract":"Background: Vaccines are a key strategy to stop the COVID19 pandemic. The present study was conducted to assess the incidence of Adverse Drug Reactions to the Covishield vaccine among healthcare workers. Materials and Methods: A cross-sectional, observational, questionnaire-based study was carried out on healthcare workers of R.U.H.S. College of Medical Sciences, Jaipur, Rajasthan. The study tool consisted of a digital questionnaire. Results: The present study was carried out among 316 healthcare workers who received the first dose of the Covishield vaccine. 83 (26.26%) participants complained of side effects after receiving the first dose of the Covishield vaccine. Fatigue (64), fever (52), body ache (40), swelling at the vaccination site (35), headache (25), and pain in the limb (18) were the most prevalent symptoms. Most post-vaccination symptoms were found to be mild. 67 participants showed side effects of vaccination within 24 hours while 16 showed side effects after 24 hours. Conclusion: This study reflects that onefourth of participants complained of side effects after receiving the first dose of the Covishield vaccine. These side effects are not severe and should not be an obstacle to the successful control of the Covid-19 pandemic in India.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133171442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myopia Prevalence and its Correlation with Demographic Characteristics Before the COVID-19 Pandemic among Acehnese School Children (6-19 years) in Indonesia 2019冠状病毒病大流行前印尼亚齐6-19岁学龄儿童近视患病率及其与人口统计学特征的相关性
Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.125
Yusni Yusni, F. Meutia
{"title":"Myopia Prevalence and its Correlation with Demographic Characteristics Before the COVID-19 Pandemic among Acehnese School Children (6-19 years) in Indonesia","authors":"Yusni Yusni, F. Meutia","doi":"10.31689/rmm.2023.30.2.125","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.125","url":null,"abstract":"The prevalence of myopia in school-age children has increased dramatically year by year. Myopia is an impact on academic achievement, and blindness, and increases the economic burden. The research objective was to analyze the prevalence of myopia and its relationship with demographic characteristics (age and gender) in school-age children. This study was a cross-sectional design. The respondents were male (M), female (F), and school-age children (aged 6-19 years). The total subjects were 1171 school students, Elementary Schools (n=661; M=326, F=335), Junior High Schools (n=307; M=138, F=169), and High Schools (n=203; M=84, F=119). Data analysis was descriptive and chi-square tests (p<0.05). We found that the prevalence of myopia in school-age children was 14.61%. The highest rate of myopia is at the age of 19 years, girls (15.73%) more than boys (13.32%), in the late adolescent group (23.53%) more than the early adolescent group (18.75%), and childhood age (9.32%). Myopia in high school-age children (23.15%) was more than in junior high school students (20.85%), and elementary school students (9.07%). There was a relationship between age (p<0.001*), age group (p<0.001*), and school level (p<0.001*), but otherwise, there was no association between gender (p=0.24) with myopia in school-age children. In conclusion: myopia prevalence is highest at the age of 19 years, a group of late teens, high school, and females more than males. Myopia is associated with age among Acehnese school children (6-19 years) in Indonesian, so that’s why we recommend performing visual acuity tests routinely.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131410084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy 甲状旁腺切除术后术中PTH激素值与术前显像的相关性
Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.95
I. Slavu, C. Nitipir, Cristina Orlov-Slavu, Alexandru Dogaru, R. Tulin, C. Oprescu, A. Tulin
{"title":"Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy","authors":"I. Slavu, C. Nitipir, Cristina Orlov-Slavu, Alexandru Dogaru, R. Tulin, C. Oprescu, A. Tulin","doi":"10.31689/rmm.2023.30.2.95","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.95","url":null,"abstract":"Preoperative parathyroid evaluation through nuclear medicine and intraoperative hormone monitoring has significantly increased the success of the surgical intervention. Material and method: Our study is descriptive, the database is retrospective but it is maintained prospectively. The preoperative protocol included single photon emission computed tomography (SPECT) with the use of technetium-99 sestamibi tracer. We preferred this approach as it allowed 3-D localization of the adenomas. PTH values were obtained from blood drawn from the ipsilateral jugular vein at the regular intervals of 5, 10 and 15 minutes post excision. Results: We had 6 cases with false negative which led to the necessary dissection of the contralateral neck. Two had previous surgery and 4 had tumors in other locations which were observed after the surgical intervention through methodical investigations. We encountered 3 patients with false positive results. 2 had intrathyroidal adenomas and 1 was diagnosed with thyroid papillary carcinoma. Causes of a misinterpretation are related to thyroid disease in association with hyperparathyroidism, a history of parathyroid surgery or multiple locations of hyperproductive parathyroid glands.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131806390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complications of Diverticular Disease – a Quick Overview 憩室疾病的并发症-快速概述
Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.81
Andreea Nestian, A. Dobromirescu, R. Babiuc, L. Negreanu
{"title":"Complications of Diverticular Disease – a Quick Overview","authors":"Andreea Nestian, A. Dobromirescu, R. Babiuc, L. Negreanu","doi":"10.31689/rmm.2023.30.2.81","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.81","url":null,"abstract":"Diverticulosis is a chronic acquired disease defined by the presence of diverticular protrusions throughout the wall layers of the digestive tract. Colonic diverticular disease is defined as clinically manifest or symptomatic diverticulosis, either by inflammation, diverticular bleeding or segmental colitis. It is a frequent cause of hospitalization in industrialized countries and also makes a major contribution to health care costs. Due to the spread of the Western-style diet, low in fibre and high in processed foods, the prevalence of diverticulosis is now increasing globally. Obesity is a significant risk factor contributing to the increased prevalence of both diverticular disease and diverticulitis and its complications, particularly in the younger population, previously considered to be at much lower risk than the geriatric population. Diverticulitis occurs when one or more diverticula, together with adjacent colonic tissue, undergo an inflammatory process. Approximately 15% of patients who suffer an episode of acute diverticulitis will experience complications, the most common of which is peridiverticular abscess, which can be complicated by peritonitis. Less common complications are colonic lumen stenosis and fistulae. Being a relatively common disease in the general population, with a constantly increasing prevalence, and also a disease with potentially reducible complications, especially in the case of frail patients with multiple comorbidities, it is necessary not only to update the therapeutic strategies, but also to set up multidisciplinary medical teams in which communication between the specialists involved results in a personalised (personalized) approach to each case.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129391787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Candida Infections in Severely Burned Patients: 1 year Retrospective Study 严重烧伤患者念珠菌感染:1年回顾性研究
Medicina Moderna - Modern Medicine Pub Date : 2023-06-29 DOI: 10.31689/rmm.2023.30.2.87
A. Lazarescu, Andreea GROSU-BULARDA, F. Hodea, A. Crețu, M. Andrei, D. Ionescu, Vlad Morozan, T. Neagu, C. Hariga, A. Frunză, Sabina Grama, I. Lascar
{"title":"Candida Infections in Severely Burned Patients: 1 year Retrospective Study","authors":"A. Lazarescu, Andreea GROSU-BULARDA, F. Hodea, A. Crețu, M. Andrei, D. Ionescu, Vlad Morozan, T. Neagu, C. Hariga, A. Frunză, Sabina Grama, I. Lascar","doi":"10.31689/rmm.2023.30.2.87","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.2.87","url":null,"abstract":"Infections represent the most common complication occurring during the evolution of the severely burned patient, hence requiring closer study and targeted result analysis. The fungal infections are one of the most aggressive types of existing infections, their opportunistic character enabling them to cause invasive infections, ultimately leading to a higher morbidity and a higher rate of mortality. The present study focuses on the presence of Candida spp. in 19 out of a total of 70 patients admitted to the Critical Care Burn Unit in the Clinical Emergency Hospital Bucharest, between 01.01.2019-31.12.2019. No other fungal species, besides Candida spp., were identified in this patient lot. The aim of this study was to analyze the risk factors and the dynamics of the biological parameters of the patients presenting Candida spp. infections, in order to determine how these contribute to the prognostic and final outcome of these patients. We can conclude that a precise diagnostic and prompt treatment can make a significant difference in the outcome of severely burnt patients presenting with a fungal infection.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131089725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Vertebroplasty on Sagittal Parameters in Traumatic Thoracic Vertebral Fractures 创伤性胸椎骨折椎体成形术对矢状面参数的影响
Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.57
Kemal Paksoy
{"title":"The Impact of Vertebroplasty on Sagittal Parameters in Traumatic Thoracic Vertebral Fractures","authors":"Kemal Paksoy","doi":"10.31689/rmm.2023.30.1.57","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.1.57","url":null,"abstract":"Objective: It is well-established that vertebroplasty has effects on sagittal parameters due to various pathologies of the spine. Our objective in the study was to reveal the impact of vertebroplasty that was applied to compression fractures due to trauma on sagittal parameters. Material and Method: Twenty patients were included in the study. Scoliosis radiographs were shot preoperatively and at first month during the postoperative period. Spinopelvic parameters of each patient including pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), lumbar lordosis (LL), thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), cervical lordosis (CL), and sagittal vertical axis (SVA) were assessed. Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) assessments of the patients were performed as well. Results: Spinopelvic parameter values of the patients were assessed statistically through the analysis of the Paired sample T test before surgery and in the first month during the postoperative period. It was determined that the changes in the PT, SS and LL values of the patients between preoperative and first month postoperative were at the level of p 0.659, p=0.716, p=0.012; and the changes were not significant. It was determined that the changes in the TL, TK, CL, SVA, VAS and ODI values of the patients between preoperative and first month postoperative were at the level of p <0.001and the changes were significant. Conclusion: Vertebroplasty is an efficient technique for relieving pain in thoracic fractures that have a score of 4 and over, based on the thoracolumbar injury classification score and that are type A, based on the AO Spine thoracolumbar injury classification score. Elimination of pain in the acute period is effective in ameliorating the sagittal parameters of patients.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126129893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Hepatic Porphyria – Minireview  急性肝性卟啉症综述
Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.13
Aida Savu, Andrei Edu, L. Negreanu
{"title":"Acute Hepatic Porphyria – Minireview ","authors":"Aida Savu, Andrei Edu, L. Negreanu","doi":"10.31689/rmm.2023.30.1.13","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.1.13","url":null,"abstract":"Acute Hepatic Porphyria (AHP) is an uncommon and hereditary illness that belongs to a group of disorders known as porphyries. This condition results from a deficiency of the porphobilinogen deaminase enzyme, which plays a role in heme production, a crucial component of haemoglobin in the bloodstream. This deficiency leads to the accumulation of substances called porphyrins in the body, which can trigger the appearance of severe and potentially life-threatening symptoms. In the following, we will discuss classifications - with a focus on the similarities and differences between subtypes of porphyria, the pathophysiology of acute hepatic porphyria, risk factors – and their influence on the onset of the disease, clinical manifestations, diagnosis, and management – both curative and symptomatic, all of which play a very important role in understanding this rare condition.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116794192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cetuximab-Taxanes-Platinum-Fluorouracil/Capecitabine (C-TPF/C-TPX) – a Feasible Option for Recurrent HNSCC with Negative Prognostic Factors. Literature Review with a Case Presentation 西妥昔单抗-紫杉烷-铂-氟尿嘧啶/卡培他滨(C-TPF/C-TPX) -复发性HNSCC阴性预后因素的可行选择文献回顾并附个案报告
Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.23
C. Mireștean, R. Iancu, D. Iancu, Mihai Cosmin Stan, F. Bădulescu
{"title":"Cetuximab-Taxanes-Platinum-Fluorouracil/Capecitabine (C-TPF/C-TPX) – a Feasible Option for Recurrent HNSCC with Negative Prognostic Factors. Literature Review with a Case Presentation","authors":"C. Mireștean, R. Iancu, D. Iancu, Mihai Cosmin Stan, F. Bădulescu","doi":"10.31689/rmm.2023.30.1.23","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.1.23","url":null,"abstract":"Concurrent chemo-radiotherapy with Cisplatin is the standard treatment for locally advanced non-metastatic squamous cell carcinoma of the head and neck (HNSCC), but induction chemotherapy (IC) followed by chemo-irradiation, even controversial is a widely accepted option, especially in high-risk cases. A regimen including triple association (platinum-taxanes-fluorouracil) is generally considered superior in efficacy, but may be associated with severe toxicity. In the case of recurrence, the options are limited and the prognosis is generally unfavorable. Chemotherapy alone or in combination with an anti-EGFR monoclonal antibody (Cetuximab), immunotherapy or re-irradiation for selected cases are feasible options in loco-regional or metastatic repalapse. We present a case of nasopharyngeal cancer (NPC), with negative prognostic and predictive factors multimodally treated with an intensive chemotherapy regimen associating Cetuximab with a median survival higher than the median value reported in most studies. Replacing 5-Floururacil with Capecitabine and Cisplatin with Carboplatin may be an option to increase treatment tolerance and should be evaluated in randomized trials. The use of induction chemotherapy as a “new standard” before radio-chemotherapy for cases with negative prognostic factors should also be the subject of future studies. Re-challenge with platinum is also an option that needs to be re-evaluated.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125835750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Preserving Left Aberrant Hepatic Artery During Gastrectomy for Cancer – Literature Review and Case Report 胃癌胃切除术中保留左异常肝动脉-文献回顾及病例报告
Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.69
D. Georgescu, T. Georgescu, F. Bobircă, L. Serbanescu, T. Pătraşcu, M. Georgescu
{"title":"Preserving Left Aberrant Hepatic Artery During Gastrectomy for Cancer – Literature Review and Case Report","authors":"D. Georgescu, T. Georgescu, F. Bobircă, L. Serbanescu, T. Pătraşcu, M. Georgescu","doi":"10.31689/rmm.2023.30.1.69","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.1.69","url":null,"abstract":"Introduction: Identifying left aberrant hepatic artery during gastrectomy for cancer is occasional. In case of replaced left hepatic artery, its ligation can lead to hepatic injury or ischemia, while preserving it can cause difficulties during lymphadenectomy. In literature there is no consensus regarding preserving replaced left hepatic artery during gastrectomy for cancer. A recent study, analysing adverse effects of ligating an aberrant left hepatic artery, shows in pacients with over 5 times elevated transaminase levels, increase in hospital length and postoperative complications. On the other hand, there are studies that consider ligation of aberrant left hepatic artery safe, the only inconvenient being postoperative transient elevation of transminase levels, when ligated artery diameter is over 1.5 mm. Matherial and methoods: We report the case of a 65 years old male, known with myocardial infarction, admitted for epigastric pain, nausea, vomiting, dysphagia for solids and important weight loss. Upper gastrointesinal endoscopy with biopsy and computed tomography showed eso-gastric tumoral mass, signet ring cell carcinoma, no metastases. Intraopertive, we found replaced left heaptic artery arising from left gastric artery, close to the celiac trunk, its diameter being approximately 1 cm. Total radical D2 gastrectomy with mechanical eso-jejunal Roux-en-Y anastomosis was performed. Postoperative evolution was favourable surgically, but the patient had SarsCov2 infection during hospitalisation The final pathology report showed 18 lymph nodes examined, 5 being with adenocarcinoma metastases. Conclusions: Preserving replaced left hepatic artery during gastectomy for cancer is preferable, lyphadecnectomy not being affected. Potential postoperative complications resulted from ligation of replaced left hepatic artery could have chanced the prognosis.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127479436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Soluble α-klotho Protein in Acromegaly 可溶性α-klotho蛋白在肢端肥大症中的作用
Medicina Moderna - Modern Medicine Pub Date : 2023-03-23 DOI: 10.31689/rmm.2023.30.1.29
O. Pînzariu, C. Georgescu
{"title":"The Role of Soluble α-klotho Protein in Acromegaly","authors":"O. Pînzariu, C. Georgescu","doi":"10.31689/rmm.2023.30.1.29","DOIUrl":"https://doi.org/10.31689/rmm.2023.30.1.29","url":null,"abstract":"Soluble α-klotho (sαKl) is an isoform of the α-klotho protein that regulates calcium metabolism but also has anti-aging, anti-apoptotic, and tumor suppressor effects. The assumption that sαKl could inhibit the insulin-like growth factor 1 (IGF-1) signaling pathway has increased the interest of its research in acromegaly - a pathology characterized by an excess of growth hormone (GH) and IGF-1. This review aimed to identify the role of sαKl in acromegaly. Most studies have identified higher concentrations of sαKl in acromegaly versus non-GH pituitary adenomas (PAs) or healthy subjects. Also, the sαKl level was higher in active acromegaly versus controlled or cured disease. Moreover, sαKl positively correlated with GH, IGF-1, and GH-secreting PA size. The increased level of sαKl seems to be due to the autonomous secretion of GH, considering their drastic decrease after transsphenoidal surgery. The data regarding the relationship between sαKl, age, and gender in acromegaly are inconsistent. The latest research noted a correlation between sαKl and various parameters for monitoring the quality of life in acromegaly. In conclusion, sαKl could reflect the disease activity. Furthermore, sαKl would represent an alternative for monitoring acromegalic patients with discrepancies between IGF-1 and GH.","PeriodicalId":380281,"journal":{"name":"Medicina Moderna - Modern Medicine","volume":"268 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126665867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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