Acupuncture in medicine : journal of the British Medical Acupuncture Society最新文献

{"title":"Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.","authors":"Sheng-Feng Lu,&nbsp;Jun-Meng Wang,&nbsp;Jing Yuan,&nbsp;Wen-Xiu Yang,&nbsp;Li-Yao Chen,&nbsp;Tao Zhang,&nbsp;Xin-Yue Jing,&nbsp;Yi Zhuang,&nbsp;Cheng-Shun Zhang,&nbsp;Shu-Ping Fu,&nbsp;Mei-Ling Yu","doi":"10.1177/09645284211009536","DOIUrl":"https://doi.org/10.1177/09645284211009536","url":null,"abstract":"<p><strong>Background: </strong>Sympathetic and parasympathetic nerve remodeling play an important role in cardiac function after myocardial ischemia (MI) injury. Increasing evidence indicates that electroacupuncture (EA) can regulate cardiac function by modulating the autonomic nervous system (ANS), but little is known about its effectiveness on neural remodeling post-MI.</p><p><strong>Objectives: </strong>To investigate the role of EA in ANS remodeling post-MI.</p><p><strong>Methods: </strong>Adult male C57/BL6 mice were equally divided into the Control (Ctrl), MI and EA groups after generating the MI model by ligating the left anterior descending (LAD) coronary artery. Echocardiography and 2,3,5-triphenyltetrazolium (TTC) staining were employed to evaluate cardiac function and infarct size after EA treatment for five consecutive days. Serum norepinephrine (NE) levels were measured by ELISA to quantify sympathetic activation. Then, ANS remodeling was detected by immunohistochemistry (IHC), RT-qPCR, and Western blotting.</p><p><strong>Results: </strong>Our preliminary findings showed that EA increased ejection fraction and fractional shortening and reduced infarct area after MI injury. Serum NE levels in the EA group were significantly decreased compared with those in the MI group. IHC staining results demonstrated that the density of growth associated protein (GAP)43 and tyrosine hydroxylase (TH) positive nerve fibers in the EA group were decreased with increased choline acetyltransferase (CHAT) and vesicular acetylcholine transporter (VACHT). Meanwhile, the results verified that mRNA and protein expression of GAP43 and TH were significantly inhibited by EA treatment in the MI mice, accompanied by elevated CHAT and VACHT.</p><p><strong>Conclusions: </strong>EA treatment could improve cardiac function and reduce infarct size by modulating sympathetic and parasympathetic nerve remodeling post-MI, thus helping the cardiac ANS reach a new balance to try to protect the heart from further possible injury.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"681-690"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38955199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auricular acupressure for insomnia associated with attention deficit hyperactivity disorder: a case report.","authors":"Yu Hong,&nbsp;Longsheng Huang","doi":"10.1177/09645284211026314","DOIUrl":"https://doi.org/10.1177/09645284211026314","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) is a chronic condition characterized by inattention, hyperactivity and impulsiveness. ADHD, as well as medications used to treat it such as stimulants, have been found to increase the risk of sleep disorders including insomnia.1 Currently available pharmacological treatments for insomnia in children have limited efficacy and are associated with adverse effects.2 This has led to a higher demand for nonpharmacological therapies. Auricular acupressure (AA) is considered a safe intervention for the management of several health conditions. Evidence from recent studies indicates that AA can treat insomnia.3 However, to our knowledge, the effects of AA on insomnia associated with ADHD have not been reported. Here, we report a case of a boy with ADHD who presented with insomnia that appeared to be effectively treated with AA.","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"736-737"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211026314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39201999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for post-stroke cognitive impairment: a systematic review and meta-analysis.","authors":"Xu Kuang,&nbsp;Wenjuan Fan,&nbsp;Jiawei Hu,&nbsp;Liqun Wu,&nbsp;Wei Yi,&nbsp;Liming Lu,&nbsp;Nenggui Xu","doi":"10.1177/09645284211009542","DOIUrl":"https://doi.org/10.1177/09645284211009542","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the effectiveness and safety of acupuncture for the treatment of post-stroke cognitive impairment (PSCI).</p><p><strong>Methods: </strong>The Cochrane Library, Embase, Medline, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical (VIP), Wanfang, and Chinese Biological Medicine (CBM) databases were electronically searched from their inception to 10 April 2019. The Montreal Cognitive Assessment (MoCA) scale and Mini-Mental State Examination (MMSE) scale were used as outcomes to assess effectiveness with respect to cognitive function. Assessment of risk of bias (ROB) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment were performed by two reviewers independently. Data were analyzed using Review Manager (RevMan) 5.3.</p><p><strong>Results: </strong>A total of 28 trials with 2144 participants were included in the qualitative synthesis and meta-analysis. Four of the 28 trials (14%) were assessed as being at overall low ROB, 24 of the 28 trials (86%) were assessed as having overall high ROB. The quality of evidence for both MoCA and MMSE were deemed to be very low by the GRADE criteria. Results indicated that acupuncture groups may be benefiting more than non-acupuncture groups with respect to variation of MoCA scores (merged mean difference (MMD): 2.66, 95% confidence interval (CI): 2.18 to 3.13, <i>p</i> < 0.00001; heterogeneity: χ² = 35.52, <i>p</i> = 0.0007, <i>I</i>² = 63%), and the heterogeneity decreased in both subgroup analysis and sensitivity analysis. In addition, acupuncture groups might be benefiting more than non-acupuncture groups in terms of changes in MMSE score (MMD = 2.97, 95% CI = 2.13 to 3.80, <i>p</i> < 0.00001; heterogeneity: χ² = 269.75; <i>p</i> < 0.00001; <i>I</i>² = 92%), and the heterogeneity decreased in subgroup analysis. Only one RCT addressed adverse events, and the symptoms were mild and did not affect treatment and evaluation.</p><p><strong>Conclusion: </strong>Acupuncture could be effective and safe for PSCI. Nevertheless, the results should be interpreted cautiously due to the high ROB of included trials and very low quality of evidence for assessed outcomes.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"577-588"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38971373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture and lamotrigine for acute short unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome: a case report.","authors":"Armando Criscuolo,&nbsp;Silvia Strumia,&nbsp;Giorgio Di Concetto,&nbsp;Ruggero M Corso","doi":"10.1177/09645284211009908","DOIUrl":"https://doi.org/10.1177/09645284211009908","url":null,"abstract":"Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a rare, primary headache syndrome, characterized by a short-lasting headache in the first division of the trigeminal nerve, associated with ipsilateral autonomic symptoms. It is currently classified within the trigeminal autonomic cephalalgias (TACs) group. Although considered rare, in recent years, the increasing numbers of reported cases, including those of a secondary nature, has reignited interest in the scientific community. Its treatment is also considered a challenge due to the unclear pathophysiology.1 The most widely used treatments during acute episodes include lidocaine infusions or prednisone,2 while lamotrigine is the firstline drug for chronic treatment.3 Acupuncture, a key component of Traditional Chinese Medicine (TCM), is one of the most common complementary therapies worldwide and recent evidence has confirmed its efficacy and safety for migraine.4 To our knowledge, this is the first report to document the use of acupuncture as a complementary therapy alongside conventional lamotrigine.","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"724-725"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexion relaxation reinstated after acupuncture in a chronic low back pain patient: a case report.","authors":"Nobuari Takakura,&nbsp;Miho Takayama,&nbsp;Judith M Schlaeger,&nbsp;Hiroyoshi Yajima","doi":"10.1177/09645284211009906","DOIUrl":"https://doi.org/10.1177/09645284211009906","url":null,"abstract":"Up to 19.6% of adults have chronic low back pain (cLBP), which is the leading cause of disability worldwide.1,2 Acupuncture is recommended as one of the initial treatment options for cLBP, but this is based on lowquality evidence.3 The flexion relaxation phenomenon (FRP) is an electrical silencing of the lumbar muscles with full trunk flexion in LBP-free subjects. The FRP is often absent in patients with cLBP and is an important test to objectively assess their improvement.4 However, to our knowledge, there are no reports on the use of acupuncture and the measurement of FRP in cLBP patients.","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"721-723"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39030185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture combined with multidisciplinary care for recovery after traumatic multiple rib fractures: a prospective feasibility cohort study.","authors":"Kun Hyung Kim,&nbsp;Chan Kyu Lee,&nbsp;Hyun Min Cho,&nbsp;Youngwoong Kim,&nbsp;Seon Hee Kim,&nbsp;Myung Jun Shin,&nbsp;Jung Eun Kim,&nbsp;Yu Kyung Shin,&nbsp;Soo Jin Lee,&nbsp;Junepill Seok,&nbsp;Ju Hee Choi,&nbsp;Minkyung Kim,&nbsp;Young Hee Kim","doi":"10.1177/09645284211009539","DOIUrl":"https://doi.org/10.1177/09645284211009539","url":null,"abstract":"<p><strong>Introduction: </strong>Acute pain significantly delays early physiological recovery and results in chronic functional disability in patients with traumatic multiple rib fractures (MRFs). This prospective cohort study aimed to investigate the feasibility of acupuncture combined with multidisciplinary care during recovery in patients with traumatic MRFs.</p><p><strong>Methods: </strong>Twenty patients with traumatic MRFs who were admitted to a regional trauma centre in South Korea were enrolled. A combination of acupuncture and multidisciplinary inpatient ward management was provided at the trauma ward. Patients were permitted to continue acupuncture treatments at outpatient clinics for 3 months after the traumatic events. Clinical outcomes, including pain, acute physiological recovery, quality of life, patient satisfaction with the care provided, respiratory function and use of opioids, were evaluated up to 6 months after trauma.</p><p><strong>Results: </strong>Seventeen (85%) participants completed the 6-month follow-up. One patient withdrew consent during admission due to discomfort after three sessions of acupuncture. The proportion of patients with above-moderate level of pain decreased from 95% at baseline to 41% at 6 months. Quality of life appeared to deteriorate consistently throughout the study period. Around 80% of respondents expressed satisfaction with the acupuncture treatments and stated that they found acupuncture to be acceptable. Over 94% of respondents reported slight or considerable improvement.</p><p><strong>Conclusion: </strong>The provision of acupuncture combined with multidisciplinary care for recovery in patients with traumatic MRFs was feasible in a regional trauma centre in South Korea. Randomised trials are needed to investigate the role of acupuncture combined with multidisciplinary care in the future.</p><p><strong>Trial registration number: </strong>KCT0002911 (Clinical Research Information Service).</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"603-611"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39023965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators of and barriers to implementing a traditional Chinese medicine collaborative model of care for axial spondyloarthritis: a qualitative study.","authors":"Yu Heng Kwan,&nbsp;Warren Fong,&nbsp;Xiang Ling Ang,&nbsp;Xiu Yan Chew,&nbsp;Sungwon Yoon,&nbsp;Chuen Seng Tan,&nbsp;Bee Choo Tai,&nbsp;Youyi Huang,&nbsp;Marcel Bilger,&nbsp;Jie Kie Phang,&nbsp;Hui Chin Tan,&nbsp;Su-An Quek,&nbsp;Sing Yee Clara Eng,&nbsp;Choy Tip Tan,&nbsp;Bao Qiang Dong,&nbsp;Hwee Ling Koh,&nbsp;Ying Ying Leung,&nbsp;Swee Cheng Ng,&nbsp;Kok Yong Fong,&nbsp;Julian Thumboo,&nbsp;Truls Østbye","doi":"10.1177/09645284211009543","DOIUrl":"https://doi.org/10.1177/09645284211009543","url":null,"abstract":"<p><strong>Background: </strong>Conventional therapy may be inadequate for many patients with axial spondyloarthritis (axSpA). Traditional Chinese medicine (TCM) may be a viable alternative, but its effectiveness for axSpA is unknown. We are currently conducting a pragmatic randomised controlled trial (RCT) to investigate the effectiveness of a TCM collaborative model of care (TCMCMC), which combines usual rheumatologic care with acupuncture for patients with axSpA. This nested qualitative sub-study aims to identify facilitators of and barriers to the implementation of the TCMCMC.</p><p><strong>Methods: </strong>We conducted individual in-depth interviews with participants who had completed the acupuncture regimen to elicit opinions on the facilitators of and barriers to the implementation of the TCMCMC. The interviews were transcribed and analysed using thematic analysis.</p><p><strong>Results: </strong>Twelve participants were included, with data saturation occurring after 10 interviews. The analysis revealed both a number of important 'facilitators' and 'barriers'. Facilitators to the implementation of the TCMCMC included effectiveness of TCM to relieve symptoms, inadequacy of conventional treatment and positive social perceptions of TCM. Barriers included scepticism towards TCM, inability of TCM to provide instant relief, needle-related discomfort, variable effectiveness of TCM influenced by physicians' skills and experience and the high cost of TCM. Recommendations to overcome barriers included further patient education about TCM.</p><p><strong>Conclusion: </strong>Policymakers should take into account the various feasibility factors identified in this study when developing and implementing a TCMCMC.</p><p><strong>Trial registration number: </strong>NCT03420404 (ClinicalTrials.gov).</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"629-636"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39029208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for perimenopausal insomnia: a case report.","authors":"Chaoran Pan,&nbsp;Zhengyan Wang,&nbsp;Feng Zhang,&nbsp;Yue Zeng,&nbsp;Xingliang Chen,&nbsp;Jingxian Huang,&nbsp;Chao Wang","doi":"10.1177/09645284211026316","DOIUrl":"https://doi.org/10.1177/09645284211026316","url":null,"abstract":"Half a billion women in the United States are expected to go through menopause within the estimated age range (35–55 years) in the next decade, 31%–42% of whom will suffer from insomnia, according to an epidemiological study published in 2017.1 Among all menopausal symptoms, insomnia is extremely common. It can be defined as having trouble falling asleep, early awakening and/or difficulty in falling asleep after waking.2 Perimenopausal insomnia (PI) reduces quality of life and puts a huge burden on people’s family and work. Currently, pharmacotherapies like hormone replacement therapy (HRT) and sedative and hypnotic drugs have been proven effective; however, side-effects often cause new discomfort, and the efficacy is not always ideal. Long-term HRT, for instance, might increase the risk of endometrial cancer, breast cancer and stroke.3 Hence, alternative treatments without side-effects are desirable. Acupuncture, a non-pharmacological therapy with minimal side-effects, has been considered to be a reasonable option for insomnia treatment. Nevertheless, evidence for acupuncture treatment of PI is inadequate.4 Therefore, we present the case of a patient diagnosed with PI who appeared to be successfully treated by acupuncture.","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"740-741"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39159865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Student knowledge, attitudes, and beliefs about acupuncture: an exploratory study.","authors":"Mark D Sodders,&nbsp;Melissa P Osborn,&nbsp;Monica S Vavilala","doi":"10.1177/09645284211009904","DOIUrl":"https://doi.org/10.1177/09645284211009904","url":null,"abstract":"","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"718-720"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38919974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture inhibits IL-17/IL-17R and post-receptor MAPK signaling pathways in a rat model of chronic obstructive pulmonary disease.","authors":"Xin-Fang Zhang,&nbsp;Shui-Ying Xiang,&nbsp;Jing Lu,&nbsp;Yin Li,&nbsp;Shu-Jun Zhao,&nbsp;Chuan-Wei Jiang,&nbsp;Xiang-Guo Liu,&nbsp;Zi-Bing Liu,&nbsp;Jie Zhang","doi":"10.1177/0964528421996720","DOIUrl":"https://doi.org/10.1177/0964528421996720","url":null,"abstract":"<p><strong>Objective: </strong>Interleukin (IL)-17, as a T-helper 17 cell (Th17) cytokine, plays a key role in chronic obstructive pulmonary disease (COPD) pathophysiology including chronic inflammation and airway obstruction, which lead to decreased pulmonary function. The aim of this study was to investigate the effect of acupuncture on IL-17, its receptor (IL-17R) and the mitogen-activated protein kinase (MAPK) signaling pathway, in a rat model of COPD.</p><p><strong>Methods: </strong>The COPD model was induced in Sprague Dawley rats by exposure to cigarette smoke for 12 weeks. The model rats were treated with electroacupuncture (EA) at BL13 and ST36. The lung function and histology of the rats were observed. IL-17, tumor necrosis factor (TNF)-α, and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA) in bronchoalveolar lavage fluid (BALF) and in plasma. The leukocytes and macrophages in the BALF were counted. The expression levels of IL-17R were assayed in lung tissue by real-time polymerase chain reaction (PCR), western blotting, and immunohistochemistry. MAPK signaling pathway molecules including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK)1/2 and p38, and their phosphorylated forms, were observed in the lung by western blotting.</p><p><strong>Results: </strong>Compared with the control group rats, lung function decreased and there was a severe inflammatory infiltration of the pulmonary parenchyma in the COPD rats. EA effectively improved lung function and alleviated the inflammatory infiltration in the lungs of COPD rats. EA also reversed the elevated total leukocyte and macrophage counts, the high levels of IL-17 and TNF-α, and the low IL-10 content in COPD rats. Meanwhile, EA downregulated the increased mRNA and protein expression of IL-17R, and significantly inhibited the elevated levels of phosphorylated JNK, ERK1/2, and p38 in the lungs of COPD rats.</p><p><strong>Conclusion: </strong>Our results suggest that the protective effects of acupuncture therapy on the lungs of COPD rats are likely related to inhibition of IL-17/IL-17R and the post-receptor MAPK signaling pathways.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"663-672"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0964528421996720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25474095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}