2002 IEEE Ultrasonics Symposium, 2002. Proceedings.最新文献_第10页

Subharmonic performance of contrast microbubbles: an experimental and numerical investigation 对比微泡的次谐波性能:实验与数值研究

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192683

W. Shi, L. Hoff, F. Forsberg

引用次数: 18

Development of ultrasonic techniques with buffer rod in molten aluminum 铝液缓冲棒超声技术的发展

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193520

Y. Ono, J. Moisan, C. Jen, D. R. França

引用次数: 13

Microbubble destruction-reperfusion in the non-invasive measurement of the vascular targeting effects of the anti-cancer drug ZD6126 微泡破坏-再灌注在无创测量抗癌药物ZD6126血管靶向作用中的应用

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192691

R. Karshafian, P. Burns, X. Qi, Mingyu Zhang

{"title":"Microbubble destruction-reperfusion in the non-invasive measurement of the vascular targeting effects of the anti-cancer drug ZD6126","authors":"R. Karshafian, P. Burns, X. Qi, Mingyu Zhang","doi":"10.1109/ULTSYM.2002.1192691","DOIUrl":"https://doi.org/10.1109/ULTSYM.2002.1192691","url":null,"abstract":"A new and promising strategy in cancer therapy targets the proliferating endothelium of a tumour's blood vessels rather than the cells of the cancer itself. Among other advantages, such therapies may evade the drug resistance that many tumours acquire during treatment, rendering the drugs appropriate for long term use. However, because the tumour vasculature lies below the threshold of detection for conventional radiological techniques, new methods are required to determine the effect of such therapy on the tumour microvasculature. The combination of microbubble contrast and nonlinear imaging methods such as pulse inversion Doppler have been shown capable of detecting (but not resolving) flow at the capillary level. In this study, we use a combination of microbubble destruction-reperfusion flow measurement and real time contrast Imaging to assess the effects of an anti-vascular agent ZD6126 (AstraZeneca Inc, NJ) on experimental VX-2 tumours in the rabbit. The active component of this drug, N-acetyl colchinol, causes tubulin depolymerisation, thereby inducing neovascular endothelial cell rounding and subsequent vascular collapse. The effect is selective to tumour blood vessels (whose endothelial cells rely on tubulin for their structure) and is thought to be an acute one, occurring within hours of administration of the drug. Our objectives in this study were to make haemodynamic measurements of tumour blood flow rate and vascular volume, then to use these to determine dose response to the anti-vascular drug and to demonstrate the evolution of this effect with time following drug administration. We intended that the method used should employ a commercially available scanner and be suitable for translation to clinical contrast imaging of breast cancers.","PeriodicalId":378705,"journal":{"name":"2002 IEEE Ultrasonics Symposium, 2002. Proceedings.","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133722068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A highly efficient 20 MHz piezo-composite transducer for nondestructive characterization of multilayer plastics 用于多层塑料无损表征的高效20mhz压电复合传感器

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193499

Q. Xue, A. Abbate, G. Elfbaum, Y. Shui, Haodong Wu

{"title":"A highly efficient 20 MHz piezo-composite transducer for nondestructive characterization of multilayer plastics","authors":"Q. Xue, A. Abbate, G. Elfbaum, Y. Shui, Haodong Wu","doi":"10.1109/ULTSYM.2002.1193499","DOIUrl":"https://doi.org/10.1109/ULTSYM.2002.1193499","url":null,"abstract":"Fabrication of piezo-composite transducers over 20 MHz by the dice-and-fill method is a challenge to the industry. This paper reports a newly developed 20 MHz single element composite transducer using the dice-and-fill method. The transducer exhibited significant improvement in sensitivity of more than 10 dB in measurement of plastics as compared to standard piezo-ceramic transducers having similar size and electrical impedance. The high efficiency of the composite transducer was achieved by optimizing composite design to a configuration with maximum thickness coupling coefficient of the material. Meanwhile, the polymer and ceramic phases of the composite efficiently oscillate in phase. This design also allows the piezo-composite to be fabricated for frequencies higher than 20 MHz with a low aspect ratio where lateral modes usually dominate. However, with the optimized design, lateral modes are suppressed and almost invisible within usable bandwidths up to 40 MHz. Measurement of thin barrier layer samples using the 20MHz composite transducer demonstrated consistent results for a thickness of 0.084 mm, while the standard 20 MHz transducers are only able to resolve thickness above 0.100 mm.","PeriodicalId":378705,"journal":{"name":"2002 IEEE Ultrasonics Symposium, 2002. Proceedings.","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133739328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Utilization of the high-frequency piezoelectric ceramic hollow spheres for exposimetry and tissue ablation 高频压电陶瓷空心球在暴露测量和组织消融中的应用

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192575

O. Al-Bataineh, R. Meyer, R.E. Newnharn, N. Smith

{"title":"Utilization of the high-frequency piezoelectric ceramic hollow spheres for exposimetry and tissue ablation","authors":"O. Al-Bataineh, R. Meyer, R.E. Newnharn, N. Smith","doi":"10.1109/ULTSYM.2002.1192575","DOIUrl":"https://doi.org/10.1109/ULTSYM.2002.1192575","url":null,"abstract":"Miniature, high-frequency piezoelectric ceramic hollow spheres were evaluated for potential use as hydrophones for exposimetry of high intensity ultrasound fields and as minimally invasive ablation devices. As a hydrophone, the hollow sphere has unique characteristics regarding its geometry, dimensions and sensitivity, which make it ideal for use in exposimetry of high pressure fields. Spheres with diameters ranging from 0.7 to 1.0 mm and with resonance frequencies from 1.8 to 2.7 MHz were used as hydrophones. A relative (reciprocal) calibration method was performed to determine the end-of-cable sensitivity as well as the directivity of the hollow sphere hydrophones. An almost constant sensitivity was reported for the spherical hydrophones and an omni-directional receive pattern was also demonstrated. The hollow sphere hydrophone was shown to have twice the sensitivity of a needle type hydrophone but with no pre-amplification stages and could withstand four times the pressure. As a minimally invasive interstitial ablation device, several in vitro experiments were conducted using two different size spheres. The results demonstrated an increased necrosed tissue volume for increasing exposure time. With a 1.0 mm diameter sphere (f = 1.87 MHz), the necrosed tissue diameter as a function of exposure times was 2.35 /spl plusmn/ 0.34, 3.00 /spl plusmn/ 0.37 and 4.61 /spl plusmn/ 1.13 mm for 5, 10 and 15 second sonications, respectively. Using a 0.7 mm diameter sphere (f = 2.70 MHz), the size of the ablated tissue was 1.50 /spl plusmn/ 0.01 and 1.63 /spl plusmn/ 0.31 mm for 5 and 10 seconds sonications, respectively. As a tissue ablation device, the hollow sphere was able to produce controllable lesion diameters with sharp boundaries between the normal and necrosed tissue.","PeriodicalId":378705,"journal":{"name":"2002 IEEE Ultrasonics Symposium, 2002. Proceedings.","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2002-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131778523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Novel optical observation technique for shear horizontal wave in SAW resonators on 42/spl deg/YX-cut lithium tantalate 42/spl度/ yx切割钽酸锂表面波共振腔剪切水平波光学观测新技术

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193359

A. Miyamoto, S. Wakana, A. Ito

引用次数: 21

Temperature stability of surface acoustic wave resonators on the in-plane rotated 33/spl deg/Y-cut quartz 面内旋转33/声压角/ y形石英表面声波谐振器的温度稳定性

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193362

S. Kanna, K. Iizawa, T. Yamazaki, M. Takagi

引用次数: 7

Calculation of COM parameters for an arbitrary IDT cell 计算任意IDT单元的COM参数

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193399

S. Malocha, B. Abbott

引用次数: 7

3D quantification of ultrasound images: Application to mouse embryo imaging in vivo 超声图像的三维量化:在小鼠胚胎体内成像中的应用

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1192599

D. Vray, A. Discher, J. Lefloc'h, W. Mai, P. Clarysse, Q. Pham, J. Montagnat, M. Janier

引用次数: 7

Temperature sensors based on GaPO/sub 4/ 基于GaPO/sub 4/的温度传感器

2002 IEEE Ultrasonics Symposium, 2002. Proceedings. Pub Date : 2002-10-08 DOI: 10.1109/ULTSYM.2002.1193552

P. Krempl, C. Reiter, W. Wallnofer, J. Neubig

引用次数: 8