Journal Of The Indonesian Medical Association最新文献

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High vs Low Dose Proton Pump Inhibitor (PPI) related Mortality in Hospitalized Coronavirus Disease-19 (COVID-19): A Retrospective Cohort Study 高剂量与低剂量质子泵抑制剂(PPI)相关的住院冠状病毒病-19 (COVID-19)死亡率:一项回顾性队列研究
Journal Of The Indonesian Medical Association Pub Date : 2022-08-03 DOI: 10.47830/jinma-vol.72.2-2022-802
F. Liwang, N. Prihartono, Haya Harareed, Lucas Welfried Panjaitan
{"title":"High vs Low Dose Proton Pump Inhibitor (PPI) related Mortality in Hospitalized Coronavirus Disease-19 (COVID-19): A Retrospective Cohort Study","authors":"F. Liwang, N. Prihartono, Haya Harareed, Lucas Welfried Panjaitan","doi":"10.47830/jinma-vol.72.2-2022-802","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.2-2022-802","url":null,"abstract":"Introduction: The role of proton pump inhibitor (PPI) in Coronavirus Disease-19 (COVID-19) is still debatable. PPI is commonly used to prevent or treat upper gastrointestinal bleeding and/or dyspeptic symptoms. However, previous studies showed that PPI may lead to adverse outcomes in COVID-19 patients, thus the dose of PPI may play an important role. This study aimed to compare the risk of mortality between high vs low dose PPI in hospitalized COVID-19 patients. \u0000Methods: We performed retrospective cohort study from two COVID-19 referral centers in Jakarta between June 2021 and September 2021. We included hospitalized COVID-19 patients, moderate-critically ill cases, who had been given intravenous PPI for more than 7 days. We defined high dose PPI for omeprazole >40 mg/day or pantoprazole >40 mg/day, and low dose PPI for omeprazole ≤40 mg/day or pantoprazole ≤40 mg/day. \u0000Results: Of the total 365 patients (median age[Q1–Q3] 55 [45–64] years old), 216 subjects were given high dose PPI. Subjects with high dose PPI had a significantly higher mortality rate than the low dose PPI according to bivariate analysis (54.2% vs 26.1%; p<0.001), but quite similar length of stay (median[Q1–Q3] 12.5 [9–16] vs 13 [9–18] days). After conducting a multivariate analysis to control the confounders, we found that high dose PPI still led to higher mortality (aOR 3.04; 95%CI 1.22–7.60; p=0.017). \u0000Conclusion: High dose PPI may increase risk of mortality in hospitalized COVID-19 patients.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"9 15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123262894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pentingnya Mendeteksi Penyakit Jantung Bawaan Lebih Dini: Skrining Fase Prenatal dan Postnatal 及早发现先天性心脏病的重要性:产前和产后检查
Journal Of The Indonesian Medical Association Pub Date : 2022-08-03 DOI: 10.47830/jinma-vol.72.2-2022-822
Bayu Eka Putra, Radityo Prakoso
{"title":"Pentingnya Mendeteksi Penyakit Jantung Bawaan Lebih Dini: Skrining Fase Prenatal dan Postnatal","authors":"Bayu Eka Putra, Radityo Prakoso","doi":"10.47830/jinma-vol.72.2-2022-822","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.2-2022-822","url":null,"abstract":"Penyakit Jantung Bawaan: Seberapa Sering dan Apa Implikasinya?Penyakit jantung bawaan (PJB) dapat ditemukan pada 1% dari keseluruhan kehamilan per tahunnya. Artinya, dari 100 bayi akan ada 1 bayi yang mengalami PJB.1 Data terbaru dari Global Burden of Disease Study 2017 bahkan menunjukkan prevalensinya mencapai 1.6 - 1.7% untuk wilayah Asia Tenggara, termasuk Indonesia didalamnya.2 Di sisi lain, Indonesia memiliki laju pertumbuhan penduduk sebanyak 1.39% dengan per tahunnya lahir sebanyak 4.2-4.8 juta bayi.3 Dengan demikian, dapat diperkirakan bahwa jumlah pasien dengan PJB yang lahir di Indonesia adalah sebanyak 71.400 hingga 81.600 bayi per tahunnya.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130935963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of 50m Sprint Training on Increasing Speed and Power of Dollyo Chagi Kicks in Taekwondo Athletes 50米短跑训练对跆拳道运动员多力插踢速度和力量的影响
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-560
Tamara Tsania, D. Utomo, A. Abdurrachman, D. Tinduh
{"title":"The Effect of 50m Sprint Training on Increasing Speed and Power of Dollyo Chagi Kicks in Taekwondo Athletes","authors":"Tamara Tsania, D. Utomo, A. Abdurrachman, D. Tinduh","doi":"10.47830/jinma-vol.72.1-2022-560","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-560","url":null,"abstract":"Introduction: Several training techniques are used to improve the performance of taekwondo athletes, one of which is sprint running. Sprinting is one of the branches of athletic sports which requires strength, muscle power, agility and speed. Dollyo chagi kicks is most often used both in attack and defense in taekwondo competition. To be a profesional athlete, they must have sport components such as muscle strengh, muscle power, speed, flexibility, agility, and endurance. The winner of the taekwondo competition is determined by the number of points earned. The author choose the speed an power of dollyo chagi because it is reliable to get points taekwondo matches.Methods: This is a quasi-experimental study with one-group pre-test and post-test design. Using purposive sampling techniques, seventeen junior taekwondo athletes (9 males and 8 female) were recruited. The athletes were trained with 50-meter sprint run for 4 weeks with intensity of 3 sets and 4 times a week. Result: Speed of dollyo chagi kicks increase significantly 17.74% (p <0.05) and power of dollyo chagi kicks increase significantly 23.06% (p <0.05). Conclusion: 50m sprint training can increase the speed and power of dollyo chagi kicks in taekwondo athletes. \u0000 ","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116886381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Mobilisasi Dini di Intensive Care Unit (ICU): Tinjauan Pustaka 及早动员重症监护单位:文献综述
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-315
D. M. Sari, S. C. Widjanantie, D. Poerwandari, A. Paulus, D. Tedjasukmana, N. Nusdwinuringtyas, A. Ratnawati, Hening Laswati Putra
{"title":"Mobilisasi Dini di Intensive Care Unit (ICU): Tinjauan Pustaka","authors":"D. M. Sari, S. C. Widjanantie, D. Poerwandari, A. Paulus, D. Tedjasukmana, N. Nusdwinuringtyas, A. Ratnawati, Hening Laswati Putra","doi":"10.47830/jinma-vol.72.1-2022-315","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-315","url":null,"abstract":"Pasien yang dirawat di Intensive Care Unit (ICU) sering mengalami kelemahan otot yang tidak terkait dengan penyakit utamanya saat masuk ICU. Kelemahan ini dapat berkembang menjadi sindroma klinis yang dikenal sebagai ICU-Acquired Weakness (ICU-AW). Saat ini belum didapatkan pengobatan spesifik yang efektif untuk ICU-AW sehingga pencegahan ICU-AW melalui kontrol faktor risiko terkait seperti imobilisasi menjadi sangat penting. Mobilisasi dini (MD) telah diketahui memiliki berbagai manfaat terhadap kemajuan perkembangan pasien dengan ventilasi mekanik maupun yang tidak menggunakan ventilasi mekanik. Sisi lain, pelaksanaan MD perlu mempertimbangkan kriteria keamanan dan hambatan dalam  pelaksanaannya. Berbagai panduan dalam aplikasi pelaksanaan MD dapat ditemukan, yang bertujuan mendapatkan hasil yang maksimal dengan meminimalisir kejadian yang tidak diinginkan. \u0000  \u0000 ","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124982516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Education Models on the Improvement of Public Knowledge of Chronic Kidney Disease 教育模式对提高公众对慢性肾病知识的影响
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-611
Vitarani Dwi Ananda Ningrum, Rahma Yuantari, Dian Medisa, Irwan Nuryana Kurniawan
{"title":"The Effects of Education Models on the Improvement of Public Knowledge of Chronic Kidney Disease","authors":"Vitarani Dwi Ananda Ningrum, Rahma Yuantari, Dian Medisa, Irwan Nuryana Kurniawan","doi":"10.47830/jinma-vol.72.1-2022-611","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-611","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) is a global health problem with consistently increasing prevalence and incidence, poor prognosis, and high cost. CKD ranks third in funding in Indonesia, reaching IDR 2.3 trillion/year in 2018. Integrated Guidance Post (Posbindu) program affiliated to PHC (Puskesmas) with community cadres has been launched as a community empowerment effort to suppress CKD incidence. This study aimed to strengthen the capacity of Posbindu cadres as the health driving force about CKD to encourage public awareness of CKD risk factors. Method: This quasi-experimental study with one group pretest-posttest design compared four education models for Posbindu cadres in four PHC in Yogyakarta to improve their knowledge of CKD. All education models used the smart module with models 3 and 4 explicitly involving health-worker collaboration. Model 1 used posters, model 2 used leaflets, while model 4 also used posters and leaflets. Knowledge of CKD was assessed through a previously-validated questionnaire with four knowledge domains. Result: All of the 86 cadres were women aged 43.7±8.6 years, mostly with at least high-school education and no risk factors for CKD predisposition. The results showed that model 4 significantly improved knowledge of CKD risk factors, symptoms and examination, and prevention behavior. Meanwhile, improvement in the last domain about CKD treatment was likely affected by model 3. Conclusion: This study confirmed health-worker collaboration’s significance in increasing public knowledge of CKD. Adding various printed education media effectively increased knowledge of CKD, particularly in cadres with higher educational attainment.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129085496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Effectiveness of Cipto Mangunkusumo Hospital Ultraviolet Germicidal Irradiation (UVGI) Chamber for N95 Respirators Disinfection in COVID-19 pandemics: A Preliminary Study Cipto Mangunkusumo医院紫外线杀菌室(UVGI)消毒N95口罩在COVID-19大流行中的效果初步研究
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-583
R. Restuti, H. Priyono, R. Saleh, A. Sriyana, P. A. Yusuf, T. Airlangga, A. Prayitno, Gortap Sitohang, Fitri Arman, Suko Dwi Priyanto
{"title":"The Effectiveness of Cipto Mangunkusumo Hospital Ultraviolet Germicidal Irradiation (UVGI) Chamber for N95 Respirators Disinfection in COVID-19 pandemics: A Preliminary Study","authors":"R. Restuti, H. Priyono, R. Saleh, A. Sriyana, P. A. Yusuf, T. Airlangga, A. Prayitno, Gortap Sitohang, Fitri Arman, Suko Dwi Priyanto","doi":"10.47830/jinma-vol.72.1-2022-583","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-583","url":null,"abstract":"Introduction: During the COVID-19 pandemic, where the disease might spread in a medical facility setting, the common problems found in every country is the shortage of personal protective equipment (PPE) for medical personnel – especially the disposable N95 respirators. Thus, a higher amplitude to disinfect and reuse N95 is urgently needed. In this study, we designed an effective and safe disinfection methods through an Ultraviolet Germicidal Irradiation (UVGI) chamber in Dr. Cipto Mangunkusumo Hospital to control the shortage of PPE by disinfecting and reusing disposable N95 respirators. Purpose: To evaluate the dosage and effectiveness of UV-C radiation for disposable N95 respirators disinfection in our designated UVGI chamber. Methods: This study used a cross-sectional design to determine the dose and the effectiveness of UV-C radiation in eradicating SARS-CoV 2 on disposable N95 respirators. Results: Using two different distances from the light source, we confirmed the inverse square law of UV-C radiation power. Irradiation for 2 hours with a radiation dose of 1080 mJ/cm2 resulted in undetected SARS-CoV-2 gene based on PCR examination in 10 out of 10 samples. Conclusion: This UVGI chamber is a potential solution for hospitals or medical facilities to overcome the limitations that occurred in the pandemic by disinfecting PPE.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125454458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Incidence of Positive Visual Inspection of Acetic Acid in Dr Cipto Mangunkusumo General Hospital Followed by Liquid Based Cytology, HPV testing and Colposcopy: A Cross Sectional Study 在Dr Cipto Mangunkusumo总医院进行液体细胞学检查、HPV检测和阴道镜检查后醋酸阳性的发生率:一项横断面研究
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-750
J. Indarti, Heru Prasetyo, Kristian Alda
{"title":"The Incidence of Positive Visual Inspection of Acetic Acid in Dr Cipto Mangunkusumo General Hospital Followed by Liquid Based Cytology, HPV testing and Colposcopy: A Cross Sectional Study","authors":"J. Indarti, Heru Prasetyo, Kristian Alda","doi":"10.47830/jinma-vol.72.1-2022-750","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-750","url":null,"abstract":"Introduction : Cervical cancer is most common cancer in women in Asia Oceania and worldwide. VIA(Visual Inspection after Acetic acid) is being used as an alternative in low- and middle-income countries due to the minimal equipment required. Data from recent systematic reviews and multicentre trials show that VIA to be moderately sensitive for precancerous lesions, as compared with Pap testing. This study aim to determine the incidence of positive VIA, LBC, HPV DNA testing and colposcopy findings obtained from positive VIA cases in Dr. Cipto Mangunkusumo General Hospital.Methods: This was a cross-sectional study. Data was collected from cervical cancer screening by VIA examination at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia in 2017. Age, VIA results were recorded. The results showed abnormal and predictive cancer lesions (acetowhite lesion) were defined as a “positive test.” The positive VIA result followed by LBC, HPV DNA testing, and Colposcopy. Only 25 performed LBC and HPV DNA test, and 30 of the VIA positive were performed Colposcopy. Results: A total of 1.960 subjects were recruited for this study. The mean age of the subjects was 34.5 years, and 908 (46 %) subjects belong to the 30-40 years age group. Negative VIA result were found in 1893 subjects (96,58%) and 67 subjects (3,42%) had positive results. From 25 VIA positive subject whose gone through LBC and HPV test, 9 subjects (36%) had abnormal LBC, 3 subjects (12%) had positive HPV DNA test. From 30 positive VIA whose got colposcopy examination 17 subjects (56,6 %) had abnormal colposcopy.Conclusions: The number of VIA screening participants in RSCM, Jakarta, Indonesia with positive VIA results is low. Further studies regarding the validation of VIA are required to evaluate its diagnostic value.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132011043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hubungan Oklusi Vena Retina Dengan Serum Lipid Profil
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-418
Wida Dwitiya Hita
{"title":"Hubungan Oklusi Vena Retina Dengan Serum Lipid Profil","authors":"Wida Dwitiya Hita","doi":"10.47830/jinma-vol.72.1-2022-418","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-418","url":null,"abstract":"Oklusi vena retina atau Retinal Vein Occlusion (RVO) adalah sumbatan yang terjadi pada vena retina sehingga mengakibatkan gangguan perdarahan di dalam bola mata. Oklusi vena dapat terjadi pada vena retina cabang atau Branch Retinal Vein Occlusion (BRVO) maupun vena retina sentral atau Central Retinal Vein Occlusion (CRVO). Penyakit ini berpotensi untuk menimbulkan kebutaan.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128674290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Cyanotic Congenital Heart Disease at Dr. Soetomo General Hospital Surabaya 泗水Soetomo综合医院青紫型先天性心脏病的特点
Journal Of The Indonesian Medical Association Pub Date : 2022-06-19 DOI: 10.47830/jinma-vol.72.1-2022-762
Clara Alverina, I. K. A. Utamayasa, Y. Sembiring
{"title":"Characteristics of Cyanotic Congenital Heart Disease at Dr. Soetomo General Hospital Surabaya","authors":"Clara Alverina, I. K. A. Utamayasa, Y. Sembiring","doi":"10.47830/jinma-vol.72.1-2022-762","DOIUrl":"https://doi.org/10.47830/jinma-vol.72.1-2022-762","url":null,"abstract":"Introduction. Cyanotic congenital heart disease (CHD) is an abnormality of the heart that causes blood with low oxygen content to circulate directly to the body.Objective. To evaluate the profile of cyanotic congenital heart disease at Dr. Soetomo General Hospital Surabaya.Methods. This is a descriptive study using medical records of cyanotic CHD patients aged ≤18 years old from June 2018 – May 2020. Gender, age, nutritional status, sign and symptom, type of cyanotic CHD, complication and treatment were taken as the variables.Result. Out of 116 patients in this study, the majority were male (58.62%). Most patients first diagnosed at the age of 0 – <1 year (76.72%) with normal nutritional status (51.72%). Tetralogy of Fallot (TOF) is the most common type (42.24%). Murmur was the most common sign and symptom (92.24%). Frequently observed complications were pneumonia (37.07%).Conclusion. Patients with cyanotic CHD are mostly male, diagnosed at the age of 0 – <1 year with normal nutritional status. TOF is the most common type. Most patients present with murmurs. Predominant complication is pneumonia.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115806626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hubungan antara Psikobiotik dengan Gangguan Kecemasan
Journal Of The Indonesian Medical Association Pub Date : 2022-06-16 DOI: 10.47830/jinma-vol.71.6-2021-238
B. Atmaja, Vania Rafelia
{"title":"Hubungan antara Psikobiotik dengan Gangguan Kecemasan","authors":"B. Atmaja, Vania Rafelia","doi":"10.47830/jinma-vol.71.6-2021-238","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.6-2021-238","url":null,"abstract":"Kecemasan memiliki manifestasi yang melibatkan rasa takut dan cemas berlebih yang berdampak pada kehidupan sehari-hari. Prevalensi kecemasan diperkirakan mencapai 10.6% dalam satu tahun dan 16.6% seumur hidup di dunia. Psikobiotik menjadi salah satu terapi kecemasan yang menjanjikan. Tulisan ini dilakukan dengan mencari sumber dari jurnal dan buku teks terkait dengan patogenesis kecemasan, hubungan otak dengan saluran cerna, mikrobiota dan psikobiotik, dan hubungan antara psikobiotik dengan kecemasan. Kecemasan melibatkan disregulasi neurotransmitter seperti gamma-aminobutyric-acid, serotonin, dan noradrenaline. Metabolisme triptofan melalui jalur kynurenine dan hormon yang disekresi oleh saluran pencernaan juga berperan dalam kecemasan. Selain melalui N. vagus, faktor inflamasi dari kortisol dalam aksis hipotalamus-pituitari-adrenal menjadi penghubung antara saluran cerna dan otak dalam hal kecemasan. Psikobiotik berperan memproduksi neurotransmitter yang mengalami disregulasi saat kondisi cemas. Produksi asam lemak rantai pendek, metabolisme triptofan, dan microbe-associated molecular pattern pada psikobiotik membuat adanya faktor protektif terhadap kebocoran usus dan mengurangi inflamasi yang dihasilkan oleh bakteri patogen. Asam lemak rantai pendek berinteraksi dengan peptida kolesistokinin, peptide tyrosine tyrosine, dan glucagon like peptide-1. Proses hubungan antara psikobiotik dan kecemasan ini diperantarai oleh N. vagus. Dengan demikian, psikobiotik berperan dalam membantu mengurangi kecemasan. \u0000 ","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125801717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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