Neurobiology of Sleep and Circadian Rhythms最新文献_第9页

Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017 2017年，在伊朗克尔曼沙阿的一个多发性硬化症中心调查了多发性硬化症患者的睡眠质量和疲劳

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-05-01 DOI: 10.1016/j.nbscr.2020.100050

Saba Karimi , Milad Jalilian , Alireza Abdi , Habibolah Khazaie , Pegah Ahmadi Sarbarzeh

{"title":"Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017","authors":"Saba Karimi , Milad Jalilian , Alireza Abdi , Habibolah Khazaie , Pegah Ahmadi Sarbarzeh","doi":"10.1016/j.nbscr.2020.100050","DOIUrl":"10.1016/j.nbscr.2020.100050","url":null,"abstract":"<div><h3>Background</h3><p>Multiple sclerosis (MS) is an autoimmune disease of the nervous system which appears with de-myelination of the central nervous system. Sleep disorder and fatigue are very common in MS patients and are part of the main debilitating factors in patients. The present study was conducted to survey sleep quality and fatigue in MS patients.</p></div><div><h3>Methods</h3><p>A descriptive-analytical study was conducted on 87 MS patients, who were referred to the Kermanshah MS Center in 2017. Data collection tools include a demographics form, fatigue severity scale, and Pittsburg sleep quality inventory. The questionnaires were self-reporting. The collected data was analyzed in SPSS23.</p></div><div><h3>Results</h3><p>The mean age of the participants was 35.50±9.25 years and the majority of the participants were married (54; 62.1%). Quality of sleep was related to family history of MS and history of using medications (antidepressants like tricyclics, MAOIs, SSRIs, and SNRIs and anxiety drugs such as diazepam, oxazepam, and alprazolam (p < 0.05). Moreover, there was a significant relationship between length of sleep and history of using medicines (p < 0.05). Finally, the results showed that there was a strong statistical relationship between performance during the day and fatigue (p < 0.05).</p></div><div><h3>Conclusions</h3><p>The results recommend holding relaxation and exercise courses by nurses to ease fatigue in MS patients. Clinics can also play a more effective role by being more supportive and holding more efficient training programs. The program is taught by the researchers.</p></div><div><h3>Trial registration</h3><p>This study was carried out following the permission from Ethics Committee, Department of Research and Technology, Kermanshah University of Medical Sciences (approval number: KUMS.REC.1395.680).</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"8 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2020.100050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37974918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Delayed Sleep-Wake Phase Disorder 延迟睡眠-觉醒阶段障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_6

Gregory S. Carter, R. Robert Auger

引用次数: 1

Shift Work Sleep Disorder 轮班工作睡眠障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_11

Alok Sachdeva, Cathy A Goldstein

引用次数: 1

Irregular Sleep-Wake Rhythm Disorder 不规则睡眠-觉醒节律障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_10

Danielle Goldfarb, K. Sharkey

引用次数: 1

Non-physiologic Methods of Assessment Relevant to Circadian Rhythm Sleep-Wake Disorders 与昼夜节律睡眠-觉醒障碍相关的非生理性评估方法

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_5

Vincent A. LaBarbera, K. Sharkey

引用次数: 1

Circadian melatonin profile in opium and amphetamine dependent patients: A preliminary study 鸦片和安非他明依赖患者的昼夜褪黑激素特征:初步研究

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-11-01 DOI: 10.1016/j.nbscr.2019.100046

Habibolah Khazaie MD , Hamid Reza Ahmadi MD , Amir Kiani PhD , Mohammad Rasoul Ghadami MD

{"title":"Circadian melatonin profile in opium and amphetamine dependent patients: A preliminary study","authors":"Habibolah Khazaie MD , Hamid Reza Ahmadi MD , Amir Kiani PhD , Mohammad Rasoul Ghadami MD","doi":"10.1016/j.nbscr.2019.100046","DOIUrl":"10.1016/j.nbscr.2019.100046","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of this study was to investigate the relationship between opium and amphetamine dependency with the serum melatonin levels in the presence of circadian rhythm sleep disorders (CRSD).</p></div><div><h3>Participants</h3><p>Forty four male amphetamine-dependent and opium-dependent patients with CRSD and with more than one year substance dependency were enrolled in this study. Control group consisted of twelve healthy male subjects.</p></div><div><h3>Design</h3><p>The diagnoses of sleep disorders were established by a psychiatrist and were made on the basis of the criteria of ICSD-II using the patients’ sleep logs. Blood samples were drawn every 4 h through an intravenous catheter. Serum melatonin levels were assayed using an enzyme-linked immunosorbent assay (ELISA) kit. Repeated Measures Analysis of variance (ANOVA) was used to assess differences between the melatonin levels at six separate times.</p></div><div><h3>Finding</h3><p>The serum melatonin levels of the control subjects were significantly higher than both opium-dependent and amphetamine-dependent patients at 24:00, 4:00 and 8:00. The serum melatonin level of the opium-dependent patients were significantly lower than the amphetamine-dependent patients at 24:00 (26.9 ± 11.4 vs. 41 ± 19.4, respectively; p = 0.006) and were significantly higher than the amphetamine-dependent patients at 16:00 (12.7 ± 5.1 vs. 8.9 ± 4.1, respectively; p = 0.011).</p></div><div><h3>Conclusion</h3><p>This is an evidence of negative effects of substance dependence on circadian cycle of melatonin secretion among opium and amphetamine dependent patients.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"7 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.100046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43443040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series 在妊娠晚期褪黑素谱和后代的健康状况在白班和夜班工人:一个案例系列

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2019.04.001

P.A. Nehme , F.G. Amaral , B. Middleton , A. Lowden , E. Marqueze , I. França-Junior , J.L.F. Antunes , J. Cipolla-Neto , D.J. Skene , C.R.C. Moreno

{"title":"Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series","authors":"P.A. Nehme , F.G. Amaral , B. Middleton , A. Lowden , E. Marqueze , I. França-Junior , J.L.F. Antunes , J. Cipolla-Neto , D.J. Skene , C.R.C. Moreno","doi":"10.1016/j.nbscr.2019.04.001","DOIUrl":"10.1016/j.nbscr.2019.04.001","url":null,"abstract":"<div><p>Successful pregnancy requires adaptation in maternal physiology. During intrauterine life the mother's circadian timing system supports successful birth and postnatal development. Maternal melatonin is important to transmit circadian timing and day length to the fetus. This study aims to describe the third trimester of pregnancy among day (n = 5) and night (n = 3) workers by assessing their melatonin levels in a natural environment. Additionally, we describe the worker's metabolic profiles and compare the health status of the newborns between groups of day and night working mothers. Our results indicate an occurrence of assisted delivery (cesarean and forceps) among night workers. Moreover, the newborns of night workers showed lower Apgar index and breastfeeding difficulty indicating a worse condition to deal with the immediate outside the womb environment. Additionally, there was lower night-time melatonin production among pregnant night workers compared to day workers. These findings may be related to light-induced suppression of melatonin that occurs during night work. We conclude that night work and consequent exposure to light at unconventional times might compromise the success of pregnancy and the health of the newborn. Further studies need to be carried out to monitor pregnancy and newborn health in pregnant night workers.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 70-76"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37362396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases 临床一例睡眠嗜睡症患者睡眠宏观与微观结构的比较

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2019.02.001

Alyssa Cairns , Richard Bogan

{"title":"Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases","authors":"Alyssa Cairns , Richard Bogan","doi":"10.1016/j.nbscr.2019.02.001","DOIUrl":"10.1016/j.nbscr.2019.02.001","url":null,"abstract":"<div><p>The purpose of this study was to elucidate the differentiating or grouping EEG characteristics in various hypersomnias (type 1 and type 2 narcolepsy (N-1 and N-2) and idiopathic hypersomnia (IH) compared to an age-matched snoring reference group (SR). Polysomnogram sleep EEG was decomposed into a 4-frequency state model. The IH group had higher sleep efficiency (SE; 92.3% vs. 85.8%; sp < 0.05), lower WASO (IH = 35.4 vs. N-1 = 65.5 min; p < 0.01), but similar (i.e. high) arousal indices as N-1 (~33/h). N-1 and N-2 had earlier REM latency than IH and SR (N-1 = 64.8, N-2 = 76.3 vs. IH/SR = 118 min, p < 0.05). N-1 and N-2 showed an increase in MF1 segments (characteristic of stage 1 and REM) across the night as well as distinct oscillations every 2 h, but MF1 segment timing was advanced by 30 min compared to the SR group (p < 0.05). This suggests the presence of circadian organization to sleep that is timed earlier or of increased pressure and/or lability. MF1 demonstrated a mixed phenotype in IH, with an early 1<sup>st</sup> oscillation (like N-1 and N-2), 2<sup>nd</sup> oscillation that overlapped with the SR group, and a surge prior to wake (higher than all groups). This phenotype may reflect a heterogeneous group of individuals, with some having more narcolepsy-like characteristics (i.e. REM) than others. LF domain (delta surrogate) was enhanced in IH and N-1 and more rapidly dissipated compared to N-2 and SR (p < 0.05). This suggests an intact homeostatic sleep pattern that is of higher need/reduced efficiency whereas rapid dissipation may be an underlying mechanism for sleep disruption.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 62-69"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37359314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Brain dynamics during the sleep onset transition: An EEG source localization study 睡眠开始过渡期间的脑动力学:脑电图源定位研究

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2018.11.001

Antonio Fernandez Guerrero , Peter Achermann

{"title":"Brain dynamics during the sleep onset transition: An EEG source localization study","authors":"Antonio Fernandez Guerrero , Peter Achermann","doi":"10.1016/j.nbscr.2018.11.001","DOIUrl":"10.1016/j.nbscr.2018.11.001","url":null,"abstract":"<div><p>EEG source localization is an essential tool to reveal the cortical sources underlying brain oscillatory activity. We applied LORETA, a technique of EEG source localization, to identify the principal brain areas involved in the process of falling asleep (sleep onset, SO). We localized the contributing brain areas of activity in the classical frequency bands and tracked their temporal evolution (in 2-min intervals from 2 min prior to SO up to 10 min after SO) during a baseline night and subsequent recovery sleep after total sleep deprivation of 40 h.</p><p>Delta activity (0.5–5 Hz) gradually increased both in baseline and recovery sleep, starting in frontal areas and finally involving the entire cortex. This increase was steeper in the recovery condition. The evolution of sigma activity (12–16 Hz) resembled an inverted U-shape in both conditions and the activity was most salient in the parietal cortex. In recovery, sigma activity reached its maximum faster than in baseline, but attained lower levels. Theta activity (5–8 Hz) increased with time in large parts of the occipital lobe (baseline and recovery) and in recovery involved additionally frontal areas. Changes in alpha activity (8–12 Hz) at sleep onset involved large areas of the cortex, whereas activity in the beta range (16–24 Hz) was restricted to small cortical areas. The dynamics in recovery could be considered as a “fast-forward version” of the one in baseline.</p><p>Our results confirm that the process of falling asleep is neither spatially nor temporally a uniform process and that different brain areas might be falling asleep at a different speed potentially reflecting use dependent aspects of sleep regulation.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 24-34"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2018.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37359313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques 成年食蟹猕猴睡眠/觉醒、活动和咖啡因反应的电生理特征

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2018.08.001

Anushka V. Goonawardena, Stephen R. Morairty, Gabriel A. Orellana, Adrian R. Willoughby , Tanya L. Wallace , Thomas S. Kilduff

{"title":"Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques","authors":"Anushka V. Goonawardena, Stephen R. Morairty, Gabriel A. Orellana, Adrian R. Willoughby , Tanya L. Wallace , Thomas S. Kilduff","doi":"10.1016/j.nbscr.2018.08.001","DOIUrl":"10.1016/j.nbscr.2018.08.001","url":null,"abstract":"<div><p>Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics, sleep/wake architecture and electroencephalographic (EEG) activity in a diurnal non-human primate (NHP) to evaluate the utility of this species for pharmacological manipulation of the sleep/wake cycle. Adult, 9–11 y.o. male cynomolgus macaques (<em>n</em> = 6) were implanted with telemetry transmitters to record EEG and electromyogram (EMG) activity and Acticals to assess locomotor activity under baseline conditions and following injections either with vehicle or the caffeine (CAF; 10 mg/kg, i.m.) prior to the 12 h dark phase. EEG/EMG recordings (12–36 h in duration) were analyzed for sleep/wake states and EEG spectral composition. Macaques exhibited a sleep state distribution and architecture similar to previous NHP and human sleep studies. Acute administration of CAF prior to light offset enhanced wakefulness nearly 4-fold during the dark phase with consequent reductions in both NREM and REM sleep, decreased slow wave activity during wakefulness, and increased higher EEG frequency activity during NREM sleep. Despite the large increase in wakefulness and profound reduction in sleep during the dark phase, no sleep rebound was observed during the 24 h light and dark phases following caffeine administration. Cynomolgus macaques show sleep characteristics, EEG spectral structure, and respond to CAF in a similar manner to humans. Consequently, monitoring EEG/EMG by telemetry in this species may be useful both for basic sleep/wake studies and for pre-clinical assessments of drug-induced effects on sleep/wake.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 9-23"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2018.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37359312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7