Tropical Parasitology最新文献_第2页

The search for serological assays in Strongyloides infection. 类圆线虫感染血清学检测方法的研究。

Tropical Parasitology Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI: 10.4103/tp.tp_9_25

Tuhina Banerjee

引用次数: 0

Assessment of nutritional status among post-kala-azar dermal leishmaniasis patients in endemic areas of northern West Bengal, India. 印度西孟加拉邦北部流行地区黑热病后皮肤利什曼病患者营养状况评估

Tropical Parasitology Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI: 10.4103/tp.tp_47_24

Anwesha Samanta, Diyasha Patra, Abhijit Chaudhury, Pabitra Saha, Ashif Ali Sardar, Supriya Halder, Ardhendu Kumar Maji, Subhasish Kamal Guha, Sonali Das

{"title":"Assessment of nutritional status among post-kala-azar dermal leishmaniasis patients in endemic areas of northern West Bengal, India.","authors":"Anwesha Samanta, Diyasha Patra, Abhijit Chaudhury, Pabitra Saha, Ashif Ali Sardar, Supriya Halder, Ardhendu Kumar Maji, Subhasish Kamal Guha, Sonali Das","doi":"10.4103/tp.tp_47_24","DOIUrl":"10.4103/tp.tp_47_24","url":null,"abstract":"Context: Nutritional status played significant roles in preventing infection of pathogens, expression of disease severity, and prognosis following treatment. Leishmaniasis is a neglected tropical disease affecting the poorest people and is generally undernourished. In the Indian subcontinent, malnutrition is found to be associated with visceral leishmaniasis (VL) but such reports for post kala-azar dermal leishmaniasis (PKDL) are not available.Objectives: Assessment of nutritional status among PKDL cases from West Bengal, India.Methodology: PKDL cases were searched by door-to-door visits. The nutritional status of the study participants was assessed by analyzing clinical, anthropometrical, and biochemical parameters. The data were analyzed using standard statistical methods with Minitab software.Results: A total of 42 PKDL (Group A), 38 with VL history (Group B), and 80 healthy control participants (Group C) were included. We noticed a higher rate of ocular and dermal abnormalities due to Vitamin A deficiency among PKDL patients. A lower range of body mass index was recorded among both Group A and B. The mean hemoglobin and Vitamin B12 level of Group A were significantly lower than Group C. The mean white blood cell count was significantly higher in Group A than other two groups.Conclusion: The study revealed that PKDL patients were undernourished as evident by few clinical, anthropometrical, and biochemical parameters. The initiative of providing nutrient-rich food during the treatment of leishmaniasis by the Government of West Bengal is justified. A case-control study is highly suggested to evaluate the impact of such food supply during treatment on disease prognosis.","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"15 1","pages":"42-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary study of a prototype fatty acid and retinal binding peptide epitope for Strongyloides stercoralis antibody detection. 一种检测粪类圆线虫抗体的脂肪酸与视网膜结合肽表位原型的初步研究。

Tropical Parasitology Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI: 10.4103/tp.tp_10_24

Thitimakorn Namhong, Chompunoot Wangboon, Jeeraphong Thanongsaksrikul, Poom Adisakwattana, Kanyarat Thueng-In

{"title":"Preliminary study of a prototype fatty acid and retinal binding peptide epitope for Strongyloides stercoralis antibody detection.","authors":"Thitimakorn Namhong, Chompunoot Wangboon, Jeeraphong Thanongsaksrikul, Poom Adisakwattana, Kanyarat Thueng-In","doi":"10.4103/tp.tp_10_24","DOIUrl":"10.4103/tp.tp_10_24","url":null,"abstract":"Context: Laboratory diagnosis of strongyloidiasis is most often based on the detection of antibodies against antigens in an enzyme-linked immunosorbent assay (ELISA).Aims: The aim of the study was to validate the efficacy of the B-cell epitope peptide antigens of fatty acid and retinal binding protein in using antibodies against Strongyloides stercoralis.Settings and design: Patient samples were identified by an anonymous code and collected from volunteers at Suranaree University of Technology Hospital, Thailand.Subjects and methods: The synthesized peptides and cell lysate of Strongyloides ratti were used as antigens in an in-house ELISA format. A total of 78 serum samples were collected from patients infected with S. stercoralis, other parasites, and healthy persons.Statistical analysis used: The receiver operating characteristic curve was used to assess the diagnostic performance of peptide antigens and analysis of variance was utilized to examine differences in peptide reactivity between groups.Results: The peptide-1 and cell lysate of S. ratti could clearly differentiate serums among infected and noninfected groups. The peptide-1, peptide-2 of S. stercoralis, and lysate of S. ratti antigen had been measured to reveal sensitivities at about 75.00%, 50.00%, and 75.00% with 75.86%, 86.21%, and 89.66% specificities, respectively.Conclusions: These results could be useful for routine clinical laboratory diagnostic testing and possibly apply for surveillance investigations in the future.","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"15 1","pages":"21-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinosporidiosis. Rhinosporidiosis。

Tropical Parasitology Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI: 10.4103/tp.tp_18_25

Sivanantham Krishnamoorthi

引用次数: 0

Uncommon clinical presentation by a common pathogen. 一种常见病原体引起的罕见临床表现。

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_26_24

Alisha Aggarwal, Vibhor Tak, Daisy Khera

引用次数: 0

Three decades of research in lymphatic filariasis-lessons learned. 三十年淋巴丝虫病研究的经验教训。

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_22_24

Suma Krishnasastry

{"title":"Three decades of research in lymphatic filariasis-lessons learned.","authors":"Suma Krishnasastry","doi":"10.4103/tp.tp_22_24","DOIUrl":"https://doi.org/10.4103/tp.tp_22_24","url":null,"abstract":"Lymphatic filariasis (LF), one of the 21 Neglected Tropical Diseases (NTD) which is the second leading cause for disability globally. Wuchereria Bancrofti, Brugia malayi and Brugia timori are the parasites causing this infection. World Health Assembly in 1997 declared LF to be eliminated and the Global Program to eliminate LF (GPELF) was launched by WHO in 2000 with the two strategies viz, 1) stop transmission of infection through Mass Drug Administration (MDA) and 2) to alleviate the suffering of the people affected with the disease through Morbidity Management and Disability Prevention (MMDP. The 'Filariasis research unit' recommended by WHO TDR and ICMR was established in Alappuzha, Kerala in 1989 for research studies related to LF. Over the last three decades 23 studies have been completed, which included different trials to find out the dose, effectiveness and safety of the various drugs used in preventive chemotherapy as single drug or combinations, for treatment of microfilaraemia,, various studies related to morbidity management in filarial disease, socio-economic aspects of filarial disability, Pharmacokinetic study of antifilarial drugs, Study on lymphatic filariasis in children, Studies on dignostics of LF, efficacy of drugs in management of lymphedema etc. In this article an attempt is made to explain the lessons learned from these studies and its importance in development of policy decision making for GPELF.","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"14 2","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation the effect of the aqueous extract of Chara vulgaris (L.) on visceral leishmaniasis. 研究水提取物对内脏利什曼病的影响。

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_1_24

A A Al-Maphregy Ghusoon, A H Al-Magdamy Buthaina

{"title":"Investigation the effect of the aqueous extract of Chara vulgaris (L.) on visceral leishmaniasis.","authors":"A A Al-Maphregy Ghusoon, A H Al-Magdamy Buthaina","doi":"10.4103/tp.tp_1_24","DOIUrl":"https://doi.org/10.4103/tp.tp_1_24","url":null,"abstract":"Background: Visceral leishmaniasis (VL) is a parasitic disease that affects public health. It is described by weight reduction, irregular fever bouts, anemia, and amplification of the spleen and liver.Materials and methods: Three concentrations (15.6, 31.2, and 62.5 μg/mL) were used to find the potency of an aqueous extract of Chara vulgaris algae in the treatment of VL. A cytotoxicity assay was performed to show the cytotoxic effect of this extract on human cells. High-performance liquid chromatography (HPLC) test was done to determine the active compounds in the extract. Histopathological sections for infected liver and spleen were performed, as were liver function tests (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase), which were assessed after 1 month of treatment.Results: As cytotoxicity assay, results showed that there were no significant differences between the cells treated and those not treated with the extract. HPLC test demonstrated that phenolic and terpene compounds are the main active compounds in the extract. P-coumaric acid and ursolic acid present the highest percent among other phenolic and terpene compounds (21.84%, 17.82%), respectively. Histopathological sections showed that this extract had a significant effect in the treatment of infected tissues, and this effect was very clear after the end of the treatment period. As for the liver function tests, a significant increase (P < 0.01) in the studied liver enzymes was found in the infected group of mice compared to the healthy group, whereas in the infected and treated groups, a clear and gradual decrease in the level of enzymes was observed.","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"14 2","pages":"84-94"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dirofilariasis in the hiding in oral cavity of a patient from Karnataka, India. 印度卡纳塔克邦一名患者口腔藏匿处的迪罗丝虫病。

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_6_24

Sreelatha Shankaran Veetil, Asem Ali Ashraf, Jerlin Koshy, Vimal Kumar Karnaker

引用次数: 0

Rising case-fatality rate of kala-azar (visceral leishmaniasis) in India: An unexpected challenge to the kala-azar elimination program? 印度卡拉扎（内脏利什曼病）病死率上升：消除卡拉扎病计划面临意想不到的挑战？

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_57_23

Muniaraj Mayilsamy, Rajamannar Veeramanoharan, Paramasivan Rajaiah

引用次数: 0

Free-living amoebic encephalitis - Case series. 自由生活阿米巴脑炎--病例系列。

Tropical Parasitology Pub Date : 2024-07-01 Epub Date: 2024-09-03 DOI: 10.4103/tp.tp_37_23

Sithara Nasar Thottathil Puthanpurayil, Aiswarya Mukundan, Suryakala Ravi Nair, Anu Pudurkara John, Mithuna Rohini Thampi, Reena John, Rakesh Sehgal

{"title":"Free-living amoebic encephalitis - Case series.","authors":"Sithara Nasar Thottathil Puthanpurayil, Aiswarya Mukundan, Suryakala Ravi Nair, Anu Pudurkara John, Mithuna Rohini Thampi, Reena John, Rakesh Sehgal","doi":"10.4103/tp.tp_37_23","DOIUrl":"https://doi.org/10.4103/tp.tp_37_23","url":null,"abstract":"Introduction: Free-living amoeba is ubiquitous in fresh water, mud, and moist soil; although seldom pathogenic to humans, Naegleria fowleri, Acanthamoeba spp., and Balamuthia spp. are known to cause infections of the central nervous system.Methods: We report two interesting cases, both of which presented with a rapid-onset and fulminant course. The first case details a 36-year-old male with a history of surgically corrected nasal bone fracture 15 years back, who presented with acute onset of fever, headache and convulsions.Results: Direct smears of cerebrospinal fluid (CSF) revealed motile trophozoites resembling N. fowleri and were later confirmed by molecular diagnosis (polymerase chain reaction [PCR]). Subsequently, the source was identified as water used for religious purposes. Unfortunately, the patient succumbed to cardiac arrest. The second case is that of a 4-year-old boy from Palakkad district, Kerala, who presented with sudden onset of nasal discharge, fever, headache, vomiting, seizures and altered sensorium. His CSF smear examination showed motile trophozoites resembling Acanthamoeba spp. While undergoing treatment, he seized thrice before going into cardiac arrest. Despite extensive resuscitation measures, the child could not be revived and passed away. The postmortem CSF sample sent for molecular analysis confirmed infection by Acanthamoeba spp.Conclusion: Rapid progression and lack of definite treatment options make this a highly fatal condition. Although clinical presentations of both patients were indicative of pyogenic meningitis, parasitic infection was suspected when the CSF was found turbid with no bacteria, high protein, and low sugar. High index of suspicion helped us to get an early preliminary diagnosis from direct microscopy.","PeriodicalId":37825,"journal":{"name":"Tropical Parasitology","volume":"14 2","pages":"108-112"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0