Herald of Pancreatic Club最新文献

{"title":"Study of intestinal dysbiosis (“dysbacteriosis”): state of problem and new trends","authors":"Y. Tsimmerman","doi":"10.33149/vkp.2019.04.06","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.06","url":null,"abstract":"Intestinal dysbiosis (“dysbacteriosis”) is a clinical and laboratory (clinical and microbiological) secondary syndrome that develops in a number of diseases and clinical syndromes and is characterized by changes in the quantitative and qualitative (species) composition of microbial associations (normal flora) in certain biotopes (large and small intestine) with the translocation of its various representatives into unusual biotopes. \u0000The main causes of the development of colic dysbiosis are: antibacterial therapy with the use of broad-spectrum antibiotics; hormone therapy; use of cytostatics; radiation therapy; bowel surgery; acute intestinal infectious diseases (dysentery, salmonellosis, etc.); immunodeficiency states of various genesis; unbalanced nutrition; lack of dietary fiber; excessive consumption of preservatives and xenobiotics; intestinal movement disorders (chronic constipation, diarrhea); mental stress conditions, etc. \u0000There are direct (bacteriological cultures) and indirect (determination of short-chain volatile fatty acids by gas-liquid chromatography, respiratory tests, etc.) methods for diagnosing intestinal dysbiosis. \u0000Treatment of intestinal dysbiosis (“dysbacteriosis”) should be individualized and complex, taking into account its severity (degree), preferential localization (colon, small intestine), nature of the prevailing conditionally pathogenic microflora, presence of clinical symptoms and its characteristic features. Adequate treating of the underlying disease that caused intestinal dysbiosis; restoration of the impaired functions of the intestine, its parietal (contact, membrane) and abdominal digestion; increasing the overall resistance of the organism due to the restoration of its immunological and non-specific protection; correction of dysbiosis of the colon and small intestine are crucial. Diet, intestinal antibiotics, pro-, prebiotics, synbiotics are important components of treatment. In recent years, fecal transplantation has been more widely applied.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129286489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News of European pancreatology (by materials of the 51st Meeting of the European Pancreatic Club)","authors":"N. Gubergrits, N. Byelyayeva, G. Lukashevich, A. Klochkov, P. Fomenko, L. Yaroshenko, A. Yuryeva, V. Rakhmetova","doi":"10.33149/vkp.2019.04.01","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.01","url":null,"abstract":"This article presents an overview of the results of practical and basic research in the field of pancreatology, which were presented during the 51st Meeting of the European Pancreatic Club (2019). Achievements of leading European pancreatologists in the study of the etiology, pathogenesis, diagnosis, treatment of pancreatitis, pancreatic tumors are briefly described. The article presents clinical features of acute and chronic pancreatitis, depending on the variety of concomitant pathology, genetic characteristics, bad habits, drugs taken. New opportunities for the differential diagnosis of chronic pancreatitis and pancreatic cancer using miRNA are considered, as well as the feasibility of determining the soluble urokinase-type plasminogen activator receptor (suPAR) in order to differentiate benign and malignant pancreatic tumors. Approaches to the diagnosis of abdominal pain, use of computed tomography for the diagnosis of sarcopenia are described. Results of basic research analyzing the mechanisms of pancreatic cancer development are presented. Modern theory on the role of microbiota and syndrome of bacterial overgrowth in the pancreatic oncogenesis processes is revealed. Pathogenetic features of the formation of exocrine pancreatic insufficiency and effectiveness of its correction via enzyme replacement therapy with the use of modern drugs are emphasized. Results of randomized controlled studies that proved effectiveness and safety of microtablet preparation in correction of exocrine pancreatic insufficiency in patients undergoing pancreatoduodenectomy are presented. \u0000 ","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"24 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114133256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of the termination of mechanical jaundice after antegrade and retrograde decompressive surgeries in mechanical jaundice of various genesis","authors":"V. I. Podoluzhny, K. Krasnov, N. V. Zarutskaja","doi":"10.33149/vkp.2019.04.08","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.08","url":null,"abstract":"Aim: to determine in a comparative aspect the effectiveness of various minimally invasive decompressive operations in mechanical jaundice of different genesis. \u0000Materials and methods. In 135 patients with mechanical jaundice, the rate of bile duct resolution after cholecystostomy and percutaneous cholangiostomy was studied on the background of pancreatic head tumor. In 643 patients with obstructive bile duct disease in cholelithiasis, timing of the termination of jaundice after minimally invasive retrograde (endoscopic papillosphincterotomy (EPT) and EPT with transpapillary drainage) and percutaneous antegrade (cholecystostomy and cholangiostomy) of decompressive operations was studied. \u0000Result. Upon cholelithiasis and hyperbilirubinemia less than 100 μmol/l, jaundice is terminated after both variants of retrograde decompression within 3–5 days, antegrade interventions increase these terms by half. Comparison of retrograde and antegrade decompressive surgeries in mechanical jaundice of medium and severe degree on the background of cholelithiasis indicates that the rate of termination of bile stasis is the highest after EPT with transpapillary drainage. Isolated EPT and percutaneous cholangiostoma with medium-grade gallstones increase the duration of jaundice termination by an average of one week. Upon hyperbilirubinemia more than 200 μmol/l, cholangiostomy is not worse than transpapillary drainage. The longest termination period of obstructive jaundice (28–30 days) is observed after superimposition of microcholecystostoma. In patients with jaundice of a mild degree of tumor genesis, no differences in the results were revealed after both variants of percutaneous decompression. Upon hyperbilirubinemia above 100 μmol/l, when cholangio- and cholecystostomy were compared, a higher rate of decrease in serum bilirubin was observed after percutaneous interventions with a cholecystostomy. \u0000Conclusion. At all severity levels of mechanical jaundice on the background of cholelithiasis, the best way of decompression is endoscopic papillotomy with transpapillary drainage. In obturation bile stasis upon the pancreatic head tumor, the best decompressive effect is observed after percutaneous cholecystoostomy.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133231050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic resections for pancreatic neuroendocrine tumors: case series and discussion","authors":"I. Khomiak, O. Duvalko, A. Khomiak, I. Tereshkevich, A. Malik","doi":"10.33149/vkp.2019.04.05","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.05","url":null,"abstract":"Neuroendocrine tumor of the pancreas (pNET) is a wide-spread oncological disease, and its treatment is a widely discussed topic in modern pancreatology. Functioning pNET mainly manifest with hormonal hypersecretion syndrome (accordingly to the type of hormone), whereas nonfunctioning tumors may not produce any symptoms and remain unnoticed, complicating the diagnosis and postponing medical care. Course of the disease and patient’s prognosis largely depend on the stage of the disease and tumor histology. Higher tumor grade, lymph node and liver metastasis, and a larger primary tumor generally portend relatively poor survival. Prognosis of the patients with pNET improves substantially when the disease has been diagnosed and treated on the early stages. Endocrine testing, imaging modalities among which CT, MRI and endoscopic ultrasound are considered most useful; and histological evidence are all required to accurately diagnose pNETs. Recently an “aggressive” approach to pNET treatment has become most popular in academic centers throughout the world. Surgical resection of the tumor is considered the most effective treatment option and a gold treatment standard. Laparoscopic pancreatic resections also play major role in the treatment of pNET. Laparoscopic approach is safe and effective modality, so the number of laparoscopic operations has been growing last years. Among the benefits of minimally invasive surgery are lesser postoperative pain, shorter hospital length of stay, better cosmetic appearance and shorter disease-related inability of work period. In these case series characteristics of the early diagnosis and successful laparoscopic surgical treatment for the patients with pNET of the right anatomical segment of the pancreas are described.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"8 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134288626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of Shidnitsa mineral waters in complex rehabilitation of patients with chronic pancreatitis with concomitant diabetes mellitus","authors":"L. Babinets, G. M. Sasyk","doi":"10.33149/vkp.2019.04.04","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.04","url":null,"abstract":"Relevance. Rehabilitation of patients with chronic pancreatitis (CP) combined with diabetes mellitus (DM) requires a complex systemic and personified approach, since such comorbidity is characterized by complicated interactions of these nosology items, with more lesions of pancreas as the main organ involved in the formation and depth pathological manifestations of each patient, as well as the involvement of adjacent organs of the gastrointestinal tract, other organs and systems. Process of integrated rehabilitation, which purpose is to maximally restore the lost functions of the above organs, especially the pancreas, should include, in addition to standard protocol approaches, the adjuvant effective techniques that showed their practical effectiveness but require research and scientific substantiation. Such techniques include the use of therapeutic mineral water (MW) both in resorts and in outpatient practice according to the place of residence of patients. \u0000The aim of the study is to investigate the effectiveness of rehabilitation of patients with CP and concomitant DM with the use of the drug ademetionin in the sublingual form (Agepta) and the course of treatment with drinking MW of the Shidnitsa deposit. \u0000Material and methods of research. 77 patients with CP and concomitant DM were examined. According to treatment programs, patients were divided into 3 groups: Group 1 (protocol treatment (PT) — 26 patients) — received enzyme preparation of pure pancreatin, proton pump inhibitor (pantoprazole 40 mg), anesthetics (mebeverin) and/or prokinetic (motilium), metformin 1000 mg twice a day); Group 2 (PT + ademetionin — 26 patients) — in addition to PT received a drug ademetionin (sublingual tablets Agepta 400 mg) 1 tablet 2 times per day 30–60 min before eating, holding under tongue at least 15–20 min — until complete dissolution, 1 month course; Group 3 — in addition to PT and Agepta in the above-mentioned scheme, they took the course of treatment by drinking MW of the Shidnitsa deposit according to the proposed scheme. \u0000Results. Positive dynamics in all groups of comparison was revealed, but its intensity differed in those groups. Improvement of exocrine and endocrine pancreatic function was found: level of fecal α-elastase increased by 58.5% in Group 1, by 82.6% in Group 2, by 93.4% in Group 3; level of blood glucose decreased by 9.2% in Group 1, by 13.3% in Group 2, by 19.5% in Group 3; level of HbA1c — by 4.9% in Group 1, by 9.2% in Group 2, by 12.2% in Group 3; changes in the coprogram — by 24.5% in Group 1, by 38.6% in Group 2, by 55.2% in Group 3. \u0000Discussion. There was a statistically significant improvement in the results of Group 2 as compared to Group 1 (p<0.05), which indicates the effectiveness of use of ademetionin (Agepta sublingual tablets) in a comprehensive correction program for patients with CP and DM. However, the most evident dynamics of indicators of exocrine and endocrine pancreatic function was found in Group 3 as compared t","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"65 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128023509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic gastritis and carcinogenesis issues","authors":"M. Karimov, G. Sobirova, U. K. Abdullayeva","doi":"10.33149/vkp.2019.04.09","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.09","url":null,"abstract":"Risk factors contributing to the transformation of chronic atrophic gastritis into gastric cancer are analyzed. Detection and monitoring of patients with precancerous conditions/lesions (precancerous changes), proper screening of H. pylori make early diagnosis of gastric cancer real. Features of precancerous conditions are given in order of increasing risk of developing gastric cancer. Adenomatous polyps of the stomach take the first place. Subsequent precancerous conditions include: cancer of the operated stomach, Menetria disease (hypertrophic gastropathy), B12-deficient anemia, and gastric ulcer. A definition of intestinal metaplasia subtypes is proposed as a risk factor for gastric cancer, dividing into complete and incomplete one, taking into account reduction in the expression of gastric mucins MUC1, MUC5AC and MUC6. Currently, the development of gastric cancer (mainly of the “intestinal type”) is considered as a multistage process involving the sequence of mucosal change, such as chronic inflammation, atrophy, intestinal metaplasia, dysplasia and adenocarcinoma. Role of the organism’s genetic susceptibility to H. pylori infection, factors of pathogenicity contributing to epithelial metaplasia, are analyzed. Role of Toll-like type 4 receptors (TLR4) involved in the recognition of H. pylori is clarified. It is with this type of receptors that the development of an excessive immune response of the host is associated, resulting in damage to the mucous membrane in H. pylori-infected individuals. In particular, carriers of TLR4+896A> G polymorphism have a more severe atrophy of the stomach and degree of inflammation, as well as an increased risk of non-cardiac gastric cancer.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126228523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary dyskinesia: traditional and modern views","authors":"N. Gubergrits, N. Byelyayeva, G. Lukashevich, P. Fomenko, A. Yuryeva, E. N. Koval","doi":"10.33149/vkp.2019.04.10","DOIUrl":"https://doi.org/10.33149/vkp.2019.04.10","url":null,"abstract":"Traditional and modern views on pathogenesis, clinical manifestations, diagnosis and treatment of the gallbladder and biliary sphincters dysfunctions are analyzed in the article. Functions of bile and its role in the process of digestion are highlighted. Diagnostic criteria for biliary dysfunctions are described in detail in accordance with the Rome Consensus IV (mandatory and confirmatory); clinical and diagnostic criteria for the classical variants of biliary dyskinesia, namely hypo- and hyperkinetic dyskinesia of the gallbladder, are being presented. Treatment of biliary dysfunctions is described according to the Rome Consensus IV, taking into account the type of dyskinesia. It is reasonable to follow the basic principles of dietary nutrition in diseases of the biliary tract, as well as to protect the mucous membrane of the upper gastrointestinal tract from mechanical, thermal and chemical effects. It is important to eat in a relaxed atmosphere, not in a hurry. The antispasmodics that are used for biliary dysfunctions are listed: M-cholinolytics, myotropic antispasmodics, calcium and sodium channel blockers, etc. Importance of ursodeoxycholic acid in treatment of functional biliary diseases is emphasized. The use of ursodeoxycholic acid preparations in biliary dyskinesia is based on its ability to reduce the lithogenicity of bile, as well as exert an anti-inflammatory effect on the mucous and muscular layer of the biliary tract, which indirectly contributes to the normalization of impaired motility and secretion. Advantages of the combined drug Engilen consisting of milk thistle, artichoke and turmeric are highlighted. With the ineffectiveness of conservative treatment and the results of the examination, confirming structural changes (stenosis) in the ending area of common bile and/or pancreatic duct, decision on endoscopic treatment can be made.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123030939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hygienic assessment of the nutritional status of patients with multi-drug-resistant pulmonary tuberculosis","authors":"S.Ch. Mamedsakhatova","doi":"10.33149/VKP.2019.03.09","DOIUrl":"https://doi.org/10.33149/VKP.2019.03.09","url":null,"abstract":"Introduction. The priority direction of hygienic science at the present stage is the study of the nutritional status of patients with multi-drug-resistant tuberculosis (MDR-TB) of the lungs. \u0000The aim of study is to identify the basic patterns of formation of the structure of the nutritional status of patients with MDR-TBof the lungs in order to adopt a reasonable system of measures for their optimization(from a hygienic point of view). \u0000Materials and research methods. The actual nutrition of 103 patients with MDR-TBof the lungs was studied using a specially prepared standardized questionnaire, which included information on previous and yesterday nutrition. Nutritional status was determined by evaluating anthropometric indices (height, body mass, chest circumference), on the basis of which the Quetelet index was calculated. Surveyed control group included 20 relatively healthy patients. Bioimpedancemetrywas a special research method. \u0000Results and discussion. In the case of multiple correlation analysis, a high direct correlation of the total protein level with the indicator of fat mass according to bioimpedancemetry (r=0.63; p<0.01)was found in patients with MDR-TB of the lungs. \u0000Conclusion. There is a need for prevention and correction of excess fatty tissue and a lack of muscle mass, which can be achieved with the help of physical exercise, rational nutrition and nutritional support.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129421194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic hernia: formation mechanisms, clinical picture, treatment tactics","authors":"N. Gubergrits, N. Byelyayeva, A. Klochkov, G. Lukashevich, P. Fomenko, A. V. Yur’eva","doi":"10.33149/VKP.2019.03.10","DOIUrl":"https://doi.org/10.33149/VKP.2019.03.10","url":null,"abstract":"The article presents current data on etiology, pathogenesis of diaphragmatic hernia. Types of diaphragmatic hernia are described in detail, namely: axial, paraesophageal, mixed; transient and fixed. Pathogenesis of the formation of hiatal hernia includes: failure of the connective tissue structures involved in the formation of the esophago-gastric junction; significant increase in intra-abdominal pressure; increase in motor activity of the esophagus (hypermotor dyskinesia). Clinical manifestations and peculiarities of pain, including pseudo-coronary pain, differential diagnosis, are described. Recommendations for non-drug treatment, including lifestyle and nutritional changes, are presented. Particular attention is paid to pantoprazole as a means of choice for therapy of patients. Advantages of pantoprazole as compared with other proton pump inhibitors are presented: selectivity of action depending on pH, absence of “decussation” with the metabolism of other drugs, efficacy, duration of acid suppressive action, safety, favorable pharmacoeconomic characteristics.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132173956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early chronic pancreatitis: is a clinical diagnosis possible?","authors":"N. Gubergrits, N. Byelyayeva, A. Klochkov, G. Lukashevich, V. S. Rachmetova","doi":"10.33149/VKP.2019.03.03","DOIUrl":"https://doi.org/10.33149/VKP.2019.03.03","url":null,"abstract":"A “fatal chain” in pancreatology is discussed in the present article; peculiar attention is paid to an early chronic pancreatitis (CP), being one of the little-studied “links” in this range and corresponding to the latent period of CP(persistence of inflammation with the presence of biomarkers of CP, which does not meet the diagnostic criteria of proven or late CP, as well as the appearance of signs of exocrine pancreatic insufficiency in the form of reduced functional test results to 70% of normal). Features of the different stages of the pancreatic diseases’ course are presented, substantiatinganeed for a practical identification of the “early CP” diagnosis: \"for\" - the possibility of timely diagnosis, the identification of patients with an increased risk of prostate cancer; \"against\": the lack of specific antifibrotic, anti-inflammatory therapy, an increase in financial costs, no impact on the clinical outcome.Advantages and disadvantages of using the “early CP” diagnosis in practice are considered. The authors cite the provisions of the International Consensus on early CP, and list the current diagnostic criteria for this diseaseelaborated by the Japanese Pancreas Society. Advantages and disadvantagesof the instrumental and laboratory diagnostic methods are analyzed, including probable early CP biomarkers (interleukin-8, prostaglandin E2). The most suitable therapeutic tactics for management of patients with early CP are presented, including correction of the exocrine and endocrinepancreatic function, as well as the use of antifibrotic drugs.","PeriodicalId":378182,"journal":{"name":"Herald of Pancreatic Club","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122382165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}