US Cardiology ReviewPub Date : 2023-06-26eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.31
Kevin Lee, Iva Minga, Eryn Cameron, Juan Pablo Salazar Adum, Amit Pursnani
{"title":"A Case of Primary Cardiac B-cell Lymphoma Diagnosed with Cardiac MRI.","authors":"Kevin Lee, Iva Minga, Eryn Cameron, Juan Pablo Salazar Adum, Amit Pursnani","doi":"10.15420/usc.2022.31","DOIUrl":"10.15420/usc.2022.31","url":null,"abstract":"<p><p>Primary cardiac tumors account for only 0.3% of all cardiac tumors; of these, lymphomas account for only 2% of all primary cardiac tumors. Cardiac lymphomas have a grim prognosis, often less than 1 year due to delays in diagnosis and treatment. Cardiac MRI is the gold standard for the imaging of cardiac tumors. We describe the case of a 76-year-old man with no significant past medical history who presented to the emergency department with a large pericardial effusion that was found to be consistent with cardiac lymphoma on cardiac MRI prior to tissue diagnosis of a primary cardiac diffuse large B-cell lymphoma. The clinical and radiological features of cardiac lymphoma are reviewed, and the therapeutic management and side-effects that the patient experienced are discussed.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e08"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47503180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-06-09eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.33
Jingwen Huang, Rebecca Steinberg, Matthew J Brown, Stéphane Rinfret, Olga Toleva
{"title":"Invasive Evaluation for Coronary Vasospasm.","authors":"Jingwen Huang, Rebecca Steinberg, Matthew J Brown, Stéphane Rinfret, Olga Toleva","doi":"10.15420/usc.2022.33","DOIUrl":"10.15420/usc.2022.33","url":null,"abstract":"<p><p>Vasospastic angina (VSA) occurs at rest and on exertion, with transient electrocardiographic ischemic changes. VSA presents with spontaneous coronary artery spasm (CAS); it has been associated with stable angina, acute coronary syndromes, and sudden cardiac death. CAS can be identified in normal arteries or non-obstructive coronary atherosclerosis, but is also prevalent in patients with coronary artery disease. The diagnosis is made with invasive coronary reactivity testing with provocation using acetylcholine (Ach). Epicardial spasms can be visualized through coronary angiography as a reversible epicardial vessel narrowing, while the diagnosis of microvascular spasm can be made when angina symptoms and ECG changes happen following intracoronary Ach without epicardial spasm. Identification of CAS allows for risk stratification and specific therapies targeting endothelial dysfunction and paradoxical vascular smooth muscle cell constriction. Therapies include calcium channel blockers as monotherapy or in a combination of a dihydropyridine and non-dihydropyridine. Short-acting nitrates offer acute symptomatic relief but long-acting nitrates should be used sparingly. This current update on invasive evaluation of VSA discusses unified Ach protocols.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":"1 1","pages":"e07"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42919751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-05-25eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.37
Chirag Bavishi
{"title":"Transcatheter Left Atrial Appendage Closure: Devices Available, Pitfalls, Advantages, and Future Directions.","authors":"Chirag Bavishi","doi":"10.15420/usc.2022.37","DOIUrl":"10.15420/usc.2022.37","url":null,"abstract":"<p><p>Transcatheter left atrial appendage closure has emerged as a non-pharmacological alternative to long-term anticoagulation for stroke prevention in appropriately selected patients with AF. In this concise review, the Food and Drug Administration-approved and some other left atrial appendage closure devices that are under investigation are discussed. Currently, Watchman Flx and Amplatzer Amulet are the only two devices that have been approved for commercial use by the Food and Drug Administration. A brief overview of device designs, clinical data on efficacy and safety, major limitations of left atrial appendage closure devices, and perspectives on future direction are provided. The current generation of devices is effective; however, efforts should continue on innovations and refinement of device technology.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e05"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49403160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-05-25eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.16
Ajitha Kulasekaran, Lorna Swan
{"title":"Pregnancy and Congenital Heart Disease: Moving Beyond the Current Risk Stratification Tools.","authors":"Ajitha Kulasekaran, Lorna Swan","doi":"10.15420/usc.2022.16","DOIUrl":"10.15420/usc.2022.16","url":null,"abstract":"<p><p>Women with congenital heart disease have increased risks of complications during pregnancy. Several risk scoring tools have been developed to quantify the likelihood of adverse cardiac outcomes during pregnancy. This article describes how comprehensive pre-pregnancy or early pregnancy counseling needs to go well beyond these risk scores. Non-cardiac risk factors and adverse obstetric and fetal outcomes are vital components of the dialogue between the multidisciplinary team and the patient embarking on, or contemplating, pregnancy.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e06"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49177516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-04-28eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.32
Sundeep Kumar, Rafey Feroze, Farshad Forouzandeh
{"title":"Role of Mechanical Circulatory Support in Acute MI Management.","authors":"Sundeep Kumar, Rafey Feroze, Farshad Forouzandeh","doi":"10.15420/usc.2022.32","DOIUrl":"10.15420/usc.2022.32","url":null,"abstract":"<p><p>Cardiogenic shock complicating acute MI carries high mortality and morbidity in many cases. Mechanical circulatory support devices are often used in these cases, aimed at improving patient-centered outcomes, although there is a lack of large randomized clinical trial-based evidence for many of such devices. Various circulatory support devices are available with their associated risks and benefits. Ideal circulatory support device intends to unload the myocardium, halt the spiral of ischemia, provide support for revascularization, and/or allow time for myocardial recovery. In this review paper, the commonly used mechanical circulatory support devices available for use in acute myocardial infarction settings are discussed, and the pros and cons of these devices are examined, considering the contemporary data for each. While this is an evolving field, the authors believe this paper can be helpful to review the current status of the use of mechanical support devices in the setting of acute MI and highlight some of the unmet needs in this field.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e04"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44964803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-04-04eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.26
Alexander G Truesdell, Rhian Davies, Moemen Eltelbany, Michael Megaly, Carolyn Rosner, Lindsey A Cilia
{"title":"Mechanical Circulatory Support for Complex High-risk Percutaneous Coronary Intervention.","authors":"Alexander G Truesdell, Rhian Davies, Moemen Eltelbany, Michael Megaly, Carolyn Rosner, Lindsey A Cilia","doi":"10.15420/usc.2022.26","DOIUrl":"10.15420/usc.2022.26","url":null,"abstract":"<p><p>Technological and procedural innovations presently permit the safe and effective performance of increasingly complex percutaneous coronary interventions, while new mechanical circulatory support devices offer circulatory and ventricular support to patients with severely reduced left ventricular systolic function and deranged cardiovascular hemodynamics. Together, these advances now permit the application of complex percutaneous coronary interventions to higher-risk patients who might otherwise be left untreated. Increasing observational data support the use of mechanical circulatory support in appropriate complex and high-risk patients as part of a larger multidisciplinary heart team treatment plan. In-progress and upcoming randomized clinical trials may provide higher-quality evidence to better guide management decisions in the near future.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":"1 1","pages":"e03"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67576837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cerebral Embolic Protection Devices: Current State of the Art.","authors":"Ankit Agrawal, Toshiaki Isogai, Shashank Shekhar, Samir Kapadia","doi":"10.15420/usc.2022.12","DOIUrl":"10.15420/usc.2022.12","url":null,"abstract":"<p><p>Transcatheter aortic valve replacement (TAVR) has become a first-line treatment for severe aortic stenosis with intermediate to high-risk population with its use increasingly expanding into younger and low-risk cohorts as well. Cerebrovascular events are one of the most serious consequential complications of TAVR, which increase morbidity and mortality. The most probable origin of such neurological events is embolic in nature and the majority occur in the acute phase after TAVR when embolic events are most frequent. Cerebral embolic protection devices have been designed to capture or deflect these emboli, reducing the risk of peri-procedural ischaemic events. They also carry the potential to diminish the burden of new silent ischemic lesions during TAVR. Our review explores different types of these device systems, their rationale, and the established clinical data.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e02"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44730991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2023-02-09eCollection Date: 2023-01-01DOI: 10.15420/usc.2022.22
Essa Hariri, Anna Scandinaro, Mazen M Al Hammoud, Ashley Kasper, Craig Parris, Beka Bakhtadzi, Andrew Higgins
{"title":"Clozapine-induced Cardiomyopathy: A Case Report.","authors":"Essa Hariri, Anna Scandinaro, Mazen M Al Hammoud, Ashley Kasper, Craig Parris, Beka Bakhtadzi, Andrew Higgins","doi":"10.15420/usc.2022.22","DOIUrl":"10.15420/usc.2022.22","url":null,"abstract":"<p><p>The diagnosis and treatment of new-onset systolic dysfunction can be challenging, particularly in patients presenting with cardiogenic shock. We present a case of a young African-American man who was admitted for cardiogenic shock following an admission a month earlier for treatment- resistant psychosis. He was diagnosed with medication-induced cardiomyopathy, which resolved with a remarkable recovery of his systolic function after discontinuation of the culprit medication, clozapine.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e01"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45670331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2022-11-29eCollection Date: 2022-01-01DOI: 10.15420/usc.2022.02
Aleksandra Cieplucha, Werner Budts, Marc Gewillig, Alexander Van De Bruaene
{"title":"Fontan-associated Liver Disease in Adults: What a Cardiologist Needs to Know. A Comprehensive Review for Clinical Practitioners.","authors":"Aleksandra Cieplucha, Werner Budts, Marc Gewillig, Alexander Van De Bruaene","doi":"10.15420/usc.2022.02","DOIUrl":"10.15420/usc.2022.02","url":null,"abstract":"<p><p>Nowadays most patients with a univentricular heart after Fontan repair survive until adulthood. One of the hallmarks of Fontan circulation is permanently elevated central venous pressure, which leads to congestive hepatopathy. Subsequently, liver fibrosis, cirrhosis, or hepatocellular carcinoma may occur, all of them constituting an entity called Fontan-associated liver disease (FALD). Given that these complications convey poor prognosis, the need for life-long hepatic surveillance is not in doubt. Many serum biomarkers and sophisticated imaging techniques have been proposed to avoid invasive liver biopsy in this cohort, but none proved to be a relevant surrogate of liver fibrosis seen in histopathological specimens. The surveillance models proposed to date require an extensive diagnostic work-up, which can be problematic, particularly in resource-depleted countries. Moreover, the question of combined heart-liver transplant is gaining more attention in the Fontan cohort. The aim of this study is to provide practical information on the pathophysiology of FALD and to propose a simplified framework for the routine assessment of liver status in Fontan patients that would be helpful in the decision-making process.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e25"},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48785665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US Cardiology ReviewPub Date : 2022-11-18eCollection Date: 2022-01-01DOI: 10.15420/usc.2022.11
Vikram Sharma, Arpit Sothwal, Jai Parekh, Sidakpal Panaich
{"title":"Advanced Steering Maneuvers for Special Situations in Mitral Valve Transcatheter Edge-to-edge Repair.","authors":"Vikram Sharma, Arpit Sothwal, Jai Parekh, Sidakpal Panaich","doi":"10.15420/usc.2022.11","DOIUrl":"10.15420/usc.2022.11","url":null,"abstract":"<p><p>The use of transcatheter percutaneous edge-to-edge mitral valve repair with the MitraClip (Abbott) for the treatment of mitral regurgitation has rapidly expanded since it received Food and Drug Administration approval. Currently, patients with more complex mitral valve anatomies are undergoing this procedure with progressively improving clinical outcomes. This review focuses on the advanced steering maneuvers needed for the technical success of the MitraClip procedure and discusses several scenarios where such advanced steering maneuvers may be needed. These include an anterior transseptal puncture, low or high transseptal puncture with unfavorable transseptal height to mitral valve, large gap height, patients with mitral regurgitation due to dehiscence of a prior mitral valve annuloplasty ring, placing multiple/adjacent MitraClips, or redo edge-to-edge mitral valve repair. Knowledge and mastery of such advanced steering maneuvering techniques can allow operators to complete the procedure successfully with low rate of complications even in difficult scenarios.</p>","PeriodicalId":37809,"journal":{"name":"US Cardiology Review","volume":" ","pages":"e24"},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45320880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}