Human Microbiome Journal最新文献_第4页

Current and future targets for faecal microbiota transplantation 粪便微生物群移植的当前和未来目标

Human Microbiome Journal Pub Date : 2019-03-01 DOI: 10.1016/j.humic.2018.08.004

James Roger Mcilroy , Jonathan P. Segal , Benjamin H. Mullish , Mohammed Nabil Quraishi , Antonio Gasbarrini , Giovanni Cammarota , Gianluca Ianiro

{"title":"Current and future targets for faecal microbiota transplantation","authors":"James Roger Mcilroy , Jonathan P. Segal , Benjamin H. Mullish , Mohammed Nabil Quraishi , Antonio Gasbarrini , Giovanni Cammarota , Gianluca Ianiro","doi":"10.1016/j.humic.2018.08.004","DOIUrl":"10.1016/j.humic.2018.08.004","url":null,"abstract":"<div><p>The human gastrointestinal tract is home to the most diverse microbial ecosystem in the human body and is made up of bacteria, viruses and eukarya. Collectively known as the gut microbiota, our knowledge of these microbial communities has historically been restricted by the relative limitations of culturing techniques. However, the recent development and utilisation of next-generation sequencing techniques has enhanced our understanding of its structure, diversity and function.</p><p>There is emerging evidence that the gut microbiota plays a pivotal role in both health and disease. Perturbations to the structure and function of the gut microbiota are known to be associated with certain disease states. Therefore, manipulating the gut microbiota in an attempt to restore structure and function represents a promising therapeutic strategy. Recently, there has been a surge in clinical and scientific interest in manipulating the gut microbiota using a method called faecal microbiota transplantation. This increase in interest has gathered after it was shown in randomised controlled trials to be highly effective in treating recurrent <em>Clostridium difficile</em> infection.</p><p>Despite success in treating recurrent <em>Clostridium difficile,</em> there remain many unknowns about how best to optimise its preparation, regulation, mode of delivery and safety. This review aims to summarise the literature surrounding the current knowledge regarding faecal microbiota transplantation and explore potential future research avenues that aim to enhance the safety, efficacy and utilisation of faecal microbiota transplantation.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"11 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Association of gut dysbiosis with intestinal metabolites in response to antibiotic treatment 肠道生态失调与肠道代谢物对抗生素治疗反应的关联

Human Microbiome Journal Pub Date : 2019-03-01 DOI: 10.1016/j.humic.2018.11.004

Tariq Jamal Khan , Mohammed Nihal Hasan , Esam I. Azhar , Muhammad Yasir

{"title":"Association of gut dysbiosis with intestinal metabolites in response to antibiotic treatment","authors":"Tariq Jamal Khan , Mohammed Nihal Hasan , Esam I. Azhar , Muhammad Yasir","doi":"10.1016/j.humic.2018.11.004","DOIUrl":"10.1016/j.humic.2018.11.004","url":null,"abstract":"<div><p>Gut microbiota (GM) is associated with metabolism, provides energy-harvesting efficiency and protection against opportunistic pathogens through competitive exclusion to the host. Previous studies highlighted the temporary as well as permanent alteration to GM resulting from different antibiotics treatment. The diverse class of antibiotics may damage the metabolic homeostasis and can alter the level of intestinal metabolites [including amino acids, bile acids (BAs), glucose, short chain fatty acids (SCFAs)] through alteration in abundance of metabolically active bacteria. The antibiotics administration causes the disturbed profile of related microbial metabolites, especially that of BAs, primary and secondary BAs (conjugated or unconjugated BAs). The antibiotics intake causes the reduced bacterial diversity that makes the individuals susceptible towards diseases. To a large extent, we tried to clarify the adverse effects of classes of antibiotics on the GM composition, and the consequent impacts of dysbiosis on the BAs feedback loop between liver and gut, which involves the farnesoid-X-receptor-fibroblast growth factor (FXR-FGF) pathway. The current review discusses the antibiotics-GM-BAs nexus during <em>Clostridium difficile</em> infection (CDI) and the recommended therapy includes faecal microbial transplant (FMT) in countering the exposure of harmful antibiotic and bacteriotherapy as an alternative therapeutic intervention in treating the recurrent CDI.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"11 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45166471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Exhaustive repertoire of human vaginal microbiota 人类阴道微生物群的详尽曲目

Human Microbiome Journal Pub Date : 2019-03-01 DOI: 10.1016/j.humic.2018.11.002

Khoudia Diop , Jean-Charles Dufour , Anthony Levasseur , Florence Fenollar

{"title":"Exhaustive repertoire of human vaginal microbiota","authors":"Khoudia Diop , Jean-Charles Dufour , Anthony Levasseur , Florence Fenollar","doi":"10.1016/j.humic.2018.11.002","DOIUrl":"10.1016/j.humic.2018.11.002","url":null,"abstract":"<div><p>Bacteria that colonize the vaginal microbiota of women play an important role in health and homeostasis. Disruption of the proportion of bacteria predisposes to dysbiosis like bacterial vaginosis or severe gynecological conditions such as preterm birth, pelvic inflammatory disease and also sexually transmitted diseases. Knowledge about normal and abnormal vaginal microbiota has become a little clearer in recent years. Culture techniques have made it possible to isolate and describe many bacterial species, whereas molecular methods have highlighted the limits of culture by showing that the vagina was a complex ecosystem containing a wide range of non-cultured or difficult-to-identify bacteria. Based on an exhaustive review of the scientific literature, we built the repertoire of all the bacteria found using culture-based and/or independent methods on the human vagina. So, whether they are valid or not, we inventoried 581 bacteria identified in the human vagina distributed into 10 taxa, mainly in the phyla of <em>Actinobacteria</em>, <em>Bacteroidetes</em>, <em>Firmicutes</em>, and <em>Proteobacteria</em> with 206 distinct genera classified in 96 different families. This repertoire is essential for microbiologists and clinicians and represents the starting point for a Vaginal Microbiome Project such a project aimed to map the human vaginal microbiota, to better understand the dysbioses or infections caused by its imbalance in order to offer more appropriate treatments.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"11 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43249064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

Increasing and eliminating the (Fecal coliforms, thermotolerant coliform and fecal streptococcus) bacteria by resin of the poly (para carboxy acid phenol-d-Glucose) to clean up waste water 利用聚对羧酸苯酚-葡萄糖树脂净化废水，增加和消除粪便大肠菌群、耐热大肠菌群和粪便链球菌

Human Microbiome Journal Pub Date : 2019-03-01 DOI: 10.1016/j.humic.2018.11.003

Safia Miloudi , Messaoud Chaib , Moulkheir Ayat , Abdelkader Rahmouni

{"title":"Increasing and eliminating the (Fecal coliforms, thermotolerant coliform and fecal streptococcus) bacteria by resin of the poly (para carboxy acid phenol-d-Glucose) to clean up waste water","authors":"Safia Miloudi , Messaoud Chaib , Moulkheir Ayat , Abdelkader Rahmouni","doi":"10.1016/j.humic.2018.11.003","DOIUrl":"10.1016/j.humic.2018.11.003","url":null,"abstract":"<div><p>In this research paper we represent a novel synthetic antibacterial phenolic polymer (pAP-DG) containing carboxylic acid group in para position. The study of poly (p-carboxylic acid phenol <span>d</span>-Glucose) as an antibacterial resin was focused on the development of antimicrobial polymers to clean up the water of pathogenic bacteria. The polycondensation reaction was realized between p-carboxy acid phenol (pAP) and <span>d</span>-Glucose (DG) as monomers; using sulfuric acid as homogeneous catalyst.</p><p>The obtained polymer was used via <em>fecal coliform</em> (TC), <em>thermotolerant coliforms</em> (CTT) and <em>fecal streptococci</em> (ST) bacteria to evaluate the water quality. The antibacterial activity of the synthesized resin was carried out by the contact method so the capacity of this resin was confirmed. In general, the polymer has a good antimicrobial activity against the microorganisms tested; the resulting polymer was characterized by various spectroscopy methods such as: <sup>1</sup>H NMR, <sup>13</sup>C NMR, DSC and FTIR and a mechanism has been proposed for this polycondensation reaction.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"11 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48143019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel targets to develop new antibacterial agents and novel alternatives to antibacterial agents 开发新的抗菌剂和新的抗菌剂替代品的新靶点

Human Microbiome Journal Pub Date : 2019-03-01 DOI: 10.1016/j.humic.2019.01.001

Tafere Mulaw Belete

{"title":"Novel targets to develop new antibacterial agents and novel alternatives to antibacterial agents","authors":"Tafere Mulaw Belete","doi":"10.1016/j.humic.2019.01.001","DOIUrl":"10.1016/j.humic.2019.01.001","url":null,"abstract":"<div><p>Antibacterial agents have saved many lives and helped the growth of modern medicine over the past half century. The emergence of drug resistance, jeopardizing the effectiveness of these life-saving treatments. This clearly highlights the urgent need for new and improved antibacterial drugs with a novel target and new molecular structure agent to obviate cross-resistance. This paper reviewed the possible new ways to discover novel antibacterial agents. The most widely studied new bacterial targets for novel drug development are quorum sensor biosynthesis, bacterial virulence factor, bacteria cell division machinery, Bacterial cell wall synthesis, PDF inhibitor, isoprenoid biosynthesis, shikimate synthesis pathway, biofilm synthesis and fatty acid biosynthesis. These new discovery routes have given rise to agents that are in preclinical trials. This review also discusses the alternatives approaches that act <em>bacteria</em> or any approaches that target the host. The most advanced approaches that are on clinical development are phages and other approaches that are on preclinical development are antimicrobial peptides. These alternatives ways may use as adjunctive therapies, which suggest that conventional antibacterial agents are still essential.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"11 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2019.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47988710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

Tetracycline-like resistome of ancient human guts 古代人类肠道中类似四环素的抵抗组

Human Microbiome Journal Pub Date : 2018-12-01 DOI: 10.1016/j.humic.2018.07.001

Tasha M. Santiago-Rodriguez , Gino Fornaciari , Stefania Luciani , Gary A. Toranzos , Isolina Marota , Valentina Giuffra , Naseer Sangwan , Raul J. Cano

引用次数: 4

New microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tract 上消化道手术中断后患者粪便群落中新的微生物基因组变异

Human Microbiome Journal Pub Date : 2018-12-01 DOI: 10.1016/j.humic.2018.10.002

Ranjit Kumar , Jayleen Grams , Daniel I. Chu , David K. Crossman , Richard Stahl , Peter Eipers , Kelly Goldsmith , Michael Crowley , Elliot J. Lefkowitz , Casey D. Morrow

{"title":"New microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tract","authors":"Ranjit Kumar , Jayleen Grams , Daniel I. Chu , David K. Crossman , Richard Stahl , Peter Eipers , Kelly Goldsmith , Michael Crowley , Elliot J. Lefkowitz , Casey D. Morrow","doi":"10.1016/j.humic.2018.10.002","DOIUrl":"10.1016/j.humic.2018.10.002","url":null,"abstract":"<div><p>Recent studies have shown that microbe strains in normal individuals fecal microbe community are relatively stable over time. Given the role the gut microbe community plays in human health, it is important to understand if disruption of the gastrointestinal tract environment results in emergence of new genomic variants. To address this, we have used a new technique called Window-based single nucleotide similarity (WSS) to analyze the impact of several surgical procedures of the human gastrointestinal tract on the stability of the fecal microbes. Previously, we established a WSS boundary score cutoff to determine if microbe genomic variants were similar. Based on analysis of normal individuals from the Human Microbiome Project, 93% of microbes in paired fecal samples up to 1 year apart were above the cutoff, indicating similar (stable) microbes. For the current study, we analyzed fecal samples from 18 patients undergoing Roux-en-Y gastric bypass (RYGB) or 6 patients undergoing gastric sleeve for extreme obesity. From comparison of the pre-RYGB versus 1–2 year post RYGB samples from the same patients, 65% of the WSS were above the boundary cutoff, while for pre versus 1–2 year samples post surgery for patients undergoing sleeve gastrectomy, 75% of the WSS were above the cutoff. In contrast, analysis of fecal samples from 5 patients pre and post removal of segments of the sigmoid colon revealed that 97% of WSS scores were above the cutoff. Our study establishes emergence of new microbe genomic variants in the fecal community following alteration of the upper gastrointestinal environment.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"10 ","pages":"Pages 37-42"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43098367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Microbiome and the immune system: From a healthy steady-state to allergy associated disruption 微生物组和免疫系统:从健康的稳定状态到过敏相关的破坏

Human Microbiome Journal Pub Date : 2018-12-01 DOI: 10.1016/j.humic.2018.10.001

Soraya Mezouar , Yannick Chantran , Justin Michel , Alexandre Fabre , Jean-Christophe Dubus , Marc Leone , Youssouf Sereme , Jean-Louis Mège , Stéphane Ranque , Benoît Desnues , Pascal Chanez , Joana Vitte

{"title":"Microbiome and the immune system: From a healthy steady-state to allergy associated disruption","authors":"Soraya Mezouar , Yannick Chantran , Justin Michel , Alexandre Fabre , Jean-Christophe Dubus , Marc Leone , Youssouf Sereme , Jean-Louis Mège , Stéphane Ranque , Benoît Desnues , Pascal Chanez , Joana Vitte","doi":"10.1016/j.humic.2018.10.001","DOIUrl":"10.1016/j.humic.2018.10.001","url":null,"abstract":"<div><p>Microbiome and the immune system are constantly shaping each other, in a mutual aim to thrive, defining the unstable equilibrium of the healthy individual. Microbiome is growingly involved in dysimmune conditions such as allergy, asthma, autoimmunity, and primary or acquired immune deficiencies. The current epidemics of allergic diseases and asthma has long been linked to the microbial environment through the hygiene hypothesis. Progress in the understanding of the microbiome-immune system crosstalk has unraveled a tight connection between microbial communities and the development of allergic diseases and asthma. Disruption of the microbiome affects the immune response of the host and paves the way for disease pathogenesis. Conversely, disease and therapeutic interventions affect microbial communities. We aimed at providing the reader with a view of the state-of-the art of microbiome – immune system crosstalk, with special focus on the loopholes giving potential grip to the pathogenesis of microbiome-related dysimmunity.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"10 ","pages":"Pages 11-20"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46503319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Potential clinical usefulness of gut microbiome testing in a variety of clinical conditions 肠道微生物组检测在多种临床条件下的潜在临床用途

Human Microbiome Journal Pub Date : 2018-12-01 DOI: 10.1016/j.humic.2018.08.003

Karl J. Morten , Eleonora Staines-Urias , Julian Kenyon

引用次数: 2

Comparative therapeutic efficacy study of Lactobacilli probiotics and citalopram in treatment of acute stress-induced depression in lab murine models 乳酸杆菌益生菌与西酞普兰治疗小鼠急性应激性抑郁症的疗效比较研究

Human Microbiome Journal Pub Date : 2018-12-01 DOI: 10.1016/j.humic.2018.08.001

Abdalla M. Abdrabou, Enass Y. Osman, Osama A. Aboubakr

{"title":"Comparative therapeutic efficacy study of Lactobacilli probiotics and citalopram in treatment of acute stress-induced depression in lab murine models","authors":"Abdalla M. Abdrabou, Enass Y. Osman, Osama A. Aboubakr","doi":"10.1016/j.humic.2018.08.001","DOIUrl":"10.1016/j.humic.2018.08.001","url":null,"abstract":"<div><p>A relationship between Microbiome and its effect on depression has been suspected in earlier studies. Here we examined whether the addition of Lactobacillus probiotics which flourishes the gut-microbiota will have a beneficial adjuvant therapeutic effect on treatment of depression or even considering it as a main treatment line in the future for treatment of depression or anxiety like behavior after further studies. Mice receiving probiotics in their diet exhibited mostly similar anxiolytic and anti-depressive effects of the mice that received SSRI anti-depressant citalopram and displayed enhanced outcomes which were shown in the Tail Suspension test – which is considered a high output tool in assessing anti-depression medications –, Super oxidase dismutase concentration in the brain tissue and HPLC analysis of Kynurenine biomarker in the brain. Taken together these data support the link between healthy gut microbiome and its effect on depression-like behavior and suggest that probiotics may even have a similar therapeutic effect of anti- depressants in treatment of depression.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":"10 ","pages":"Pages 33-36"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2018.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41639885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11