Transplantation Reports最新文献

Effect of tacrolimus formulation on neurocognition in older kidney transplant recipients: A randomized controlled trial 他克莫司制剂对老年肾移植受者神经认知的影响：一项随机对照试验

Transplantation Reports Pub Date : 2025-05-31 DOI: 10.1016/j.tpr.2025.100178

Hadia Lala Gul , Macey Sockolov , Katherine Howes , Amanpreet Kaur , Michelle Occhipinti , Heejung Bang , Muna Alnimri , Yihung Huang , Joy Dray , Ling-Xin Chen

{"title":"Effect of tacrolimus formulation on neurocognition in older kidney transplant recipients: A randomized controlled trial","authors":"Hadia Lala Gul , Macey Sockolov , Katherine Howes , Amanpreet Kaur , Michelle Occhipinti , Heejung Bang , Muna Alnimri , Yihung Huang , Joy Dray , Ling-Xin Chen","doi":"10.1016/j.tpr.2025.100178","DOIUrl":"10.1016/j.tpr.2025.100178","url":null,"abstract":"<div><h3>Background</h3><div>Tacrolimus is known to cause neurotoxicities that may be more severe in older individuals. We aimed to compare the neurocognitive side effects of immediate release (IR) and LCP tacrolimus in older kidney transplant recipients in the early post-transplant period.</div></div><div><h3>Methods</h3><div>In this single center, open-label, randomized and controlled trial of 64 kidney transplant recipients aged 60 or above, participants were randomized to LCP tacrolimus or IR tacrolimus between 4- and 8-weeks post-transplantation and followed for 6-weeks. The primary outcome of neurocognitive performance at 6-weeks compared with baseline was assessed by the Montreal Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSST). Secondary outcomes included health-related quality of life as measured by the Quality of Life in Essential Tremor Questionnaire (QUEST) and Organ Transplant Symptom and Wellbeing Instrument (OTSWI).</div></div><div><h3>Results</h3><div>32 patients were randomized to IR tacrolimus and 31 to LCP tacrolimus. In the IR tacrolimus arm, the MOCA score increased by 1.2 points (SD 2.1) and the DSST score increased by 1.0 points (SD 7.8). In the LCP tacrolimus arm, the MOCA score increased by 0.2 points (SD 2.9) and the DSST score increased by 1.3 points (SD 7.5). No statistically significant difference was detected between arms in MOCA, DSST, QUEST or OTSWI scores. There was a trend toward improvement in tremor severity in the LCP tacrolimus arm.</div></div><div><h3>Conclusions</h3><div>No improvement was found in MoCA or DSST performance in patients switched to LCP tacrolimus as compared to IR tacrolimus after 6 weeks of exposure in the early post-transplant period.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 3","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging technologies in corneal transplantation: innovations, challenges, and global implications 角膜移植的新兴技术：创新、挑战和全球影响

Transplantation Reports Pub Date : 2025-05-31 DOI: 10.1016/j.tpr.2025.100180

Khayry Al-Shami , Salman Almurabi , Andreea Pop , Clara Vincent , Aniela Popescu , Iulia Cezara Pop , Noor S. Bader , Hala Faour , Rahaf Barhoush , Saja Karaja

{"title":"Emerging technologies in corneal transplantation: innovations, challenges, and global implications","authors":"Khayry Al-Shami , Salman Almurabi , Andreea Pop , Clara Vincent , Aniela Popescu , Iulia Cezara Pop , Noor S. Bader , Hala Faour , Rahaf Barhoush , Saja Karaja","doi":"10.1016/j.tpr.2025.100180","DOIUrl":"10.1016/j.tpr.2025.100180","url":null,"abstract":"<div><div>Precision, reduction of rejection rates, and reduction of dependency on long-term immune suppression are being advanced by advancements in corneal transplantation (CT) using femtosecond laser-assisted keratoplasty (FLAK), Descemet membrane endothelial keratoplasty (DMEK), and Bowman layer transplantation (BLT). Also, technologies such as bioengineered tissues, CRISPR-Cas9 gene editing, and bioadhesives seek to enhance graft integration and survival in mechanisms to supply a global shortage of donor corneas, particularly in low-income countries with the greatest demand. Despite this, bioengineered corneas represent an alternative to traditional transplants that incur ethical and practical hurdles, including regulation, cost, and biases in resource allocation. The application of artificial intelligence (AI), in particular diagnosis and surgical planning, in ophthalmology in general, and especially in corneal disease management, has great promise. However, the 'black box' decision-making of AI, its biases, and lack of transparency could be barriers to accountability and consistent use in practice. The other obstacle is the high costs that discourage access to and availability of advanced technologies for many low- and middle-income countries (LMICs), whose healthcare infrastructures are also limited. To ensure these innovations can be integrated into mainstream corneal care, particularly serving the needs of underserved populations, we need to address these technological, economic, and ethical issues. However, these technologies require more clinical trials and policy considerations for their optimization for accessible, effective, global eye care.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 3","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voriconazole-induced Periostitis Following Lung Transplantation: Case Series 肺移植后伏立康唑引起的骨膜炎：病例系列

Transplantation Reports Pub Date : 2025-05-31 DOI: 10.1016/j.tpr.2025.100179

Gouji Toyokawa , Miho Yamaguchi , Takafumi Yamaya , Mitsuaki Kawashima , Chihiro Konoeda , Koh Okamoto , Masaaki Sato

引用次数: 0

Xenotransplantation: The next quarter century 异种移植：下一个四分之一个世纪

Transplantation Reports Pub Date : 2025-03-17 DOI: 10.1016/j.tpr.2025.100177

A. Joseph Tector , Matt Tector , Rodrigo Vianna , Andrew Adams

{"title":"Xenotransplantation: The next quarter century","authors":"A. Joseph Tector , Matt Tector , Rodrigo Vianna , Andrew Adams","doi":"10.1016/j.tpr.2025.100177","DOIUrl":"10.1016/j.tpr.2025.100177","url":null,"abstract":"<div><div>Transplantation has become a preferred therapy for the treatment of end stage organ failure, improving the quality and duration of recipients lives. The major limitation of organ transplantation is the shortage of suitable donor organs available for clinical use. Xenotransplantation using genetically modified pig organs could provide an unlimited source of organs, allowing all patients in need to receive a transplant in a timely fashion. Xenotransplantation was limited to the experimental realm because of the presence of anti-pig antibodies that are present in the blood of every human (1, 2).</div><div>The development of genetic engineering tools, especially CRISPR/Cas9 and somatic cell nuclear transfer made it possible to create pigs missing key glycan pig antigens so that the antibodies did not bind to the new pig (3-5). Preclinical results using kidneys from new donor pigs has improved to the point where nonhuman primate recipients are living for more than 4 years (Andrew Adams personal communication). The improvements in survival seen in preclinical models has led to clinical attempts at heart and kidney xenotransplantation (6, 7). Thus far in the first 5 clinical xenotransplant cases success has been modest, with only one graft (kidney) functioning past 60 days to date. The other patients receiving pig xenografts (2 hearts and 2 kidneys) succumbed to early antibody mediated rejection (AMR) (7-9). Nevertheless, the developments in preclinical and compassionate use xenotransplantation have resulted in the first FDA approved clinical trial with renal xenotransplantation. This article will deal with the issues that are likely to be the focus of the next 25 years with regards to development of clinical xenotransplantation.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 2","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Ischemia-reperfusion injury in liver transplant rejuvenation 肝移植返老还童中的靶向缺血再灌注损伤

Transplantation Reports Pub Date : 2025-02-26 DOI: 10.1016/j.tpr.2025.100176

Kenneth J. Dery, Fady Kaldas, Jerzy W. Kupiec-Weglinski

{"title":"Targeting Ischemia-reperfusion injury in liver transplant rejuvenation","authors":"Kenneth J. Dery, Fady Kaldas, Jerzy W. Kupiec-Weglinski","doi":"10.1016/j.tpr.2025.100176","DOIUrl":"10.1016/j.tpr.2025.100176","url":null,"abstract":"<div><h3>Background</h3><div>Hepatic ischemia-reperfusion injury (HIRI) is a multifaceted pathophysiological process involving a cascade of interconnected cellular events. The initial ischemic stress, followed by the reestablishment of blood circulation to the liver, triggers a feed-forward innate immune-driven response that exacerbates the hepatocellular injury. HIRI poses a significant clinical challenge in liver transplantation (LT), as it can result in tissue damage, organ dysfunction, and poor clinical outcomes.</div></div><div><h3>Methods and results</h3><div>This review highlights current key issues in HIRI translational research, as revealed by recent bibliometric studies. It examines the mechanisms that facilitate homeostatic regulation after HIRI. Additionally, it addresses refined pharmacological strategies aimed at mitigating oxidative stress and inflammation. Hot topic areas in HIRI research include autophagy, donation after circulatory death, and NLRP3-dependent inflammasome activation following LT. New pharmacological agents, such as anti-oxidative compounds, metabolic modulators, and plant-derived compounds, are being explored to influence inflammatory responses. There is a strong clinical emphasis on broadening the donor pool by utilizing marginal donor grafts and advanced machine perfusion techniques. Enhancing translational research through the development of human-relevant organoids or ex vivo liver perfusion systems is essential for connecting laboratory discoveries with clinical practices in life-saving surgical procedures.</div></div><div><h3>Conclusion</h3><div>A comprehensive approach that emphasizes the regulatory mechanisms of cellular responses to oxygen stress and immune cell activation, alongside innovative donor organ preservation, like machine perfusion, will shape the future direction of HIRI research by enhancing graft viability and revitalizing suboptimal donor organs.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 2","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing drug-drug interactions of Tacrolimus with Fluconazole and/or Verapamil and developing the predictive model for Tacrolimus concentrations in kidney transplant recipients 评估他克莫司与氟康唑和/或维拉帕米的药物相互作用，并建立肾移植受者他克莫司浓度的预测模型

Transplantation Reports Pub Date : 2025-02-24 DOI: 10.1016/j.tpr.2025.100175

Mingkwan Na Takuathung , Kajohnsak Noppakun , Chotiwit Sakuludomkan , Nahathai Dukaew , Nuttapong Chailungkar , Naruemon Suyayai , Nut Koonrungsesomboon

{"title":"Assessing drug-drug interactions of Tacrolimus with Fluconazole and/or Verapamil and developing the predictive model for Tacrolimus concentrations in kidney transplant recipients","authors":"Mingkwan Na Takuathung , Kajohnsak Noppakun , Chotiwit Sakuludomkan , Nahathai Dukaew , Nuttapong Chailungkar , Naruemon Suyayai , Nut Koonrungsesomboon","doi":"10.1016/j.tpr.2025.100175","DOIUrl":"10.1016/j.tpr.2025.100175","url":null,"abstract":"<div><div>Maintaining optimal tacrolimus serum concentrations is crucial for kidney transplant recipients due to its narrow therapeutic window and pharmacokinetic variability. The use of CYP3A4/5 inhibitors, such as fluconazole and verapamil, can increase tacrolimus serum concentrations. Understanding these interactions is vital for predicting and optimizing tacrolimus levels. This study aimed to investigate the impact of co-administering fluconazole, verapamil, or their combination on tacrolimus concentration/dose (C/D) in kidney transplant recipients and develop a predictive model for these scenarios. This retrospective study involved kidney transplant recipients treated with tacrolimus and co-administered fluconazole and/or verapamil. The Generalized Estimating Equations (GEE) approach was used to explore predictive variables associated with tacrolimus C/D. A total of 177 kidney transplant recipients were included. Repeated measure correlation analysis revealed positive correlations between tacrolimus C/D and dosages of fluconazole (<em>b</em> = 0.37, 95 % CI = 0.29 to 0.45, <em>p</em> < 0.001) and verapamil (<em>b</em> = 0.15, 95 % CI = 0.07 to 0.23, <em>p</em> < 0.001). This study offers a predictive model for optimizing tacrolimus levels when fluconazole and/or verapamil are co-administered in kidney transplant recipients.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 2","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 vaccine evaluation among solid organ transplant recipients at a single academic center 单一学术中心实体器官移植受者COVID-19疫苗评估

Transplantation Reports Pub Date : 2025-02-21 DOI: 10.1016/j.tpr.2025.100174

Kristen Lay , Marina Feffer , David Slade , Fritzie S. Albarillo

{"title":"COVID-19 vaccine evaluation among solid organ transplant recipients at a single academic center","authors":"Kristen Lay , Marina Feffer , David Slade , Fritzie S. Albarillo","doi":"10.1016/j.tpr.2025.100174","DOIUrl":"10.1016/j.tpr.2025.100174","url":null,"abstract":"<div><h3>Background</h3><div>Solid organ transplant recipients (SOTRs) may have a higher risk of serious disease and death due to COVID-19. It is necessary to determine the main motivators and demotivators for SOTRs to receive COVID-19 vaccinations to improve patient education.</div></div><div><h3>Methods</h3><div>A voluntary and anonymous survey was created using questions adopted from the Center for Disease Control COVID-19 Vaccine Confidence: Rapid Community Assessment. Questions included demographics, vaccination status and opinions in multiple choice and free response format. The survey was distributed in July 2023 and was open for one month.</div></div><div><h3>Results</h3><div>A total of 127 SOTRs responded which included patients 18 years and older who received one of the following transplants: heart (12.6 %), lung(s) (37.01 %), liver (31.5 %), kidney (11.81 %), and liver and kidney (7.09 %). The overwhelming majority of respondents received a primary vaccination series (97.64 %). Among the vaccinated, 68.55 % received a bivalent booster vaccination and 32.28 % have received a second booster vaccination. The greatest motivating factors among vaccinated were “protecting my health” (84.68 %) “protecting the health of family and friends” (66.13 %), and “to protect the health of the community” (36.29 %). Only 3 SOTRs were unvaccinated, all of whom reported that they felt the vaccine was unsafe.</div></div><div><h3>Conclusion</h3><div>While the overwhelming majority of SOTRs were vaccinated against COVID-19 to protect their health and the health of others, a minority have hesitations about receiving booster vaccinations. Targeting patient education towards these concerns will improve the protection of the SOTR community.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 2","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current state of artificial intelligence in liver transplantation 人工智能在肝移植中的应用现状

Transplantation Reports Pub Date : 2025-02-10 DOI: 10.1016/j.tpr.2025.100173

Ashley E. Montgomery , Abbas Rana

{"title":"Current state of artificial intelligence in liver transplantation","authors":"Ashley E. Montgomery , Abbas Rana","doi":"10.1016/j.tpr.2025.100173","DOIUrl":"10.1016/j.tpr.2025.100173","url":null,"abstract":"<div><div>Over the past few decades, substantial progress has been made in the field of liver transplantation. Yet, challenges remain in the field due to an increasing organ allograft shortage as well as significant waitlist mortality. With these challenges, organ allocation policies have been developed and are constantly being modified to result in more efficient organ allocation. One tool that has been explored to improve the field of liver transplantation is artificial intelligence, which is an umbrella term for techniques such as machine learning and deep learning. This review article explores the use of artificial intelligence in the field of liver transplantation. Specifically, studies have shown potential applications of artificial intelligence in improving waitlist mortality models, assessing allograft characteristics, using large language models for research question development and patient education, developing post-transplant models, as well as predicting multiple risk factors such as cardiovascular disease, infection, graft failure, malignancy, graft fibrosis, and pneumonia. However, even with these studies, several limitations for the use of artificial intelligence exist such as biased data sets leading to biased model development, lack of extensive validation of the artificial intelligence models, and the need for large datasets for model development. With additional studies evaluating the use of artificial intelligence and wide-scale validation of these studies highlighted, the use of artificial intelligence may transform the field of transplantation in the future.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 2","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-target combination of antibiotics as salvage therapy for severe infection caused by pan-resistant Burkholderia cenocepacia following lung transplantation 多靶点联合抗生素抢救治疗肺移植术后广泛耐药结核杆菌严重感染

Transplantation Reports Pub Date : 2025-02-01 DOI: 10.1016/j.tpr.2024.100170

Nadim Cassir , Benjamin Coiffard , Linda Hadjadj , Julien Bermudez , Liliane Okdah , Lucile Ailhaud , Sophie Alexandra Baron , Martine Reynaud-Gaubert , Xavier Benoit D'Journo , Sami Hraiech , Jean-Marc Rolain

{"title":"Multi-target combination of antibiotics as salvage therapy for severe infection caused by pan-resistant Burkholderia cenocepacia following lung transplantation","authors":"Nadim Cassir , Benjamin Coiffard , Linda Hadjadj , Julien Bermudez , Liliane Okdah , Lucile Ailhaud , Sophie Alexandra Baron , Martine Reynaud-Gaubert , Xavier Benoit D'Journo , Sami Hraiech , Jean-Marc Rolain","doi":"10.1016/j.tpr.2024.100170","DOIUrl":"10.1016/j.tpr.2024.100170","url":null,"abstract":"<div><div><em>Burkholderia cepacia</em> complex (Bcc) is an important group of opportunistic pathogens most frequently affecting patients with cystic fibrosis and responsible for life-threatening infections. Therapeutic options are limited owing to high levels of resistance of the organism, either intrinsic or acquired, to many antimicrobial agents. We describe here the successful treatment of a patient with cystic fibrosis who developed post-transplant lung abscesses and sternal osteitis caused by pan-resistant <em>Burkholderia cenocepacia.</em> He was treated with a combination of ceftazidime-avibactam, ciprofloxacin, meropenem, minocycline, sulfadiazine, and tobramycin. Repurposing multitarget drugs including old and new antibiotics, and their combinations with synergistic effects is a promising strategy to overcome clinical therapeutic impasses with difficult-to-treat-resistance (DTR) bacteria.</div></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":"10 1","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergent management of severe post-TIPS bleed in patient with end-stage liver disease and coronary artery disease 终末期肝病和冠状动脉疾病患者tips术后严重出血的紧急处理

Transplantation Reports Pub Date : 2025-02-01 DOI: 10.1016/j.tpr.2024.100168

Mohammad Arammash , Barbara Hamilton , Charles Rickert

引用次数: 0