Transplantation Reports最新文献

{"title":"Lymphocytes cross-matching as retrospective tool for hyper-acute rejection diagnosis in heart transplantation.","authors":"Tomasz Urbanowicz ,&nbsp;Dominika Konecka-Mrówka ,&nbsp;Jerzy Nożyński ,&nbsp;Marek Jemielity","doi":"10.1016/j.tpr.2020.100055","DOIUrl":"10.1016/j.tpr.2020.100055","url":null,"abstract":"<div><h3>Background</h3><p>Lymphocyte cross-matching (CDC) is considered as important screening test that is unfrequently performed preoperatively in heart transplantation procedures. This test is desired to identify the risk for hyper-acute rejection in immediate postoperative period.</p></div><div><h3>Patient and method</h3><p>There were 57 patients (51 men and 6 women) in mean age of 44 +/- 14 between 2010 and 2019 screened for CDC tests. All patients were low risk for rejection including negative panel reactive antibody preoperative test. Preoperative donor's blood samples and lymph nodes were obtained during retrieval. Recipients blood samples were collected before surgery. CDC test were obtained retrospectively. Endomyocardial biopsies including immunopathological staining were performed on 6th and 14th postoperative day.</p></div><div><h3>Results</h3><p>The results obtained from cross-match test revealed 4 patients with lymphocytic T and B incompatibility (positive for cellular and humoral hyper-acute rejection) and 3 more for Lymphocytes B hyper-acute rejection (humoral rejection). All patients were hemodynamically stable. Successful therapy including high doses of polyvalent immunoglobulins and steroids parenteral infusions were proven by endomyocardial biopsies samples.</p></div><div><h3>Conclusion</h3><p>The lymphocytic cross-match testing is useful as postoperative examination. It help to find high risk patients for hyper-acute rejection. It allows for introduction immediate immunosuppressive therapeutic adjustment.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45317772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of National Medical Center of Specialties “La Raza” in the endoscopical management of bile duct complications after liver transplantation","authors":"Lorena Noriega-Salas ,&nbsp;José Cruz Santiago ,&nbsp;Germán Bernáldez-Gómez ,&nbsp;Arlette Robledo-Meléndez ,&nbsp;Guillermo Meza-Jiménez ,&nbsp;Claudia Hernández","doi":"10.1016/j.tpr.2020.100058","DOIUrl":"10.1016/j.tpr.2020.100058","url":null,"abstract":"<div><h3>Introduction</h3><p>Liver transplantation is a standardized treatment for the management of chronic liver failure, as well as, in selected cases of unresectable tumors and acute liver failure. Transplant programs show improvements that impact in the whole survival, however, bile duct complications remain the main cause of morbidity and mortality in transplant programs worldwide.</p></div><div><h3>Material and methods</h3><p>For statistical purposes, the liver transplant program activity has been divided into 2 Phases, the first one from 2009 to 2017 and the second from 2018 to the present. The files of patients with at least 6 months of follow-up were included.</p></div><div><h3>Results</h3><p>Throughout the program there is a record of 22 transplants, according to the division mentioned in two Phases, with a total of 9 transplants in 9 years in Phase 1 and 12 transplants in 2 years in Phase 2. With 33% (3) of complications for Phase 1 and 25% (3) for Phase 2.In all patients the management was endoscopic.</p></div><div><h3>Conclusions</h3><p>Bile duct complications are associated with identifiable risk factors, however, the patient's evolution is multifactorial. Both the decrease in the frequency of complications and the effectiveness in their management show improvement according to the establishment of the multidisciplinary team of Liver Transplantation.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45701693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living donor liver transplantation for more than 30-year survived patients with native liver after Kasai operation for biliary atresia","authors":"Takashi Kobayashi ,&nbsp;Kohei Miura ,&nbsp;Masayuki Kubota ,&nbsp;Yoshiaki Kinoshita ,&nbsp;Jun Sakata ,&nbsp;Kazuyasu Takizawa ,&nbsp;Tomohiro Katada ,&nbsp;Yuki Hirose ,&nbsp;Kizuki Yuza ,&nbsp;Takuya Ando ,&nbsp;Yohei Miura ,&nbsp;Masayuki Nagahashi ,&nbsp;Hitoshi Kameyama ,&nbsp;Toshifumi Wakai","doi":"10.1016/j.tpr.2020.100052","DOIUrl":"10.1016/j.tpr.2020.100052","url":null,"abstract":"<div><h3>Objectives</h3><p>A number of patients have developed liver failure after the Kasai operation for biliary atresia (BA), even after long-term postoperative course. We report our experience regarding four cases of biliary atresia required and treated with living donor liver transplantation (LDLT) during adulthood.</p></div><div><h3>Methods</h3><p>All four patients underwent Kasai operation for BA from 1974 to 1983 and had been followed-up for more than 30 years in our institute. Then, they developed liver failure and treated with LDLT. These four patients’ records were reviewed retrospectively. All data are described using the median value.</p></div><div><h3>Results</h3><p>Three female and one male were included. Kasai operation was performed at the age of 61 days. The type of biliary obstruction was type III-b1-ν in all. The survival period of the native liver was 440 months. The age at LDLT was 37 years. The reasons of deterioration of native liver were recurrent cholangitis in two and pregnancy and delivery in other two. The age of living donor was 40 years. Right liver grafts were used in all. Percentage of the real graft volume per standard liver volume was 47%. All patients were alive and overall graft survival rate was 100% at a follow-up period of 65 months after LDLT.</p></div><div><h3>Conclusion</h3><p>Even after more than 30 year-survival with native liver after Kasai operation, liver failure may be caused by recurrent cholangitis or pregnancy and delivery. LDLT may be effective treatment for those adult patients if an adequate living donor is available.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46855916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial haemorrhage in kidney, liver and heart recipient patients: A centre experience and literature review","authors":"Serhat Cömert ,&nbsp;Mehmet Nur Altınörs","doi":"10.1016/j.tpr.2020.100041","DOIUrl":"10.1016/j.tpr.2020.100041","url":null,"abstract":"<div><h3>Objectives</h3><p>Major haemorrhagic events, including perplexing condition, intracerebral haemorrhage (ICH) are associated with significant morbidity and mortality. Treatment is planned on individual basis. A major portion of the injurious processes take place during the hours following the development of haematoma.</p><p>Organ transplantation naturally has a critical postoperative period. The complications may involve various systems of the body. We aimed to find out the incidence of haemorrhage into different compartments of the intracranial cavity in liver, kidney and heart recipient patients. We searched for possible mechanisms leading to this situation.</p></div><div><h3>Materials and Methods</h3><p>We retrospectively reviewed the medical files of 2524 patients who underwent either renal, liver or heart transplantations at Ankara Hospital of Başkent University during the years 1985 and 2016.</p><p>The keywords \"kidney transplantation\", \"liver transplantation\", “heart transplantation”, \"intracerebral haemorrhage\", \"subdural haemorrhage\" and \"epidural haemorrhage\" were also used to find the kidney, liver and heart recipient patients who experienced haemorrhage in different compartments of the intracranial cavity.</p></div><div><h3>Results</h3><p>Our research revealed that 25 patients have experienced intracerebral haemorrhage (ICH) at different times following kidney, liver or heart transplantation. In this group, 20 patients were kidney-transplanted, 3 patients were liver-transplanted, and 2 patients were heart-transplanted. The group included 11 female and 14 male patients. The age range was between 20 and 63 years (Table 1). One patient had an intracranial aneurysm and epidural haematoma while other 4 patients had subdural haematoma in addition to ICH. Sites of intracerebral haematoma included right frontal lobe (3 patients), right parietal lobe (5 patients), right temporal lobe (3 patients), right thalamus (4 patients), right basal ganglia (4 patients), left temporal lobe (2 patients) and left frontal lobe (4 patients). Twelve patients were treated medically. Eleven patients with subdural haemorrhage, epidural haemorrhage or intraparenchymal haemorrhage underwent craniotomy and evacuation of the haematoma. In two patients with midline shift and intraventricular extension, external ventricular drainage (EVD) was inserted. Nine patients after surgery died within 2 days to 4 months.</p></div><div><h3>Conclusion</h3><p>Neurological complications such as intraparenchymal haemorrhage, subdural haematoma or epidural haematoma were not uncommon in kidney, liver or heart recipients. The occurrence of these complications was associated with prolonged PT and APTT time, trauma or thrombocytopenia. These complications contributed to prolongation of hospital stay, increased in-hospital mortality, and decreased graft and patient survival.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45151519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligation Of The Left Renal Vein In Liver Transplant Recipients Diagnosed With A Spontaneous Splenorenal Shunt – Case Report","authors":"Jacek Pawlicki,&nbsp;Adam Kurek,&nbsp;Grzegorz Oczkowicz,&nbsp;Robert Król","doi":"10.1016/j.tpr.2020.100053","DOIUrl":"10.1016/j.tpr.2020.100053","url":null,"abstract":"<div><h3>Introduction</h3><p>For patients diagnosed with hepatic cirrhosis and portal hypertension, qualified for liver transplantation, the presence of portosystemic collateral circulation constitutes a typical phenomenon. One of its types is the spontaneous splenorenal shunt. Large or multiple ones may cause the steal syndrome and graft hypoperfusion. An attempt to remove such shunts directly is technically difficult and fraught with complications. An easier and safer method would involve ligating the left renal vein. The aim of this paper is to present a case where proper perfusion of a transplanted liver is ensured by the left renal vein ligation, performed in a recipient with a splenorenal shunt, and to review the scientific reports devoted to portosystemic shunts in liver transplant recipients.</p></div><div><h3>Case report</h3><p>A 63-year-old female with alcoholic liver disease was qualified for liver transplantation. The CT-angiography showed numerous splenorenal shunts with diameter up to 13 mm. During the anhepatic phase of the liver transplantation a very weak effusion from the portal vein was observed, which improved significantly following clamping of the left renal vein. Thus renal vein orifice was ligated in order to achieve the correct graft reperfusion. Postoperative Doppler ultrasound showed a correct portal blood flow. The early liver and renal function was good. Finally, in the 7th month, the patient underwent a re-transplantation due to biliary necrosis caused by late hepatic artery thrombosis.</p></div><div><h3>Conclusion</h3><p>Ligation of the left renal vein efficiently prevents the steal syndrome in the liver transplant recipients with splenorenal shunt and ensures good graft perfusion.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46394106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of alpha-herpesvirus infection following kidney transplantation: Our experience (7 cases)","authors":"Hirofumi Uehara,&nbsp;Hajime Hirano,&nbsp;Tomohisa Matsunaga,&nbsp;Koichiro Minami,&nbsp;Kazumasa Komura,&nbsp;Naokazu Ibuki,&nbsp;Teruo Inamoto,&nbsp;Hayahito Nomi,&nbsp;Haruhito Azuma","doi":"10.1016/j.tpr.2020.100051","DOIUrl":"10.1016/j.tpr.2020.100051","url":null,"abstract":"<div><h3>Background</h3><p>Kidney transplantation is the definitive treatment for patients with end-stage kidney diseases. Quality of life and longevity following transplantation are nearly equal to those of healthy individuals. Immunosuppression has improved graft survival but leaves the patient susceptible to viral infections. Alpha-herpesviruses belong to a subfamily of herpesviruses and are widely distributed in nature. The human alpha-herpesviruses include herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus (VZV). HSV-1, HSV-2 and VZV often reactivate in the setting of immune suppression after kidney transplantation. The management of infectious disease in transplantation are major contributors to improved outcomes in organ transplantation.</p></div><div><h3>Objectives</h3><p>The aim of this study was to report cases of alpha-herpesvirus infection following kidney transplantation.</p></div><div><h3>Methods</h3><p>From July 2014 to December 2018, we performed 55 kidney transplantations at Osaka Medical College Hospital. All alpha-herpesvirus infection cases following kidney transplantation were retrospectively evaluated.</p></div><div><h3>Results</h3><p>We treated 7 patients with alpha-herpesvirus infection. Median age was 60; 2 patients were female. All patients were able to be treated with acyclovir and valacyclovir. A patient was complicated by postherpetic neuraglia (chronic pain). A patient was complicated by secondary bacterial infection and treated with antibiotic.</p></div><div><h3>Conclusion</h3><p>The human alpha-herpesviruses include HSV-1, HSV-2 and VZV often reactivate after kidney transplantation. This case report demonstrates the successful medical treatment of alpha-herpesvirus infection cases following kidney transplantation.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41683519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Liver Transplantation in a highly dependent Down Syndrome patient","authors":"Marina Guitton Rodrigues ,&nbsp;Paula Marcela Vilela Castro ,&nbsp;Tiago Careli de Almeida ,&nbsp;Bruno Carrijo Cunha ,&nbsp;Fernanda Ribeiro Danziere ,&nbsp;Francisco Antonio Sergi Filho ,&nbsp;Beimar Edmundo Zeballos Sempertegui ,&nbsp;Juan Rafel Branez ,&nbsp;Leonardo Toledo Mota ,&nbsp;Marcelo Perosa de Miranda ,&nbsp;Regina Gomes dos Santos ,&nbsp;e Tércio Genzini","doi":"10.1016/j.tpr.2020.100054","DOIUrl":"10.1016/j.tpr.2020.100054","url":null,"abstract":"<div><p>Despite the malformations commonly associated with Down Syndrome, the average life expectancy of individuals nowadays may reach 60-70 years of age. With these increased survival rates, the spectrum of diseases reported in these patients has been growing, particularly autoimmune diseases. This report describes a 44-year-old patient with Down Syndrome with a high degree of family dependence and end-stage liver disease (MELD-Na 38) caused by overlapping Primary Sclerosing Cholangitis and Autoimmune Hepatitis, who needed Liver Transplantation. Here, we point out two relevant aspects: the overlap of rare autoimmune diseases in patients with Trisomy 21 and the performance of Liver Transplantation in these patients. We then highlight the ethical dilemma between organ scarcity and the use of the graft in patients with neurocognitive disorders.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44666371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe infection with skin necrosis of the leg after simultaneous pancreas and kidney transplantation. Case report.","authors":"Grzegorz Witkowski ,&nbsp;Marta Matejak-Górska ,&nbsp;Marek Durlik","doi":"10.1016/j.tpr.2020.100049","DOIUrl":"10.1016/j.tpr.2020.100049","url":null,"abstract":"<div><p>The increase potential of immunosupression have reduced the incidence of transplanted organs rejection but also increased patients susceptibility to opportunistic infections and cancer.</p><p>37-year-old male patient was admitted to the Department of General and Transplantation Surgery due to edema of the right leg with signs of infection. Pharmacological treatment was not effective enough and surgical necrosectomy was performed. After that negative pressure wound therapy was started and split-thick skin grafting was done. After few weeks patient was discharged without any signs of active infection, with good healing wound.</p><p>Cutaneous infection in immunocompromised patients should be treated quickly with aggressive surgical debridement and wide-spectrum antibiotics because of the high risk of life-threating complications in this population.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41464430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De novo colorectal cancer after liver and kidney transplantation–Microenvironment disturbance","authors":"Rui Caetano Oliveira ,&nbsp;Edgar Tavares-Silva ,&nbsp;Ana Margarida Abrantes ,&nbsp;Hugo Antunes ,&nbsp;Paulo Teixeira ,&nbsp;Ana Gomes ,&nbsp;Ricardo Martins ,&nbsp;Emanuel Furtado ,&nbsp;Arnaldo Figueiredo ,&nbsp;Beatriz Costa ,&nbsp;Maria Augusta Cipriano ,&nbsp;José Guilherme Tralhão ,&nbsp;Maria Filomena Botelho","doi":"10.1016/j.tpr.2020.100057","DOIUrl":"10.1016/j.tpr.2020.100057","url":null,"abstract":"<div><p>Colorectal cancer (CRC) is a major health burden and may arise as a complication of solid organ transplantation. Our study aimed to assess the incidence of the CRC in kidney and liver transplanted patients at a tertiary and reference center and to describe their clinical and pathological features.</p><p>Twelve patients, 10 men and two women, with a mean age of 60 years, composed our cohort, ten of them submitted to CRC resection. Transplanted organ was liver in five patients and kidney in seven. Regarding overall survival, patients submitted to renal transplantation were all deceased 5 years after CRC diagnosis, while those subjected to hepatic transplantation had a survival of 60% at the fifth year.</p><p>Pathology examination showed seven patients with advanced disease (stage III/IV) and high amount of necrosis. Tumor microenvironment was disturbed, with low inflammatory infiltrate, absence of natural killer cells and no PD-L1 expression. CRC exhibited microsatellite instability in 40%, with expression of cancer stem cell markers (CD133, CD44 and ALDH1), as well as P53 (50%) and KRAS mutations (41.7%).</p><p>CRC cancer after kidney and hepatic transplantation is a rare, but aggressive and deadly event. Regular follow-up should be instituted in these patients.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42263350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor specific anti HLA sensitization is associated with inferior short term outcome in ABO- incompatible renal transplantation","authors":"Sonia Mehrotra,&nbsp;Raj Kumar Sharma,&nbsp;Kavita Vishwakarma,&nbsp;Narayan Prasad,&nbsp;Amit Gupta,&nbsp;Dharmendra S. Bhadauria,&nbsp;Anupama Kaul","doi":"10.1016/j.tpr.2020.100059","DOIUrl":"10.1016/j.tpr.2020.100059","url":null,"abstract":"<div><p>Sixty six patients were evaluated for donor specific anti HLA sensitization before they received ABO incompatible kidney transplantation. Each recipient was evaluated by complement dependent cytotoxicity (CDC) crossmatch, flow cytometric crossmatch, single antigen bead assay (SAB) and lysate based solid phase crossmatch .The desensitization protocol was started10 to 12 days prior kidney transplant for ABO incompatible and anti HLA incompatible transplants at our center. Patients were evaluated for antibody mediated rejection (ABMR), donor specific anti HLA sensitization, graft survival with anti HLA DSA positivity in ABO-incompatible kidney transplant recipients.</p><p>Antibody mediated rejection (ABMR) was seen in five (7.5%) out of 66 patients. In non-sensitized group-A, ABMR was seen in 4.0% and in sensitized group (group-B) ABMR was seen in 18.75% with DSA positivity. Graft loss within one month post-transplant was seen in 2 patients due to ABMR in the sensitized group -B with pre-transplant positive DSA and in none in the non-sensitized group-A (p value = 0.05). Both these two patients sensitized group -B had flow CM, SAB DSA and Lysate CM positivity, with total MFI strength by SAB was above 5000, these two patients with CDC and flow CM negative after desensitization and had SAB DSA MFI strength came down to ≤1000.In this study patient survival was 97% and graft survival was 95% at one year, at four years Patient survival was 91.6% and graft survival was 91.5% follow up period. Anti HLA DSA positivity with ABO- incompatibility is associated with poor graft survival.</p></div>","PeriodicalId":37786,"journal":{"name":"Transplantation Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tpr.2020.100059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48914363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}