Multi-target combination of antibiotics as salvage therapy for severe infection caused by pan-resistant Burkholderia cenocepacia following lung transplantation

Q4 Medicine

Transplantation Reports Pub Date : 2025-02-01 DOI:10.1016/j.tpr.2024.100170

Nadim Cassir , Benjamin Coiffard , Linda Hadjadj , Julien Bermudez , Liliane Okdah , Lucile Ailhaud , Sophie Alexandra Baron , Martine Reynaud-Gaubert , Xavier Benoit D'Journo , Sami Hraiech , Jean-Marc Rolain

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引用次数: 0

Abstract

Burkholderia cepacia complex (Bcc) is an important group of opportunistic pathogens most frequently affecting patients with cystic fibrosis and responsible for life-threatening infections. Therapeutic options are limited owing to high levels of resistance of the organism, either intrinsic or acquired, to many antimicrobial agents. We describe here the successful treatment of a patient with cystic fibrosis who developed post-transplant lung abscesses and sternal osteitis caused by pan-resistant Burkholderia cenocepacia. He was treated with a combination of ceftazidime-avibactam, ciprofloxacin, meropenem, minocycline, sulfadiazine, and tobramycin. Repurposing multitarget drugs including old and new antibiotics, and their combinations with synergistic effects is a promising strategy to overcome clinical therapeutic impasses with difficult-to-treat-resistance (DTR) bacteria.

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多靶点联合抗生素抢救治疗肺移植术后广泛耐药结核杆菌严重感染

洋葱伯克霍尔德菌复合体（Bcc）是一组重要的机会性病原体，最常影响囊性纤维化患者，并导致危及生命的感染。由于该生物体对许多抗微生物药物具有高水平的内在或获得性耐药性，因此治疗选择有限。我们在这里描述了一例囊性纤维化患者的成功治疗，该患者在移植后出现肺脓肿和胸骨骨炎，这是由泛耐药伯克霍尔德菌引起的。给予头孢他啶-阿维巴坦、环丙沙星、美罗培南、米诺环素、磺胺嘧啶和妥布霉素联合治疗。包括新旧抗生素在内的多靶点药物的再利用及其协同作用是克服难治性耐药（DTR）细菌的临床治疗僵局的一种有希望的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation Reports Medicine-Transplantation

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

101 days

期刊介绍： To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI