Retina (Philadelphia, Pa.)最新文献_第5页

MULTIMODAL IMAGING CHARACTERISTICS AND FUNCTIONAL CORRELATES IN RIP HEALING. 撕裂愈合的多模态影像特征及其功能相关性。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003542

Francesco Romano, Federico Zicarelli, Mariano Cozzi, Alice Ingrid Bertoni, Matteo Giuseppe Cereda, Ferdinando Bottoni, Giovanni Staurenghi, Alessandro Invernizzi

{"title":"MULTIMODAL IMAGING CHARACTERISTICS AND FUNCTIONAL CORRELATES IN RIP HEALING.","authors":"Francesco Romano, Federico Zicarelli, Mariano Cozzi, Alice Ingrid Bertoni, Matteo Giuseppe Cereda, Ferdinando Bottoni, Giovanni Staurenghi, Alessandro Invernizzi","doi":"10.1097/IAE.0000000000003542","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003542","url":null,"abstract":"Purpose: To report the imaging and functional features of the repair tissue following retinal pigment epithelium (RPE) tears.Methods: This cross-sectional observational study included patients with RPE tears secondary to neovascular age-related macular degeneration and at least 12 months of follow-up. The following variables were analyzed: best-corrected visual acuity; retinal sensitivity using microperimetry; outer retinal layers status and RPE resurfacing on optical coherence tomography; fibrosis; autofluorescence signal recovery using blue-light and near-infrared autofluorescence.Results: Overall, 48 eyes were included (age: 82 ± 5 years) and 34 of them showed signs of healing. Retinal pigment epithelium resurfacing was noticed in 22 cases, whereas fibrosis appeared in 21 eyes. Autofluorescence improved in 17 cases using blue-light infrared autofluorescence and 7 eyes on near-infrared autofluorescence. Outer retinal layers were more frequently preserved when RPE resurfacing and autofluorescence improvement occurred ( P < 0.05). Although best-corrected visual acuity was higher for smaller RPE tears ( P = 0.01), retinal sensitivity of the healing tissue was positively affected by autofluorescence improvement ( P < 0.001) and by absence of fibrosis ( P = 0.03).Conclusion: Autofluorescence signal recovery after rip occurrence possibly reflects the underlying status of the RPE and is associated with better functional outcomes. Our findings highlight the importance of blue-light infrared autofluorescence and especially near-infrared autofluorescence assessment in the setting of rip healing.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1844-1851"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40420944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF PAIN EXPERIENCE IN PATIENTS UNDERGOING SUB-TENON'S ANESTHESIA VERSUS PERIBULBAR ANESTHESIA DURING ELECTIVE VITREORETINAL SURGERY. 选择性玻璃体视网膜手术中骨下麻醉与球周麻醉患者疼痛体验的比较。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003566

Matteo Ripa, Chiara Schipa, Nikolaos Kopsacheilis, Mikes Nomikarios, Carlo De Rosa, Pasquale De Rosa, Lorenzo Motta

{"title":"COMPARISON OF PAIN EXPERIENCE IN PATIENTS UNDERGOING SUB-TENON'S ANESTHESIA VERSUS PERIBULBAR ANESTHESIA DURING ELECTIVE VITREORETINAL SURGERY.","authors":"Matteo Ripa, Chiara Schipa, Nikolaos Kopsacheilis, Mikes Nomikarios, Carlo De Rosa, Pasquale De Rosa, Lorenzo Motta","doi":"10.1097/IAE.0000000000003566","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003566","url":null,"abstract":"Purpose: To assess and compare the patients' discomfort and pain experienced during anesthesia, pars plana vitrectomy, and 24 hours postoperatively after sub-Tenon's injection (STI) versus peribulbar block (PB) in elective vitreoretinal surgery.Methods: Retrospective study involving 80 patients who underwent elective vitreoretinal surgery receiving either PB (Group 1, n = 40) or STI (Group 2, n= 40) between January 2021 and March 2022. Patients' pain experienced during the procedure and 24 hours postoperatively were assessed using a pain scale and a two-section questionnaire. One hour postoperatively, patients were asked to rate the level of pain they felt during the entire procedure by pointing at a 0 to 100 Visual Analog Scale. Subsequently, patients answered a two-section questionnaire regarding pain and discomfort felt 24 hours postoperatively.Results: According to Visual Analog Scale measurements, patients experienced significantly more pain during PB than during STI 1 hour after surgery. Patients undergoing PB experienced more pain than those who underwent STI, experiencing burning and discharge feeling. Patients undergoing STI had a lower pain level score 24 hours postoperatively despite similar discomfort.Conclusion: Sub-Tenon's injection has a lower pain score than PB during the procedure and 24 hours postoperatively, representing a valuable procedure to deliver analgesia in vitreoretinal surgery.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1852-1858"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40617767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Removal of MIRAgel Scleral Buckle Implants: The Direct Aspiration Technique. MIRAgel巩膜扣植入物的移除:直接抽吸技术。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000002620

Paolo Santorum, Antonia Maria Luce De Vitto, Enrico Bertelli

引用次数: 5

DETECTION AND CHARACTERISTICS OF UNRUPTURED RETINAL ARTERIAL MACROANEURYSMS. 未破裂视网膜动脉大动脉瘤的检测及特点。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003548

Saori Sakaguchi, Yuki Muraoka, Naomi Nishigori, Masaharu Ishikura, Shin Kadomoto, Manabu Miyata, Tomoaki Murakami, Sotaro Ooto, Akitaka Tsujikawa

{"title":"DETECTION AND CHARACTERISTICS OF UNRUPTURED RETINAL ARTERIAL MACROANEURYSMS.","authors":"Saori Sakaguchi, Yuki Muraoka, Naomi Nishigori, Masaharu Ishikura, Shin Kadomoto, Manabu Miyata, Tomoaki Murakami, Sotaro Ooto, Akitaka Tsujikawa","doi":"10.1097/IAE.0000000000003548","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003548","url":null,"abstract":"Purpose: To determine the presence of unruptured retinal arterial macroaneurysms (RAMs) and to examine the characteristics of the detected lesions.Methods: This retrospective observational study included the affected and contralateral eyes of 50 patients (100 eyes) with symptomatic, unilateral, ruptured RAMs who visited the Department of Ophthalmology at the Kyoto University Hospital (April 2014-April 2020) and were followed up for at least 6 months after the onset. The presence and characteristics of unruptured RAMs were examined by reviewing the findings of color fundus photography and infrared scanning laser ophthalmoscopy performed before the onset or during the follow-up period.Results: Unruptured RAMs were detected in six of the 50 patients. Some patients had bilateral or multiple unruptured RAMs, and a total of 12 unruptured RAMs were detected in eight eyes of the six patients. Among the detected lesions, eight exhibited a longitudinal increase in their diameter during the follow-up period, whereas six exhibited ruptures.Conclusion: Unruptured RAM is not an uncommon retinal vascular abnormality and can enlarge and progress to ruptured RAM.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1909-1914"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40575043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

ISOLATED RETINAL VASCULITIS: Prognostic Factors and Expanding the Role of Immunosuppressive Treatment in Retinal Vasculitis Associated With Positive QuantiFERON-TB Gold Test. 孤立性视网膜血管炎:与定量铁- tb金试验阳性相关的视网膜血管炎的预后因素和扩大免疫抑制治疗的作用。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003558

Sukhum Silpa-Archa, Withawat Sapthanakorn, C Stephen Foster

{"title":"ISOLATED RETINAL VASCULITIS: Prognostic Factors and Expanding the Role of Immunosuppressive Treatment in Retinal Vasculitis Associated With Positive QuantiFERON-TB Gold Test.","authors":"Sukhum Silpa-Archa, Withawat Sapthanakorn, C Stephen Foster","doi":"10.1097/IAE.0000000000003558","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003558","url":null,"abstract":"Purpose: To identify prognostic factors for poor visual outcomes in patients with isolated retinal vasculitis and to elucidate the outcome of immunosuppressive treatment without the use of antituberculosis drugs for patients with retinal vasculitis associated with a positive QuantiFERON-TB Gold In-Tube (QFT) test.Methods: A retrospective chart review was performed of patients presenting with retinal vasculitis. After the diagnosis of active retinal vasculitis had been confirmed by fluorescein angiography and other possible causes of retinal vasculitis had been excluded, patients were categorized into two groups by their QFT result. Potential associated factors between the poor and good visual outcome groups were statistically analyzed by the chi-square test and logistic regression model with generalized estimating equations.Results: Seventy-three eyes (48 patients) were enrolled in this study. After univariate analysis, multivariate logistic regression analysis was performed and revealed that logMAR visual acuity at the initial visit ( P = 0.01) and outer retinal disruption ( P = 0.03) were the two factors significantly associated with poor visual outcomes. Systemic corticosteroids were administered without the use of antituberculosis drugs to all 16 cases of presumed tuberculous retinal vasculitis associated with positive QFT (26 eyes), 10 (63%) of whom were given nonsteroidal immunosuppressive drugs and achieved inflammatory control and treatment success.Conclusion: Risk factors leading to poor visual outcome in patients with isolated retinal vasculitis have been identified. Immunosuppressive treatment without antituberculosis drugs seems to be a promising regimen for selected patients with presumed tuberculous retinal vasculitis under vigilant care.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1897-1908"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40620124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CHANGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY PARAMETERS AFTER INTERNAL LIMITING MEMBRANE PEELING COMPARED WITH NONPEELING IN EPIRETINAL MEMBRANE SURGERY. 视网膜前膜手术中内限制膜剥离与非剥离后光学相干断层血管造影参数的变化。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003567

Maximilian Gabriel, Daniel Djavid, Felix Innauer, Domagoj Ivastinovic, Gerald Seidel, Christoph Mayer-Xanthaki, Siamak Ansari-Shahrezaei, Andreas Wedrich, Anton Haas

{"title":"CHANGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY PARAMETERS AFTER INTERNAL LIMITING MEMBRANE PEELING COMPARED WITH NONPEELING IN EPIRETINAL MEMBRANE SURGERY.","authors":"Maximilian Gabriel, Daniel Djavid, Felix Innauer, Domagoj Ivastinovic, Gerald Seidel, Christoph Mayer-Xanthaki, Siamak Ansari-Shahrezaei, Andreas Wedrich, Anton Haas","doi":"10.1097/IAE.0000000000003567","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003567","url":null,"abstract":"Purpose: To prospectively compare microvascular changes of internal limiting membrane (ILM) peeled and nonpeeled eyes in patients with idiopathic epiretinal membranes using optical coherence tomography angiography.Methods: Forty-two patients with epiretinal membranes underwent vitrectomy with (n = 22) or without ILM peeling (n = 20). The mean superficial capillary plexus foveal avascular zone area change between preoperative and three-month postoperative readings served as the main outcome measure. Secondary outcome parameters included mean changes in superficial capillary plexus parafoveal vessel density, central foveal thickness, retinal volume, and best-corrected visual acuity.Results: Mean superficial capillary plexus foveal avascular zone area change (μm 2 ) was 59 ± 74 in the ILM nonpeeling group compared with -12 ± 86 in the ILM peeling group ( P = 0.007). Similarly, mean superficial capillary plexus parafoveal vessel density change (%) was higher in the ILM nonpeeling group (ILM nonpeeling 4 ± 4, ILM peeling -2 ± 6, P = 0.003). The mean retinal volume reduction was higher in the ILM peeling group, and this difference also reached statistical significance ( P = 0.036). There were no intergroup differences in mean central foveal thickness change and mean best-corrected visual acuity change ( P = 0.409 and P = 0.440, respectively). Epiretinal membrane/ILM separation was achieved in 23 of 51 patients.Conclusion: The macular microvasculature demonstrated more remodeling in the ILM nonpeeling group after three months.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1867-1873"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40633614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study. 超宽视场荧光素血管造影显示视网膜血管床区视网膜静脉闭塞:波的研究。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003549

Wenying Fan, Alan Fleming, Jano Van Hemert, Charles C Wykoff, David M Brown, Gavin Robertson, Kang Wang, Khalil Ghasemi Falavarjani, Srinivas R Sadda, Michael Ip

{"title":"RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study.","authors":"Wenying Fan, Alan Fleming, Jano Van Hemert, Charles C Wykoff, David M Brown, Gavin Robertson, Kang Wang, Khalil Ghasemi Falavarjani, Srinivas R Sadda, Michael Ip","doi":"10.1097/IAE.0000000000003549","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003549","url":null,"abstract":"Purpose: To compute retinal vascular bed area (RVBA) in square millimeters on distortion corrected ultra-widefield fluorescein angiography images in eyes with retinal vein occlusion (RVO).Methods: Prospective observational study. The peripheral distortion of baseline ultra-widefield fluorescein angiography (Optos 200Tx) images of 30 patients with RVO from the WAVE study (NCT01710839) and 13 control eyes of normal subjects was corrected using the stereographic projection method to compute RVBA in square millimeters.Results: In comparison with age- and sex-matched normal control eyes, eyes with RVO had a decreased global RVBA for the entire retina (50.5 ± 20.4 mm 2 vs. 62.6 ± 12.2 mm 2 , P = 0.023). Eyes with RVO and the unaffected fellow eye had a similar RVBA globally (50.5 ± 20.4 mm 2 vs. 46.2 ± 18.9 mm 2 , P = 0.523). The RVBA was observed to negatively correlate with nonperfusion area (R = -0.47, P = 0.009). However, RVBA was not related to the severity of macular edema ( P > 0.05).Conclusion: Eyes with RVO have a similar RVBA to the unaffected fellow eyes but with a reduction when compared with normal control eyes. Retinal vascular bed area appears to be a surrogate biomarker of retinal ischemia on ultra-widefield fluorescein angiography but not the extent of macular edema.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1883-1888"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40617769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

CLINICAL FEATURES AND PROGNOSIS IN IDIOPATHIC EPIRETINAL MEMBRANES WITH DIFFERENT TYPES OF INTRARETINAL CYSTOID SPACES. 特发性视网膜前膜伴不同类型视网膜内囊样间隙的临床特征及预后。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003537

Xiaohan Yang, Zengyi Wang, Yanping Yu, Xijin Wu, Biying Qi, Lingzi Liu, Ke Zhang, Xinbo Wang, Wu Liu

{"title":"CLINICAL FEATURES AND PROGNOSIS IN IDIOPATHIC EPIRETINAL MEMBRANES WITH DIFFERENT TYPES OF INTRARETINAL CYSTOID SPACES.","authors":"Xiaohan Yang, Zengyi Wang, Yanping Yu, Xijin Wu, Biying Qi, Lingzi Liu, Ke Zhang, Xinbo Wang, Wu Liu","doi":"10.1097/IAE.0000000000003537","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003537","url":null,"abstract":"Purpose: To observe the characteristics and prognosis of different types of intraretinal cystoid spaces in idiopathic epiretinal membranes (iERMs).Methods: Two hundred and seven consecutive patients with symptomatic iERM who underwent vitrectomy between September 2016 and December 2019 were included. According to spectral-domain optical coherence tomography images, intraretinal cystoid spaces were classified into cystoid macular edema (CME) and microcystic macular edema (MME). Other optical coherence tomography characteristics, including ectopic inner foveal layers, central foveal thickness, and interdigitation zone integrity, were also evaluated.Results: Intraretinal cystoid spaces were presented in 30.1% of the iERMs, 21.5% were CME-type, 66.2% were MME-type, and 12.3% were combined-type. Compared with CME, eyes with MME-type and combined-type showed a significantly lower best-corrected visual acuity (BCVA) preoperatively and postoperatively. Cystoid macular edema is always presented in earlier stages (92.9%) and has no significant effects on BCVA (PStage I = 0.927, PStage II = 0.985). Conversely, MME is the primary type in advanced stages associated with a longer duration of symptoms (P = 0.037) and lower preoperative BCVA (P = 0.008). After surgery, cystoid spaces were newly occurred in 33 eyes (21.6%), with no effects on BCVA (P = 0.668). In the multiple regression analysis, the presence of MME was a risk factor for preoperative BCVA (P = 0.001). However, it is not an independent predictor for the postoperative VA.Conclusion: Our research further proved that MME is an adverse factor for preoperative and postoperative VA in iERMs. Moreover, we underlined the importance of distinguishing between CME and MME, which may affect prognosis differently.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1874-1882"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QUANTITATIVE ANALYSIS OF CHORIOCAPILLARIS ALTERATIONS IN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY DURING RADIATION RETINOPATHY. 放射性视网膜病变时扫描源相干断层-血管造影绒毛膜毛细血管改变的定量分析。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003559

Christelle Gilli, Laurent Kodjikian, Olivier Loria, Charles Jabour, Laurence Rosier, Maxime Nhari, Anh Minh Nguyen, Joël Herault, Juliette Thariat, Julia Salleron, Thibaud Mathis

{"title":"QUANTITATIVE ANALYSIS OF CHORIOCAPILLARIS ALTERATIONS IN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY DURING RADIATION RETINOPATHY.","authors":"Christelle Gilli, Laurent Kodjikian, Olivier Loria, Charles Jabour, Laurence Rosier, Maxime Nhari, Anh Minh Nguyen, Joël Herault, Juliette Thariat, Julia Salleron, Thibaud Mathis","doi":"10.1097/IAE.0000000000003559","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003559","url":null,"abstract":"Purpose: To evaluate choriocapillaris alterations following proton beam therapy irradiation using swept-source optical coherence tomography-angiography, and to assess their correlation with the grade of radiation retinopathy (RR).Methods: Eyes with uveal melanoma evaluated before and after irradiation with proton beam therapy were included, as well as the healthy fellow eye. The gradation of RR was based on a previously published classification. Choriocapillaris flow voids area was analyzed using Phansalkar thresholding. Retinal vascularization was described by foveal avascular zone (FAZ) perimeter, FAZ area, FAZ circularity index, and percentage of nonperfusion area (PAN) in the superficial capillary plexus (SCP) or deep capillary plexus.Results: A total of 157 eyes of 83 patients were analyzed. Overall, there was a significant difference between the control group, the uveal melanoma before proton beam therapy group, and the grades of RR in the uveal melanoma after proton beam therapy group for FAZ perimeter ( P < 0.001), FAZ area ( P < 0.001), FAZ-circularity index ( P < 0.001), PAN-SCP ( P < 0.001), PAN-deep capillary plexus ( P < 0.001), and choriocapillaris flow voids area ( P < 0.001). Moreover, choriocapillaris flow voids area was significantly increased in the early stages of RR ( P = 0.003) and was further significantly correlated with FAZ perimeter ( P < 0.001), FAZ area ( P < 0.001), FAZ-circularity index ( P = 0.010), PAN-SCP ( P < 0.001), and PAN-deep capillary plexus ( P < 0.001).Conclusion: Quantitative optical coherence tomography-angiography alterations in the choriocapillaris microvascularization are an early biomarker of RR and are correlated to the severity of the disease.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1995-2003"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40620125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CLINICAL OUTCOMES OF PATIENTS WITH ENDOPHTHALMITIS AFTER DEXAMETHASONE INTRAVITREAL IMPLANT. 地塞米松玻璃体内植入后眼内炎患者的临床疗效。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003546

Annika G Samuelson, Ankur Nahar, Samir N Patel, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Eugene Yu-Chuan Kang, John W Hinkle, Rebecca R Soares, Ajay E Kuriyan, Sunir J Garg

{"title":"CLINICAL OUTCOMES OF PATIENTS WITH ENDOPHTHALMITIS AFTER DEXAMETHASONE INTRAVITREAL IMPLANT.","authors":"Annika G Samuelson, Ankur Nahar, Samir N Patel, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Eugene Yu-Chuan Kang, John W Hinkle, Rebecca R Soares, Ajay E Kuriyan, Sunir J Garg","doi":"10.1097/IAE.0000000000003546","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003546","url":null,"abstract":"Purpose: To report a case series of endophthalmitis associated with intravitreal dexamethasone injections in a single practice and to discuss the clinical findings and visual outcomes of each case.Methods: All endophthalmitis cases following intravitreal dexamethasone injections performed from January 1, 2014 to October 20, 2020 were identified using Wills Eye/MidAtlantic billing records. The diagnosis, clinical information, and microbiology were confirmed for each case. Data were analyzed using Excel (Microsoft Excel, Redmond, WA).Results: Four cases of endophthalmitis were identified from 3,925 intravitreal dexamethasone injections in a single practice and one case was referred from an outside institution, resulting in an incidence of 0.102% (1 in 981 injections). Mean age was 82.3 years (range, 63-88 years) with a mean of 11.3 intravitreal dexamethasone injections performed (range, 2-30 injections) before endophthalmitis. Cases presented with endophthalmitis a mean (SD) of 3.6 (1.64) days after causative injection. Three cases grew gram-positive organisms. All patients responded to intravitreal antibiotics. Mean logarithm of the minimal angle of resolution visual acuity at causative injection, endophthalmitis presentation, 3 months, and last follow-up was 0.44 (20/55), 2.22 (20/3,319), 1.18 (20/303), and 1.46 (20/577), respectively.Conclusion: Endophthalmitis following intravitreal steroid injections may occur more frequently than other intravitreal injections. Dexamethasone-attributed endophthalmitis remains uncommon, and prompt intravitreal antibiotic treatment seems to be effective in this series.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1915-1920"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40633618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1