RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study.

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI:10.1097/IAE.0000000000003549

Wenying Fan, Alan Fleming, Jano Van Hemert, Charles C Wykoff, David M Brown, Gavin Robertson, Kang Wang, Khalil Ghasemi Falavarjani, Srinivas R Sadda, Michael Ip

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引用次数: 2

Abstract

Purpose: To compute retinal vascular bed area (RVBA) in square millimeters on distortion corrected ultra-widefield fluorescein angiography images in eyes with retinal vein occlusion (RVO).

Methods: Prospective observational study. The peripheral distortion of baseline ultra-widefield fluorescein angiography (Optos 200Tx) images of 30 patients with RVO from the WAVE study (NCT01710839) and 13 control eyes of normal subjects was corrected using the stereographic projection method to compute RVBA in square millimeters.

Results: In comparison with age- and sex-matched normal control eyes, eyes with RVO had a decreased global RVBA for the entire retina (50.5 ± 20.4 mm 2 vs. 62.6 ± 12.2 mm 2 , P = 0.023). Eyes with RVO and the unaffected fellow eye had a similar RVBA globally (50.5 ± 20.4 mm 2 vs. 46.2 ± 18.9 mm 2 , P = 0.523). The RVBA was observed to negatively correlate with nonperfusion area (R = -0.47, P = 0.009). However, RVBA was not related to the severity of macular edema ( P > 0.05).

Conclusion: Eyes with RVO have a similar RVBA to the unaffected fellow eyes but with a reduction when compared with normal control eyes. Retinal vascular bed area appears to be a surrogate biomarker of retinal ischemia on ultra-widefield fluorescein angiography but not the extent of macular edema.

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超宽视场荧光素血管造影显示视网膜血管床区视网膜静脉闭塞:波的研究。

目的:计算视网膜静脉闭塞(RVO)眼畸变校正超宽视场荧光素血管造影图像视网膜血管床面积(RVBA)的平方毫米。方法:前瞻性观察研究。采用立体投影法对来自WAVE研究(NCT01710839)的30例RVO患者和13例正常受试者对照眼的基线超宽视场荧光素血管造影(Optos 200Tx)图像的外周畸变进行校正，计算RVBA(平方毫米)。结果:与年龄和性别匹配的正常对照眼相比，RVO眼的全视网膜RVBA降低(50.5±20.4 mm2 vs. 62.6±12.2 mm2, P = 0.023)。有RVO的眼与未受影响的眼整体RVBA相似(50.5±20.4 mm2 vs. 46.2±18.9 mm2, P = 0.523)。RVBA与非灌注面积呈负相关(R = -0.47, P = 0.009)。RVBA与黄斑水肿的严重程度无相关性(P > 0.05)。结论:RVO眼的RVBA与未受影响眼相似，但与正常对照眼相比有所降低。在超宽视场荧光素血管造影中，视网膜血管床面积似乎是视网膜缺血的替代生物标志物，而不是黄斑水肿的程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Retina (Philadelphia, Pa.)

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