Arterial Hypertension (Russian Federation)最新文献

{"title":"The efficacy of antihypertensive therapy according to the results of the CONSONANCE program: is achieving the target blood pressure level the sole criterion?","authors":"Yu. M. Lopatin, S. V. Nedogoda, A. S. Galyavich, V. V. Kashtalap, G. I. Nechaeva, N. P. Lyamina, A. O. Nedoshivin, L. G. Ratova, I. I. Shaposhnik, A. O. Konradi","doi":"10.18705/1607-419x-2023-29-4-419-431","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-4-419-431","url":null,"abstract":"Objective . This study aims to assess the efficacy of single-pill combination ramipril/indapamide (Konsilar-D 24) in patients with grade 1 and 2 hypertension who did not achieve blood pressure (BP) control through previous therapy or did not receive antihypertensive treatment in routine clinical practice. The assessment is based on home BP monitoring (HBPM), long-term BP variability, and quality of life according to the visual analog scale (VAS) EuroQol. Design and methods . A multicenter open observational program involved 358 CONSONANCE program patients who provided home BP monitoring (HBPM) data and self-monitoring diaries for all visits. Among them, 326 patients (91,1 %) evaluated their well-being using VAS at each visit. The program protocol was approved by the independent ethics committee of the Almazov National Medical Research Centre (protocol № 200219 от 11.02.2019). All participants provided written informed consent before inclusion. Clinical BP changes were evaluated at baseline, 0,5, 1, 3 and 6 months into treatment. Patients measured their BP daily for the initial 2 weeks and then at least 3 times a week. The average of two consecutive measurements represented each reading. The effectiveness criterion for HBPM was achieving an average BP < 135/85 mm Hg. Visit-to-visit BP variability was assessed using standard deviation (SD). Patients self-assessed their quality of life by the VAS EuroQol scale from 1 to 100 points. Statistical analysis was performed with the use of Statistica 10. Quantitative variables were presented as means and standard deviations, and their changes were evaluated using paired Student’s t-test. Qualitative features were compared using McNemar’s test with Yates’ continuity correction. A p-value < 0,05 denoted statistical significance. Results . After 2 weeks of treatment, 268 (74,9 %) patients achieved clinical BP < 140/90 mm Hg, the number increased up to 356 (99,4 %) after 6 months. For home BP, 271 (75,7 %) and 326 (91,1 %) patients reached the target after 2 weeks and after 6 months, respectively. Visit-to-visit BP variability, while on unchanged antihypertensive therapy, was 4,1 ± 2,3 / 2,5 ± 1,1 mm Hg for clinical BP and 4,5 ± 3,5 / 2,8 ± 1,9 mm Hg for home BP. The initial VAS score was 54,7 ± 19,1 points, increasing to 86,6 ± 6,1 points after 6 months of treatment (a change of 31,9 ± 18,5 points; p < 0,0001). Conclusions . Optimizing antihypertensive therapy with the single-pill combination ramipril/indapamide (Consilar D 24) effectively reduces both clinical and home BP, leading to the swift achievement of the target BP level for most patients with previously uncontrolled arterial hypertension. Treatment with this single-pill combination also reduces visit-to-visit BP variability and enhances patients’ quality of life in real clinical settings.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135021590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of the study of arterial hypertension from Cesalpino to the 21&lt;sup&gt;st&lt;/sup&gt; century","authors":"A. S. Galyavich","doi":"10.18705/1607-419x-2023-29-4-432-435","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-4-432-435","url":null,"abstract":"The article describes the main milestones in the study of hypertension (HTN). In a chronological aspect, the main discoveries in the field of hypertension since the 16 th century are presented. The contribution of Russian scientists to the field and approaches to its treatment is noted. The facts related to the development of national recommendations on HTN is presented.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135831800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of echocardiographic parameters of cardiac remodeling in patients with hypertension and obstructive sleep apnea","authors":"A. Yakovlev, I. A. Efremov, A. Ryabikov, N. Yakovleva, I. V. Shirokih, S. Shilov, A. Teplyakov, E. Grakova, K. V. Kopyeva, N. A. Kokoulina","doi":"10.18705/1607-419x-2023-29-2-164-174","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-164-174","url":null,"abstract":"Objective. To study the prognostic value of echocardiographic parameters of early cardiac remodeling in patients with hypertension (HTN) and obstructive sleep apnea (OSA). Design and methods. The study included 59 men with HTN and OSA (with an apnea/hypopnea index > 15 per hour). At baseline, all patients underwent polysomnography and echocardiography with an additional assessment of the global longitudinal strain (GLS). At baseline and at 12-month follow-up, a 6-minute walk test was performed. After 12 months, the clinical course of the disease was assessed. The criteria for an unfavorable course were episodes of hospitalization, the development of acute coronary syndrome, cerebral stroke, paroxysmal atrial fibrillation, worsening of chronic heart failure with a transition to a higher NYHA functional class. Results. In groups with favorable and unfavorable clinical course, some baseline echocardiographic parameters differed significantly: interventricular septal thickness (p = 0,037), left ventricular myocardial mass index (LVMI) (p = 0,003), tricuspid annular plane systolic excursion (TAPSE) (p < 0.001), GLS (p = 0,019), peak tricuspid regurgitation (p = 0,027), left atrial volume index (p = 0,048). Regression analysis showed that baseline TAPSE and LVMI had predictive value for an unfavorable clinical course. Conclusions. Our results confirm that certain echocardiographic parameters, in particular, LVMI and TAPSE, are predictors of the development and progression of cardiovascular complications in OSA patients.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86413094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of epicardial adipose tissue and metabolic syndrome","authors":"I. Mustafina, A. Dolganov, М. K. Kutlubaev, N. Zagidullin","doi":"10.18705/1607-419x-2023-29-2-186-193","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-186-193","url":null,"abstract":"Visceral obesity is a key link in the metabolic syndrome and can affect the development of cardiovascular diseases. Objective. The aim of the study was to identify the clinical, laboratory and instrumental characteristics of patients with coronary artery disease, to analyze adverse cardiovascular events after coronary bypass surgery, according to the thickness of the epicardial adipose tissue (EAT). Design and methods. The study included 178 patients who underwent coronary bypass surgery. The median values of the thickness of the EAT was 0,4 cm. The patients were divided into 2 groups: group 1 — epicardial fat < 0,44 cm (n = 84) and group 2 — epicardial fat > 0,44 cm (n = 94). Results. The frequency of metabolic syndrome in group 1 was 59,5 %, while in group 2 — 74,5 % (p = 0,017). The thickness of the EAT correlated with blood glucose (r = 0,28, p = 0,003), body mass index (BMI) (r = 0,27, p = 0,010), waist circumference (r = 0,26, p = 0,001). End-diastolic volume of the left ventricle (p = 0,016), stroke volume (p = 0,014), thickness of the interventricular septum (p = 0,010), mass of the left ventricular myocardium (p = 0,048), left ventricular myocardial mass index (p = 0,035) were higher in the group with a higher content of EAT. The metabolic syndrome was a significant predictor of the EAT thickness. Conclusions. The EAT thickness is associated with the metabolic syndrome and its components.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75159834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for success of renal denervation in patients with resistant arterial hypertension","authors":"A. Orekhov, L. Karazhanova, A. Chinybayeva, Sholpan Zhukusheva, A. Konradi","doi":"10.18705/1607-419x-2023-29-2-175-185","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-175-185","url":null,"abstract":"Objective. Development of principles for personalized selection of patients for renal denervation (RD) based on the evaluation of procedural response predictors. Design and methods. In the period from 2016 to 2022, 91 patients with resistant arterial hypertension (RHTN) underwent a RD procedure using 2 types of catheters — monopolar and spiral. All patients were assessed for basic demographic, clinical, functional, and laboratory characteristics. The reassessment was carried out on the 7th day, then after 6 and 12 months. A predictive model for determining the probability of response to RD was constructed using the logistic regression method. Results. The final analysis included data from 91 RHTN patients, the mean age was 57,79 ± 9,5 years. At baseline, patients received 4,5 ± 1,4 antihypertensive drugs. Initial office systolic blood pressure (SBP) was 190 (interquartile range (IQR) 100; 140, 240) mm Hg, diastolic blood pressure (DBP) — 100 (IQR 60; 80, 140) mm Hg. Among the responders, a significant reduction in blood pressure (BP) was achieved, with maintenance of the antihypertensive effect during 1 year of follow-up (p < 0,001 for SBP and DBP). The multivariate regression analysis showed that the initial DPB (p < 0,001), the diameter of the right (p = 0,049) and left renal arteries (RA) (p = 0,038) were significant predictors. Based on these data, a prognostic model was developed (p < 0,001). Conclusions. Our results confirmed effectiveness and safety of RD. The stability of the clinical effect is important. However, there was a high variability in the degree of BP reduction after the procedure. The initial DBP, the diameter of the left and right RA, and the use of drugs that reduce the activity of the sympathetic nervous system can be used as possible predictors of response to RD.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84217569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-disordered breathing in the acute phase of ischemic stroke","authors":"M. Bochkarev, L. Korostovtseva, M. S. Golovkova-Kucheryavaya, V. E. Zheleznyakov, Y. Sviryaev, S. N. Yanishevsky","doi":"10.18705/1607-419x-2023-29-2-194-200","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-194-200","url":null,"abstract":"Objective. Sleep-disordered breathing (SDB) is a common cardiovascular risk factor. The aim of our study was to assess the occurrence and features of SDB in patients with acute supratentorial ischemic stroke. Design and methods. Patients 18-89 years of age with acute ischemic stroke admitted to the stroke intensive care unit within 24 hours after the symptom onset underwent respiratory monitoring during the first day of hospitalization. 1616 patients were screened between 2018 and 2021 years, respiratory monitoring was performed in 583 patients, and data from 281 patients [mean age 67 (30; 89) years, 146 males (52 %)] were included in the final analysis. Results. The mean respiratory disturbance index was 11,8 (0; 88)/h. SDB was detected in 182 patients (69,2 %), with mild severity in 28,6 %, moderate in 24,2 %, and severe in 47,2 %. Prevalent obstructive apnea type was observed in 71,1 %, central type in 14,2 %, and mixed type in 14,7 %. The TOAST stroke subtype distribution was the following: unspecified etiology was diagnosed in 52 %, cardioembolic in 26 %, atherothrombotic in 11 %, lacunar in 9 %, and other established etiology in 2 %. The majority of patients had mild stroke severity (89,4 %), moderate and severe stroke was diagnosed in 10,5 %. No significant differences in the main indices of the type and severity of sleep apnea were found in the groups based on severity and pathogenetic type of stroke. Conclusions. Our results correlate with the worldwide prevalence of SDB in patients with ischemic stroke (69,2 % and 71,1 %). Further analysis with inclusion of more patients with moderate and severe stroke is required, as well as a prospective study to assess the prognostic impact of SDB.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"43 1-6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77487727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and laboratory characteristics of COVID-19 in hospitalized hypertensive patients","authors":"A. Abilbayeva, A. Tarabayeva, G. Idrisova, R. Yegemberdiyeva, A. Abdrakhmanova, A. M. Sadykova, A. Duisenova","doi":"10.18705/1607-419x-2023-29-2-150-163","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-150-163","url":null,"abstract":"Objective. To identify clinical and laboratory differences of COVID-19 in patients with hypertension (HTN), as well as to identify factors associated with its severe course in these patients. Design and methods. A retrospective analysis of case histories of 940 patients with COVID-19 was performed. Statistical analysis was carried out by the method of contingency tables using Pearson's Chi-square test with Bonferroni correction, multiple logistic regression analysis and ROC-analysis were also applied. Results. The group of patients with COVID-19 and HTN showed a number of significant differences compared with the group of patients without HTN history. The study group was characterized by higher rates of females, people over 65, patients with severe COVID-19. They were more likely to have diabetes mellitus, coronary heart disease, and chronic kidney disease. On admission, in the group of HTN patients, leukocytosis and elevated blood glucose levels were more common, as well as pneumonia, shortness of breath and low saturation (p < 0,05). Multivariate logistic regression analysis showed that the presence of coronary heart disease (odds ratio (OR) = 3,492, 95 % confidential interval (CI): 2,016-6,048), leukocytosis (OR = 1,376, 95 % CI: 1,540-7,703), thrombocytopenia (OR = 1,779, 95 % CI: 1,031-3,071) and low SpO2 saturation (OR = 3,265, 95 % CI: 1,996-5,341) were associated with severe COVID-19 in hypertensive patients. ROC-analysis showed that the combination of the identified factors increases power of their association with the severe COVID-19 in HTN patients (AUC = 0,766). Conclusions. 1. Some indicators of hospitalized COVID-19 patients with HTN are different compared to patients with no HTN history. 2. Factors associated with severe COVID-19 in individuals with HTN do not differ from those in the general population of COVID-19 patients. 3. Severe COVID-19 in patients with HTN was strongly associated with the low SpO2 saturation and the presence of concomitant coronary heart disease.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77162674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pregnant women with pheochromocytoma: clinical cases and literature review","authors":"E. Shelepova, N. A. Osipova, A. A. Kuznetcova, A. S. Aitkulova, R. A. Bairova, U. Tsoy, I. Zazerskaya","doi":"10.18705/1607-419x-2023-29-2-220-230","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-220-230","url":null,"abstract":"Objective. To represent clinical cases of pheochromocytoma (PCC) during pregnancy and to draw attention to diagnostics, choice of proper treatment and delivery method. Design and methods. Both domestic and forensic scientific and medical publications about hypertension and PCC were analyzed. We also represent four clinical cases of the patients with PCC, who were observed and treated in Perinatal Centre of Almazov National Medical Research Centre. Results. In three cases hypertension had been diagnosed before present pregnancy, and in two cases it had been treated as essential hypertension. One woman registered increased blood pressure (BP) during pregnancy for the first time. In three cases hypertensive crises were registered. Two caesarian sections were performed because of fetoplacental circulation disorders and high risks of antenatal fetal death, both before full term. Two natural births occurred at full term and at 34 weeks due to the development of spontaneous labor. In all cases PCC was diagnosed during pregnancy, confirmed by histology and immunohistochemistry after adrenalectomy in the postpartum period. Conclusions. All patients with PCC during pregnancy must be followed by a multidisciplinary team including obstetricians, cardiologists, endocrinologists, surgeons, anesthesiologists and neonathologists. Early diagnosis and proper treatment significantly improve prognosis during pregnancy for both mother and fetus. Specialists must exclude PCC if any urgent cardiovascular situation developed during pregnancy, including first detection of increased BP.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75741508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HFA-PEFF diagnostic algorithm for diagnosing heart failure with preserved ejection fraction in hypertensive patients","authors":"O. E. Vilkova, N. Grigoryeva, M. O. Petrova, D. V. Solovyova","doi":"10.18705/1607-419x-2023-29-2-211-219","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-211-219","url":null,"abstract":"The main causes of chronic heart failure (CHF) are hypertension (HTN) and coronary heart disease (CHD). One of the diagnostic methods for heart failure with preserved ejection fraction (HFpEF) can be the HFA-PEFF diagnostic algorithm, according to which diastolic stress test (DST) is indicated for patients with an intermediate probability of heart failure (HF). Objective. The aim of the study was to compare the incidence of HFpEF in patients with HTN with CHD and hypertensive patients without CHD by transthoracic echocardiogram using a DST according to the diagnostic algorithm HFA-PEFF. Design and methods. The study enrolled 45 patients with HTN and symptoms of HF who were divided into two groups according to the presence of CHD: patients with HTN and CHD (group I), patients with HTN without CHD (group II). The major and minor criteria of the HFA-PEFF diagnostic algorithm were evaluated to make the diagnosis of HFpEF. The DST was performed applying a passive leg raising test in patients with an intermediate probability of HFpEF. Results. According to the major and minor criteria of the HFA-PEFF: 7 (21,9 %) patients in group I and 3 (23,1 %) patients in group II did not have HFpEF. The confirmed HFpEF in group I was detected in 2 (6,2 %) patients, and none patients demonstrated confirmed HFpEF in group II. The remaining patients had an intermediate probability of HFpEF. DST with passive leg raising allowed to additionally diagnose HFpEF at an early stage in 6 (26,1 %) patients with HTN and CHD and in 1 (10 %) patient with HTN without CHD. Conclusions. The HFA-PEFF diagnostic algorithm using major and minor criteria allows to make the diagnosis of HFpEF in patients with HTN and symptoms of HF and, according to this algorithm in patients with HTN and CHD was detected more often, compared to patients with HTN without CHD.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74779509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating biomarkers for the hypertension development predicting: are there any prospects?","authors":"K. Protasov","doi":"10.18705/1607-419x-2023-29-2-124-137","DOIUrl":"https://doi.org/10.18705/1607-419x-2023-29-2-124-137","url":null,"abstract":"The problem of finding reliable predictors of the arterial hypertension (HTN) development in people with initially normal blood pressure level has not been resolved yet. Objective. The purpose of this review was to present and analyze current data on the role and prospects for the use of circulating serum biomarkers in predicting the HTN development. To establish the predictive value of biomarkers and their causal relationships with HTN, the results of prospective and retrospective cohort studies, studies of Mendelian randomization, randomized controlled trials, systematic reviews and meta-analyses on the study of both previously known and relatively new potential risk factors for HTN were analyzed: uric acid, vitamin D, homocysteine, inflammatory biomarkers, soluble ST2, natriuretic peptides, and cardiac troponins. There is evidence of an independent prognostic value of uric acid and inflammatory biomarkers (C-reactive protein) in the HTN development and the possibility of their use as risk markers of HTN. Despite the found relationships of all considered biomarkers with the level of blood pressure in cross-sectional and experimental studies, their causal role in the HTN development in studies of a high level of evidence has not received unambiguous confirmation.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85097087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}