循环生物标志物对高血压发展的预测:有前景吗?

Q4 Medicine
K. Protasov
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引用次数: 0

摘要

在最初血压水平正常的人群中寻找动脉高血压(HTN)发展的可靠预测因素的问题尚未得到解决。目标。本综述的目的是介绍和分析循环血清生物标志物在预测HTN发展中的作用和前景的现有数据。为了建立生物标志物的预测价值及其与HTN的因果关系,我们分析了前瞻性和回顾性队列研究、孟德尔随机化研究、随机对照试验、系统评价和荟萃分析的结果,分析了已知的和相对较新的HTN潜在危险因素:尿酸、维生素D、同型半胱氨酸、炎症生物标志物、可溶性ST2、利钠肽和心脏肌钙蛋白。有证据表明尿酸和炎症生物标志物(c反应蛋白)在HTN的发展中具有独立的预后价值,并有可能将其用作HTN的风险标志物。尽管在横断面和实验研究中发现了所有被认为的生物标志物与血压水平的关系,但在高水平证据的研究中,它们在HTN发展中的因果作用尚未得到明确的证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating biomarkers for the hypertension development predicting: are there any prospects?
The problem of finding reliable predictors of the arterial hypertension (HTN) development in people with initially normal blood pressure level has not been resolved yet. Objective. The purpose of this review was to present and analyze current data on the role and prospects for the use of circulating serum biomarkers in predicting the HTN development. To establish the predictive value of biomarkers and their causal relationships with HTN, the results of prospective and retrospective cohort studies, studies of Mendelian randomization, randomized controlled trials, systematic reviews and meta-analyses on the study of both previously known and relatively new potential risk factors for HTN were analyzed: uric acid, vitamin D, homocysteine, inflammatory biomarkers, soluble ST2, natriuretic peptides, and cardiac troponins. There is evidence of an independent prognostic value of uric acid and inflammatory biomarkers (C-reactive protein) in the HTN development and the possibility of their use as risk markers of HTN. Despite the found relationships of all considered biomarkers with the level of blood pressure in cross-sectional and experimental studies, their causal role in the HTN development in studies of a high level of evidence has not received unambiguous confirmation.
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来源期刊
Arterial Hypertension (Russian Federation)
Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine
CiteScore
0.90
自引率
0.00%
发文量
38
期刊介绍: The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.
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