Arterial Hypertension (Russian Federation)最新文献

{"title":"The regulatory adaptive status in hypertensive patients with congestive heart failure with preserved left ventricular ejection fraction: the effects of fosinopril versus zofenopril","authors":"V. G. Tregubov, S. N. Nedvetskaya, J. Z. Shubitidze, V. Pokrovskiy","doi":"10.18705/1607-419x-2021-27-6-696-705","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-696-705","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"2 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78633059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of membrane and circulating forms of ACE 2 in pathological processes in COVID-19 infection","authors":"Y. Cheburkin, D. Sonin, A. Polozov, P. A. Mateikovich, E. Savochkina, M. Galagudza","doi":"10.18705/1607-419x-2021-27-6-608-616","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-608-616","url":null,"abstract":"The review analyzes milestone information about the function and pathogenic significance of human angiotensin-converting enzyme 2 (ACE2). ACE2 is involved in the development of diseases such as hypertension, malabsorption of certain amino acids in the intestine, and a new type of pneumonia COVID-19 caused by the SARSCoV-2 virus. Based on the latest literary sources, an assessment is made of the role of differential expression of receptor and soluble forms of this protein in the functioning of the renin-angiotensin-aldosterone system, as well as the mechanisms of ACE2 participation in the sequential chemical conversion of angiotensin II and its effect on the function of the cardiovascular system. The role of ACE2 in the development of inflammatory processes in the intestine and its effect on the composition of the intestinal microbiota are also discussed. In addition, the review presents most general data on the proteolytic activation of the S-glycoprotein of the SARS-CoV-2 virus and its participation, together with ACE2, in the process of virus introduction into the host cell. In conclusion, the hypothesis about autoimmune complications of COVID-19 associated with the formation of the S-glycoproteinACE2 immune complex and the production of autoantibodies is considered.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90913609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure control, target organ protection and metabolic disorders control using a fixed combination of azilsartan medoxomil + chlorthalidone in hypertensive patients survived after severe and extremely severe COVID-19","authors":"S. Nedogoda, A. Ledyaeva, A. Salasyuk, E. Chumachek, V. Tsoma, V. Lutova, E. Popova, D. S. Vlasov, O. Bychkova, V. Labaznikova, K. Evdokimov","doi":"10.18705/1607-419x-2021-27-6-642-652","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-642-652","url":null,"abstract":"Objective. Evaluation of the possibility of a fixed combination of azilsartan medoxomil + chlorthalidone in additional angioprotection in patients with arterial hypertension (HTN) and high pulse wave velocity (PWV) after confirmed severe or extremely severe COVID-19 (bilateral polysegmental viral pneumonia) treated by genetically engineered biological drugs, who had not previously received combined antihypertensive therapy.Design and methods. An open observational study lasting 12 weeks included 30 patients, 28–31 days after discharge from the hospital after a severe and extremely severe COVID-19, who received or had not previously received antihypertensive therapy. Patients underwent 24-hour blood pressure (BP) monitoring, applanation tonometry (augmentation index and central BP), measurement of PWV, laboratory tests before and after prescription of a fixed combination of azilsartan medoxomil + chlorthalidone.Results. At baseline, patients showed an increase in office blood pressure to 153,06/92,2 mmHg. After treatment with a fixed combination of azilsartan medoxomil + chlorthalidone, a decrease in systolic BP by 18,47% and diastolic BP by 16,24% was observed. According to ambulatory BP monitoring, the decrease in systolic BP was 19,65% and diastolic BP — 24,68%, PWV decreased by 34,4%, augmentation index — by 9,42%, central systolic BP — by 15,48% (p < 0,05). At baseline, vascular age (VA) was increased to 44,96 years compared to the passport age of 35,03 years. After treatment, there was a significant decrease in VA to 38,74 years (p < 0,01). In addition, the levels of C-reactive protein, fibrinogen, D-dimer, glucose, blood urea nitrogen and uric acid significantly decreased.Conclusions. The fixed combination of azilsartan medoxomil + chlorthalidone provides better control of BP. It also helps to improve vascular elasticity (augmentation index, PWV, central systolic BP, decrease in VA) and to reduce post-infectious inflammation in HTN patients after a severe coronavirus infection.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91269159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiopathogenetic factors and the course of hemorrhagic stroke associated with COVID-19","authors":"L. Novikova, R. F. Latypova, A. Novikov","doi":"10.18705/1607-419x-2021-27-6-662-670","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-662-670","url":null,"abstract":"Background. Acute stroke is a highly specific neurological symptom in the acute phase of COVID-19. Hemorrhagic stroke (HS) is an infrequent, but life-threatening complication of COVID-19.Objective. To analyze etiopathogenetic factors and the course of HS associated with COVID-19.Design and methods. A retrospective analysis of 27 medical histories of patients with HS associated with COVID-19 (the main group) and 14 medical histories of patients with HS not related to COVID-19 (the control group) was performed. In the main group, COVID-19 was confirmed by the positive polymerase chain reaction method. HS developed before COVID-19 symptoms in 10 (37,04%) patients and after 4–16 days of COVID-19 symptoms onset in 17 (62,96%) patients.Results. Our study indicates significant differences in blood pressure (BP), respiratory system parameters, laboratory data, neuroimaging data in patients of the main and control groups. Coagulopathy, thrombocytopenia, hypoxia, and the renal and hepatic failure play a significant role in the development of HS associated with COVID-19 compared to the classic HS (without COVID-19), where hypertension seems to be the important. At the same time BP is significantly lower in the main group.Conclusions. The etiopathogenetic factors and the course of HS associated with COVID-19 require pathogenetically different therapy compared to HS without COVID-19.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"22-23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73985037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of renin-angiotensin-aldosterone system blockers on the course of COVID-19 in patients with arterial hypertension","authors":"T. Sveklina, M. Tyuryupov, V. A. Medvedeva, S. Shustov, A. Kuchmin, V. Kozlov","doi":"10.18705/1607-419x-2021-27-6-653-661","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-653-661","url":null,"abstract":"Objective. To determine the presence or absence of the effect of therapy with renin-angiotensin-aldosterone system (RAAS) blockers in patients with COVID-19.Design and methods. We examined 57 patients who were treated in a medical unit at the FGAU CEC “Patriot” in the period from October to November 2020, with the diagnosis of “New coronavirus infection” and differed in the prescribed antihypertensive therapy. In group 1, drugs that affect the RAAS were used to treat hypertension before COVID-19 onset and during the treatment of COVID-19. In group 2, other drugs were used as the main antihypertensive agents before and during treatment for COVID-19. The severity of pneumonia in patients according to the results of computed tomography was 1–2. The patients were monitored for anthropometric indicators, body temperature, and laboratory data.Results. Groups 1 and 2 are comparable, differing only by height, but not by body mass index. The duration of treatment in group 2 was 1–2 days shorter than in group 1, but the result is not statistically significant due to the small sample. Thus, the hypothesis that differences between previous and ongoing antihypertensive therapy throughout the COVID-19 treatment period may affect the course and effectiveness of treatment has not been confirmed.Conclusions. Concomitant antihypertensive therapy with RAAS blockers does not alter the course of COVID-19 infection in patients. The duration of COVID-19 in patients receiving RAAS system blockers may be one day longer than for patients receiving other antihypertensive therapy.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89045680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced renal function in hypertension in young adults: a systematic review","authors":"A. Khudiakova, Y. Ragino","doi":"10.18705/1607-419x-2021-27-6-617-627","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-617-627","url":null,"abstract":"Objective. The aim of the systematic review was to find an answer to the question: «does an increased blood pressure affect kidney function at young age?».Design and methods. The following key words were used to search for relevant publications: “hypertensive nephropathy”, “reduction of glomerular filtration rate in arterial hypertension” in Russian and English. We used “eLIBRARY.RU — SCIENTIFIC ELECTRONIC LIBRARY” and PubMed.gov databases. The inclusion criteria were the young age of the examined patients (from 18 to 44 years), the absence of concomitant pathology. The analysis included only publications of the last 5 years (2015-2020).Results. A total of 18 articles were selected from Russian and international databases that meet inclusion criteria.Conclusions. Based on the analysis of the literature of the last 5 years we assume that increase in blood pressure disrupts kidney function in young people. However, the current data a number of limitations. Until now, gender characteristics, risk factors for decreased renal function in hypertension in young people, and most importantly, the pathogenetic basis of renal dysfunction remain unclear.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86955418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of functional adaptation of the cardiovascular system in athletes with different levels of blood pressure","authors":"E. Mestnikova, F. A. Zakharova, N. Makharova, I. A. Pinigina","doi":"10.18705/1607-419x-2021-27-6-671-682","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-671-682","url":null,"abstract":"Objective. To assess cardiovascular functional adaptation in athletes with different levels of blood pressure (BP) in the Republic of Sakha (Yakutia).Design and methods. We examined 147 professional athletes of high sportsmanship (average age 22 (18; 26) years), cyclic and speed-weightlifting sports. All athletes underwent anthropometry, measurement of office BP and daily BP monitoring, exercise test (PWC170), with determination of maximum oxygen consumption, assessment of the reserve capacity of the cardiovascular system, echocardiography.Results. Masked hypertension (MH) was detected in 40,8% of athletes, normal BP in 59,2%. All athletes showed a high tolerance to physical activity; athletes with MH showed high indices of left ventricular (LV) wall thickness and myocardial mass index compared with athletes with normal BP. The athletes with MH achieve a high level of physical performance due to a less efficient hemodynamic mechanism and energy-intense regimen. A positive correlation was found between LV wall thickness and indicators of cardiovascular functional reserves.Conclusions. MH was detected in 40,8% athletes. In athletes with different BP levels, quantitative and qualitative differences in ensuring physical performance are expressed by the ratio between the “initial” (rest) and “maximum” (test with physical load) indicators of the functional state. Thus, in athletes with MH, inefficient hemodynamic and energy-intensive processes can lead to overstrain of the cardiovascular system. Indicators of functional reserves of the cardiovascular system positively correlate with indicators of LV myocardial wall thickness and myocardial mass index, which may indirectly indicate the relation between cardiovascular overstrain in athletes with MH and target organ damage (LV hypertrophy).","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73089214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery denervation for pulmonary hypertension: a systematic review and meta-analysis of clinical studies","authors":"L. Korobchenko, N. Goncharova, H. I. Condori Leandro, A. Vakhrushev, E. Andreeva, O. Moiseeva, E. N. Mikhaylov","doi":"10.18705/1607-419x-2021-27-6-628-641","DOIUrl":"https://doi.org/10.18705/1607-419x-2021-27-6-628-641","url":null,"abstract":"Objective. To analyze the results of clinical studies on pulmonary artery denervation (PADN) for pulmonary hypertension treatment.Design and methods. Study search was conducted in PubMed/Medline, Cochrane, Elibrary databases. The analysis included studies of surgical and transcatheter PADN. To assess the effectiveness of the PADN procedure, a mean pulmonary artery pressure (mPAP) and a 6-minute walk test distance (6-MWT) were selected. For each study, the mean change in mPAP and 6-MWT were calculated and included in the analysis.Results. A total of 8 studies were analyzed: 4 randomized and 4 observational, 320 patients were included in the study, of which 222 patients underwent PADN. The etiology of pulmonary hypertension (PH) was different in each study and included patients with idiopathic PH, PH associated with heart failure, chronic thromboembolic PH. According to the combined data analysis, mPAP decreased in all studies, and the overall change in mPAP was –8,59 [95 % confidence interval (CI) –10,96; –6,23]. The average increase in 6-MWT among studies was 60,00 [95 % CI 35,74; 84,27].Conclusions. Despite serious limitations (a small number of studies and subjects enrolled, non-randomized design of a half of the studies, high heterogeneity of data), this analysis demonstrated the association of the PADN procedure with a decrease in pulmonary artery pressure and prolongation of the 6-minute walking distance in patients with PH of various etiologies.","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78056963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of associations of hypertension with 16 genetic markers selected according to genome-wide studies","authors":"E. Mazdorova, V. Maksimov, П. S. Orlov, S. Shakhmatov, A. Ryabikov, M. Voevoda, S. Malyutina","doi":"10.18705/1607-419x-2022-28-1-46-57","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-1-46-57","url":null,"abstract":"The multifactorial genesis of hypertension (HTN) enforced the investigation of genetically determined component of its etiopathogenesis in various populations.The aim of present work is to assess the associations between blood pressure (BP) and HTN and polymorphism of a number of genetic markers identified according to GWAS data, in a case-control study based on Siberian population cohort. Design and methods. Design of the work—case-control study in the groups aged 45–69 years old based on a caucasoid population cohort (Novosibirsk). The group of cases included HTN subjects with established diagnosis of HTN under the age of 50 (n = 346)). The control included subjects matched by sex and age to cases, and having at least 2 examinations (6 months apart) with BP levels not exceeding “normal” BP by ESH, 2018 (n = 168). A total of 514 people were included in the analysis. We used standardized epidemiological methods to assess HTN and cardiovascular diseases. Single nucleotide polymorphisms (SNPs) were tested using real-time PCR (ABI 7900HT). The analysis included 16 markers identified in GWAS studies (rs11646213, rs17367504, rs11191548, rs12946454, rs16998073, rs1530440, rs653178, rs1378942, rs1004467, rs381815, rs2681492, rs2681472, rs3184504, rs2384550, rs6495122, rs6773957).Results. For the polymorphism rs1378942 of cytoplasmic tyrosine kinase gene (CSK), in a multivariable-adjusted logistic regression, the carriers of the AC/CC vs. AA genotypes had odds ratio (OR) of HTN of 1,51 (p = 0,043) independent of age and sex; this excess risk was partly explained by the impact of body mass index (BMI). With respect to the quantitative phenotype, women carrying the AA genotype had diastolic BP (DBP) value 5 mm Hg lower than carriers of AC/CC genotypes (p = 0,026). In a multivariable-adjusted analysis, the polymorphism rs653178 of ataxin 2 gene (ATXN2) was associated with HTN independent of age and BMI (СС vs ТТ/ТС; OR = 0,61; p = 0,022); this relationship was realized due to the contribution of men (p = 0,027). With respect to the quantitative phenotype, in the multivariable analysis, the carriers of СС genotype had DBP value lower than those with ТТ/ТС (p = 0,022) independent of age and BMI, and due to the contribution of men. In a multivariableadjusted analysis, the polymorphism rs6773957 of adiponectin gene (ADIPOQ) was associated with HTN in women regardless of age and BMI (GG v. AA/AG; OR = 0,29; p = 0,001). In unadjusted analysis, we found the association between polymorphism rs2384550 of T box transcription factor gene (TBX3) and the level of systolic BP (SBP) in men (p = 0,043); when comparing homozygous groups, the level of SBP was significantly higher among carriers of the AA genotype versus GG (p = 0,013), but this association was attenuated to insignificant in in a multivariate analysis.Conclusions. In a case-control study based on Siberian population sample, we found the associations between qualitative and quantitative phenotypes of BP/HTN an","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75506092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of arterial hypertension in women after delivery (a literature review)","authors":"I. Gaisin, A. Iskhakova, E. Smirnova","doi":"10.18705/1607-419x-2022-28-2-126-146","DOIUrl":"https://doi.org/10.18705/1607-419x-2022-28-2-126-146","url":null,"abstract":"","PeriodicalId":37695,"journal":{"name":"Arterial Hypertension (Russian Federation)","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82402486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}