Obstetrics and Gynecology Science最新文献_第7页

Safety and efficacy of intrauterine lidocaine compared to warm isotonic sodium chloride solution for the control of pain during office hysteroscopy: a randomized controlled trial. 一项随机对照试验：利多卡因与温等渗氯化钠溶液在宫腔镜检查中的安全性和有效性比较。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-10-23 DOI: 10.5468/ogs.25131

Amira Shoab, Amira H AbdelAziz, Hesham El-Shaer, Ahmed M Maged, Wael El-Sherbiny

{"title":"Safety and efficacy of intrauterine lidocaine compared to warm isotonic sodium chloride solution for the control of pain during office hysteroscopy: a randomized controlled trial.","authors":"Amira Shoab, Amira H AbdelAziz, Hesham El-Shaer, Ahmed M Maged, Wael El-Sherbiny","doi":"10.5468/ogs.25131","DOIUrl":"10.5468/ogs.25131","url":null,"abstract":"Objective: To compare the effectiveness of intrauterine lidocaine and warm isotonic sodium chloride solution as distension media for pain reduction during office hysteroscopy.Methods: This triple-blind randomized controlled trial included 100 patients undergoing diagnostic office hysteroscopy. They were randomized into either the isotonic sodium chloride solution group, which underwent hysteroscopy using warmed isotonic sodium chloride solution as the distension medium, or the lidocaine group, which underwent hysteroscopy using 5 mL of 2% lidocaine diluted in warmed isotonic sodium chloride solution as the distension medium. The primary outcome was the pain visual analog scale score during and after the procedure.Results: The pain score reported throughout the procedure (during insertion, visualization and withdrawal) and 15 minutes after the procedure was significantly lower in women in the lignocaine group compared to the other group (1.9±1.0 vs. 3.1±0.8, 1.5±0.8 vs. 2.5±0.8, 1.7±0.8 vs. 2.8±0.7, and 1.1±0.2 vs. 1.7±0.8, respectively). Regarding complications, there were no differences between the two study groups in reported vaginal bleeding (1 vs. 2) or vasovagal reaction (0 vs. 1) with no reported cases of uterine perforation or creation of false tract. Regarding side effects, there were a significantly lower number of women who experienced lower abdominal pain, nausea and headache in the lignocaine group compared to others.Conclusion: The addition of lidocaine to isotonic sodium chloride solution as the distension medium during office hysteroscopy was associated with low pain scores during and after the procedure, short procedure time, reduced need for additional analgesia, high patient satisfaction, and low procedural difficulty scores.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"512-518"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145348990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric and perinatal outcomes in twin pregnancies conceived via assisted reproductive technology vs. spontaneous conception: a population-based cohort study. 通过辅助生殖技术与自然受孕的双胎妊娠的产科和围产期结局：一项基于人群的队列研究

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-11-06 DOI: 10.5468/ogs.25201

Eunhee Yu, Hyun Joo Lee, Sul Lee, Seung Chul Kim, Jong Kil Joo

{"title":"Obstetric and perinatal outcomes in twin pregnancies conceived via assisted reproductive technology vs. spontaneous conception: a population-based cohort study.","authors":"Eunhee Yu, Hyun Joo Lee, Sul Lee, Seung Chul Kim, Jong Kil Joo","doi":"10.5468/ogs.25201","DOIUrl":"10.5468/ogs.25201","url":null,"abstract":"Objective: To compare obstetric and perinatal outcomes between assisted reproductive technology (ART)-conceived and spontaneously conceived twin pregnancies using a nationwide Korean cohort.Methods: This retrospective cohort study used Korean National Health Insurance Service data from October 2017 to December 2021. Twin pregnancies were identified via International Classification of Diseases, 10th revision codes and classified by conception type based on embryo transfer procedure codes. Outcomes included miscarriage, preeclampsia, placenta previa, gestational diabetes mellitus (GDM), emergency cesarean section (CS), intrauterine growth restriction (IUGR), and macrosomia. Multivariable logistic regression was used to calculate adjusted odds ratios (aORs), controlling for maternal age and comorbidities. Subgroup analyses stratified by maternal age were also performed.Results: Among 36,013 twin pregnancies, those conceived via ART showed higher risks of placenta previa (aOR, 1.81; 95% confidence interval [CI], 1.57-2.08), preeclampsia (aOR, 1.31; 95% CI, 1.17-1.47), GDM (aOR, 1.32; 95% CI, 1.22-1.43), emergency CS (aOR, 1.21; 95% CI, 1.08-1.34), and IUGR (aOR, 1.18; 95% CI, 1.07-1.31). In women ≥35 years, risks were more pronounced for preeclampsia (aOR, 1.38; 95% CI, 1.19-1.61) and emergency CS (aOR, 1.22; 95% CI, 1.06-1.42).Conclusion: Twin pregnancies conceived via ART are associated with significantly increased risks of obstetric and perinatal complications compared with spontaneous conceptions. Given the growing utilization of ART, these findings underscore the importance of individualized prenatal care and vigilant perinatal monitoring in ART-conceived twin pregnancies, particularly among women of advanced maternal age.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"491-502"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic mesh sacr ocolpopexy versus lateral vaginal vault suspension in prevention of post hysterectomy vault prolapse: a randomized trial. 腹腔镜网状骶骨固定与阴道外侧拱顶悬吊预防子宫切除术后拱顶脱垂：一项随机试验。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.5468/ogs.25092

Mostafa Hussein Haider, Ahmed Salah Abo Elagha

{"title":"Laparoscopic mesh sacr ocolpopexy versus lateral vaginal vault suspension in prevention of post hysterectomy vault prolapse: a randomized trial.","authors":"Mostafa Hussein Haider, Ahmed Salah Abo Elagha","doi":"10.5468/ogs.25092","DOIUrl":"10.5468/ogs.25092","url":null,"abstract":"Objective: To compare laparoscopic mesh sacrocolpopexy (LSC) and laparoscopic lateral suspension (LLS) for preventing post hysterectomy vault prolapse.Methods: This randomized trial included 40 women who were scheduled for a hysterectomy. The patients were randomly assigned to two groups in a 1:1 ratio: group I underwent LSC immediately after hysterectomy and group II (n=20) underwent LLS immediately after hysterectomy.Results: Postoperative pelvic organ prolapse quantification measurements (anterior vaginal points anterior vaginal wall points A and posterior vaginal wall points B, vaginal apex point C, and posterior vaginal points anterior prolapse and posterior prolapse) were significantly better in the LSC group, with a lower rate of postoperative vault prolapse beyond the introitus (P=0.047). Both groups showed similar estimated blood loss, urinary tract infection, wound infection, and urinary retention rates. However, LSC was associated with significantly higher postoperative pain scores at 24 hours and 48 hours and a longer hospital stay (P<0.05).Conclusion: Although LSC demonstrated more favorable anatomical outcomes and a lower incidence of postoperative vault prolapse beyond the introitus than LLS, these findings should be interpreted with caution because of the limited sample size. Both procedures showed comparable safety profiles, although the LSC was associated with greater postoperative pain and longer hospitalization times. Given the study's exploratory design, small cohort, and short follow-up period, further large-scale multicenter studies are needed to confirm these preliminary observations and to better inform clinical practice regarding the optimal surgical approach for preventing post hysterectomy vault prolapse.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"503-511"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining the American Joint Committee on Cancer tumor nodes metastasis staging system for vulvar melanomas: role of mucosal and cutaneous differentiation. 完善外阴黑素瘤的AJCC TNM分期系统：粘膜和皮肤分化的作用。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-09-24 DOI: 10.5468/ogs.25288

Wiebren Tjalma

引用次数: 0

Enhancing evidence on isoflavones for menopausal vaginal health. 增强异黄酮对绝经期阴道健康的证据。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-08-11 DOI: 10.5468/ogs.25147

Noshaba Majeed, Shoaib Majeed, Jie Tu

引用次数: 0

Statistical analysis using ChatGPT in medical research. ChatGPT在医学研究中的统计分析。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-08-18 DOI: 10.5468/ogs.25232

Soo-Nyung Kim

{"title":"Statistical analysis using ChatGPT in medical research.","authors":"Soo-Nyung Kim","doi":"10.5468/ogs.25232","DOIUrl":"10.5468/ogs.25232","url":null,"abstract":"This study aimed to explore the utility of ChatGPT in streamlining statistical analyses within medical research, evaluating its capabilities in data management, exploratory data analysis (EDA), statistical test selection, and result interpretation. It also addresses the critical need for appropriate disclosures and ethical considerations when integrating artificial intelligence (AI) tools into a scientific workflow. We review the current landscape of AI adoption in medical research, focusing on the role of ChatGPT in statistical analysis. Practical examples from lecture materials demonstrate its application in generating virtual datasets, performing data cleaning, conducting EDA, and assisting in the selection of appropriate statistical tests. Furthermore, guidelines for transparently disclosing AI tool usage in scientific manuscripts in accordance with the International Committee of Medical Journal Editors recommendations are discussed. ChatGPT demonstrates considerable potential for accelerating various stages of statistical analysis, from initial data preparation to the interpretation of results. Its ability to rapidly generate virtual data for practice, assist in comprehensive data cleaning, and provide immediate insights through EDA can substantially enhance research efficiency. Although capable of suggesting statistical methods and interpreting outputs, human intervention remains crucial for verifying assumptions and ensuring calculation accuracy. ChatGPT can serve as a powerful assistant in medical statistical analyses, enabling researchers to conduct analyses more efficiently. However, its use requires careful data preprocessing, human verification of results, and transparent reporting to maintain scientific rigor and reproducibility. Adherence to ethical guidelines and journal policies regarding AI tool disclosure is paramount.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"467-472"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12645003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaginal microbiome and its implications in preterm birth. 阴道微生物组及其对早产的影响。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.5468/ogs.25085

Sunwha Park, Young-Ah You, Gain Lee, Young Min Hur, Yoon-Young Go, Suenie Park, Young Ju Kim

{"title":"Vaginal microbiome and its implications in preterm birth.","authors":"Sunwha Park, Young-Ah You, Gain Lee, Young Min Hur, Yoon-Young Go, Suenie Park, Young Ju Kim","doi":"10.5468/ogs.25085","DOIUrl":"10.5468/ogs.25085","url":null,"abstract":"Preterm birth (PTB), defined as birth occurring before 37 weeks of gestation, remains a major global public health challenge, affecting approximately 10% of pregnancies worldwide and contributing significantly to neonatal morbidity and mortality. Despite extensive research, the etiology of PTB is multifactorial and not yet fully understood, with ongoing debates regarding the contributions of inflammation, hormonal dysregulation, genetic predisposition, and environmental factors such as microbial dysbiosis. Recent studies have highlighted the role of the vaginal microbiome in pregnancy outcomes, particularly its association with PTB. This review consolidates current findings on the vaginal microbiome's influence on PTB, addressing microbial dysbiosis as a key risk factor. Despite differences in ethnicity, gestational age at sample collection, and analytical methodologies, a common observation is that a decrease in Lactobacillus species is associated with an increased risk of PTB. These differences influence study outcomes by affecting variations in microbial composition, host immune regulation, genetic predisposition, and environmental influences. However, a consistently observed trend is that a Lactobacillus-dominant vaginal microbiome is generally associated with a lower risk of PTB across diverse populations. This review also discusses the limitations of existing research and suggests directions for future microbiome studies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"449-457"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review. E-cadherin和N-cadherin在子宫内膜异位症及其他妇科疾病靶向治疗中的表达谱：系统综述

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.5468/ogs.25123

Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Kristina Kurbatova, Elizaveta Platonova, Karina Mailova, Assia Stepanian

{"title":"Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review.","authors":"Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Kristina Kurbatova, Elizaveta Platonova, Karina Mailova, Assia Stepanian","doi":"10.5468/ogs.25123","DOIUrl":"10.5468/ogs.25123","url":null,"abstract":"This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane Library, ClinicalTrials.gov, Scopus, Embase, and Google Scholar electronic databases. Twenty-two studies were included in the qualitative analyses. Several studies reported reduced E-cadherin expression in the ectopic and eutopic endometrium of patients with endometriosis, compared with that in the endometrium of patients without endometriosis (healthy comparison group and patients with non-malignant gynecological diseases). Moreover, some of the included studies reported higher E-cadherin concentration in endometriotic lesions than in the eutopic endometrium of patients with endometriosis. Similar results were obtained for β-catenin concentration. Some studies found that the expression levels of N-cadherin, ZEB1, ZEB2, TWIST, vimentin, SNAIL, SLUG, matrix metalloproteinases-9, and hypoxia-inducible factor-1α were higher in patients with endometriosis and that the E-cadherin levels were lower in ovarian and endometrial carcinomas than in endometriosis. These findings support the transplantation theory of endometriosis pathogenesis and highlight the potential therapeutic value of modulating E-cadherin and N-cadherin expression. Further research should be conducted to explore targeted treatment strategies for endometriosis.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"349-371"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical time in gynecologic surgery using laparoscopic articulated instruments (KGOG 4002). 妇科手术中使用腹腔镜关节器械的手术时间（kgog4002）。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.5468/ogs.25076

Hyunjoon Im, Soyeon Ahn, Kidong Kim, Min Kyung Kim, Jeong-Yeol Park, Ha Kyun Chang, Seok Ju Seong, Jong Ha Hwang

{"title":"Surgical time in gynecologic surgery using laparoscopic articulated instruments (KGOG 4002).","authors":"Hyunjoon Im, Soyeon Ahn, Kidong Kim, Min Kyung Kim, Jeong-Yeol Park, Ha Kyun Chang, Seok Ju Seong, Jong Ha Hwang","doi":"10.5468/ogs.25076","DOIUrl":"10.5468/ogs.25076","url":null,"abstract":"Objective: To estimate the learning curve of laparoscopic articulated instrument (LAI) surgery by analyzing data from a multi-institutional gynecologic surgery cohort using surgical time as the primary metric for evaluation.Methods: A total of 400 patients scheduled to undergo gynecologic surgery (adnexal surgery, myomectomy, hysterectomy, and cancer surgery) using LAI were prospectively enrolled at 14 institutes in the Republic of Korea between November 2021 and April 2022 (KGOG 4002). After excluding patients who did not undergo surgery with LAI (n=43), those in whom LAI was rarely used (n=11), and those operated on by surgeons with prior LAI experience (n=147), 199 patients were included in the analysis. Changes in surgical time according to the surgery index were evaluated using linear regression analysis.Results: Fifty-four adnexal surgeries, 40 myomectomies, 68 hysterectomies, and 37 cancer surgeries were performed by 24 surgeons. Each surgeon performed between one and 24 surgeries. Surgical time did not decrease as the surgery index increased for any type of surgery. Among surgeons who performed ≥10 surgeries, surgical time similarly showed no decrease with increasing surgery index.Conclusion: In gynecologic surgery using LAI, surgical time did not decrease despite accumulating surgical experience.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"401-407"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cauda equina syndrome following vaginal delivery. 阴道分娩后的马尾综合征。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-06-30 DOI: 10.5468/ogs.25166

Seung Jun Lee, So-Young Lee, Jun-Hwan Choi, Hyun Jung Lee

引用次数: 0