Journal of Pediatric Pharmacology and Therapeutics最新文献_第9页

Evaluation of Methicillin-Resistant Staphylococcus aureus Eradication in People With Cystic Fibrosis. 囊性纤维化患者耐甲氧西林金黄色葡萄球菌根除的评价。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-10-01 Epub Date: 2025-10-17 DOI: 10.5863/JPPT-24-00079

Eva M Byerley, Vedat O Yildiz, Shahid I Sheikh, Kimberly J Novak

{"title":"Evaluation of Methicillin-Resistant Staphylococcus aureus Eradication in People With Cystic Fibrosis.","authors":"Eva M Byerley, Vedat O Yildiz, Shahid I Sheikh, Kimberly J Novak","doi":"10.5863/JPPT-24-00079","DOIUrl":"10.5863/JPPT-24-00079","url":null,"abstract":"Objective: People with cystic fibrosis (pwCF) have impaired bacterial mucociliary clearance, which can result in colonization with pathogens like Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) in the lower airway. Although guidelines for the eradication of P. aeruginosa in CF are well-established, MRSA eradication guidelines are lacking. This study aimed to determine the rates of MRSA eradication in pwCF based on a prescribed antibiotic regimen.Methods: This retrospective chart review included pwCF with a first lifetime positive MRSA respiratory culture or first positive MRSA respiratory culture after at least 1 year of MRSA negativity (minimum of 4 negative respiratory cultures) obtained at Nationwide Children's Hospital between August 1, 2012, and February 28, 2022. Secondary outcomes assessed the impact of adding topical decontamination on MRSA eradication and the time to a subsequent MRSA-positive respiratory culture after completing the eradication regimen.Results: Sixty-two patients were included, and 16% achieved MRSA eradication. Intravenous vancomycin transitioned to oral trimethoprim-sulfamethoxazole achieved the highest eradication rate of 75% (p = 0.008). Antibiotics consisting of dual therapy with rifampin and topical decontamination had a higher rate of eradication (25%) compared with antibiotics alone, antibiotics with topical decontamination, or no antibiotics. Four patients had no subsequent MRSA-positive cultures, including 2 patients who did not receive antibiotics.Conclusions: The transition from intravenous vancomycin to oral trimethoprim-sulfamethoxazole had the highest rate of MRSA eradication. Overall rates of MRSA eradication at 12 months in patients CF using antibiotics with or without topical decontamination are low.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 5","pages":"601-606"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Not Throw Away Your Patient's Shot at Complete Vomiting Control. 不要放弃病人完全控制呕吐的机会。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01210

L Lee Dupuis, Priya Patel

引用次数: 0

Impact of a Procalcitonin Guided Antibiotic Management Strategy in Pediatric Sickle Cell Patients With Fever. 降钙素原引导下的抗生素管理策略对小儿镰状细胞病患者发热的影响。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00085

Hannah Robinson, Andrew B Gainey, Robert Daniels, Shannon DeRienzo, Deborah Hurley, Angie Brown, Carla Roberts, Anna-Kathryn Burch

{"title":"Impact of a Procalcitonin Guided Antibiotic Management Strategy in Pediatric Sickle Cell Patients With Fever.","authors":"Hannah Robinson, Andrew B Gainey, Robert Daniels, Shannon DeRienzo, Deborah Hurley, Angie Brown, Carla Roberts, Anna-Kathryn Burch","doi":"10.5863/JPPT-24-00085","DOIUrl":"10.5863/JPPT-24-00085","url":null,"abstract":"Objective: This study assessed the relationship between antibiotic durations and the use of procalcitonin (PCT) in febrile pediatric patients with sickle cell disease (SCD), including those diagnosed with acute chest syndrome (ACS) and/or vaso-occlusive crisis (VOC).Methods: This multicenter, retrospective cohort study compared antibiotic durations in febrile pediatric SCD patients between 2 cohorts, 1 utilizing PCT (PCT cohort) and 1 not utilizing PCT (no-PCT cohort). Secondary endpoints compared the impact of PCT on antibiotic durations in those also diagnosed with ACS and/or VOC.Results: A total of 258 patient encounters were included. The overall mean antibiotic duration in the PCT cohort was 4.2 days (SD 2.6) vs 4.7 days (SD 3.6) (p = 0.991). For those diagnosed with ACS (n = 17), the mean antibiotic duration was 6 days (SD 2.2) in the PCT cohort vs 9.7 days (SD 3.5) (p = 0.037; n = 7). Those diagnosed with both VOC and ACS (n = 40) averaged 5.6 days (SD 1.9) in the PCT cohort vs 9.3 days (SD 3.2) (p = 0.002; n = 9). Regression analyses revealed an increased odds of longer antibiotic duration in the no-PCT cohort for those with ACS (OR 1.51, 95% CI 1.07-2.13, p = 0.019), and for those with both VOC and ACS (OR 1.72, 95% CI 1.22-2.42, p = 0.002).Conclusions: There was not a significant difference in overall antibiotic durations between cohorts. However, in the PCT cohort there was a significant reduction of antibiotic durations seen in patients diagnosed with ACS or VOC and ACS, averaging 3.7 fewer days of antibiotics.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"464-470"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Granulocyte-Colony Stimulating Factor for Beta-Lactam Induced Neutropenia in Children With Bacterial Meningitis. 粒细胞集落刺激因子治疗细菌性脑膜炎患儿β -内酰胺诱导中性粒细胞减少症的应用。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00073

Cheng Yu Yen, Sheldon L Kaplan, Debra L Palazzi, Grant Stimes

引用次数: 0

Do Postnatal Corticosteroids Negatively Impact the Neurodevelopmental Outcomes of Extremely Preterm Infants? 产后皮质类固醇对极早产儿的神经发育结果有负面影响吗？

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-00048

引用次数: 0

The New Wave of Blocking Taste. 阻挡口味的新浪潮。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01212

Hassan Almoazen

引用次数: 0

Intravenous Ceftaroline in Extremely Premature Neonates With Coagulase-Negative Staphylococci Septicemia: A Report of 2 Cases. 静脉注射头孢他林治疗凝血酶阴性葡萄球菌败血症2例

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00087

Suzan S Assfour, Fahad A AlMoghaileth, Adli Abdelrahim, Amal K Hassouneh, Sara O Salem, Raneem S Assfour, Thanaa M Khalil, Mountasser M Al-Mouqdad

{"title":"Intravenous Ceftaroline in Extremely Premature Neonates With Coagulase-Negative Staphylococci Septicemia: A Report of 2 Cases.","authors":"Suzan S Assfour, Fahad A AlMoghaileth, Adli Abdelrahim, Amal K Hassouneh, Sara O Salem, Raneem S Assfour, Thanaa M Khalil, Mountasser M Al-Mouqdad","doi":"10.5863/JPPT-24-00087","DOIUrl":"10.5863/JPPT-24-00087","url":null,"abstract":"Sepsis is one of the primary causes of newborn morbidity and mortality, particularly in preterm infants, and coagulase-negative staphylococci (CoNS) is a major cause of bacterial infections in the neonatal intensive care unit (NICU). The treatment of late-onset neonatal staphylococcal sepsis is challenging owing to increased minimum inhibitory concentrations and the potential side effects of vancomycin. Herein, we describe 2 cases of extremely preterm newborns treated with intravenous (IV) ceftaroline (6 mg/kg/dose every 8 hours) for late-onset neonatal staphylococcal sepsis. Both cases were diagnosed with bacteremia and treated with ceftaroline. However, one of the patients died, most likely from sepsis or other factors, including chronic lung illness and prematurity, despite sterile blood cultures after starting the ceftaroline treatment. Large-scale randomized studies are required to examine the optimal dosing, safety, and effectiveness of IV ceftaroline for sepsis caused by CoNS in neonates.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"508-514"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myalgia and Rigidity as Adverse Effects of Trametinib Therapy. 曲美替尼治疗的不良反应：肌痛和僵硬。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00002

Charles J Weeks, Victoria Frame, Rohan Vuppala, David Thomas, Abigayle B Simon, Michael Stokes, Colleen McDonough

{"title":"Myalgia and Rigidity as Adverse Effects of Trametinib Therapy.","authors":"Charles J Weeks, Victoria Frame, Rohan Vuppala, David Thomas, Abigayle B Simon, Michael Stokes, Colleen McDonough","doi":"10.5863/JPPT-24-00002","DOIUrl":"10.5863/JPPT-24-00002","url":null,"abstract":"Mitogen-activated extracellular kinase inhibitors, including trametinib and selumetinib, are increasingly used to treat pediatric low-grade gliomas. Trametinib, while administered orally and with minimal myelosuppression, is reported to cause rash, diarrhea, and fatigue. Selumetinib has been associated with skin irritation, diarrhea, and musculoskeletal pain. This case report describes an 8-month-old male with a low-grade glioma (LGG) that progressed 6 months post-chemotherapy and was started on trametinib due to its liquid formulation and minimal side effect profile. However, the patient developed severe diarrhea, abdominal pain, neck pain, rigidity, and decreased stamina. These symptoms necessitated discontinuation of trametinib, after which all symptoms resolved within a week. This case highlights the first reported instance of trametinib-induced myalgia and rigidity in a pediatric patient receiving trametinib therapy for a LGG. Clinicians should consider these rare but significant adverse effects when choosing an antineoplastic therapy for the treatment of progressive LGG.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"515-519"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds. 在影响下：医用大麻对心智发育的认知作用。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01209

Marry Vuong, Kaylee Parkhill

引用次数: 0

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics. 儿科药学协会2025年儿童儿科关键潜在不适宜药物清单。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-00061

Christopher McPherson, Rachel S Meyers, Jennifer Thackray, Danielle L Stutzman, Kimberly P Mills, Sana J Said, Karisma Patel, Robert C Hellinga, Amy L Potts, Lisa Lubsch, Kelly L Matson, David S Hoff

{"title":"Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics.","authors":"Christopher McPherson, Rachel S Meyers, Jennifer Thackray, Danielle L Stutzman, Kimberly P Mills, Sana J Said, Karisma Patel, Robert C Hellinga, Amy L Potts, Lisa Lubsch, Kelly L Matson, David S Hoff","doi":"10.5863/JPPT-25-00061","DOIUrl":"10.5863/JPPT-25-00061","url":null,"abstract":"Objective: The objective was to update the KIDs List, a list of drugs and excipients that are potentially inappropriate for use in pediatric patients, accounting for emerging pharmacologic agents and published evidence.Methods: A panel of 12 pediatric pharmacists from the Pediatric Pharmacy Association (PPA) evaluated primary, secondary, and tertiary literature; FDA Pediatric Safety Communications; the UpToDate Lexidrug database; and product information for drugs that may be considered potentially inappropriate for use in pediatric patients. A PubMed search identified new publications from October 1, 2017, to November 1, 2023. All agents included in the previous publication and those anecdotally identified as candidates for the list by the authors or PPA members were evaluated. Evidence was reviewed by all authors. The draft list underwent a 30-day public comment period prior to being finalized.Results: A PubMed search yielded 917 unique titles of which 17 were deemed relevant for full review. Sixty-seven drugs and/or drug classes and 10 excipients from the original publication were also reviewed. Author and PPA member recommendations highlighted an additional 25 drugs or drug classes. The UpToDate Lexidrug database extraction yielded 1470 drugs, which were filtered to 145 agents for author review. After critical analysis and reorganization, the second edition of the KIDs List contains 39 drugs and/or drug classes and 10 excipients.Conclusions: This article updates the initial list of drugs and excipients that are potentially inappropriate for prescribing in all or a select subgroup of pediatric patients. The second edition should stimulate novel research to inform future updates.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"422-439"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0