Safaa Choayb, Yahya El Harras, Meriem Fikri, Najoua Ech-Cherif El Kettani, Mohamed Jiddane, Firdaous Touarsa
{"title":"Intracochlear schwannoma: Imaging diagnosis","authors":"Safaa Choayb, Yahya El Harras, Meriem Fikri, Najoua Ech-Cherif El Kettani, Mohamed Jiddane, Firdaous Touarsa","doi":"10.1016/j.joto.2023.03.001","DOIUrl":"10.1016/j.joto.2023.03.001","url":null,"abstract":"<div><p>Intralabyrinthine schwannomas (ILS) are rare benign tumors, often responsible for hearing loss. MRI is important in establishing the diagnosis. We present the example of a 48-year-old lady who reported a 3-years history of right-sided sensorineural deafness. MRI demonstrated a loss of the normal hypersignal of the second turn of the right cochlea compatible with intracochlear schwannoma.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 2","pages":"Pages 101-103"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validation of LittleEARS questionnaire in Hindi language","authors":"Praveen Prakash , S. Lakshmi , Adithya Sreedhar , Arena Varan Mathur , Sreeraj Konadath","doi":"10.1016/j.joto.2022.12.003","DOIUrl":"10.1016/j.joto.2022.12.003","url":null,"abstract":"<div><h3>Background</h3><p>Subjective measures of auditory development are equally important as objective measures to obtain a realistic image of the hearing status in infants and toddlers.</p></div><div><h3>Objectives</h3><p>The objectives of the current study were to translate and validate the LittleEARS questionnaire into the Hindi language, to calculate its psychometric properties and establish a regression curve of the scores obtained as a function of age, to calculate the inter-test and test retest reliability of the same. The secondary objectives were to compare the scores obtained by the normal hearing children and those with hearing impairment and to plot a regression curve of total scores obtained by the hearing-impaired children as a function of the duration of auditory training attended since their first fit of the device.</p></div><div><h3>Materials and methods</h3><p>The procedures involved conventional translation, reverse translation, and content validation before administering the questionnaire. The translated version was administered to parents of 59 children with normal hearing and 41 children with hearing impairment.</p></div><div><h3>Results</h3><p>The finalized version had good reliability and efficient internal consistency with a Cronbach alpha value of 0.96. The mean scores obtained by the normal hearing children showed a progressive pattern as a function of age.</p></div><div><h3>Conclusion</h3><p>The LittleEARS questionnaire has been successfully translated and validated into the Hindi language with excellent validity and reliability and can be used for screening and early identification of hearing impairment and in evaluating the outcome of audiological treatment approaches.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 2","pages":"Pages 71-78"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/2a/main.PMC10159752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Du , Xingjian Liu , Lili Ren , Yu Wang , Fei Ji , Weiwei Guo , Ziming Wu
{"title":"Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from?","authors":"Yi Du , Xingjian Liu , Lili Ren , Yu Wang , Fei Ji , Weiwei Guo , Ziming Wu","doi":"10.1016/j.joto.2023.01.001","DOIUrl":"10.1016/j.joto.2023.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Saccades are often observed on video head impulse tests (vHIT) in patients with Meniere's Disease (MD) and Vestibular Migraine (VM). However, their saccadic features are not fully described.</p></div><div><h3>Objective</h3><p>This study aims to identify the saccades characteristics of MD and VM.</p></div><div><h3>Methods</h3><p>75 VM patients and 103 definite unilateral MD patients were enrolled in this study. First raw saccades were exported and analyzed. The VM patients were divided into left and right based on their ears, while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.</p></div><div><h3>Results</h3><p>The MD patients have more saccades on the affected side (85% vs. 69%), and saccade velocity is more consistent than the contralateral side (shown by the coefficient of variation). The saccades occurrence rates on both sides are similar in VM (77% vs. 76%), as are other saccadic parameters. The MD patients have more significant inter-aural differences than the VM patients, manifested in higher velocity (p-value 0.000), earlier arriving (p-value 0.010), and more time-domain gathered (p-value 0.003) on the affected side.</p></div><div><h3>Conclusions</h3><p>Bilateral saccades are commonly observed in MD and VM. In contrast to MD, saccades on VM are subtle, scattered, and late-arrived. Furthermore, the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 2","pages":"Pages 79-84"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Javier Gonzalez Eslait , Paola Andrea Escudero Triviño , Yaidy Viviana Giraldo Vergara , Mónica Andrea Morales García , Vanessa Fernanda Lucero Gutiérrez
{"title":"Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction","authors":"Francisco Javier Gonzalez Eslait , Paola Andrea Escudero Triviño , Yaidy Viviana Giraldo Vergara , Mónica Andrea Morales García , Vanessa Fernanda Lucero Gutiérrez","doi":"10.1016/j.joto.2022.12.001","DOIUrl":"10.1016/j.joto.2022.12.001","url":null,"abstract":"<div><h3>Objective</h3><p>We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological & Balance Center patients.</p></div><div><h3>Design</h3><p>This is a retrospective descriptive study. Participants included Seventy-three adults with diagnoses of acute, episodic, or chronic vestibular syndromes. They were classified into the following two groups: group 1 included 46 individuals treated with ISIT plus VRT, and group 2 included 27 individuals treated only with ISIT.</p></div><div><h3>Results</h3><p>The Sensory Organization Test (SOT) for both groups showed a statistical significance for all three sensory inputs; visual systems (G1: p = 0.0003; G2: p = 0.0337), vestibular system (G1: p < 0.0001; G2: p = 0.0003), and balance as demonstrated by compound balance score (G1: p < 0.0001; G2: p = 0.0035), and balance percentage deficit (G1: p < 0.0001; G2: p = 0.0078).</p></div><div><h3>Conclusions</h3><p>The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions, and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 26-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hari Prakash Palaniswamy , Mayur Bhat , Rajashree Ganesh Bhat , Y. Krishna , B. Rajashekhar
{"title":"Development, and validation of non-speech dichotic listening test","authors":"Hari Prakash Palaniswamy , Mayur Bhat , Rajashree Ganesh Bhat , Y. Krishna , B. Rajashekhar","doi":"10.1016/j.joto.2022.12.004","DOIUrl":"10.1016/j.joto.2022.12.004","url":null,"abstract":"<div><h3>Background</h3><p>Classic dichotic listening tests using speech stimuli result in right ear advantage, due to the dominant crossed pathway for speech and language. It is presumed that similar crossed dominance could exist for non-speech stimuli too. Hence, this is an attempt to develop and validate the dichotic non-speech test using environmental stimuli and explore the effect of focused attention on this test.</p></div><div><h3>Materials and method</h3><p>Three lists of dichotic stimuli were created using these sounds with fifteen tokens in each list. Four professionals and non-professionals validated these materials. Normative estimation was obtained by administering the newly developed test on 70 adults and 70 children using a free-recall and forced-recall condition.</p></div><div><h3>Result</h3><p>The results showed a significant difference between the left ear and right scores where the left ear score was better than the right, depicting left ear advantage (LEA) for free recall condition in both groups. In the forced recall condition, LEA was not seen; rather the mean score was significantly higher in the attended ear, irrespective of the stimuli presented to the right or left ear. The test-retest reliability in free recall was good in both the ears and moderate for forced right ear conditions.</p></div><div><h3>Conclusion</h3><p>The novel test consistently showed LEA with good reliability and can be used to assess the hemispheric asymmetry in normal subjects and also in test batteries for the clinical population.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 63-69"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/31/main.PMC9937819.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theofano Tikka, Mohd Afiq Mohd Slim, Trung Ton, Anna Sheldon, Louise J. Clark, Georgios Kontorinis
{"title":"Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study","authors":"Theofano Tikka, Mohd Afiq Mohd Slim, Trung Ton, Anna Sheldon, Louise J. Clark, Georgios Kontorinis","doi":"10.1016/j.joto.2022.12.005","DOIUrl":"10.1016/j.joto.2022.12.005","url":null,"abstract":"<div><h3>Objective</h3><p>It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group.</p></div><div><h3>Methods</h3><p>This was a prospective case-control study performed in a tertiary referral center, university teaching hospital in the UK. It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period (2015–2019) compared to a gender and age matched control group. The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups<strong>.</strong></p></div><div><h3>Results</h3><p>A total of 31 SSCD patients were recruited with a matched number of control patients. The mean Vitamin D level on the SSCD group was 44.8 nmoL/l (SD: 20.8) compared to 47.5 nmoL/l (SD: 27.4) on the control group (p = 0.702). Mean Adjusted calcium level was 2.34 mmoL/l (SD: 0.7) for SSCD compared to 2.41 mmoL/l (SD: 0.11) for controls (p = 0.01), being within normal limits for both the SSCD and the control group.</p></div><div><h3>Conclusion</h3><p>Our study did not identify a link between Vitamin D levels and presence of SSCD. Normal adjusted calcium values were found in both groups. Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 49-54"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/e1/main.PMC9937815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isaac B. Thorman , Brian J. Loyd , Richard A. Clendaniel , Leland E. Dibble , Michael C. Schubert
{"title":"The minimal clinically important difference for gait speed in significant unilateral vestibular hypofunction after vestibular rehabilitation","authors":"Isaac B. Thorman , Brian J. Loyd , Richard A. Clendaniel , Leland E. Dibble , Michael C. Schubert","doi":"10.1016/j.joto.2022.11.001","DOIUrl":"10.1016/j.joto.2022.11.001","url":null,"abstract":"<div><p>Gait speed is a valid measure of both physical function and vestibular health. Vestibular rehabilitation is useful to improve gait speed for patients with vestibular hypofunction, yet there is little data to indicate how changes in gait speed reflect changes in patient-reported health outcomes. We determined the minimal clinically important difference in the gait speed of patients with unilateral vestibular hypofunction, mostly due to deafferentation surgery, as anchored to the Dizziness Handicap Index and the Activities Balance Confidence scale, validated using regression analysis, change difference, receiver-operator characteristic curve, and average change methods. After six weeks of vestibular rehabilitation, a change in gait speed from 0.20 to 0.34 m/s with 95% confidence was required for the patients to perceive a significant reduction in perception of dizziness and improved balance confidence.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 15-20"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/1f/main.PMC9937836.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10023926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hesham Saleh Almofada , Nasser K. Almutairi , Michael Steven Timms
{"title":"Long-term complications of the transmeatal approach (Open Transcanal) in cochlear implants: A follow-up study","authors":"Hesham Saleh Almofada , Nasser K. Almutairi , Michael Steven Timms","doi":"10.1016/j.joto.2022.12.002","DOIUrl":"10.1016/j.joto.2022.12.002","url":null,"abstract":"<div><h3>Objective</h3><p>Multiple alternative approaches of cochlear implant surgery have been described, such as the suprameatal approach, transcanal approach, transmeatal approach and middle cranial fossa approach. Transmeatal (open trnascanal) approach has not been adapted since first described in the clinical field. we aimed to assess the long-term complications of the transmeatal approach in a series of 131 patients at our center between 2004 and 2008.</p></div><div><h3>Methods</h3><p>This study was a retrospective case series of all patients who underwent cochlear implants with the transmeatal (open transcanal) approach from May 2004 to December 2008 at King Faisal Specialist and Research Hospital (Riyadh, Saudi Arabia), which were conducted by the same surgeon.</p></div><div><h3>Results</h3><p>Complications were observed often with various combinations—recurrent otitis externa, posterior tympanic membrane perforation, electrode extrusion, cholesteatoma, and chronic mastoiditis. The overall long-term complication rate was 16% (21/131). The gap between the implantation and the diagnosis of a complication ranged from <1 year to 11 years. Major complications were as follows: cholesteatoma in 5 (3.8%) patients, extrusion of the electrode in 5 (3.8%) patients, and tympanic membrane perforation or deep retractions in 5 (3.8%) patients. Minor complications were as follows: recurrent mastoiditis with/without concomitant temporary facial nerve palsy in 4 (3%) patients, recurrent otitis externa infections in 7 (5%) patients, and weakness of the posterior canal wall in 1 patient.</p></div><div><h3>Conclusion</h3><p>The transmeatal approach posed an high rate of complications on long-term follow-up such as cholestetoma formation, extrusion of electrode or perielectrode reaction formation to tympanic membrane and external auditory canal</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 33-37"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cátia Azevedo, Miguel Breda, Daniela Ribeiro, Fernando Milhazes Mar, Sérgio Vilarinho, Luís Dias
{"title":"Functional and patient-reported outcomes of bone-anchored hearing aids (BAHA): A prospective case series study","authors":"Cátia Azevedo, Miguel Breda, Daniela Ribeiro, Fernando Milhazes Mar, Sérgio Vilarinho, Luís Dias","doi":"10.1016/j.joto.2022.11.002","DOIUrl":"10.1016/j.joto.2022.11.002","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to evaluate the functional and patient-reported outcomes, and their correlation, after percutaneous bone-anchored hearing aid (BAHA) implantation.</p></div><div><h3>Methods</h3><p>A prospective study was conducted between January 2018 and December 2020 in a tertiary care center. All adult patients who were implanted with a percutaneous BAHA device during this evaluation period were included in the study. Complete auditory function and patients reported outcome measures (PROMs) were assessed in the preoperative period and 6 months after the implant activation. The PROMs included a generic form (Medical Outcome Study 36 Short Form Healthy Survey (MOS SF-36)), and three disease-specific forms (Hearing Handicap Inventory (HHI), Satisfaction with Amplification in Daily Life Scale (SADLS), and Tinnitus Handicap Inventory (THI)).</p></div><div><h3>Results</h3><p>Twenty-two patients with an average age of 53 years were included in the study. The overall functional gain with the BAHA in sound-field pure tone average (PTA) was 29 dB, with no statistically significant differences according to surgical indication (F(3,18) = 2.319, p = 0.110). The greater the preoperative air-bone gap, the greater the functional gain obtained (r = 0.505, p < 0.05). In the PROMs, we found a significant improvement in HHI scores (p < 0.005) and a significant increase in overall SADLS scores (p < 0.05) with the use of percutaneous BAHA devices. We did not verify any statistically significant correlation between functional and PROMs results.</p></div><div><h3>Conclusions</h3><p>The BAHA is a safe and effective alternative hearing rehabilitation option in selected patients. The PROMs results prove patient's overall satisfaction.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 7-14"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/1c/main.PMC9937820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Test re-test reliability of virtual acoustic space identification (VASI) test in young adults with normal hearing","authors":"Kavassery Venkateswaran Nisha, Prabuddha Bhatarai, Kruthika Suresh, Shashish Ghimire, Prashanth Prabhu","doi":"10.1016/j.joto.2022.12.006","DOIUrl":"10.1016/j.joto.2022.12.006","url":null,"abstract":"<div><h3>Background</h3><p>Recent developments in virtual acoustic technology has levered promising applications in the field of auditory sciences, especially in spatial perception. While conventional auditory spatial assessment using loudspeakers, interaural differences and/or questionnaires are limited by the availability and cost of instruments, the use of virtual acoustic space identification (VASI) test has widespread applications in spatial test battery as it overcomes these constraints.</p></div><div><h3>Purpose</h3><p>The lack of test-retest reliability data of VASI test narrows its direct application in auditory spatial assessment, which is explored in the present study.</p></div><div><h3>Methods</h3><p>Data from 75 normal-hearing young adults (mean age: 25.11 y ± 4.65 SD) was collected in three sessions: baseline, within 15 min of baseline (intra-session), and one week after baseline session (inter-session). Test-retest reliability was assessed using the intra-class correlation coefficient (ICC), coefficient of variation (CV), and cluster plots.</p></div><div><h3>Results</h3><p>The results showed excellent reliability for both accuracy and reaction time measures of VASI, with ICC values of 0.93 and 0.87, respectively. The CV values for overall VASI accuracy and reaction time 9.66% and 11.88%, respectively. This was also complemented by the cluster plot analyses, which showed 93.33% and 96.00% of temporal stability in the accuracy and reaction time measures, indicative of high test-retest reliability of VASI test in auditory spatial assessment.</p></div><div><h3>Conclusions</h3><p>The high temporal stability (test-retest reliability) of VASI test validates its application in spatial hearing test battery.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"18 1","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/b1/main.PMC9938009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}