鼓室内注射水凝胶纳米药物预防和治疗感音神经性听力损失

IF 1.4 Q2 OTORHINOLARYNGOLOGY

Journal of Otology Pub Date : 2023-10-01 DOI:10.1016/j.joto.2023.09.005

Tianying Zhai , Pingping Ai , Zhaohui Tang , Chaoliang He , Xuesi Chen , Shiming Yang , Nan Wu

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引用次数: 0

摘要

安全有效的药物内耳给药一直是感音神经性耳聋防治的重点。基于水凝胶的纳米药物递送系统的快速发展提供了一个新的机会。其中，热敏水凝胶促进了鼓内注射新剂型的开发。当温度升高时，这种智能生物材料可以转变为半固态。热敏水凝胶纳米给药系统有望实现安全、高效和持续的内耳给药。本文介绍了该领域的关键技术和最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss

Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity. Among them, thermo-sensitive hydrogels promote the development of new dosage form for intratympanic injection. This smart biomaterial could transform to semisolid phase when the temperature increased. Thermo-sensitive hydrogel nanodrug delivery system is expected to achieve safe, efficient, and sustained inner ear drug administration. This article introduces the key techniques and the latest progress in this field.

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来源期刊

Journal of Otology Medicine-Otorhinolaryngology

CiteScore

2.70

自引率

0.00%

发文量

461

审稿时长

18 days

期刊介绍： Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.