HIV Infection and Immunosuppressive Disorders最新文献_第5页

Disseminated form of herpes zoster in an immunocompromised patient with oculocutaneous albinism 免疫功能低下的眼皮肤白化病患者的播散型带状疱疹

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-02-27 DOI: 10.22328/2077-9828-2022-14-4-93-97

E. D. Lyutsova, V. Gadzhovska, M. Gospodinova, D. Radkova

引用次数: 0

Epidemiological features and psychoneurological disorders In humans caused by exposure to the monkeypox virus 暴露于猴痘病毒引起的人类流行病学特征和精神神经障碍

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-7-20

I. Ulyukin, V. Rassokhin, E. S. Orlova, A. Sechin

引用次数: 0

Sailors’ fear of the stigma of HIV/AIDS 水手们对艾滋病毒/艾滋病耻辱的恐惧

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-36-40

M. Kolarova-Dimitrova

{"title":"Sailors’ fear of the stigma of HIV/AIDS","authors":"M. Kolarova-Dimitrova","doi":"10.22328/2077-9828-2022-14-4-36-40","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-36-40","url":null,"abstract":"Introduction. Seafarers face many occupational, health and psychosocial problems on a daily basis. Maritime as a profession has a special combination of conditions that have a strong impact on the spread of sexually transmitted diseases (STIs) and make prevention programs difficult to succeed.Objective. To study the attitudes towards sharing and attitudes towards HIV-positive people among seafarers in the workplace.Material and methods. 100 persons practicing the maritime profession were surveyed using an anonymous questionnaire, approved by the Commission on Scientific Ethics at the Medical University — Varna.The results were statistically processed with SPSS v. 20.0, using variation, comparison and correlation analyzes.Results and discussion. Most of the respondents have sufficient experience in their profession, have higher education and have an equal distribution in deck and machine command (41% each), 18% are from the executive staff. All respondents are adamant that they would share the result of the HIV test with their family or partner, with only 24.0% stating that they would share the positive result with colleagues and 26.0% with the employer. We found a significant difference (c2 39.47; p<0.001) and a moderate dependence (r=0.34; p=0.001) on the behavior of respondents regarding the sharing of the positive result of the HIV test with members of their professional environment (colleagues and managers).The sailors are afraid to work with HIV-seropositive colleagues because their knowledge about the prevalence, risk factors and perceptions about the transmission and prevention of HIV infection have a lot of gaps.Conclusion. Despite training from unions, medical organizations and governments, the dreaded myths about HIV/AIDS persist. The degree of ignorance of the reality around HIV/AIDS is directly proportional to the stigmatization of the problem.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42919561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of CD4+ ranges based on the total number of leukocytes in people living with HIV 基于HIV感染者白细胞总数的CD4+范围预测

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-67-72

J. O. Rodríguez Velásquez, E. Prieto, C. E. Pérez Díaz, C. A. Valdés Cadena, G. F. Bulla, F. A. Barrios Arroyave, N. López, F. López

{"title":"Prediction of CD4+ ranges based on the total number of leukocytes in people living with HIV","authors":"J. O. Rodríguez Velásquez, E. Prieto, C. E. Pérez Díaz, C. A. Valdés Cadena, G. F. Bulla, F. A. Barrios Arroyave, N. López, F. López","doi":"10.22328/2077-9828-2022-14-4-67-72","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-67-72","url":null,"abstract":"Objective. To predict the amount of CD4+/μL3 in sequences of patient records with CD4 T lymphocyte values above 500 cells/μL3 and / or between 200 to 500 cells/μL3 from the absolute leukocyte count in the context of the theory of probability.Materials and methods. Two mathematical inductions were performed to find predictive mathematical relationships for CD4+/μL3 when they are above 500 cells/μL3 and between 200 to 500 cells/μL3, from the absolute count of leukocytes. Subsequently, the probability of success of the predictions was calculated, two blind studies were performed on 80 remaining data, and sensitivity and specificity were calculated for both cases.Results and discussion. If there are more than three records in time per patient, and these are above 500 CD4/μL3 cells or between 200 to 500 CD4/μL3 cells, finding that the absolute leukocyte count has a greater or equal value to three and lower to 4 for all the records, the following record will be maintained with a measurement of CD4 lymphocytes>500 or between [200, 500], if in the absolute count of leukocytes of the patient sequences a value of four is observed and CD4+ ranges from 200 to 500 cells/μL3, it can be deduced that there will be at least one measurement of CD4 +>500 cells/μL3 associated with a leukocyte measurement / μL3 greater than 3.7.Conclusions. We established two temporal mathematical patterns capable of predicting the CD4+/μL3 count from the absolute leukocyte count.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46052011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Place of radical surgery in tuberculosis treatment of central nervous system in combination with HIV infection 根治性手术在中枢神经系统结核合并HIV感染治疗中的应用

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-80-86

C. Petrov, О. N. Novitskaya

{"title":"Place of radical surgery in tuberculosis treatment of central nervous system in combination with HIV infection","authors":"C. Petrov, О. N. Novitskaya","doi":"10.22328/2077-9828-2022-14-4-80-86","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-80-86","url":null,"abstract":"Objective. On the basis of own material determine the role of radical surgery methods in treating tubercular formations of the brain in HIV-infected patients.Materials and Methods. Studied: statistical forms of the SSPB of the IOKB from 2008 to 2020, FTBPR data from 2017 to 2020, nature of the disease in 56, long-term disease dynamics — in 8, the autopsy material of 331 dead and the biopsy — 9 patients operated on with central nervous system damage (CNS).Results and Discussion. The number of patients with tuberculous meningoencephalitis increases in the structure of in-patient facilities, case-fatality rate among them grows. Need for neurosurgical care among the survivors is 25%. Long-term monitoring of operatively treated patients shows their higher survival rate, significant clinical effect of surgery, lengthening of life, increase of CD4 lymphocytes by 2,7 times in 3,5 years after the surgery. Formation of restrictive processes around tuberculous lesion in CNS was noted when taking ART with low immune status.Conclusion. Radical removal of tubercular formations of CNS in HIV is reasonable.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49198903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of new coronavirus infection and HIV infection 新型冠状病毒感染合并HIV感染

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-41-48

E. A. Belashov, A. Isakov, V. Zinserling

{"title":"Combination of new coronavirus infection and HIV infection","authors":"E. A. Belashov, A. Isakov, V. Zinserling","doi":"10.22328/2077-9828-2022-14-4-41-48","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-41-48","url":null,"abstract":"Objective. Evaluation of different options for the formulation of a pathoanatomical diagnosis in the combined course of HIV infection and a new coronavirus infection COVID19Materials and methods. The study included the protocols of clinical autopsies performed at the S. P. Botkin Clinical Infectious Diseases Hospital from March 2020 to September 2021, with the simultaneous diagnosis of HIV infection and the new coronavirus infection COVID19.Results and discussion. Among the secondary diseases in HIV infection in combination with a new coronavirus infection, no significant difference was found in comparison with HIV monoinfection. On the part of the new coronavirus infection, no relationship was found between the course of the infection and the manifestations of secondary diseases in HIV infection. In cases with a protracted new coronavirus infection against the background of a mild HIV infection, the dominant disease in thanatogenesis is COVID-19. In the presence of severe secondary diseases of HIV infection, it acts as the main infection. In cases of the presence of other competing diseases in PAD, they play a leading role in thanatogenesis, or have a significant impact on the course of the disease.Conclusion. Based on the analysis of autopsy protocols with the simultaneous diagnosis of HIV infection and the new coronavirus infection COVID19, various options for the formulation of pathoanatomical diagnosis and encryption of observations are justified","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48611454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis combined with HIV infection in Russia in the period before — and during the COVID-19 pandemic 新冠肺炎大流行前和大流行期间俄罗斯的结核病与艾滋病毒感染

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-29-35

E. Tsybikova

{"title":"Tuberculosis combined with HIV infection in Russia in the period before — and during the COVID-19 pandemic","authors":"E. Tsybikova","doi":"10.22328/2077-9828-2022-14-4-29-35","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-29-35","url":null,"abstract":"Objective. Analysis of the main epidemiological indicators characterizing the situation of tuberculosis combined with HIV infection in Russia during the period before and during the COVID-19 pandemic.Materials and methods. Information from Federal Statistical Observation Forms No. 8, No. 33 and No. 61 for 2012–2021. Rosstat data on the number of patients who died from tuberculosis and HIV infection, and the average annual population of Russia, for 2011–2021. Information from the Federal statistical Observation form No. 30 on the population of Russia covered by screening aimed at early detection of tuberculosis for the period from 2018 to 2021.Results and discussion. The COVID-19 pandemic has had a noticeable impact on the implementation of the Tuberculosis Eradication Program in Russia in less than two years, breaking the 10-year stable rate of decline in tuberculosis morbidity and mortality. The reduction in screening time during the pandemic led to an increase in the number of people with common forms of tuberculosis, which could have been sources of tuberculosis infection among the population for a long time, and especially among people infected with HIV infection. During the COVID-19 pandemic, the proportion of patients with tuberculosis combined with HIV infection increased in the structure of the incidence of tuberculosis and HIV infection. Treatment of patients with HIV infection combined with tuberculosis with multiple and broad resistance of the pathogen is of considerable complexity and creates a high risk of death and an increase in mortality among patients of this group.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47463924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-59-66

O. E. Pobegalova, N. V. Kozmovskaya, N. Monakhov, A. Kholodnaya, D. Danilenko, T. V. Antonova, A. D. Lioznov

{"title":"Time-related changes in the titer of virus neutralizing antibodies against SARS-CoV-2 after COVID-19 in patients with HIV infection","authors":"O. E. Pobegalova, N. V. Kozmovskaya, N. Monakhov, A. Kholodnaya, D. Danilenko, T. V. Antonova, A. D. Lioznov","doi":"10.22328/2077-9828-2022-14-4-59-66","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-59-66","url":null,"abstract":"Objective. To assess the time-related changes in the titer of virus neutralizing antibodies to SARS-CoV-2 in patients with HIV infection within 6 months after experienced COVID-19, and to identify factors associated with the intensity and duration of the natural humoral immune response.Materials and Methods. А prospective study was performed in 102 HIV-infected patients who had COVID-19 without previous vaccination, the titer of virus neutralizing antibodies to SARS-CoV-2 was identified by microneutralization assay using the standard method, the follow-up period was 6 months. Patients were enrolled in St. Petersburg from October 2020 to January 2022. The possible impact of clinical and laboratory characteristics of HIV infection and the severity of COVID-19 on antibody titer was assessed.Results and discussion. А high antibody titer (>1:160) was detected at 1 month in 15 patients (14.7%), at 3 months — in 5 of 44 patients; at 6 months — in 3 of 26 patients. There was a statistically significant positive correlation of the titer at 1 month with an undetectable HIV viral load and the Cd4+lymphocytes count in the blood. Cases of a late increase in antibody titer (after 3 and 6 months) were registered without COVID-19 re-infection along with improvement of the immune status on antiretroviral therapy.Conclusion. А low incidence of effective humoral immune response 1 month after COVID-19 infection was demonstrated in HIV-infected patients without vaccination against SARS-CoV-2. Single cases of delay in antibody titer increase with an immune status improvement were observed.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46731231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia 摩尔多瓦共和国对抗逆转录病毒治疗的耐药性流行情况

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-21-28

M. G. Laseeva, T. Vlasova, S. Y. Dvoretskova

{"title":"The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia","authors":"M. G. Laseeva, T. Vlasova, S. Y. Dvoretskova","doi":"10.22328/2077-9828-2022-14-4-21-28","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-21-28","url":null,"abstract":"Objective. To study the causes of virological inefficiency of ART and to analyze the prevalence of mutations of resistance to ART drugs among HIV-infected patients, who lives in the Republic of Mordovia and receiving ART.Materials and methods. We studied 37 blood tests with detectable viral load from HIV-infected patients receiving observation in the GBUZ RM «MRTSPBSPID», taking ART for more than 24 weeks. We The evaluated patient’s adherence to treatment. The analysis for drug resistance was performed by genotyping, using HIV-Resist-Seg diagnostic test systems, (the Federal State Budgetary Institution of the Central Research Institute of Rospotrebnadzor, Russia). Statistical data processing (c2 calculation) StatSoft, Inc. (2011), STATISTICA, Russia.Results and discussion: in the group of patients with mutations of resistance to antiretroviral drugs, mutations of pharmacological resistance to drugs of two and three groups are most often determined (in 87.5% of cases). The number and frequency of genetic aberrations in general did not depend on the number of already approved treatment regimens. At the same time, in patients with two or more changes of ART regimens in the anamnesis, the occurrence of mutations of drug resistance to IP was significantly higher than in HIV-infected patients with one ART regimen.Conclusion: in the Republic of Mordovia, virological inefficiency is associated equally with both a violation of ART intake (poor adherence) and the development of pharmacoresistance. It is important to determine the drug resistance of HIV in patients receiving ART.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48106273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndrome of substance abuse, violence and HIV-infection/AIDS (SAVA) and some related factors among sex workers in 4 cities in Russian Federation 俄罗斯联邦4个城市性工作者药物滥用、暴力和艾滋病毒感染/艾滋病综合征(SAVA)及其相关因素

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI: 10.22328/2077-9828-2022-14-4-73-79

A. N. Barinova, A. Lebedeva, N. Ladnaya, E. Zaytseva, S. L. Plavinskii

{"title":"Syndrome of substance abuse, violence and HIV-infection/AIDS (SAVA) and some related factors among sex workers in 4 cities in Russian Federation","authors":"A. N. Barinova, A. Lebedeva, N. Ladnaya, E. Zaytseva, S. L. Plavinskii","doi":"10.22328/2077-9828-2022-14-4-73-79","DOIUrl":"https://doi.org/10.22328/2077-9828-2022-14-4-73-79","url":null,"abstract":"Introduction. Social determinants of health are often a major topic for syndemic research. This is consistent with the fundamental idea of syndemic conditions that share common social factors and bio-social interactions. One of the earliest syndemies was the reported abuse of psychoactive substances in the United States, the experience of victimization from interpersonal violence and HIV infection (SAVA).The objective of this study was to assess the prevalence of SAVA syndrome and its relationship with risk factors for HIV infection in key groups — female sex workers (SW). Materials and methods. The analysis is based on data from a biobehavioral study carried out in 4 cities of the Russian Federation and involving 817 SWs (time-place sampling). The study included a questionnaire survey and determination of HIV status.Results and discussion. The prevalence of SAVA syndemics in the groups of SWs and MSM was relatively low because of relatively low (in comparison with IDUs) prevalence of HIV infection. Full syndemics occurred in 1.27%, [95% CI=0.30–2.24%] female sex workers. Incomplete syndemics (excluding HIV infection from definition) was detected in 7.31%, [95% CI=4.59–10.02%] of SW.SWs who were physically and sexually abused had HIV infection in 16.7% of cases, only physically abused — in 10% of cases, while among those who denied violence against them — only 6.5%.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68331650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0