The prevalence of drug resistance to antiretroviral therapy in the Republic of Mordovia

Abstract

Objective. To study the causes of virological inefficiency of ART and to analyze the prevalence of mutations of resistance to ART drugs among HIV-infected patients, who lives in the Republic of Mordovia and receiving ART.Materials and methods. We studied 37 blood tests with detectable viral load from HIV-infected patients receiving observation in the GBUZ RM «MRTSPBSPID», taking ART for more than 24 weeks. We The evaluated patient’s adherence to treatment. The analysis for drug resistance was performed by genotyping, using HIV-Resist-Seg diagnostic test systems, (the Federal State Budgetary Institution of the Central Research Institute of Rospotrebnadzor, Russia). Statistical data processing (c2 calculation) StatSoft, Inc. (2011), STATISTICA, Russia.Results and discussion: in the group of patients with mutations of resistance to antiretroviral drugs, mutations of pharmacological resistance to drugs of two and three groups are most often determined (in 87.5% of cases). The number and frequency of genetic aberrations in general did not depend on the number of already approved treatment regimens. At the same time, in patients with two or more changes of ART regimens in the anamnesis, the occurrence of mutations of drug resistance to IP was significantly higher than in HIV-infected patients with one ART regimen.Conclusion: in the Republic of Mordovia, virological inefficiency is associated equally with both a violation of ART intake (poor adherence) and the development of pharmacoresistance. It is important to determine the drug resistance of HIV in patients receiving ART.