Siriraj Medical Journal最新文献_第3页

Survey-based Study to Assess the Self-perceived Competency in and Knowledge about Reconstructive Microsurgery among Young Plastic Surgeons 以调查为基础的研究：评估年轻整形外科医生在显微修复手术方面的自我认知能力和相关知识

Siriraj Medical Journal Pub Date : 2024-05-01 DOI: 10.33192/smj.v76i5.266240

Nutthawut Akaranuchat, Natthapong Kongkunnavat, Min Yongsuvimol

{"title":"Survey-based Study to Assess the Self-perceived Competency in and Knowledge about Reconstructive Microsurgery among Young Plastic Surgeons","authors":"Nutthawut Akaranuchat, Natthapong Kongkunnavat, Min Yongsuvimol","doi":"10.33192/smj.v76i5.266240","DOIUrl":"https://doi.org/10.33192/smj.v76i5.266240","url":null,"abstract":"Objective: Microvascular free tissue transfer has become a preferred reconstructive technique for managing complex wounds and defects. The aim of this questionnaire-based study was to assess self-perceived competency in and knowledge about reconstructive microsurgery among plastic surgeons who graduated from the Faculty of Medicine Siriraj Hospital, Mahidol University during 2015-2019.\u0000Materials and Methods: Questionnaire was sent by email elicited information about the amount of microsurgery performed in practice, types of microsurgeries performed, reconstructive methods, types of flaps used, and respondent’s opinion about the microsurgery course attended during residency/fellowship training.\u0000Results: The total response rate was 87.5%. Almost all respondents work in a government hospital (90.4%), and responses came from all regions of Thailand. Thirty-eight percent of respondents reported no microsurgery cases, and the majority of those who did perform microsurgery did so less than 20 times/year. Hand reconstruction was the most common type of microsurgical procedure. The factors that negatively influence microsurgery in clinical practice include insufficiency of resources and personnel (29.1%), excessive workload (27.3%), and long operative time (23.6%). Suggestions for improvement of the microsurgical training course include having a good objective method for assessing microsurgical practices (27.7%), increasing the volume of practice on animal model (25.5%), and an appropriate number of microsurgery cases to gain necessary experience (25.5%).\u0000Conclusion: Reconstructive microsurgery was found to be a challenging procedure for many junior-level plastic surgeons. A low volume of cases limits a surgeon’s ability to develop needed skills. Important improvements in the microsurgery training course were also recommended.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Resilience in the Relationship between Adverse Childhood Experiences and Behavior Problems among Thai Adolescents in a Province of Southern Thailand: A School-Based Cross-Sectional Study 复原力在泰国南部某省泰国青少年童年不良经历与行为问题之间关系中的作用：一项校本横断面研究

Siriraj Medical Journal Pub Date : 2024-05-01 DOI: 10.33192/smj.v76i5.267232

Tikumporn Hosiri, Anawin Jongjaroen, Soisuda Imaroonrak, Thanayot Sumalrot, S. Phattharayuttawat

{"title":"Role of Resilience in the Relationship between Adverse Childhood Experiences and Behavior Problems among Thai Adolescents in a Province of Southern Thailand: A School-Based Cross-Sectional Study","authors":"Tikumporn Hosiri, Anawin Jongjaroen, Soisuda Imaroonrak, Thanayot Sumalrot, S. Phattharayuttawat","doi":"10.33192/smj.v76i5.267232","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267232","url":null,"abstract":"Objective: This study aimed to investigate the relationship between adverse childhood experiences (ACEs), behavior problems, and resilience among adolescents in Southern Thailand, with a particular focus on the role of resilience in mediating the relationship between ACEs and behavior problems. \u0000Materials and Methods: A paper-and-pencil questionnaire, covering participants’ general information, ACEs, behavior problems, and resilience, was distributed to 383 senior high school students in a province in Southern Thailand. The data was analyzed using descriptive statistics, correlation analysis, and path analysis. \u0000Results: Out of the 383 students the questionnaire was distributed to, 374 completed the questionnaire, resulting in a response rate of 97.65%. Alarmingly, 59.36% of the respondents reported experiencing at least one type of ACE. Correlation analysis revealed a significant positive association between ACEs and behavior problems (r=0.17, p<0.01) and a negative correlation with resilience (r = -0.19, p<0.01). Path analysis demonstrated that ACEs directly influenced behavior problems (β=0.23, p<0.01) and resilience (β = -0.24, p<0.01). However, the analysis did not support the hypothesis that resilience mediates the relationship between ACEs and behavior problems. \u0000Conclusion: The findings indicate a troubling prevalence of ACEs among senior high school students in Thailand, likely contributing to current adolescent behavior problems. Although the study's path analysis did not align with prior research, it emphasizes the critical role of resilience in mitigating the adverse effects of ACEs. Therefore, resilience remains a necessary skill in helping adolescents cope with the consequences of adverse childhood experiences.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion Regulation Mediates Functional Impairment in Thai Children with Attention-deficit/ hyperactivity Disorder: A Cross-Sectional Study 情绪调节对泰国注意力缺陷/多动症儿童功能障碍的调节作用：横断面研究

Siriraj Medical Journal Pub Date : 2024-05-01 DOI: 10.33192/smj.v76i5.266803

Tikumporn Hosiri, Manapawn Chukiatiwongul, Thanayot Sumalrot, Natchaphon Auampradit, Sirinadda Punyapas, Sucheera Phattharayuttawat

{"title":"Emotion Regulation Mediates Functional Impairment in Thai Children with Attention-deficit/ hyperactivity Disorder: A Cross-Sectional Study","authors":"Tikumporn Hosiri, Manapawn Chukiatiwongul, Thanayot Sumalrot, Natchaphon Auampradit, Sirinadda Punyapas, Sucheera Phattharayuttawat","doi":"10.33192/smj.v76i5.266803","DOIUrl":"https://doi.org/10.33192/smj.v76i5.266803","url":null,"abstract":"Objective: The study investigated the potential mediating effects of emotion regulation and emotion lability/negativity in the relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms and functional impairment while also examining the associations between ADHD symptoms, emotion regulation, and impaired functioning in different life domains among children with ADHD.\u0000Materials and Methods: The clinical sample comprised 118 children diagnosed with ADHD aged 6–12 years. Primary caregivers completed parent reports on symptom severity using the Thai ADHD Screening Scale–Parent Version, assessed emotion regulation and lability/ negativity via the Emotion Regulation Checklist, and evaluated functional impairment using the Weiss Functional Impairment Rating Scale–Parent Version.\u0000Results: ADHD symptoms correlated negatively with overall emotion regulation (r = −0.515, p < 0.01) and positively with lability/negativity (r = 0.583, p < 0.01). Functional impairment exhibited a negative correlation with emotion regulation (r = −0.649, p < 0.01) and a positive correlation with lability/negativity (r = 0.701, p < 0.01). Elevated ADHD symptoms were linked with increased functional impairment (r = 0.639, p < 0.01). The parallel mediational model showed that emotion lability/negativity partially mediated the association between ADHD symptoms and functional impairment (β = 0.282, p < 0.001), suggesting that ADHD symptoms and emotion lability/negativity indirectly accentuate functional impairment. Thus, heightened ADHD symptoms may exacerbate emotion lability/negativity, contributing to increased functional impairments.\u0000Conclusion: Emotion regulation difficulties, particularly emotion lability/negativity, may serve as significant risk factors. Regular monitoring and targeting these challenges hold promise in alleviating adverse functional outcomes co-occurring with elevated ADHD symptoms.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases 泰国尸检病例中内脏脂肪组织与冠状动脉粥样硬化之间的关系

Siriraj Medical Journal Pub Date : 2024-05-01 DOI: 10.33192/smj.v76i5.267374

Wanpreedee Prompetch, Peerayuht Phuangphung

{"title":"The Association between Visceral Adipose Tissue and Coronary Atherosclerosis in Thai Postmortem Cases","authors":"Wanpreedee Prompetch, Peerayuht Phuangphung","doi":"10.33192/smj.v76i5.267374","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267374","url":null,"abstract":"Objective: To determine the correlation between visceral adipose tissue (VAT) and degree of coronary artery stenosis in the Thai population.\u0000Materials and Methods: This prospective cross-sectional study was conducted in 220 Thai postmortem cases. Sex, age, weight, height, waist and hip circumferences were recorded for each case. The intra-abdominal VAT weight of each site was assessed during the autopsy procedure, and degrees of stenosis for three coronary arteries (left anterior descending artery (LAD), right coronary artery (RCA) and left circumflex artery (LCX)) were evaluated in histological examination. Descriptive statistics, bivariate correlation, and multivariate linear regression were used to determine the correlations between VAT and degrees of coronary artery stenosis.\u0000Results: There were 108 female and 112 male subjects with a mean age of 45.95 years old. Waist circumference, waist-hip ratio and VAT in the male subjects were significantly higher than in the female subjects (p<0.001). VAT was well correlated with waist circumference and waist-hip ratio (p<0.001). VAT weights were positively correlated with degrees of LAD, RCA and LCX stenosis, with coefficient correlations (r) of 0.561, 0.453 and 0.451, respectively (p<0.001). Mesenteric and peri-renal adipose tissues produced better correlations than the other sites. Multivariate linear regression showed that sex and age were correlated with stenosis in all three coronary arteries (p<0.001), and mesenteric and peri-renal adipose tissues had strong correlations with LAD stenosis (p<0.001).\u0000Conclusion: VAT weights from all sites were correlated with degrees of coronary artery stenosis. Mesenteric and peri-renal adipose tissues produced better correlations than the other sites.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"61 s281","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Predicting Psychological Well-being among Survivors of Breast Cancer in A Tertiary Care Hospital, Thailand 预测泰国一家三级医院乳腺癌幸存者心理健康的因素

Siriraj Medical Journal Pub Date : 2024-05-01 DOI: 10.33192/smj.v76i5.267634

Nuntana Singtaweesuk, Wareerat Thanoi, Nopporn Vongsirimas, Sirada Kesornsri, Piyanee Klainin-Yobas

{"title":"Factors Predicting Psychological Well-being among Survivors of Breast Cancer in A Tertiary Care Hospital, Thailand","authors":"Nuntana Singtaweesuk, Wareerat Thanoi, Nopporn Vongsirimas, Sirada Kesornsri, Piyanee Klainin-Yobas","doi":"10.33192/smj.v76i5.267634","DOIUrl":"https://doi.org/10.33192/smj.v76i5.267634","url":null,"abstract":"Objective: The primary aim of this study was to examine predicting the effect of stress, social support, self-efficacy, and resilience on psychological well-being in breast cancer survivors\u0000Materials and Methods: This predictive analysis for the descriptive cross-sectional study was conducted by the theoretical underpinning of resilience and population consisted of eligible breast cancer survivors receiving care at an outpatient clinic within a tertiary hospital setting. The data collecting was proceeded through self-administered questionnaires in line with convenient sampling. The analytical approach encompassed descriptive statistics, Pearson’s correlation coefficient, and multiple linear regression.\u0000Results: Emanating from the study included the recruitment of 123 participants, with stress, social support, and resilience collectively elucidating 43% of the variance in psychological well-being among breast cancer survivors. Notably, resilience emerged as the most influential predictor (β=.33), followed by stress (β=-.27) and social support (β=.26), all of which significantly contributed to the prediction of psychological well-being.\u0000Conclusion: Resilience, stress, and social support were three predictors of psychological well-being among survivors of breast cancer in this study. Recommendations extend to the integration of strategies that foster resilience and social support, while concurrently mitigating stress levels through activities and programs aimed at augmenting the psychological well-being of breast cancer survivors in the future.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"27 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Siriraj Medical Journal Pub Date : 2023-12-01 DOI: 10.33192/smj.v75i12.265223

Prampree Nantawong, T. Tankumpuan, Ketsarin Utriyaprasit, Natthida Owattanapanich

{"title":"Factors Related Pain Catastrophizing in Hospitalized Patients with Trauma","authors":"Prampree Nantawong, T. Tankumpuan, Ketsarin Utriyaprasit, Natthida Owattanapanich","doi":"10.33192/smj.v75i12.265223","DOIUrl":"https://doi.org/10.33192/smj.v75i12.265223","url":null,"abstract":"Objective: This study aimed to explore the factors related to pain catastrophizing (PC) in hospitalized patients with trauma within 72 hours of injury.\u0000Materials and Methods: The study was a cross-sectional correlation study. The sample was 109 patients who were admitted to ICU Trauma or General Trauma Unit within 72 hours after injury and were aged 18 years and over. They were diagnosed with at least one or multiple organs of injury with a Glasgow Coma Scale (GCS) between 13 and 15. Pearson’s product-moment correlation coefficient, spearman rank correlation, point-biserial correlation, and linear multiple regression were used to analyze the data.\u0000Results: The results showed that more than half of the sample was male (73.0%) with the age range from 18 to 91 years. During admission, the subjects complained about pain at moderate to severe levels (68.5%). The prevalence of PC was 11.9%. A few participants (2.8%) experienced anxiety. Also, more than half of them (63.3%) had ADLs in independent to absolutely independent levels. Almost 50.5% of the participants experienced poor sleep quality. Lastly, 50.5% of them were in frailty and pre-frailty conditions. There was a positive relationship between PC and anxiety (r = .439, p < .01). Finally, anxiety could explain the variance of PC by 19.3% (F1,107 = 25.571, P < .001).\u0000Conclusion: Based on the study findings, the predictor of PC was anxiety. Thus, healthcare providers should assess this factor, in order to provide interventions to reduce high levels of anxiety leading to the prevention of PC occurrences in hospitalized trauma within 72 hours after injury.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"105 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Wearing a Face Mask on the 6-Minute Walk Test in Healthy Volunteers 戴口罩对健康志愿者 6 分钟步行测试的影响

Siriraj Medical Journal Pub Date : 2023-12-01 DOI: 10.33192/smj.v75i12.264856

Simaporn Promsarn, Kanokwan Rattanasaengloet, Sutat Pipopsuthipaiboon, Nongnoot Panitchatchawal, Patharapan Lersritwimanmaen

{"title":"Effect of Wearing a Face Mask on the 6-Minute Walk Test in Healthy Volunteers","authors":"Simaporn Promsarn, Kanokwan Rattanasaengloet, Sutat Pipopsuthipaiboon, Nongnoot Panitchatchawal, Patharapan Lersritwimanmaen","doi":"10.33192/smj.v75i12.264856","DOIUrl":"https://doi.org/10.33192/smj.v75i12.264856","url":null,"abstract":"Objective: This study aimed to examine the influence of wearing different types of face masks on the results of the 6-Minute Walk Test (6MWT) in a cohort of healthy volunteers.\u0000Materials and Methods: Volunteers were partitioned into three groups (each comprising 36 individuals) with different mask-wearing conditions: NIOSH-approved N95 mask, and double-mask scenarios featuring two layers of surgical mask, and a combination of a surgical mask covered by a cloth face mask. Each participant performed two rounds of the 6MWT, one while wearing a mask and another without. Various metrics, such as the six-minute walk distance (6MWD), oxygen saturation (SpO2), and dyspnea and fatigue scores, were measured.\u0000Results: No significant differences were found in the 6MWD results between the mask-wearing and non-mask-wearing scenarios across all the mask types.Strong positive correlations were also established between the 6MWD results in the mask-wearing and non-mask-wearing conditions. However, a small cohort experienced dyspnea significantly more when wearing double surgical masks compared to not wearing a mask. Additionally, there were no major deviations in SpO2 levels or fatigue scores regardless of the type of mask used.\u0000Conclusion: The study indicated that wearing an N95 mask, or double surgical masks, or cloth-over-surgical face masks did not significantly influence the outcomes of the 6MWT in healthy individuals. However, caution is advised in the case of wearing double surgical masks, as this may induce a greater sense of dyspnea. This suggests that face masks can be worn safely during physical fitness and pulmonary function assessments, aligning with their essential role in viral spread prevention in daily life.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mobile Device Digital Photography for Teledermatology Consultation: Real-Life Situations 用于远程皮肤科咨询的移动设备数码摄影：真实场景

Siriraj Medical Journal Pub Date : 2023-12-01 DOI: 10.33192/smj.v75i12.264488

S. Bunyaratavej, Pattriya Jirawattanadon, Chudapa Sereeaphinan, Supisara Wongdama, Sanchai Sombatmaithai, C. Leeyaphan

{"title":"Mobile Device Digital Photography for Teledermatology Consultation: Real-Life Situations","authors":"S. Bunyaratavej, Pattriya Jirawattanadon, Chudapa Sereeaphinan, Supisara Wongdama, Sanchai Sombatmaithai, C. Leeyaphan","doi":"10.33192/smj.v75i12.264488","DOIUrl":"https://doi.org/10.33192/smj.v75i12.264488","url":null,"abstract":"Objective: The use of mobile phones for teledermatology consultations is increasing. In this study, we aimed to describe photographic problems in teledermatology performed via mobile phones and their effects on diagnostic decision-making.\u0000Materials and Methods: Three dermatologists independently reviewed the medical histories and photographs of patients taken by primary-care physicians for teledermatology between January 2018 and August 2020. The consensus of the dermatologists’ decision-making was categorized into “definite diagnoses given,” “probable diagnoses given,” and “unable to provide any diagnosis.” Relationships between photographic errors and dermatologist decision-making were investigated. Factors related to photographic problems were evaluated.\u0000Results: In all, 899 images from 220 patients were reviewed. The most common purpose of teledermatology was to make a diagnosis. The most frequent diagnoses were eczema, infection, and autoimmune diseases. Consultants gave definite diagnoses for 63.2% of patients and probable diagnoses for another 29.5%. However, diagnoses were not made in 7.3% of cases. Defocusing and non-eczematous lesions were significantly associated with the inability to give diagnoses (P = 0.002 and 0.037, respectively). Pictures from peripheral areas showed higher frequencies of distortion errors, improper framing, wasted space, and improper background, while truncal regions tended to have lighting problems. The outpatient department setting was associated with a lack of overview and defocusing.\u0000Conclusion: Focusing was the central factor for making diagnoses in teledermatology. Lighting should be more concerned in truncal regions. While using smartphone cameras, distortion should be aware. These factors should be considered to improve the effectiveness of teledermatology.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss 外用 5%杜鹃花酸溶液与 2%米诺西地尔溶液治疗女性脱发的疗效和安全性比较

Siriraj Medical Journal Pub Date : 2023-12-01 DOI: 10.33192/smj.v75i12.266001

K. Thanomkitti, Chutipon Pruksaeakanan, Chanika Subchookul, Norramon Charoenpipatsin, D. Triwongwaranat, S. Varothai, Rattapon Thuangtong, Tanyalak Chumnumrat

{"title":"Efficacy and Safety of Topical 5% Azelaic Acid Solution Versus 2% Minoxidil Solution in the Treatment of Female Pattern Hair Loss","authors":"K. Thanomkitti, Chutipon Pruksaeakanan, Chanika Subchookul, Norramon Charoenpipatsin, D. Triwongwaranat, S. Varothai, Rattapon Thuangtong, Tanyalak Chumnumrat","doi":"10.33192/smj.v75i12.266001","DOIUrl":"https://doi.org/10.33192/smj.v75i12.266001","url":null,"abstract":"Objective: To determine the efficacy and safety of 5% azelaic acid solution in comparison with 2% minoxidil solution in the treatment of FPHL.\u0000Materials and Methods: Twenty-six FPHL patients with Ludwig grade I or II were randomly treated with 5% azelaic acid solution or 2% minoxidil solution twice daily for 6 months. At baseline, 2, 4, and 6 months, hair density and hair shaft diameter were assessed at the targeted fixed area. At 6 months, patient and investigator assessments of hair growth were performed using a 7-point scale.\u0000Results: Hair density and hair shaft diameter in the patients treated with 5% azelaic acid and 2% minoxidil solution were significantly increased compared to the baseline in all cases and visits (P < 0.05). There were no statistically significant differences in hair density and hair shaft diameter changes between both groups (P > 0.05). Both the investigator and patient assessments were comparable between both groups at 6 months. Pruritus was the major adverse effect reported in both groups, but only mild and all could be tolerated.\u0000Conclusion: 5% Azelaic acid solution might be an effective treatment for FPHL, comparable with 2% minoxidil, and could be an alternative treatment for FPHL in minoxidil-allergic patients and pregnant women.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138622289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Low-Concentration Atropine in Myopia Progression: A Systematic Review 评估低浓度阿托品对近视发展的影响：系统回顾

Siriraj Medical Journal Pub Date : 2023-12-01 DOI: 10.33192/smj.v75i12.265388

Stella Nathania, Jovita Jutamulia, Gabriella Hafidha Badruddin

{"title":"Assessing Low-Concentration Atropine in Myopia Progression: A Systematic Review","authors":"Stella Nathania, Jovita Jutamulia, Gabriella Hafidha Badruddin","doi":"10.33192/smj.v75i12.265388","DOIUrl":"https://doi.org/10.33192/smj.v75i12.265388","url":null,"abstract":"Objective: Low-concentration atropine (LCA) eye drop is used as a promising treatment for the management of myopia but its effectiveness has not been widely evaluated. Therefore, this study aimed to analyze the efficacy of LCA eye drop for myopia progression.\u0000Materials and Methods: This review was conducted following the PRISMA guidelines and a comprehensive literature search was performed on 3 online databases including PubMed, Cochrane, and ProQuest. The keywords used included ‘Low-concentration atropine eye drop’, ‘Atropine’, ‘Eye Drop’, ‘Myopia’, and their Mesh. All studies included were available in English and full-text format. Myopia progression rates were analyzed from all studies, and Rayyan, an online-based tool was used in the screening process.\u0000Results: The results showed that 3 randomized control trials (RCT), 2 cohort studies, and 3 case reports with a total of 1389 participants were analyzed. The majority studies were conducted in Asia, while one RCT was performed in Australia. The participants ranged from 4-12 years old, while atropine eye drop concentrations used were 0.01%, 0.025%, 0.05%, 0.1%, 0.125%, and 0.2%. All studies showed a slower progression rate of myopia in the atropine group compared to the control (-0.31 D vs. -0.90 D; -0.05 D vs. -1.05 D; -0.27 D vs. -0.81 D; -0.28 D vs. -0.54 D; -0.36 D vs. -0.90 D;−0.31 D vs. −0.76 D; -0.31 vs. -0.53 D; -0.38 D vs. -0.55 D) with P < 0.05.\u0000Conclusion: LCA eye drop showed promising effects in slowing myopia progression. However, further investigation is needed, particularly in non-Asian countries.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" 1275","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0