Siriraj Medical Journal最新文献_第10页

Sleep Quality and Associated Factors in Elderly Patients with Type-2 Diabetes Mellitus 老年2型糖尿病患者的睡眠质量及相关因素

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.260818

Nopakoon Nantsupawat, Sitthichai Khamchet, Nida Buawongpong, K. Pinyopornpanish, T. Nantsupawat, C. Angkurawaranon, Yanee Choksomngam

{"title":"Sleep Quality and Associated Factors in Elderly Patients with Type-2 Diabetes Mellitus","authors":"Nopakoon Nantsupawat, Sitthichai Khamchet, Nida Buawongpong, K. Pinyopornpanish, T. Nantsupawat, C. Angkurawaranon, Yanee Choksomngam","doi":"10.33192/smj.v75i5.260818","DOIUrl":"https://doi.org/10.33192/smj.v75i5.260818","url":null,"abstract":"Objective: The prevalence of poor sleep quality has been greatly escalating over the past years, along with the surging of type 2 Diabetes Mellitus (DM). The aging population is most concerned as sleep quality is notably impaired and influences the diabetic condition. This study aimed to observe the sleep quality and factors related to poor sleep quality in elderly patients with type-2 DM.\u0000Materials and Methods: A cross-sectional study of patients with type 2 DM, aged 60 years and above was conducted. The questionnaires included demographic data, the Thai version of the Pittsburgh Sleep Quality Index (T-PSQI), the Thai version of the Diabetic-39, and the Thai Geriatric Depression Scale-15. Factors associated with sleep quality were analyzed using the logistic regression model.\u0000Results: Among 385 participants with a mean age of 67 years old was 63.90% female. The prevalence of poor sleep quality was 9.88%. No association was found between sleep quality and glycemic levels. The related factors for poor sleep quality were sex (aOR = 2.57, p = 0.035, 95%CI = 1.06-5.93), body mass index (aOR =1.09, p = 0.028, 95% CI = 1.00-1.20), and diabetic complications. Diabetic retinopathy showed highest odd ratio (aOR = 6.28, p = 0.021, 95% CI = 1.32-29.94).\u0000Conclusion: The prevalence of poor sleep quality was low in the current study. We found a strong association between diabetic complications and poor sleep quality. Evaluation of sleep quality may help to enhance overall health and care for diabetic geriatric patients.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41405947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes Comparison of Early versus Late Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome 早期与晚期表面活性物质替代治疗新生儿呼吸窘迫综合征的疗效比较

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.261175

Chutinun Wongkhonkaen, Pongsatorn Paopongsawan, Junya Jirapradittha, P. Kiatchoosakun

{"title":"Outcomes Comparison of Early versus Late Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome","authors":"Chutinun Wongkhonkaen, Pongsatorn Paopongsawan, Junya Jirapradittha, P. Kiatchoosakun","doi":"10.33192/smj.v75i5.261175","DOIUrl":"https://doi.org/10.33192/smj.v75i5.261175","url":null,"abstract":"Objective: To compare durations of invasive mechanical ventilator (IMV), other types of ventilator support and neonatal outcomes between neonates who received early versus late surfactant replacement therapy (E-SRT vs. L-SRT).\u0000Materials and Methods: This retrospective study included neonates with gestational age (GA) less than 35 weeks or birth weight (BW) less than 2,000 grams, born between January 1, 2017 to December 31, 2021. Neonates who received SRT before 2 hours of life were defined as E-SRT and neonates who received SRT later were defined as L-SRT. Durations of IMV, other types of ventilator support, neonatal outcomes and length of stays were documented.\u0000Results: Eighty-three neonates had received SRT with 52 (62.7%) had E-SRT and 31 (37.3%) had L-SRT. Neonates in E-SRT group had significantly lower GA and BW than neonates in L-SRT group (median GA 27 vs. 30 weeks; p = 0.002 and median BW 885 vs. 1330 grams; p = 0.003) and had longer duration of IMV but not significant (median 19.0 vs. 10.5 days; p = 0.219). There were no significant differences in durations of other types of ventilator support. After adjusted for sex, GA and BW, there were no significant differences in neonatal outcomes between neonates in each group. Ventilator-associated pneumonia (VAP) and septicemia were independent factors associated with prolonged IMV, ventilator supports and length of stays.\u0000Conclusion: Timing of SRT was not associated with duration of IMV. VAP and septicemia were important factors prolonging ventilator durations and length of stays and should be prevented.Keywords: surfactant replacement therapy, respiratory distress syndrome, timing of surfactant, neonatal outcomes","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48634057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity And Reliability of The Thai Version of The Family Dermatology Life Quality Index 泰国版家庭皮肤科生活质量指数的有效性和可靠性

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.260735

Kanokvalai Kulthanun, P. Tuchinda, C. Rujitharanawong, Waratchaya Panjapakkul, L. Chularojanamontri

{"title":"Validity And Reliability of The Thai Version of The Family Dermatology Life Quality Index","authors":"Kanokvalai Kulthanun, P. Tuchinda, C. Rujitharanawong, Waratchaya Panjapakkul, L. Chularojanamontri","doi":"10.33192/smj.v75i5.260735","DOIUrl":"https://doi.org/10.33192/smj.v75i5.260735","url":null,"abstract":"Objective: This study aimed to investigate the validity and reliability of the Thai version of FDLQI.\u0000Materials and Methods: Patients and their accompanying family members attending the Dermatology Outpatient Clinic at Siriraj Hospital were asked to complete the Dermatology Life Quality Index (DLQI), FDLQI, and the global question of their QoL (GQoL). The severity of the disease was assessed by physicians, the patients and the family members of the patients.\u0000Results: One hundred family members accompanying 92 patients with dermatological diseases (63% with inflammatory skin diseases and 37% with non-inflammatory skin diseases) were included. The mean age of the family members was 43.5±12.1 years and 70% were women. They had been mostly employed (74%) and graduated from universities (65%). Validity was demonstrated by a positive correlation between FDLQI and GQoL scores (rs=0.695, P<0.001), and between FDLQI and severity of the patient's disease (rs=0.578, P<0.001) as evaluated by family members. The FDLQI showed high internal consistency (Cronbach’s alpha=0.84) and test-retest reliability (ICC= 0.85).\u0000Conclusion: The construct validity, internal consistency, and test-retest reliability of the Thai FDLQI demonstrated acceptable validity and reliability. The Thai version of FDLQI can be used to assess the QoL of family members of patients with any dermatological diseases.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45156938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Routine Fogarty Catheter Occlusion of Fistula in Esophageal Atresia with Tracheoesophageal Fistula Surgery: A Retrospective Study 气管食管瘘术治疗食管闭锁的常规Fogarty导管封堵术的回顾性研究

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.260704

Darunee Sripadungkul, N. Miyazawa, Eri Shinto, Yuko Kanke, Haruto Fujita

{"title":"Routine Fogarty Catheter Occlusion of Fistula in Esophageal Atresia with Tracheoesophageal Fistula Surgery: A Retrospective Study","authors":"Darunee Sripadungkul, N. Miyazawa, Eri Shinto, Yuko Kanke, Haruto Fujita","doi":"10.33192/smj.v75i5.260704","DOIUrl":"https://doi.org/10.33192/smj.v75i5.260704","url":null,"abstract":"Objective: We aimed to analyze the outcomes of patients who underwent surgical repair of congenital esophageal atresia (EA) with a distal tracheoesophageal fistula (EA/TEF) or a Gross type C with successful routine Fogarty catheter occlusion of TEF.\u0000Materials and Methods: We retrospectively reviewed the medical records of patients who underwent surgical repair of Gross type C with successful routine Fogarty catheter occlusion of fistula between April 2010 and November 2016.\u0000Results: Nineteen patients were enrolled and included for analysis. Mean gestational age was 38.7 (1.9) weeks with 2 (10.5%) neonates born prematurely. Mean birthweight was 2569.3 (425.3) g. Five (26.3%) patients required mechanical ventilation (MV) before surgical repair of TEF. Median post-operative required MV after TEF surgery was 4 (3-6) days. The most common of post-operative complications were wound dehiscence (10.5%) and pneumothorax (10.5%). Long-term complications were gastroesophageal reflux disease (36.8%) and tracheomalacia (31.6%).\u0000Conclusion: The success rate of routine TEF occlusion with a Fogarty catheter was 86.4%. Routine Fogarty catheter occlusion of TEF can be used safely with experienced personnel, low incidence of aspiration and satisfied ventilation. There was no serious complication associated with placement of Fogarty catheter or catheter dislodgement, and it did not occur during any of the procedures.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":"514 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41309467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse Events of Traditional Medicines and Herbal Products in The Thai Health Product Vigilance Center Database and The Ayurved Clinic of Applied Thai Traditional Medicine, Siriraj Hospital 泰国保健品警戒中心数据库和Siriraj医院应用泰国传统医学阿育吠陀诊所中的传统药物和草药不良事件

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.261512

S. Niyomnaitham, Narichat Chuensakun, Slita Prachakit, Chidapa Pakjamsai, P. Akarasereenont

{"title":"Adverse Events of Traditional Medicines and Herbal Products in The Thai Health Product Vigilance Center Database and The Ayurved Clinic of Applied Thai Traditional Medicine, Siriraj Hospital","authors":"S. Niyomnaitham, Narichat Chuensakun, Slita Prachakit, Chidapa Pakjamsai, P. Akarasereenont","doi":"10.33192/smj.v75i5.261512","DOIUrl":"https://doi.org/10.33192/smj.v75i5.261512","url":null,"abstract":"Objective: The aim of this study was to categorize adverse events (AEs) and symptoms related to traditional medicines (TMs) and herbal products (HPs) using the Thai Vigibase program (TVP).\u0000Materials and Methods: TVP collected spontaneous AE reports including causality assessment of medical products in Thailand. For prospective data, Naranjo’s algorithm (NJA) was used to determine the level of causality.\u0000Results: There were a total of 1,133 AE case reports extracted from TVP and featured 1,229 TMs/HPs (310 TMs/HPs names) and 1,592 symptoms (204 symptom names). Andrographis paniculata was the product most frequently linked to AEs, with six cases of confirmed urticaria, 37 probable cases, and 24 possible causalities, 15 patients were given 23 TMs/HPs and this related to 33 AEs. The Ya Hom No.24 Tablets had the most reported AEs at 17.4% with only one causality, which was most probably linked to chest burning pain. There was also one case of herbal decoction relieving menopausal symptoms that was certainly related to chest fullness, feeling hot and cold, suffocation feeling, and sweating increase. Ayurved Siriraj Brand Ya Lom No.65 Pills, also reported one case that was linked to fatigue and drowsiness.\u0000Conclusion: Reports from both data sources found a similar pattern in AE type and TMs/HPs. Naranjo’s algorithm might be one of useful tools to help assess the causality between TMs/HPs and AEs. The results of this study serve as a good reference for causality between TMs/HPs and their AEs for all Thai traditional medicine practitioners.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43614021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Kolb Learning Style and Academic Performances in Orthopedic Residents 骨科住院医师Kolb学习风格与学习成绩的关系

Siriraj Medical Journal Pub Date : 2023-05-01 DOI: 10.33192/smj.v75i5.261255

C. Iramaneerat, S. Thanapipatsiri, Thasaneeya Ratanaroutai Noppartjamjomras, T. Harnroongroj

{"title":"The Relationship between Kolb Learning Style and Academic Performances in Orthopedic Residents","authors":"C. Iramaneerat, S. Thanapipatsiri, Thasaneeya Ratanaroutai Noppartjamjomras, T. Harnroongroj","doi":"10.33192/smj.v75i5.261255","DOIUrl":"https://doi.org/10.33192/smj.v75i5.261255","url":null,"abstract":"Objective: The assimilating and converging Kolb learning style were reported to have positive correlation with critical thinking ability in Orthopedic resident. However, the relationship between Kolb learning styles and academic performance remained controversy. The objective of this study is to report the relationship between Kolb learning style and academic performance in Orthopedic residents.\u0000Materials and Methods: The causal comparative cross-sectional study on 48 Orthopedic residents of academic year 2020 was conducted. The demographic characteristics of the participants were reviewed. The scores from the multiple choices question (MCQ) in-training examination, the objective structured clinical examination (OSCE) and the global performance rating scale were collected to represent academic performances of each Miller’s pyramid of assessment level. The Kolb learning style inventory were allocated. The statistical analysis was performed and p < 0.05 was considered statistically significant difference.\u0000Results: The response rate was 100%. There was no statistically significant difference of MCQ in-training examination, OSCE and global performance rating scale among each learning style as p=0.789, 0.493 and 0.407, respectively. The assimilating and converging styles were the 2 learning styles which had the academic performance scores above the average scores in all assessments.\u0000Conclusion: This study could not demonstrate the significant difference of academic performances among Kolb learning style in Orthopedic residents. However, the assimilating and converging style had the consistent scores above average scores in all domains. The Orthopedic learning experience should focus on the development of reflective observation, abstract conceptualization and active experimentation to facilitate effective improvement in academic performance of the residents.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48422465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nationwide Survey and System Analysis of Emergency Triage System in Lao People's Democratic Republic 老挝全国急诊分流制度调查与系统分析

Siriraj Medical Journal Pub Date : 2023-04-01 DOI: 10.33192/smj.v75i4.260580

Lamngeun Silavong, Ketsarin Utriyaprasit, N. Wanitkun, C. Viwatwongkasem

{"title":"A Nationwide Survey and System Analysis of Emergency Triage System in Lao People's Democratic Republic","authors":"Lamngeun Silavong, Ketsarin Utriyaprasit, N. Wanitkun, C. Viwatwongkasem","doi":"10.33192/smj.v75i4.260580","DOIUrl":"https://doi.org/10.33192/smj.v75i4.260580","url":null,"abstract":"Objective: To assess the present status of the emergency department (ED) triage system in 162 hospitals across the Lao People's Democratic Republic (Lao PDR).\u0000Materials and Methods: The Lao PDR nationwide survey participants recruited ED administrators. The EDs were randomly recruited. The standard questionnaire package was used for data collection including patients’ demographics and triage systemic factors. Descriptive analysis was applied to analysis the outcome of interest.\u0000Results: A majority of triage officers were emergency room nurses (58.6%), general physicians (20.4%), or both (11.1%). Most hospitals (89.5%) used informal triage scales such as clinical experiences or colors to prioritize ED patients. Only 17 hospitals (10.5%) had a formal triage scale in their ED care systems and used it in their practice.\u0000Conclusion: These findings provide knowledge of the ED triage system in the Lao PDR. The results indicate that the Lao PDR lacks a formal ED triage scale but uses a variety of informal scales. Thus, it is necessary to set up a standard triage system at all hospitals to standardize ED healthcare across the country.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46369079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effectiveness of Video and Face-to- Face Sessions to Educate Hospitalized Patients on Cancer Pain Management 对住院病人进行肿瘤疼痛管理教育的视频和面对面会议的比较效果

Siriraj Medical Journal Pub Date : 2023-04-01 DOI: 10.33192/smj.v75i4.261563

Isaraporn Tipapakoon, Suratsawadee Wangnamthip, Natinee Benjangkhaprasert, Nattaya Bunwatsana, Skaorat Panchoowong, P. Euasobhon

{"title":"Comparative Effectiveness of Video and Face-to- Face Sessions to Educate Hospitalized Patients on Cancer Pain Management","authors":"Isaraporn Tipapakoon, Suratsawadee Wangnamthip, Natinee Benjangkhaprasert, Nattaya Bunwatsana, Skaorat Panchoowong, P. Euasobhon","doi":"10.33192/smj.v75i4.261563","DOIUrl":"https://doi.org/10.33192/smj.v75i4.261563","url":null,"abstract":"Objective: Patients’ lack of knowledge of cancer pain management affects pain outcomes. This study compared the effectiveness of cancer pain management achieved in a previous retrospective study (“P-group”), in which hospitalized cancer pain individuals received no pain education, with the pain management achieved by 2 study groups. One group received pain management information via video sessions (“V-group”) and the other via face-to-face coaching (“F-group”). The study’s secondary aims were to compare the 2 interventions’ psychological, quality-of-life, and opioid-consumption impacts.\u0000Materials and Methods: This single-blinded, randomized, controlled trial enrolled hospitalized cancer pain patients aged between 18 and 70 with an Eastern Clinical Oncology Group performance status < 4. They were assigned to V- and F-groups to receive information on managing cancer pain. “Successful pain control” was defined as “no to mild pain” or a numerical rating scale score < 4 on Day 6. Pain intensity and opioid consumption (morphine-equivalent daily dosage) were recorded daily from baseline to Day 6. Psychological status (Hospital Anxiety and Depression Scale) and quality of life (Functional Assessment of Cancer Therapy–General) were assessed at baseline and Day 6.\u0000Results: Fifty-nine participants were analyzed (V-group: 31; F-group: 28). Both groups had significantly higher successful pain outcomes than the P-group (P < .001). The V- and F-groups had no significant differences in successful pain control (20 [65%] vs 19 [68%]; P = .787), psychological effects, quality of life, or opioid consumption.\u0000Conclusions: Video sessions are an alternative means of educating hospitalized cancer pain patients and reducing healthcare providers’ workloads.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45337613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological and Oncologic Outcomes of Consolidation Chemotherapy in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiation 局部晚期直肠癌新辅助放化疗后巩固化疗的病理和肿瘤学结果

Siriraj Medical Journal Pub Date : 2023-04-01 DOI: 10.33192/smj.v75i4.261259

Thikhamporn Tawantanakorn, T. Akaraviputh, V. Chinswangwatanakul, S. Ithimakin, J. Petsuksiri, A. Trakarnsanga

{"title":"Pathological and Oncologic Outcomes of Consolidation Chemotherapy in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiation","authors":"Thikhamporn Tawantanakorn, T. Akaraviputh, V. Chinswangwatanakul, S. Ithimakin, J. Petsuksiri, A. Trakarnsanga","doi":"10.33192/smj.v75i4.261259","DOIUrl":"https://doi.org/10.33192/smj.v75i4.261259","url":null,"abstract":"Objective: The current standard of care for locally advanced rectal cancer is associated with multimodality therapy. Neoadjuvant chemoradiation significantly decreased the locoregional recurrence rate and improved survival. However, distant metastasis develops rather than local recurrence, which becomes the leading cause of death. This study aimed to evaluate the oncological outcomes of total neoadjuvant therapy (TNT) in locally advanced rectal cancer.\u0000Materials and Methods: This retrospective study recruited 18 patients diagnosed with locally advanced rectal adenocarcinoma (cT3-4 or cN1-2), treated with consolidation TNT. The primary endpoint was pathological complete response (pCR). The secondary endpoint included postoperative outcomes, local recurrences, and distant metastases.\u0000Results: The pathologic complete response was observed in 27.8% of consolidation therapy cases. Downstaging of the T-category was achieved in 10 (55.6%) patients, and downstaging of the N-category was achieved in 14 (77.8%) patients. Only one patient who achieved pCR developed distant metastasis, whereas all patients with pathological stage III developed distant metastasis.\u0000Conclusions: TNT is a promising approach for patients with locally advanced rectal cancer. This strategy improved complete pathologic response rates in TNT, and pCR was found to be associated with fewer local recurrences and greater disease-free survival.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48754036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential of Vitamin-D-Binding Protein as a Urinary Biomarker to Distinguish Steroid-Resistant from Steroid-Sensitive Idiopathic Nephrotic Syndrome in Iraqi Children 维生素d结合蛋白作为区分伊拉克儿童类固醇耐药和类固醇敏感特发性肾病综合征的尿液生物标志物的潜力

Siriraj Medical Journal Pub Date : 2023-04-01 DOI: 10.33192/smj.v75i4.260831

Ali Mohammed Abd Alridha, D. Kadhim, A. Alkhazrajy

{"title":"The Potential of Vitamin-D-Binding Protein as a Urinary Biomarker to Distinguish Steroid-Resistant from Steroid-Sensitive Idiopathic Nephrotic Syndrome in Iraqi Children","authors":"Ali Mohammed Abd Alridha, D. Kadhim, A. Alkhazrajy","doi":"10.33192/smj.v75i4.260831","DOIUrl":"https://doi.org/10.33192/smj.v75i4.260831","url":null,"abstract":"Objective: To determine the ability of uVDBP to discern SRNS from steroid-sensitive nephrotic syndrome (SSNS) in Iraqi children.\u0000Materials and Methods: This cross-sectional study enrolled children with SRNS (n=31) and SSNS (n=32) from the pediatric nephrology clinic of Babylon Hospital for Maternity and Pediatrics over three months. Patients' characteristics in terms of demographics, clinical data, and urinary investigations were collected. Quantitative analysis of uVDBP levels was undertaken via a commercially available ELISA kit.\u0000Results: The median uVDBP values were significantly higher (p-value<0.001) in the SRNS group (median=10.26, IQR=5.91 μg/mL) than in the SSNS group (median=0.953, IQR=4.12 μg/mL). A negative correlation was noted between uVDBP levels and estimated glomerular filtration rate (eGFR) (Spearman's rho coefficient= − 0.494, p=0.001). Nevertheless, the rise in uVDBP concentrations was still considerable in children with SRNS whose eGFR measurements were above 60 mL/min/1.73 m2. The study revealed a good discriminatory power for uVDBP as a predicting parameter to distinguish SRNS from SSNS (AUC= 0.909, p<0.0001. The optimal uVDBP cut-off value of 5.781 μg/mL was associated with a sensitivity of 0.839 and specificity of 0.844 to differentiate SRNS from SSNS.\u0000Conclusion: Considering its significant discriminatory strength, uVDBP can be considered as a potential marker to noninvasively distinguish children with SRNS from those with SSNS.","PeriodicalId":37270,"journal":{"name":"Siriraj Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41832209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0