Primate Biology最新文献

{"title":"A case of gallstones in an African green monkey (<i>Chlorocebus aethiops</i>).","authors":"Dina Kleinlützum,&nbsp;Roland Plesker","doi":"10.5194/pb-4-33-2017","DOIUrl":"https://doi.org/10.5194/pb-4-33-2017","url":null,"abstract":"<p><p>Spontaneous cholelithiasis was found in a male African green monkey (<i>Chlorocebus aethiops</i>) at necropsy. Choleliths varied in size, shape and colour. Gallstones were analysed using accepted analytical methods. Results showed that the gallstones were composed of cholesterol and protein in varying proportions. Histologically, the gallbladder showed diffuse mild to moderate lymphocytic infiltration. The etiology of the cholelithiasis in the examined individual remains unknown.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular T-cell lymphoma in a patas monkey (<i>Erythrocebus patas</i>).","authors":"Karen Lampe,&nbsp;Jens-Christian Rudnick,&nbsp;Fabian Leendertz,&nbsp;Martina Bleyer,&nbsp;Kerstin Mätz-Rensing","doi":"10.5194/pb-4-39-2017","DOIUrl":"https://doi.org/10.5194/pb-4-39-2017","url":null,"abstract":"<p><p>A 9-year-old female captive patas monkey (<i>Erythrocebus patas</i>) presented with poor general condition, inability to stand, petechiae, anaemia, thrombocytopenia, and leukocytosis. Due to poor response to treatment, the animal was euthanized 16 days later. Postmortem examination revealed hemorrhages in several organs and bilateral cerebral infarctions. Histologically, prominent accumulations of large neoplastic lymphocytes in cerebral and meningeal blood vessels were demonstrated within the lesions and in other organs (e.g., bone marrow, ovary, intestine). Immunohistochemically, neoplastic cells expressed CD3 and Ki-67. PCR revealed a lymphocryptovirus (LCV) infection, while Epstein-Barr nuclear antigen 2 (EBNA2) could not be demonstrated within neoplastic cells by means of immunohistochemistry. Based on the pathological findings, an intravascular lymphoma (IVL) of T-cell origin was diagnosed. To the authors' knowledge, this is the first report on this rare entity in a nonhuman primate.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37688285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspect Guillain-Barré syndrome in a male rhesus macaque (<i>Macaca mulatta</i>).","authors":"Tamara Becker,&nbsp;Florian Pieper,&nbsp;David Liebetanz,&nbsp;Martina Bleyer,&nbsp;Annette Schrod,&nbsp;Kerstin Maetz-Rensing,&nbsp;Stefan Treue","doi":"10.5194/pb-4-27-2017","DOIUrl":"https://doi.org/10.5194/pb-4-27-2017","url":null,"abstract":"<p><p>Guillain-Barré syndrome (GBS) is a rare, mainly acute inflammatory polyneuropathy in humans. It is frequently post-infectious with auto antibodies being formed against myelin sheaths, resulting in a progressive and more-or-less severe paralysis of the motor neuron and cranial nerves. Mortality is low and 60 % of the patients recover completely from the disease after intensive treatment. In animals, there are a few diseases that closely resemble GBS, but cases of GBS in monkeys seem to be scarce. In this case report, the clinical course of a progressive tetraplegia in a male rhesus macaque is described. Clinical, cerebrospinal fluid (CSF), electroneurography (ENG) and electromyography (EMG), and pathological findings revealed symptoms very similar to human GBS.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2017-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous lung pathology in a captive common marmoset colony (<i>Callithrix jacchus</i>).","authors":"Martina Bleyer,&nbsp;Marius Kunze,&nbsp;Eva Gruber-Dujardin,&nbsp;Kerstin Mätz-Rensing","doi":"10.5194/pb-4-17-2017","DOIUrl":"https://doi.org/10.5194/pb-4-17-2017","url":null,"abstract":"<p><p>Data on spontaneous pathology are substantially scarce for common marmosets, compared to other laboratory animals, but is essential for the interpretation of histological findings in the context of toxicological and experimental studies. Especially if common marmosets are used as experimental animals in respiratory research, detailed knowledge on the spectrum, occurrence, and incidence of spontaneous histopathological pulmonary lesions in this non-human primate species is required. In this study, lung tissue of 638 common marmosets from the marmoset colony of the German Primate Center was examined histologically. The analysis revealed a high incidence of predominantly mild and multifocal interstitial pneumonia (32.99 %) of unknown etiology in most cases. Only few marmosets exhibited lobar pneumonia (1.41 %) and bronchopneumonia (0.94), which were mainly caused by bacterial pathogens such as <i>Bordetella bronchiseptica</i> and <i>Klebsiella pneumoniae</i>. Lung immaturity and atelectasis were common histological findings in newborn marmosets. Typical background lesions included anthracosis (8.15 %), hemosiderosis (1.72 %), extramedullary hematopoiesis (11.6 %), mineralization (10.97 %), and inflammatory cell foci (10.34 %). In addition, three cases of pulmonary arteriopathy (0.47 %) and 1 case of foreign-body granuloma (0.16 %) were detected in the marmoset study cohort. The high prevalence of circulatory disturbances (congestion, edema, hemorrhage) and changes in air content (secondary atelectasis, alveolar emphysema) could partly be explained by euthanasia-related artifacts or agonal changes. The present study provides a comprehensive overview of the range and incidence of spontaneous pulmonary histopathology in common marmosets, serving as valuable reference data for the interpretation of lung lesions in toxicological and experimental marmoset studies.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection systems for antibody responses against herpes B virus.","authors":"Stefan Pöhlmann,&nbsp;Astrid Krüger,&nbsp;Wali Hafezi,&nbsp;Stefan Schneider,&nbsp;Jens Gruber,&nbsp;Michael Winkler,&nbsp;Artur Kaul","doi":"10.5194/pb-4-9-2017","DOIUrl":"https://doi.org/10.5194/pb-4-9-2017","url":null,"abstract":"<p><p>Herpes B virus (BV) infection is highly prevalent among adult Asian macaques and rarely causes severe disease in infected animals. In contrast, BV infection of humans can induce fatal encephalitis in the absence of treatment. Therefore, the development of diagnostic tests for specific and sensitive detection of antibodies against BV is an important task. The cross-reactivity of antibodies against BV with related simplex viruses of other primates may afford an opportunity to obtain sensitive detection systems without the need to work with the highly pathogenic BV. Moreover, it has been proposed that use of recombinant viral glycoproteins may allow for a detection of antibody responses against BV with high specificity. However, limited data are available for both approaches to BV diagnostic. Here, we report that simian agent 8 (SA8; infects African green monkeys)- and herpesvirus papio 2 (HVP-2; infects baboons)-infected cells allow for a more sensitive detection of antibody responses against BV in macaques than lysates of herpes simplex virus type 1 and 2 (HSV-1/2; infect humans)-infected cells and a commercial HSV ELISA (Enzygnost^® Anti-HSV/IgG). In addition, we show that sera from BV-infected macaques frequently contain antibodies against the recombinant BV glycoprotein gD (BV gD) that has been previously proposed as a diagnostic target for discriminating BV- and HSV-induced antibodies. However, we found that antibodies of some HSV-infected human patients also reacted with BV gD. In contrast, only sera of HSV-1- and HSV-2-infected humans, but not sera from BV-infected macaques, reacted with HSV-1/2 gG. Collectively, these results suggest that both SA8 and HVP-2 allow for sensitive and comparable detection of BV-directed antibody responses in macaques and that the combination of BV gD and HSV-1/2 gG needs to be complemented by a least one additional viral glycoprotein for reliable discrimination between antibody responses against BV and HSV-1/2 in humans.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2017-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-dependent change of coalitionary strategy in male Barbary macaques.","authors":"Eva-Maria Rathke,&nbsp;Andreas Berghänel,&nbsp;Annie Bissonnette,&nbsp;Julia Ostner,&nbsp;Oliver Schülke","doi":"10.5194/pb-4-1-2017","DOIUrl":"https://doi.org/10.5194/pb-4-1-2017","url":null,"abstract":"<p><p>Inter- and intra-specific variation in the propensity to form coalitions has been explained by variation in the availability of suitable partners, distribution of fighting ability, coalition profitability, and costs of coordination. Male coalition formation can be an alternative reproductive strategy to one-on-one competition to maximize male reproductive success. Here we focus on age as a state variable to explain within-group variation in individual propensity to form coalitions against other group members. We specifically test the prediction that males conditionally switch from a solo strategy for achievement of high mating success to a cooperative strategy after reaching post-prime age in male Barbary macaques (<i>Macaca sylvanus</i>). We combined new observations with data collected in 2006 and 2008 on the same individuals from one captive group living in semi-natural conditions at Affenberg Salem, Germany, and found that in all years males between 5 and 13 years formed significantly fewer coalitions than males 14 years and older (post-prime). More importantly, we found those males that aged into the post-prime phase to have switched their reproductive strategy and to form significantly more coalitions in 2014 compared to 2008. These first longitudinal data together with earlier cross-sectional analyses in this and other primate species suggest that group-level measures of coalition propensity may be strongly affected by the age composition of groups and that male coalition formation can be a conditional reproductive strategy.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"4 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online resources for improving the care and use of non-human primates in research.","authors":"Mark J Prescott","doi":"10.5194/pb-3-33-2016","DOIUrl":"https://doi.org/10.5194/pb-3-33-2016","url":null,"abstract":"<p><p>Published literature and scientific events provide opportunities to expand knowledge and develop skills in the care and use of non-human primates (NHPs) in research. Increasingly, these traditional routes of information exchange are being complemented by dedicated online resources aimed at sharing best practice in NHP care and use, and enhancing the training and professional development of laboratory staff working with NHPs. This article outlines some key online resources from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and other organisations with an interest in NHP research, and the ways in which the resources can be integrated into staff training and research practices to enhance animal welfare, quality of science and application of the 3Rs.</p>","PeriodicalId":37245,"journal":{"name":"Primate Biology","volume":"3 ","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25526329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}