Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine最新文献

{"title":"Correlation of D-dimer Measurement Values Using Quantum Dots Fluorescence Immunochromatographic Assay and Latex-Enhanced Immunoturbidimetric Assay.","authors":"Alif Ainudin, Ferdy Royland Marpaung, Paulus Budiono Notopuro","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>D-dimer, a fibrin degradation product, is widely used in the diagnosis of thrombotic disorders and in clinical decision-making. Quantum dots (QDs) fluorescence immunochromatography has emerged as a rapid method for detecting protein biomarkers; however, comparative data with the established latex-enhanced immunoturbidimetric assay remain limited.</p><p><strong>Methods: </strong>A laboratory-based method comparison study was conducted using 80 consecutively collected plasma samples from patients at Dr. Soetomo General Academic Hospital, Surabaya. D-dimer levels were measured using a QDs fluorescence immunochromatography assay (QD-S2000, Vazyme, China) and a latex-enhanced immunoturbidimetric assay (Sysmex CS-2500, Sysmex Corporation, Japan).Correlation and agreement between methods were assessed using Spearman correlation analysis and Bland-Altman plots.</p><p><strong>Results: </strong>Among the 80 samples (60% female, 40% male), a very strong correlation was observed between the two methods (Spearman r = 0.951, p < 0.001). Bland-Altman analysis demonstrated good agreement, with most data points falling within the 95% limits of agreement. Although the QDs fluorescence immunochromatography method consistently produced higher absolute D-dimer values, both assays showed comparable trends across the measurement range.</p><p><strong>Conclusion: </strong>QDs fluorescence immunochromatography and the latex-enhanced immunoturbidimetric assay demonstrated strong correlation and acceptable agreement in D-dimer measurement. Despite yielding higher absolute values, the QDs-based method showed consistent performance, supporting its potential as a reliable and rapid alternative for clinical D-dimer assessment.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"281-287"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypophosphatasia with Coexisting Endocrinopathies: A Diagnostic Dilemma.","authors":"Anil K Chokkalla, Niyutchai Chaithongdi, Megan Bell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adult-onset hypophosphatasia presents a diagnostic challenge due to confounding clinical and analytical factors. Although rare, the consequence of missed diagnosis is significant, as it can potentiate skeletal mineralization defects. Despite the recent development of diagnostic criteria, integration into routine clinical practice remains limited, partly due to the variable course of disease progression. Effective management often requires a multidisciplinary team, including rheumatologists, orthopedic surgeons, endocrinologists, medical geneticists, dentists, physical and occupational therapists, pain specialists and clinical biochemists. Here, we present a case of adult-onset autosomal dominant hypophosphatasia, where diagnosis was complicated by coexisting endocrine disorders, Addison's disease and primary hypothyroidism. Persistently decreased alkaline phosphatase activity had been observed for over a decade and were initially attributed to hypothyroidism. However, an endocrinologist's clinical suspicion led to genetic testing, confirming hypophosphatasia. Although the patient exhibited no additional symptoms such as premature tooth loss, osteopenia, or osteoporosis, this incidental finding prompted a referral to medical genetics, carrier screening to support family planning, and cascade testing for family members.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"379-382"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An optimized method for setting Internal Quality Control targets (mean and limits) for multi-instrument Internal Quality Control strategies in hematology?","authors":"Tony Badrick, Mathieu Bernard, Lionel Tabard, Jean-Marc Giannoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Internal Quality Control (IQC) procedures must evolve as laboratory practices change to meet the requirements of higher patient volumes and the greater need for comparability of results across laboratories. This study developed a strategy to detect significant errors in routine hematology analytical processes using a novel approach to setting IQC material targets (mean and limits) across multiple instruments. This has not been described for hematology laboratories before.</p><p><strong>Content: </strong>The approach described used a common IQC sample mean and limits determined from a manufacturer-based peer group using the same IQC material. The limits involved a new parameter, the random error of the peer group analyzers around their own mean (SD_intra90), to detect bias or imprecision. The model was assessed over five months using 17 analyzers that measured hemoglobin and red cell count. Using a common mean requires that the different analyzers exhibit no significant bias.</p><p><strong>Summary: </strong>The model effectively controls analytical error in a network of laboratories using the same measurement system. This model aligns with the best theoretical principles for patient risk reduction and harmonizes practices for acceptance and rejection across the network.</p><p><strong>Outlook: </strong>The model presents an approach to IQC that meets the demands of real-world practice.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"306-318"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Trimester-Specific Reference Intervals for TSH and Thyroid Hormones in Pregnant Women living in Oran, Western Algeria.","authors":"Assia Besbes, Belkacem Chafi, Houria Messid Bouziane Meflah, Kheira Meriem Arabi, Mourad Nachi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>The thyroid gland undergoes physiological changes during pregnancy, leading to variations in reference intervals (RIs) for TSH and free thyroid hormones across the different trimesters. To ensure accurate interpretation of these tests, the American Thyroid Association (ATA) recommends the use of trimester-specific and population-based reference intervals. The aim of our study was: to establish trimester-specific reference intervals of TSH, FT3, and FT4 in pregnant women living in Oran western Algeria.</p><p><strong>Materials and methods: </strong>The reference intervals were established accordingly to the CLSI guideline (EP28-A3c ). The study included 401 apparently healthy pregnant women, classified as follows: 120 in the first trimester, 154 in the second trimester, and 127 in the third trimester. Reference subjects were selected based on NACB exclusion criteria. Hormone assays were performed using the Roche Cobas e411 analyzer.</p><p><strong>Results: </strong>The established RIs corresponding to the 2.5th and 97.5th percentiles were in the First, Second and Third trimester for TSH: 0.25-3.57 mIU/L, 0.15-3.43 mIU/L,0.57-4.23 mIU/L, FT4 : 11.41-20 pmol/L, 10.56-18 pmol/L, 9.43-17.54 pmol/L, and FT3 : 3.16-7.02 pmol/L, 3.02-7.54 pmol/L, 3.2-7.37 pmol/L.</p><p><strong>Conclusion: </strong>In the absence of population-specific reference intervals for TSH and thyroid hormones in our country, establishing such values represents a significant advancement, enabling more accurate diagnosis and improved management of thyroid disorders.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"288-296"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Survey on Knowledge, Attitudes, and Practices regarding Reference Interval Utilization in Clinical Laboratories in Nepal.","authors":"Vivek Pant, Santosh Pradhan, Dipesh Tamrakar, Anuradha Kadel, Nikita Kharal, Tony Badrick","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Reference intervals (RIs) are critical for accurate clinical decision-making, yet many laboratories rely on manufacturer-provided RIs without local validation. This study assessed the knowledge, attitudes, and practices (KAP) of clinical laboratories in Nepal regarding RI utilization, highlighting challenges and opportunities for standardization in alignment with ISO 15189:2022 accreditation.</p><p><strong>Methods: </strong>A nationwide cross-sectional KAP survey was conducted among 56 laboratory professionals. Data were collected via an online questionnaire, covering demographics, RI knowledge, current practices, challenges, and attitudes toward national standardization. Descriptive and inferential statistics (chi-square, Fisher's exact tests) were used for analysis.</p><p><strong>Results: </strong>While 71.4% of respondents correctly defined RIs as the 2.5th-97.5th percentiles, 28.6% held misconceptions. Most laboratories relied on manufacturer-provided RIs (87.5%) or published literature (67.9%). Key challenges to derive one's own RI included method variability and recruiting reference individuals. Accredited labs (ISO 15189) demonstrated better knowledge of RI (93.3% vs. 63.4%, p=0.032) and higher confidence in using current RI (26.7% vs. 7.3%, p=0.047). Strong interest existed in national RI standardization (92.9%) and training (85.7% preferred hands-on workshops).</p><p><strong>Conclusions: </strong>This survey of higher tier clinical laboratories in Nepal reveals that while these laboratories generally understand the importance of reference intervals, significant gaps in practice and standardization remain. The findings highlight an urgent need for inclusive strategies that also address the unique constraints of smaller, widespread laboratories, which perform a large proportion of routine testing in the country. The intense interest in a national program presents an opportunity to improve. Multicenter studies and RI validation integration into accreditation are needed to improve diagnostic accuracy.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"219-226"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Point Pooled Sera (TriPPS) QC for Laboratory Analyte Error Detection: A Machine Learning based Quality Control in Laboratory.","authors":"Prakruti Dash, Sudeshna Rout, Bharath Kumar Koppisetty, Chhabi Rani Panda, Dharashree Priyadarshini, Tanushree Roy, Saurav Nayak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Reliable internal quality control (IQC) is vital for ensuring analytical accuracy in clinical laboratories. Conventional rule-based QC systems, such as Westgard and Levey-Jennings, often exhibit retrospective detection and limited sensitivity to small but clinically meaningful shifts. This study introduces the Triple-Point Pooled Sera (TriPPS) Quality Control system, a novel, machine-learning-based framework integrating in-house pooled sera with adaptive algorithms for enhanced error detection.</p><p><strong>Methods: </strong>Residual patient sera were pooled to create stable, matrix-relevant IQC material for 60 consecutive analytical days. Sodium and potassium were used as representative analytes. Three complementary machine learning models were applied: k-Nearest Neighbour (k-NN) for trend detection, Isolation Forest (IF) for random error identification, and Gaussian Process Regression (GPR) for systematic bias modeling. Controlled ±1% daily biases and stochastic random errors were introduced to simulate analytical drift. Detection lag, sensitivity, and anomaly classification were evaluated.</p><p><strong>Results: </strong>The k-NN algorithm effectively identified trend errors within 0-2 days of bias onset, while IF accurately detected random fluctuations with minimal false positives. GPR modeled nonlinear systematic drift with high fidelity, capturing bias progression that is overlooked by linear methods. The integration of pooled sera enhanced the system's stability, reproducibility, and cost efficiency across all error types.</p><p><strong>Conclusion: </strong>The TriPPS system demonstrates a scalable, data-driven approach to laboratory quality control by combining pooled sera with machine learning algorithms. This framework enhances analytical vigilance, facilitates proactive error identification, and provides a practical, resource-efficient solution for real-time QC monitoring in clinical chemistry laboratories.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"336-344"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Free Testosterone and DHEA-S with Dyslipidemia in Women with Polycystic Ovarian Syndrome- a case-control study.","authors":"K Lavanya, N Palaniappan, Santhi Silambanan, V M Vinodhini, Mahesh Kumar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a multisystem disorder presenting with menstrual irregularities, infertility, and features of hyperandrogenism. Hyperandrogenism predisposes to the critical clinical features of PCOS. This find aimed to study the association of androgenic hormones such as dehydroepiandrosterone sulfate (DHEA-S) and free testosterone with lipid profile in PCOS women.</p><p><strong>Methods: </strong>This case-control study was conducted in the Department of Biochemistry at a tertiary care hospital in Chennai. Patients were recruited from the Department of Obstetrics and Gynecology. Participants were aged 18-40 years. Blood samples were collected for analysis of lipid profile, DHEA-S, and free testosterone. DHEA-S and free testosterone were analyzed by ELISA. Ethics approval and written informed consent were obtained. Based on the distribution of the data, appropriate statistical tools were used. P-value ≤ 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Most of the participants were aged between 21 and 30 years. HDL-c was decreased in PCOS patients compared to healthy individuals; however, no statistically significant difference was found. Free testosterone showed an association with triglyceride. The areas under the curves of DHEA-S and free testosterone were 0.638 and 0.765, respectively.</p><p><strong>Conclusion: </strong>DHEA-S and free testosterone showed good area under the curves. But free testosterone performed better with a higher area under the curve as well as its association with triglyceride. The cut-off values to diagnose PCOS were 3.0 μg/mL and 2.5 pg/mL for DHEA-S and free testosterone, respectively, with adequate sensitivity and specificity. Since free testosterone performed better in ROC curve than DHEA-S, free testosterone is considered to be a potential biomarker of identifying hyperandrogenism in PCOS women.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Gasdermin D as a Biomarker for Pyroptosis in Early Detection of Newly Diagnosed Type 2 Diabetes Mellitus.","authors":"Mimoh Sharma, Anil Kumar, Akash Garwal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pyroptosis, a caspase-mediated inflammatory cell death pathway driven by Gasdermin D (GSDMD), has emerged as a potential mechanistic link between metabolic stress, β-cell injury, and chronic inflammation in Type 2 diabetes mellitus (T2DM). This study evaluated plasma GSDMD as a biomarker for newly diagnosed T2DM and explored its metabolic and inflammatory correlates. In a hospital-based case-control study, 130 newly diagnosed T2DM patients and 130 age- and sex-matched normoglycemic controls were recruited. Anthropometric indices, glycemic parameters, βFins, HOMA-IR, HOMA-β, lipid profile, and hs-CRP were measured using standard methods. Plasma GSDMD, IL-18, and IL-1β were quantified by ELISA. Group differences, correlations, multivariable logistic regression, and receiver operating characteristic (ROC) analyses were performed. T2DM patients exhibited higher BMI, adverse lipid profile, increased hs-CRP, and marked elevation of GSDMD, IL-18, and IL-1β compared with controls (all p<0.0001). Plasma GSDMD correlated positively with FBS, HbA1c, HOMA-IR, IL-18, IL-1β, and hs-CRP, and negatively with HOMA-β, indicating close links to hyperglycemia, insulin resistance, β-cell dysfunction, and systemic inflammation. In adjusted models, GSDMD remained an independent predictor of T2DM (OR 1.18 per 10 pg/mL, 95% CI 1.09-1.29), alongside IL-18, hs-CRP, higher BMI, and lower HDL-C. ROC analysis showed excellent diagnostic performance for GSDMD (AUC 0.98, 95% CI 0.96-0.99; cutoff 17.5 pg/mL; sensitivity 93.0%; specificity 97.0), superior to IL-18, IL-1β, and hs-CRP. Plasma GSDMD is markedly elevated in T2DM and integrates metabolic and inflammatory information, functioning as an independent risk factor and highly accurate diagnostic biomarker. These findings support GSDMD-mediated pyroptosis as a promising target for early diagnosis and risk stratification in T2DM.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"297-305"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of best practices for quality assurance in laboratories in Portuguese-speaking countries.","authors":"Flávia Martinello, Alice Berlanda Seidler, Maria Elisabeth Menezes, Helena Correia, Silvânia Da Veiga Leal, Armandina Miranda, Ana Faria","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Laboratories (labs) play a fundamental role in screening, diagnosis, prognosis, and treatment of diseases. For a laboratory result to be useful, it must have guaranteed quality. In this context, there is no informative data on the best practices adopted by labs in Portuguese-speaking countries (PSC). This information is essential for formulating policies and educational strategies intended for this target audience.</p><p><strong>Objective: </strong>To identify and assess adherence to laboratory best practices by clinical analysis labs in Portuguese-speaking countries.</p><p><strong>Methods: </strong>A digital questionnaire consisting of 47 questions on laboratory best practices and quality management was sent to participants in the National Program for External Quality Assessment of Portugal and other labs involved in the Laboratory Quality Improvement Project for PSC-ProMeQuaLab, except from Brazil. Data were collected anonymously between July 7 and September 30, 2024 and analysed with descriptive statistics.</p><p><strong>Results: </strong>59 labs (ambulatory and hospital) participated in the study, but 5 institutions did not consent to the disclosure of their data, even if anonymously. Of the 54 included labs, most were from Portugal (39; 72%), followed by Cabo Verde (9; 16%), Guinea-Bissau (4; 7%), São Tomé and Príncipe (1; 2%), and 1 lab did not specify its country of origin. 57% of the labs have an implemented management system, and half of them are certified. Most labs belong to public services (63%), have a professional responsible for the management system (85%), conduct an annual training plan (85%), use quality indicators for the pre-analytical (87%) and post-analytical (83%) phases, and perform internal (70%) and external (89%) quality control. Opportunities for improvement were identified, as only 59% of labs record the causes of rejection of control sample results, 65% develop a competency matrix, 66% construct control charts, and 72% use quality specifications to assess analytical performance.</p><p><strong>Conclusion: </strong>Portuguese labs contributed the most to these results. Laboratory best practices are implemented, but there are opportunities for improvement. Conducting training and involving more labs from PSC will contribute to the implementation and harmonization of laboratory best practices, which can contribute to ensuring the quality of results and patient safety.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative colitis initially misdiagnosed as irritable bowel syndrome: A case report.","authors":"Swathi Nalla, Burra Sai Ruthvik, G Tulja Rani, Illa Asha Latha","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) and early ulcerative colitis (UC) share overlapping gastrointestinal symptoms, which may lead to misdiagnosis and delay in appropriate treatment.</p><p><strong>Case presentation: </strong>The patient presenting with abdominal pain and altered bowel habits was initially diagnosed with IBS based on symptoms, physical examination, and past medical history, in the absence of alarm features. However, despite one week of symptomatic treatment, the patient's condition worsened.</p><p><strong>Diagnostic assessment: </strong>Further evaluation including complete blood profile, abdominal ultrasonography, colonoscopy, and colonic biopsy was subsequently performed, which confirmed a diagnosis of inflammatory bowel disease consistent with ulcerative colitis.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic pitfalls in differentiating IBS from early UC based solely on clinical presentation. Clinicians should maintain a high index of suspicion and pursue appropriate laboratory and endoscopic investigations when symptoms persist or worsen, to avoid misdiagnosis, treatment delay, and disease progression.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"37 2","pages":"372-378"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}