Chemical Engineering Science: X最新文献_第8页

Fully resolved scalar transport for high Prandtl number flows using adaptive mesh refinement 使用自适应网格细化的高普朗特数流的完全解析标量传输

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-19 DOI: 10.1016/j.cesx.2019.100047

A. Panda, E.A.J.F. Peters, M.W. Baltussen, J.A.M. Kuipers

引用次数: 3

Biodistribution of orally administered 99mTc-heparin to assess eosinophilic esophagitis associated inflammation 口服99mtc -肝素评估嗜酸性食管炎相关炎症的生物分布

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-28 DOI: 10.1016/j.cesx.2019.100049

Hedieh Saffari , Russell M. Condie , Brian R. Watson , Jeffrey J. Krstyen , Kathryn A. Peterson , John M. Hoffman , Gerald J. Gleich , Leonard F. Pease III

{"title":"Biodistribution of orally administered 99mTc-heparin to assess eosinophilic esophagitis associated inflammation","authors":"Hedieh Saffari , Russell M. Condie , Brian R. Watson , Jeffrey J. Krstyen , Kathryn A. Peterson , John M. Hoffman , Gerald J. Gleich , Leonard F. Pease III","doi":"10.1016/j.cesx.2019.100049","DOIUrl":"10.1016/j.cesx.2019.100049","url":null,"abstract":"<div><p>Here we explore the biodistribution of <sup>99m</sup>Tc-heparin, an orally administered radiopharmaceutical candidate expected to identify localized inflammation in eosinophilic esophagitis (EoE). Heparin binds to eosinophil granule proteins in inflamed regions of gastrointestinal (GI) organs, and <sup>99m</sup>Tc signals their location. This article evaluates the biodistribution of this conjugate first within the esophagus by modeling the reactive transport of <sup>99m</sup>Tc-heparin based on the kinetics of <sup>99m</sup>Tc-heparin binding to non-human primate esophagi and second in the remainder of the body by measuring organ specific uptake using single-photon emission computed tomography/computed tomography imaging. Results show that binding and dissociation rate constants remain similar, and that optimal imaging occurs after drinking of the agent is complete. We also find that <sup>99m</sup>Tc-heparin remains within the GI tract simply transporting through the gut and out. These findings provide a new avenue to clinically explore the utility of <sup>99m</sup>Tc-heparin to detect eosinophil associated inflammation in the GI tract.</p></div>","PeriodicalId":37148,"journal":{"name":"Chemical Engineering Science: X","volume":"4 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cesx.2019.100049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48969095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hopper discharge of elongated particles of varying aspect ratio: Experiments and DEM simulations 不同长径比的细长颗粒的漏斗排出:实验和DEM模拟

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-09-19 DOI: 10.1016/j.cesx.2019.100040

Henna Tangri , Yu Guo , Jennifer S. Curtis

{"title":"Hopper discharge of elongated particles of varying aspect ratio: Experiments and DEM simulations","authors":"Henna Tangri , Yu Guo , Jennifer S. Curtis","doi":"10.1016/j.cesx.2019.100040","DOIUrl":"10.1016/j.cesx.2019.100040","url":null,"abstract":"<div><p>Steady flow of particulate or granular materials and bulk solids through a hopper plays a critical role in many industrial and process engineering applications. The present work investigates hopper discharge of non-spherical particles, specifically cylindrical particles, from a rectangular hopper. The behavior of steel cylindrical particles with varying aspect ratio (both varying diameter with constant length and varying length with constant diameter) was explored experimentally and via DEM simulations. In addition, the effects of fill height, particle friction, hopper orifice width and hopper cone angle on hopper discharge rate of non-spherical particles were studied via DEM simulations and compared with previously published experimental correlations, experimental results of spherical particles. The results indicate that DEM simulations are fully capable of reproducing trends that are established experimentally. The results with particles of high aspect ratio indicate a different trend than that previously observed with rounded particles. As the fill height increases, the mass discharge rate increases and then asymptotes; further increases in fill height cause a decrease in the mass discharge rate. Further, the effect of particle friction showed a significant influence on the hopper discharge behavior. In addition, a decrease in the hopper angle from 90 degree to critical angle 55 degree decreases the mass discharge rate flow and further decrease in hopper angle increases the discharge rate rapidly.</p></div>","PeriodicalId":37148,"journal":{"name":"Chemical Engineering Science: X","volume":"4 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cesx.2019.100040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44779265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

The effect of polydispersity on the conversion kinetics of starch oxidation and depolymerisation 多分散性对淀粉氧化解聚转化动力学的影响

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-16 DOI: 10.1016/j.cesx.2019.100044

T.M. Hoogstad , G. Konings , P.L. Buwalda , A.J.B. Boxtel , L. Kiewidt , J.H. Bitter

{"title":"The effect of polydispersity on the conversion kinetics of starch oxidation and depolymerisation","authors":"T.M. Hoogstad , G. Konings , P.L. Buwalda , A.J.B. Boxtel , L. Kiewidt , J.H. Bitter","doi":"10.1016/j.cesx.2019.100044","DOIUrl":"10.1016/j.cesx.2019.100044","url":null,"abstract":"<div><p>Biobased feedstocks offer a potent source of building blocks for biobased products. However, these feedstocks (e.g. starch, cellulose) are generally highly polydisperse in molecular weight. To study the effect of polydispersity on conversion kinetics, the influence of molecular size on the oxidation and depolymerisation rates of starch was investigated. Kinetic experiments for the homogeneous TEMPO/hypochlorite catalysed oxidation of amylopectins with different molecular sizes showed that large starch molecules oxidise and depolymerise at a higher rate than small molecules. In addition, increasing degrees of oxidation inhibit the rate of further oxidation exponentially. These results demonstrate that polydispersity is an important factor in the conversion of these feedstocks. A model was formulated that assigns individual kinetic parameters to starch fractions of different molecular weight and degree of oxidation. The model predicts 2-D product distributions over molecular weight and degree of oxidation, and predicts asymmetrical distribution shifts as a result of substrate polydispersity.</p></div>","PeriodicalId":37148,"journal":{"name":"Chemical Engineering Science: X","volume":"4 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cesx.2019.100044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43986448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A new mathematical model for nucleation of spherical agglomerates by the immersion mechanism 基于浸没机制的球形团块成核新数学模型

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-21 DOI: 10.1016/j.cesx.2019.100048

Omid Arjmandi-Tash, Jonathan D. Tew, Kate Pitt, Rachel Smith, James D. Litster

{"title":"A new mathematical model for nucleation of spherical agglomerates by the immersion mechanism","authors":"Omid Arjmandi-Tash, Jonathan D. Tew, Kate Pitt, Rachel Smith, James D. Litster","doi":"10.1016/j.cesx.2019.100048","DOIUrl":"https://doi.org/10.1016/j.cesx.2019.100048","url":null,"abstract":"<div><p>Initial wetting of crystals by binder droplets is a key rate process in spherical agglomeration, however there are no models to predict the kinetics and formation of agglomerate nuclei. Two new mathematical models are introduced for agglomerate nucleation by an immersion mechanism; immersion rate limited model and collision rate limited model. The <em>agglomerate nucleation number</em> developed in this work predicts different regimes; <em>immersion rate limited</em>, <em>collision rate limited</em> and <em>intermediate</em>. In an immersion rate limited regime, agglomerate size increases with square root of time. In a collision rate limited regime, size increases linearly with time if the bulk crystal volume fraction, <em>φ<sub>Pb</sub></em>, is constant, or with an exponential decay rate for batch crystallisation with decreasing <em>φ<sub>Pb</sub></em>. The timescale for nucleation is less than ten minutes for a broad range of conditions, significantly less than most crystallisation timescales. These models have great promise for population balance modelling and spherical agglomeration optimisation.</p></div>","PeriodicalId":37148,"journal":{"name":"Chemical Engineering Science: X","volume":"4 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cesx.2019.100048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137389290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical and experimental analysis of combustion in microchannels with controlled temperature 可控温度微通道燃烧的数值与实验分析

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-12 DOI: 10.1016/j.cesx.2019.100034

M.A. Bucci , A. Di Stazio , C. Chauveau , G. Dayma , G. Legros , P. Dagaut , S. Chibbaro

引用次数: 8

Influence of gas fraction on wall-to-liquid heat transfer in dense bubbly flows 致密气泡流动中气体分数对壁液传热的影响

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-09-16 DOI: 10.1016/j.cesx.2019.100037

A. Panda, Y.E.J. Weitkamp, A.H. Rajkotwala, E.A.J.F. Peters, M.W. Baltussen, J.A.M. Kuipers

引用次数: 7

Dynamics and modelling of bubble formation in asymmetric parallel microchannels 不对称平行微通道中气泡形成的动力学与建模

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-09-12 DOI: 10.1016/j.cesx.2019.100039

Qiuying Shen , Chong Zhang , Cong Duan, Sheng Mi, Chunying Zhu, Taotao Fu, Youguang Ma

引用次数: 6

Direct numerical simulations of water flooding process through digitized porous rocks 数字化多孔岩石水驱过程的直接数值模拟

Chemical Engineering Science: X Pub Date : 2019-11-01 Epub Date: 2019-10-09 DOI: 10.1016/j.cesx.2019.100041

H.V. Patel , S. Das , J.A.M. Kuipers , E.A.J.F. Peters

引用次数: 3

A new mathematical model for nucleation of spherical agglomerates by the immersion mechanism 浸没机制下球形团聚体成核的新数学模型

Chemical Engineering Science: X Pub Date : 2019-10-01 DOI: 10.1016/j.ces.2019.115258

O. Arjmandi-Tash, J. D. Tew, K. Pitt, Rachel M. Smith, J. Litster

引用次数: 6