Archives of Clinical Trials最新文献

{"title":"The efficacy of pulsed radiofrequency stimulation of the glenohumeral joint and suprascapular nerve for chronic shoulder pain and function compared to physiotherapy and exercise program without pain management","authors":"Aet Ristmägi, Olli Jauhiainen, Sanna Suominen, H. Heikkilä","doi":"10.33425/2768-4598.1008","DOIUrl":"https://doi.org/10.33425/2768-4598.1008","url":null,"abstract":"Background: Degenerative tendon diseases are primarily treated conservatively in primary health care and the most important treatment modality is physiotherapy-guided therapeutic rehabilitation. Method: In this prospective observational study, we investigated the effect of two different treatment approaches in patients with chronic shoulder pain. Physiotherapy-guided treatment was compared to interventional pain treatment with radiofrequency nerve stimulation (pRF) before exercise therapy. The primary outcomes were active shoulder mobility and shoulder function assessed by SPADI questionnaire at two and 6-month controls. Results: The results of this study show that pRF treatment combined to physiotherapy seem to effect shoulder function more than physiotherapy alone. With regard to patients with chronic pain and decreased shoulder mobility (65%), pRF treatment showed a significant greater effect in relieving pain and increasing functional outcome assessed by SPADI. Also short-term pain and impairment reduction for 8-12 weeks occurred in patients with chronic rotator cuff lesions. A direct comparison between the rehabilitation programs strengthened the assumption that effective pain management could be necessary to obtain optimal effect of physiotherapy and physical training in patients with chronic (> 3 months) shoulder pain. Conclusion: PRF can be performed in an outpatient department and provides the clinician with an alternative or additional approach to oral drug treatment and intra-articular injection. Further, it may prove to be a useful treatment for patients who are unfit or unwilling to consider surgical intervention Level of evidence: IV.","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133151819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma gangrenosum: mis-diagnosed as necrotizing fasciitis and review of local experience in patients’ characteristics, associated disease and therapy","authors":"C. S. Wong, Martin MH Chung,, Johann Lok, Nigel Trendell Smith, M. W. Chan, Adrian KC Cheng, Yuk-Ming Lau, C. Yeung, H. Chan","doi":"10.33425/2768-4598.1005","DOIUrl":"https://doi.org/10.33425/2768-4598.1005","url":null,"abstract":"","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128739961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health issues in Pakistan and COVID-19 pandemic","authors":"J. Shirazi, Anam Sharmeen","doi":"10.33425/2768-4598.1003","DOIUrl":"https://doi.org/10.33425/2768-4598.1003","url":null,"abstract":"","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117169381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Step towards COVID-19 Inactivated Vaccine Development in Egypt","authors":"M. Saad, A. Saleh, Islam Ryan, M. Amin, M. S. Saleh, Tayseer Abdulaal, Wael A. Hassan, M. Samir, A. Raouf, A. Khattab, N. Fahmy, Mohamed I Shindy, S. Abdelgayed, M. Seadawy, A. Zekri, Hossam M Fahmy,, Khaled Amer","doi":"10.33425/2768-4598.1001","DOIUrl":"https://doi.org/10.33425/2768-4598.1001","url":null,"abstract":"The current worldwide COVID-19 pandemic is causing severe human health problems, with high mortality rates and huge economic burdens requiring the urgent development of a safe and effective vaccine. Here, preclinical evaluation of an inactivated SARS-CoV-2 vaccine candidate (EgySerVac-20) is reported. Oropharyngeal swabs and nasopharyngeal aspirates obtained from Egyptian patients with laboratory-confirmed SARS-CoV-2 infection were isolated using Vero cells and were then genetically characterized. Vaccine inactivation was performed using diluted formaldehyde, followed by safety testing for the inactivated vaccine. To determine the high humoral immune responses against SARSCOV-2 infection, the safety and capacity of the vaccine prepared with alum adjuvant were tested. The immunogenicity and efficacy of the vaccine candidate was tested in vitro by a neutralization assay and in vivo using mouse models. Our results revealed a cytopathic effect which was observed 48 hours post infection and the viral particles were identified by rRT-PCR as SARS-CoV-2. Propagation of the isolated virus in ten serial passages on the Vero cells yielded a virus titer 7.5 log10 TCID50/ml. Complete inactivation of SARS-CoV-2 was observed at 37°C in 24 hours post treatment by diluted formaldehyde. Inactivated SARS-CoV-2 infected fluid safety was determined by absence of cytopathic effect by repeated passage in Vero cell line, indicating loss of virus infectivity. Virus inactivated by diluted formaldehyde showed no deaths or clinical symptoms in mice groups post intraperitoneal inoculation (0.5ml/mouse). EgySerVac-20 inactivated vaccine has safely induced high levels of neutralizing antibodies titers in mice, where 0.1 ml immunization dose showed protective efficacy against SARS-CoV-2 challenge in mice. This finding will support the future preclinical and clinical trials evaluation for our SARS-CoV-2 vaccine candidate in primates and human, respectively.","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128021583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Carbetocin with Ergometrine for the prevention of postpartum hemorrhage","authors":"C. Koliafas","doi":"10.33425/2768-4598.1004","DOIUrl":"https://doi.org/10.33425/2768-4598.1004","url":null,"abstract":"","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134498375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}