Archives of Clinical Trials最新文献

Risk of ovarian hyperstimulation syndrome in infertile patients with PCOS treated by HP HMG HP - HMG治疗不孕PCOS患者卵巢过度刺激综合征的风险

Archives of Clinical Trials Pub Date : 2022-12-31 DOI: 10.33425/2768-4598.1028

Manar Tareq Mohammed, Hamza Elmahaishi,, Narges R Ben Halim, M. Elmahaishi

{"title":"Risk of ovarian hyperstimulation syndrome in infertile patients with PCOS treated by HP HMG","authors":"Manar Tareq Mohammed, Hamza Elmahaishi,, Narges R Ben Halim, M. Elmahaishi","doi":"10.33425/2768-4598.1028","DOIUrl":"https://doi.org/10.33425/2768-4598.1028","url":null,"abstract":"Polycystic ovarian syndrome (PCOS) is the commonest endocrinopathy affecting women in reproductive age group. The prevalence may vary from 8.7% to 17% depending on clinical criteria used. PCOS in women having IVF presents multiple challenges ranging from a poor to an exaggerated response, poor fertilization, poor blastocyst conversion and ovarian hyperstimulation syndrome (OHSS). OHSS is at increased risk in PCOS patients receiving fertility treatments varying from mild to severe cases which can be life threatening. Aim of the study: The presence of OHSS in infertile PCOS patients who followed non-pituitary down regulation protocol by using HP HMG injections. Materials and methods: The study type was case series study. It was done in Lamis IVF center - Misurata / Libya during the period 1- 9 -2021 to 31- 8 -2022. 118 infertile patients with PCOS were randomly selected for the study. All patients were selected started ovulation induction with non-pituitary down regulation protocol using highly purified HMG injections. Results: The age of the patients ranges between 18 and 45 years with a mean age of 30 years. The mean number of retrieved oocytes was 19.33 ± 10. The study also showed that the mean number of mature oocytes picked up was 9.41 ± 5.5 with mean success of 77.6%. Hyperstimulation syndrome was reported only in one case (prevalence of 0.8%) which was mild (needed no admission). Regarding the embryo, the mean number of transfers was 2.36 ± 0.6 with two cases showed no fertilization and 82 cases were associated with poor sperm. Conclusion: In our study OHSS in PCOS patients treated by highly purified HMG injections developed in only one case which was mild (needed no admission).","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127419251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Matryoshka code of COVID-19 mRNA vaccines: overlapping viral sequences? COVID-19 mRNA疫苗的套列码:病毒序列重叠?

Archives of Clinical Trials Pub Date : 2022-12-31 DOI: 10.33425/2768-4598.1027

A. Sfera, S. Hazan, Dan O. Sfera, Z. Kozlakidis

引用次数: 0

Clinical Diagnosis of Pleuroparenchymal Fibroelastosis 胸膜实质纤维弹性病的临床诊断

Archives of Clinical Trials Pub Date : 2022-12-31 DOI: 10.33425/2768-4598.1026

C. Tetikkurt

{"title":"Clinical Diagnosis of Pleuroparenchymal Fibroelastosis","authors":"C. Tetikkurt","doi":"10.33425/2768-4598.1026","DOIUrl":"https://doi.org/10.33425/2768-4598.1026","url":null,"abstract":"Pleuroparenchymal fibroelastosis (PPFE) is an extremely rare interstitial lung disease (ILD) characterised by fibroelastotic changes predominating in the subpleural lung parenchyma with visceral pleural fibrosis involving the upper lobes. It has distinctive clinical, radiological, and pathological manifestations. Diagnosis constitutes literally a stalemate because of its rarity, unavailability of an agreed diagnostic consensus, and requirement of tissue biopsy for an accurate final diagnosis that can not be performed in most of the patients owing to the comorbid complications of the disease itself. Identification of PPFE may also pose great difficulties due to the coexistence of other interstitial lung diseases. PPFE usually exhibits a persistently deteriorating prognostic course culminating in fatal complications including respiratory failure, pulmonary hypertension, cor pulmonale, or pneumothorax. Presence of disease relevant complications frequently preclude invasive tissue biopsy interventions in these patients leading to a diagnostic challenge for clinicians. This review aims to provide a definitive diagnosis based on entirely the clinical manifestatins of PPFE by shedding light on the pathogenesis, clinical, and radiologic findings of the disease. Histopathological tissue evaluation was also included in the diagnostic approach for patients whose condition was suitable for an invasive biopsy intervention. With this review, it is concluded that an approach consisting of exclusively clinical manifestations will ensure adequate support for an accurate PPFE diagnosis without any requirement for histopathological tissue examination.","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122827899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis Of Inflammatory Bowel Disease in Mildly Elevated Faecal Calprotectin: Observation From A Clinical Audit In District Hospital In The UK 轻度升高的粪钙卫蛋白对炎性肠病的诊断:来自英国地区医院临床审计的观察

Archives of Clinical Trials Pub Date : 2022-11-30 DOI: 10.33425/2768-4598.1023

Shamnad Shakeer

引用次数: 0

Total Wrist Replacement: State of the Art, Challenges and Pitfalls: A Comparative Review 全腕部置换术:现状、挑战和缺陷:比较回顾

Archives of Clinical Trials Pub Date : 2022-11-30 DOI: 10.33425/2768-4598.1024

I. Schmidt

{"title":"Total Wrist Replacement: State of the Art, Challenges and Pitfalls: A Comparative Review","authors":"I. Schmidt","doi":"10.33425/2768-4598.1024","DOIUrl":"https://doi.org/10.33425/2768-4598.1024","url":null,"abstract":"Background Total wrist replacement (TWR) as motion-preserving procedure continues to be critically discussed in the literature, although the complication rates have been significantly reduced with the current 3rd generation designs compared with older types. Possible reasons for this are often also a lack of knowledge about the currently available evidence, the complication management, and the lack of practical experience by the surgeons. Methods Based on an extended review of literature and own experience, the aim of this article is to give practicable insights for the clinician on: (1) biomechanical fundamentals, (2) differences in design, survivorship and functional outcome between the recent types, (3) possible pitfalls, and (4) failures and salvage options. Results The goal of TWR is that the overall wrist motion is maintained respectively improved despite it works with a locked midcarpal joint. Regarding survivorship and functional outcome the Maestro is (was) being superior over all other types that is (was) based on features in design. There is no scientific evidence as to why the Maestro was withdrawn from the marketplace by the company. For assessment of instability and/or impingement the use of dynamic radiographs is recommended. The problem of TWR is unchanged failure of the carpal components primarily based on mechanical dysbalance, and secondarily followed by metal and/or polyethylene wear, but surgical revision of asyptomatic periprosthetic osteolysis without safe radiagraphic signs of loosening is only required in not more than 20% of cases. For a failed TWR, revision TWR or conversion to total wrist arthrodesis are viable salvage options. Conclusions The knowledge about recent evidence and features in design of the available types, exact assessment of radiographic findings, presence of technical skills by the surgeons, and observance of the patient's expectations are the basic requirements for a successful TWR.","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127585881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segmental muscle innervation as a basic anatomophysiological knowledge for diagnostic procedure of neuromuscular disorders and thus, a way for accurate EMG diagnosis of single root injury. Retrospective study in patients with radicular symptoms 节段性肌肉神经支配是神经肌肉疾病诊断的基本解剖生理学知识，是准确诊断单根损伤的一种方法。根状症状患者的回顾性研究

Archives of Clinical Trials Pub Date : 2022-11-30 DOI: 10.33425/2768-4598.1021

Olga Kwast-Rabben, H. Heikkilä, M. Fagerlund, E. Nordh

{"title":"Segmental muscle innervation as a basic anatomophysiological knowledge for diagnostic procedure of neuromuscular disorders and thus, a way for accurate EMG diagnosis of single root injury. Retrospective study in patients with radicular symptoms","authors":"Olga Kwast-Rabben, H. Heikkilä, M. Fagerlund, E. Nordh","doi":"10.33425/2768-4598.1021","DOIUrl":"https://doi.org/10.33425/2768-4598.1021","url":null,"abstract":"Background: An accurate identification of the injured nerve roots by EMG in patients with symptomatic CSD requires that the examined muscles are innervated by a single nerve root. In the present retrospective study, the authors address the question of whether such innervation of chosen muscles in the upper extremity can be identified. Methods: Scored EMG results of chosen muscles with the hypothesized innervation by C6, C7 or C8 nerve roots, collected from 42 patients, were compiled as single EMG variables and compared with the respective MRI data, possibly responsible for injury of those roots, using Spearman’s rho (SRC) analysis. Subsequently, each EMG variable was adopted as specific diagnostic method for single root injury and tested for its specificity and then sensitivity in relation to the data of the highest ranked MRI, used as a ‘gold standard method’ Results: SRC results showed positive rank correlation, with the highest p-values, between EMG and the respective MRI variables, in 64 included extremities. Consequently, the assumed EMG-C6, -C7 and -C8 methods showed a high specificity (97% - 100%) against the respective highest ranked MRI. The relative sensitivity of the EMG methods calculated in this way were 38% for the C6-root, 87% for the C7 and 50% for the C8. Conclusions: The results corroborate the presumed innervation of the chosens muscles by single C6, C7, or C8 nerve root, thus allowing the use of needle EMG examination of those muscles for accurate identification of injured single nerve roots in patients with symptomatic CSD.","PeriodicalId":371381,"journal":{"name":"Archives of Clinical Trials","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122168615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of zolpidem administration on postoperative pain in patients after total knee arthroplasty: Study protocol for a randomized controlled trial 唑吡坦对全膝关节置换术后疼痛的影响:一项随机对照试验的研究方案

Archives of Clinical Trials Pub Date : 2022-08-30 DOI: 10.33425/2768-4598.1020

Takeo Mammoto, N. Taguchi, Shunji Takei, Y. Imoo, Enbo Ma

引用次数: 0

COVID-19 mRNA vaccines and pathological cell-cell fusion: an unintended consequence COVID-19 mRNA疫苗和病理性细胞-细胞融合:意外后果

Archives of Clinical Trials Pub Date : 2022-08-30 DOI: 10.33425/2768-4598.1019

A. Sfera, Karina G. Thomas, Dan O. Sfera, Jonathan J. Anton, Christina V. Andronescu, Nyla Jafri, Sarvin Sasannia, Z. Kozlakidis

引用次数: 0

Huangqi-Guizhi-Wuwu Decoction in the Treatment of Diabetic Nephropathy (CKD2-4): A Study Protocol for a Prospective, Open, Multicenter and Controlled Trail 黄芪桂枝五物汤治疗糖尿病肾病(CKD2-4):一项前瞻性、开放、多中心、对照的研究方案

Archives of Clinical Trials Pub Date : 2022-08-30 DOI: 10.33425/2768-4598.1017

Lu Liu, Yulong Xue, Yangyang Zhao, Jian Xie, Q. Guan, Yue Zhou, Jing-Chun Pan, Chang-Chuan Bai, Da-Peng Wang

引用次数: 0

Reversible Acute Onset Coma Following Iodinated Contrast Agent During Carotid Angioplasty And Stenting: Unusual Case Report 颈动脉成形术和支架置入术中使用碘造影剂后可逆性急性发作昏迷:罕见病例报告

Archives of Clinical Trials Pub Date : 2022-08-30 DOI: 10.33425/2768-4598.1016

R. Galimi, Miriam Galimi

引用次数: 0