Journal of Rangpur Medical College最新文献

{"title":"Study of Serum Lipid Profile and Aminotransferases (ALT and AST) in Non-obese, Non-diabetic Nonalcoholic Fatty Liver Disease","authors":"Asm Mazedul Islam, M. Muttalib, Md Nazrul Islam, M. Haque, Mohammad Rafiqul Hoque, -. Maknunnahar","doi":"10.3329/jrpmc.v7i2.62643","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62643","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver diseases characterized by simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is the most common cause of cryptogenic cirrhosis. NAFLD is associated with obesity, insulin resistance, hypertension, type 2 diabetes mellitus, and dyslipidemia. \u0000Objective: The study aimed to assess the changes in lipid profile and aminotransferases (ALT and AST) in Non-alcoholic fatty liver disease (NAFLD). \u0000Methods: This observational cross-sectional study was carried out in the department of Biochemistry, Mymensingh Medical College in cooperation with the Centre for Nuclear Medicine and Ultrasound, Mymensingh from January 2012 to June 2013 after the approval of the protocol. A total of 120 subjects were included through purposive sampling, among them, 60 subjects were with fatty liver disease (group-I) and another 60 were without fatty liver (group-II) with ultrasonography. The sampling method was purposive (non-random). Relevant laboratory investigations were performed by using established methods to achieve the objectives. \u0000Results: The majority of the subjects with NAFLD (33.33%) were in 51-60 years (in Group-I). Mean serum total cholesterol, triacylglycerol, LDL-cholesterol, and HDL-cholesterol were 203.33±21.83, 184.41±33.31, 126.28±18.75, and 40.17±6.32 mg/dl in group-I and 167.65±9.83, 128.77±11.65, 101.74±9.29 and 40.16±3.55 mg/dl in group-II respectively. Significant differences were found in the case of total cholesterol (p<0.001), triacylglycerol (p<0.001), and LDL-cholesterol (<0.001), but no significant difference was found in the case of HDL-cholesterol (p>0.05). Serum ALT and AST were 49.43±16.98, 45.20±13.56 U/L in group-I and 32.83±4.54, 28.68±4.31 U/L in the group- II respectively. Significant differences were found in case of ALT (p <0.001) and AST (p <0.001). \u0000Conclusion: Nonalcoholic fatty liver disease is associated with dyslipidemia and with the elevation of serum ALT and AST. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:35-39","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132538669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ramadan Risk Stratification by International Diabetes Federation and Diabetes & Ramadan International Alliance (IDF-DAR) Risk Calculator in Bangladeshi People with Diabetes Mellitus who wished to Fast in 2022","authors":"Md Shahed Morshed, Md. Firoj Hossain, M. A. Hannan, Md Ahamedul Kabir, Mobarak Hosen, Satyajit Mallick, M. J. Alam, Mohammad Nurul Amin, M. Faruque, S. Rahman","doi":"10.3329/jrpmc.v7i2.62638","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62638","url":null,"abstract":"Background: Risk stratification is an essential and first component of the pre-Ramadan assessment of patients with diabetes mellitus (DM) who wish to fast. Limited data are reported from Bangladesh regarding risk stratification of people with DM who wish to fast. \u0000Objective: To determine the risk status of people with DM who wish to fast during Ramadan. \u0000Methods: This cross-sectional observational study was done among Muslim people of DM with at least one year of experience of Ramadan in previous years after their diagnosis. Along with baseline characteristics, the individual 14 risk elements of the International Diabetes Federation and Diabetes & Ramadan International Alliance (IDF-DAR) risk calculator- 2021 were assessed. Patients were categorized into low, moderate, and high risk with a total score of 0-3, 3.5-6, and ≥6.5 respectively. Moderate and high-risk patients were counseled about their risk of fasting and requested to reconsider their wishes. \u0000Results: Among 569 participants, (mean age 50.97±12.02 years, male-female ratio 36.2:63.8) 37.8%, 38.8%, and 23.4% had high, moderate, and low risk respectively. Risk scores were significantly higher in older age (p<0.001), male sex (p=0.024), residence in Chattagram than Rajshahi division (p=0.009) as well as housewife and businessman than other occupations (p=0.012). Despite knowing the risks of fasting, 88.8% of people with high risk and 96.8% of people with moderate risks still wished to fast. The people who still wished to fast despite knowing their risks of fasting had significantly lower percent of macrovascular disease (p=0.039), lower creatinine levels (p<0.001), with a lower percent of dipstick proteinuria (p=0.010), and use of insulin (p=0.021) than those who changed their decision. \u0000Conclusions: Nearly 90% of persons with DM with moderate/high risk for fasting still wished to fast despite their exemption. These at-risk population needs guidance, monitoring, and follow-up for safe fasting. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:4-11","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114255213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melioidosis: A Case Report of Confirmed Burkholderia Pseudomallei in Rangpur Medical College Hospital, Rangpur","authors":"Md Helal Miah, Tania Begum, Md Shafiul Alam, A. Mondol, Md Mahfuj Ul Anwar","doi":"10.3329/jrpmc.v7i2.62649","DOIUrl":"https://doi.org/10.3329/jrpmc.v7i2.62649","url":null,"abstract":"Bangladesh is an example of a highly populous, agricultural country where melioidosis may be a significantly underdiagnosed cause of infection and death. Melioidosis is caused by a highly pathogenic, soil-borne, Gram-negative bacterium, Burkholderia pseudomallei. Diabetes mellitus is the most common risk factor. Disease manifestations vary from pneumonia or localized abscess to acute septicemia or arthritis. Culture is considered the current gold- standard for diagnosis. For the intensive phase (10 to 14 days), ceftazidime or meropenem is the drug of choice. For the eradication phase (3 to 6 months), oral trimethoprim/ sulfamethoxazole is the drug of choice. Surgery (drainage of abscess) has an important role in the management of melioidosis. A 48-year-old male, health worker of an NGO, working at Cox’s Bazar presented with fever for 1 month and gradual increasing pain and swelling of the left knee for 7 days followed by cellulitis and multiple abscess formation in the left leg. B. pseudomallei isolated from blood culture and successfully treated with meropenem. \u0000J Rang Med Col. September 2022; Vol. 7, No. 2:69-72","PeriodicalId":370900,"journal":{"name":"Journal of Rangpur Medical College","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116237780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}