Medical hypothesis, discovery & innovation in optometry最新文献

{"title":"Effects of mitomycin-C on tear film function following photorefractive keratectomy for mild-to-moderate myopia","authors":"K. Shahraki, Sadegh Saeidi, Paria Ghasemi Boroumand, K. Shahraki","doi":"10.51329//mehdioptometry140","DOIUrl":"https://doi.org/10.51329//mehdioptometry140","url":null,"abstract":"Background: Mitomycin C (MMC) is used to prevent corneal opacity after photorefractive keratectomy (PRK). This study sought to determine the effect of MMC on tear film function after PRK in eyes with mild-to-moderate myopia.Methods: This prospective, contralateral eye comparison was conducted on 30 eyes of 15 patients with low-to-moderate myopia referred to Alzahra Eye Hospital, Zahedan, Iran. The eyes of the control group underwent PRK with a balanced salt solution, while the fellow eyes in the intervention group underwent PRK with 0.02% MMC for 25 s. The tear breakup time test (TBUT) and basic Schirmer test results of eyes in the control and intervention groups were compared at baseline and 1, 3, and 6 months postoperatively. Tear osmolarity was recorded and compared at baseline and 3 months postoperatively. Results: The mean ± standard deviation (SD) age of participants was 27.53 ± 7.04 years. No statistically significant differences were observed in the means ± SDs for tear osmolarity, TBUT, and basic Schirmer test values (all P > 0.05) between MMC-treated eyes and untreated fellow eyes at baseline and during postoperative follow-up. The means ± SDs for tear osmolarity, TBUT, and basic Schirmer test results were comparable in both groups between the baseline and postoperative follow-ups (all P > 0.05). Conclusions: Single application of a standard dose of MMC (0.02%) for 25 s in PRK did not change tear stability, tear production, or variation in tear dynamics up to 6 months postoperatively in eyes with low-to-moderate myopia. Future longitudinal studies with a longer follow-up and a larger sample size are warranted to confirm our findings.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery & innovation in optometry","volume":"118 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131776629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urban inequality: a hypothetic risk factor for myopia","authors":"A. Nouraeinejad","doi":"10.51329/mehdioptometry139","DOIUrl":"https://doi.org/10.51329/mehdioptometry139","url":null,"abstract":"Background: Myopia is a common refractive error with an expected increase in prevalence. Inequalities in access to ocular health care for sight-threatening or life-threatening ocular diseases have been described. Urbanization is a risk factor for both the incidence and progression of myopia; however, socioeconomic inequalities in urban settings are a new concept in myopia incidence.Hypothesis: Considering the proven impact of inequalities existing in general and ocular health, urban inequality could be a new risk factor for both the incidence and progression of myopia. Inequalities in urban infrastructure vary between countries; however, there are currently various manifestations of urban inequality, and scholars are concerned about intra-urban inequality as a public health risk. Considering the significant influence of urban inequality on health of children, and because myopia develops and progresses faster during childhood, the effect of urban inequality on myopia must be examined. Although urban inequality could be a putative risk factor for myopia, a causal relationship should be investigated. However, myopia is multifactorial in etiology, originating from the interaction of environmental and genetic factors. Thus, causality between urban inequality and myopia should be investigated through a randomized, controlled trial with strict matching of genetic backgrounds and environmental factors. Conclusions: Several risk factors for myopia have been proposed, and studies have confirmed causal relationships with most of these factors. Considering the proven impact of urban inequality on both general and ocular health, experimental studies are necessary to confirm the possible causal relationship between urban inequality and myopia. Certainly, there will be substantial challenges in the implementation phase.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery & innovation in optometry","volume":"326 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127261571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue light-blocking efficiency of blue light-blocking and driving spectacle lenses","authors":"Bon-Yeop Koo, Myoung-Hee Lee","doi":"10.51329/mehdioptometry136","DOIUrl":"https://doi.org/10.51329/mehdioptometry136","url":null,"abstract":"Background: Retinal damage caused by blue light can result in glare, decreased visual acuity, and accelerated macular degeneration. In clinical practice, blue light-blocking glasses, such as driving glasses, are used to block blue light effectively. This study was aimed at measuring light transmittance to analyze the blue light-blocking efficiencies of blue light-blocking and driving spectacle lenses manufactured with tinting, coating, and only materials and at distinguishing the difference between the two spectacle lenses. \u0000  \u0000Methods: Blue light-blocking and driving spectacle lenses used to measure light transmittance were manufactured with tinting (blue light blocking lenses by tinting or “BTL” and driving spectacle lenses by tinting or “DTL,” respectively), coating (blue light blocking lenses by coating or “BCL” and driving spectacle lenses by coating or “DCL,” respectively), and only materials (blue light blocking lenses by material or “BML” and driving spectacle lenses by material or “DML,” respectively). \u0000  \u0000Results: Compared to BTL, DTL had a significantly greater decrease in the light transmission efficiency for visible and blue lights (P < 0.05). The blue light hazard function was lower for BML and DML than for conventional coating lenses in both visible and blue lights, although without significant differences between visible and blue lights (P > 0.05). \u0000  \u0000Conclusions: The blue light-blocking spectacle lenses had the highest blue light-blocking efficiency when manufactured with tinting, coating, and only materials, in order. With DML, the blue light-blocking efficiency was lower compared to DTL but higher compared to DCL. Therefore, DML could provide a balanced glare control and clear retinal image overall.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132765372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcomes after management of bilateral cataract and retinal detachment in atopic dermatitis","authors":"Sofia Noreen, Konstantinos Katsikatsos, Alia Z. Al-Mousawi, D. Kalogeropoulos, Ash Sharma, K. Lett, A. Mitra, S. Ch'ng","doi":"10.51329/mehdioptometry133","DOIUrl":"https://doi.org/10.51329/mehdioptometry133","url":null,"abstract":"Background: Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disorder of childhood with a broad spectrum of ocular manifestations, including keratoconjunctivitis, keratoconus, cataract, and rhegmatogenous retinal detachment (RRD). This study was aimed at reporting the visual outcomes in patients with bilateral cataract and RRD in the context of AD. \u0000Methods: This was a retrospective, observational case series. A thorough history, clinical features, and surgical management of seven consecutive patients who presented to the Birmingham and Midland Eye Centre with bilateral cataract and RRD secondary to severe AD were investigated. \u0000Results: Fourteen eyes of seven patients with AD were analyzed. Twelve of the 14 eyes had cataract (85.7%). Seven patients had anterior or posterior subcapsular cataract (58.3%); 13 of the 14 eyes had RRD (92.8%). Most cases were bilateral or simultaneous (85.7% and 71.4%, respectively). Eight eyes had involvement of the temporal quadrant (61.5%): three eyes had giant retinal tears (23%) and five eyes with proliferative vitreoretinopathy (38.5%). Three eyes underwent scleral buckle surgery with or without cryotherapy (21.4%), and eight eyes had PPV (57.1%) combined with other procedures. Two eyes (15.4%) had persistent RRD postoperatively. The latest recorded postoperative best-corrected distance visual acuity was 6/36 or better in 10 (71.4%) eyes. \u0000Conclusions: Temporal RRD was commonly observed in retinal detachment secondary to AD. Surgical repair was often challenging because of proliferative vitreoretinopathy and significant cataract. A further multidisciplinary study involving dermatologists would be helpful in identifying a larger high-risk population for AD and earlier detection of asymptomatic retinal tears or holes, which would allow preventive treatment and limit sight-threatening complications.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121060499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causative link between coronavirus disease vaccination and central serous chorioretinopathy: reality or illusion?","authors":"A/Prof. Fatemeh Heidary MD, MPH, FAAO, FICO, Reza Gharebaghi MD MPH FAAO PhDc","doi":"10.51329/mehdioptometry135","DOIUrl":"https://doi.org/10.51329/mehdioptometry135","url":null,"abstract":"Background: Most COVID-19 vaccines were authorized for emergency use. Despite a large number of vaccines that have been administered, adverse ocular effects have been reported. This paper summarized the reports about central serous chorioretinopathy (CSCR) following coronavirus disease vaccination. \u0000Methods: In this short communication, we have included relevant publications about CSCR after coronavirus disease vaccination from the beginning of the pandemic until January 2022. \u0000Results: The CSCR occurrence after vaccination has been reported for many years. However, a few studies are available about CSCR after coronavirus disease vaccination. Most cases revealed the development of CSCR within one week of vaccination that subsequently resolved. \u0000Conclusions: The timeline of the CSCR diagnosis developing a few days after vaccination suggests a causative link. However, in view of the millions of administered doses of vaccines along with boosters, the causative link between CSCR and vaccines remains uncertain. Additional studies are needed to confirm a causal claim.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124451297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-coated contact lens-based ophthalmic drug delivery system to manage Acanthamoeba keratitis: a preliminary hypothesis","authors":"M. Sadeghi, P. Tajzadeh, S. Zarei‐Ghanavati, M. Arefnezhad","doi":"10.51329/mehdioptometry134","DOIUrl":"https://doi.org/10.51329/mehdioptometry134","url":null,"abstract":"Background: Acanthamoeba species can cause devastating contact lens (CL)-related microbial keratitis. Its culture is less sensitive, and little evidence is available for the safety or efficacy profile of medications. Therefore, early diagnosis and optimal treatment remain difficult. The aim of this study was to present the hypothesis that a novel chitosan-coated CL-based ophthalmic drug delivery system has therapeutic and prophylactic effects on acanthamoeba keratitis. \u0000Hypothesis: CL-based drug delivery is a popular sustained-release drug delivery that extends the drug release time, thus increasing its bioavailability and treatment efficacy. Chitosan, a derivative of chitin, has antioxidant and broad-spectrum antimicrobial properties against fungi, yeasts, and bacteria. It acts against microbial cells; however, whether its mechanism of action is microbiostatic or microbicidal remains unknown. It exhibits wound healing and film-forming properties. Chitosan composite films permit high transmittance of visible light, making it transparent and therefore desirable for the development of CLs. Chitosan/Ag/ZnO blend films exhibit antimicrobial activities. Further, soft CLs coated with chitosan, sodium hyaluronate, polylysine hydrobromide, and sodium alginate show drug delivery properties and reduced bacterial growth. Recently, concentration-dependent anti-amoebic activities of chitosan and nano-chitosan against the trophozoite and cystic forms of Acanthamoeba have been reported. Based on the existing evidence, we hypothesized that a chitosan-coated CL-based ophthalmic drug delivery system could have therapeutic and prophylactic effects on acanthamoeba keratitis or subsequent endophthalmitis. \u0000Conclusions:  CLs or intraocular implants with chitosan-based nanocoatings alone or in combination with routine treatment may be preventive or therapeutic for acanthamoeba keratitis or endophthalmitis. Experimental studies and further clinical trials are required to explore the efficacy and safety profile. Moreover, randomized controlled trials in healthy eyes with soft or hard CLs or orthokeratology lenses for refractive error correction may shed light on the prophylactic effect of this novel drug delivery system. Other forms of ophthalmic drug delivery systems using chitosan-based nanocoatings should be studied additionally.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134459494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binocular vision parameters in chronic heavy alcoholics: Short-term outcomes of alcohol detoxification","authors":"K. Nagaraj, V. Kamath, Aditya Goyal","doi":"10.51329/mehdioptometry131","DOIUrl":"https://doi.org/10.51329/mehdioptometry131","url":null,"abstract":"Background: Alcohol consumption is rising in developing countries such as India, and alcohol addiction has systemic and ocular impacts. This study aimed to investigate the binocular functions of chronic heavy alcoholics before and after alcohol detoxification. \u0000Methods: A prospective before–after study was designed and conducted at Treda De-Addiction Centre, Bengaluru, India. Males in the age range of 30–40 years who had been alcohol addicts for more than six years and met the inclusion criteria were recruited. We performed a routine optometric examination followed by detailed binocular vision assessment, including accommodative, vergence, and oculomotor tests on the first day of rehabilitation and one month after initiation of rehabilitation. \u0000Results: Twenty-five males with of the age (mean ± standard deviation [SD]) 36.24 ± 4.33 years were evaluated. The pre- and post-detoxification mean ± SD of the monocular (right eye: 5.98 ± 3.50, 6.60 ± 3.49; left eye: 6.18 ± 3.69, 7.10 ± 3.78) and binocular accommodative facility (7.10 ± 3.93, 7.40 ± 4.51) did not change significantly (all P > 0.05). Eighteen (72%) of the participants had non-strabismic binocular vision anomalies (NSBVA), among whom the accommodative infacility and convergence insufficiency were higher in frequency and remained constant after alcohol detoxification. Furthermore, the binocular vision parameters showed no statistically significant difference between the pre- and post-detoxification values (all P > 0.05). \u0000Conclusions: The binocular vision parameters did not change significantly after one month of alcohol detoxification in the chronic heavy drinkers. Most long-term alcoholics had NSBVA with no change after rehabilitation, indicating that short-term alcohol detoxification may not aid in the recovery of binocular parameters. However, further validation is required. Assessing the impact of vision therapy in addition to a longer period of abstinence can confirm or refute the persistence of observed effects of chronic alcohol consumption on binocular functions and NSBVA in this population.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115338237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual snow: a neuro-ophthalmic syndrome","authors":"Valeria Albano, S. Guerriero, G. Alessio","doi":"10.51329/mehdioptometry132","DOIUrl":"https://doi.org/10.51329/mehdioptometry132","url":null,"abstract":"Background: The visual snow syndrome (VSS) is a rare disease characterized by persistent positive visual phenomena that are enigmatic and may be underestimated. It manifests as the perception of tiny, simultaneous, diffuse, and mobile dots frequently throughout the visual field. Although it affects brain networks, ocular examination is also indicated. This paper was aimed to review recent studies on VSS to identify the best clinical approach. \u0000Methods: In this narrative review, PubMed/Medline, Directory of Open Access Journals, and Embase were searched using the following terms: “Visual snow”, “Persistent aura”, “Persistent positive visual phenomena”, “Visual aura”, “Migraine”, “TV static”, “Migraine aura status”, and “Visual disturbance”. We searched relevant publications from January 2014 to January 2021 to find the best clinical approach. \u0000Results: VSS may be reconstituted as a distinct entity, although the symptoms may be consistent with typical migraine visual aura. For approximately two-thirds of patients, symptoms worsen and reduce their ability for activities of daily living. It often causes psychogenic detriment of the patient and their capacity to function socially and vocationally. Comprehensive history-taking and ocular examination are required to rule out other causes. However, all ocular and radiological findings may be normal. \u0000Conclusions: VSS is a neuro-ophthalmic disorder characterized by continuous chronic and recurrent visual disturbances that involve the entire visual field and may respond to empiric antimigraine or anti-seizure treatments. It may reduce the ability for activities of daily living; therefore, proper diagnosis by eye care professionals is necessary to determine its diagnosis and management.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132134865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}