Causative link between coronavirus disease vaccination and central serous chorioretinopathy: reality or illusion?

Abstract

Background: Most COVID-19 vaccines were authorized for emergency use. Despite a large number of vaccines that have been administered, adverse ocular effects have been reported. This paper summarized the reports about central serous chorioretinopathy (CSCR) following coronavirus disease vaccination. Methods: In this short communication, we have included relevant publications about CSCR after coronavirus disease vaccination from the beginning of the pandemic until January 2022. Results: The CSCR occurrence after vaccination has been reported for many years. However, a few studies are available about CSCR after coronavirus disease vaccination. Most cases revealed the development of CSCR within one week of vaccination that subsequently resolved. Conclusions: The timeline of the CSCR diagnosis developing a few days after vaccination suggests a causative link. However, in view of the millions of administered doses of vaccines along with boosters, the causative link between CSCR and vaccines remains uncertain. Additional studies are needed to confirm a causal claim.